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12501. Integrative neuroscience. Full Text available with Trip Pro

Integrative neuroscience. A fundamental impediment to an "Integrative Neuroscience" is the sense that scientists building models at one particular scale often see that scale as the epicentre of all brain function. This fragmentation has begun to change in a very distinctive way. Multidisciplinary efforts have provided the impetus to break down the boundaries and encourage a freer exchange of information across disciplines and scales. Despite huge deficits of knowledge, sufficient facts about

2003 Neuropsychopharmacology

12502. Gene therapy for psychiatric disorders. Full Text available with Trip Pro

Gene therapy for psychiatric disorders. There has been tremendous progress in developing techniques for manipulating genetic material, and the birth of gene therapy as a discipline has been one consequence of this. Most considerations of gene therapy in the nervous system have focused on attempts to transfer novel genes in for the purpose of protecting neurons from neurological insults. In this review, the author considers the progress in that field and the possible application of related gene

2003 American Journal of Psychiatry

12503. Measuring risks and outcomes in substance use disorders prevention research. (Abstract)

to organize the domains considered here as examples, the multifactorial model of complex disorders with elaborations emphasized by the discipline of developmental psychopathology is applied. Risks reviewed include family history, childhood maltreatment, peer relationships, and psychopathology. The substance involvement dimensions germane as outcomes include substance type, consumption quantity and frequency, and substance-related problems. Comprehensive diachronic evaluation over critical developmental

2002 Journal of Consulting and Clinical Psychology

12504. Attitudes toward psychiatry among students entering medical school. (Abstract)

, as reported in the North American sample. In comparison with other disciplines, psychiatry was regarded as more interesting and intellectually challenging, but also as lacking a scientific foundation, not being enjoyable and failing to draw on training experiences.Our findings suggest that psychiatry has an image problem that is widespread, reflecting community perceptions and the specialist interests of medical students on recruitment. If psychiatry is to improve its 'attractiveness' as a career option

2003 Acta Psychiatrica Scandinavica

12505. Developing strategies for psychopharmacological studies in preschool children. (Abstract)

are needed.With preschoolers being increasingly treated with psychopharmacological agents, the need for investigations to address the safety and efficacy of these medications is becoming a central issue for researchers from many disciplines.

2003 Journal of the American Academy of Child and Adolescent Psychiatry

12506. Maternal panic disorder: infant temperament, neurophysiology, and parenting behaviors. (Abstract)

) than controls. PD mothers also displayed less sensitivity toward their infants and reported parenting behaviors concerning infant sleep and discipline that have been associated with child problems.While infants with PD mothers did not show early behavioral differences from controls, they did display neurophysiological divergences consistent with higher arousal/arousability. Such neurophysiological divergences (elevated salivary cortisol and disturbed sleep) might be important early indicators

2003 Journal of the American Academy of Child and Adolescent Psychiatry

12507. The ascidian tadpole larva: comparative molecular development and genomics. (Abstract)

The ascidian tadpole larva: comparative molecular development and genomics. Evolution is of interest not only to developmental biology but also to genetics and genomics. We are witnessing a new era in which evolution, development, genetics and genomics are merging to form a new discipline, a good example of which is the study of the origin and evolution of the chordates. Recent studies on the formation of the notochord and the dorsal neural tube in the increasingly famous Ciona intestinalis

2003 Nature Reviews. Genetics

12508. Evolutionary and ecological functional genomics. (Abstract)

Evolutionary and ecological functional genomics. A unique combination of disciplines is emerging--evolutionary and ecological functional genomics--which focuses on the genes that affect ecological success and evolutionary fitness in natural environments and populations. Already this approach has provided new insights that were not available from its disciplinary components in isolation. However, future advances will necessitate the re-engineering of scientific attitudes, training

2003 Nature Reviews. Genetics

12509. The ETHNIC(S) mnemonic: a clinical tool for ethnogeriatric education. (Abstract)

culturally appropriate geriatric care. ETHNIC(S) can serve as a clinically applicable tool for eliciting and negotiating cultural issues during healthcare encounters and as a new instructional strategy to be incorporated into ethnogeriatric curricula for all healthcare disciplines.

2002 Journal of the American Geriatrics Society

12510. Genetic disease in the 1960s: a structural revolution. (Abstract)

Genetic disease in the 1960s: a structural revolution. From about 1955 to about 1975, an explosion of new institutions, disciplines, databases, interventions, practices, techniques, and ideas turned technically driven human genetics from a medical backwater to an exotic and appealing medical research frontier. In the early 1960s, health care professionals were attracted to the new insights of cytogenetics, including the chromosomal explanation of Down syndrome and of other congenital defects

2002 American Journal of Medical Genetics

12511. Defects of blastogenesis. (Abstract)

pattern formation in all vertebrates, experimental animals indeed are a most valuable approach to an understanding of the causal and formal aspects of development and are beginning to forge essential, strong bonds between molecular biologists and clinicians in a mutually supportive discipline of developmental biology. However, to grieving parents of a stillborn fetus with, say, Pentalogy of Cantrell, sirenomelia or otocephaly, mouse data offer little comfort or reassurance about recurrence; thus

2002 American Journal of Medical Genetics

12512. Subspecialty certification in geriatric psychiatry. (Abstract)

, diplomates must sit for recertification every 10 years. Thus far, about 63% of the diplomates who have needed to do so have been recertified.It is estimated that 5,000 geriatric psychiatrists will be needed to meet future healthcare needs. Thus, the demand for this expertise will be increasing, and it is anticipated that board-certified geriatric psychiatrists will continue to play leading roles in educating practitioners from multiple disciplines.

2003 The American Journal of Geriatric Psychiatry

12513. Biogerontology research in Spain. (Abstract)

and scientific advances in other disciplines to the understanding the biology of ageing and the molecular basis of cellular senescence, that will benefit actual and future ageing population.

2003 Experimental Gerontology

12514. Barriers to and benefits of leisure time physical activity in the elderly: differences across cultures. (Abstract)

Network, a practice-based research network. Analytical variables included ethnicity, age, sex, income, education, marital status, and LTPA. Fisher exact test was used to analyze the 100 sedentary elders (LTPA <500 kcal/wk; 63 MAs and 37 EAs). Self-consciousness and lack of self-discipline, interest, company, enjoyment, and knowledge were found to be the predominant barriers to LTPA in both groups. Both groups held similar beliefs about benefits gained from exercise, such as improved self-esteem, mood

2003 Journal of the American Geriatrics Society

12515. Geriatric medicine fellowship programs: a national study from the Association of Directors of Geriatric Academic Programs' Longitudinal Study of Training and Practice in Geriatric Medicine. (Abstract)

. Of the 51 programs offering second-year fellowship training, PDs reported 61 post-first-year fellows (median 1, range: 0-7). During the past 10 years, 27 new allopathic geriatric medicine fellowship programs opened; there are now 119 programs. There are also seven osteopathic programs. The recruitment of high-quality U.S. medical school graduates into these programs remains a challenge for the discipline. Furthermore, the retention of first-year fellows for additional years of academic training has been

2003 Journal of the American Geriatrics Society

12516. Stress and aging: theoretical and empirical challenges for interdisciplinary research. (Abstract)

Stress and aging: theoretical and empirical challenges for interdisciplinary research. Research on stress is multifaceted and undertaken at many levels of analysis. Discipline differences in definition and measurement have contributed to divergent findings. Although there is general agreement that stress plays a role in aging, there is less consensus about the precise nature of the relationship and the mechanisms. Predictions about positive and negative relations between stress and aging depend

2003 Neurobiology of Aging

12517. Unraveling monogenic channelopathies and their implications for complex polygenic disease. Full Text available with Trip Pro

potential of excitable tissues. Although it remains true that diseases of excitable tissue still most clearly illustrate this family of disease, ion-channel disorders now cover the gamut of medical disciplines, causing significant pathology in virtually every organ system, producing a surprising range of often unanticipated symptoms, and providing valuable targets for pharmacological intervention. Many of the features shared among the monogenic ion-channel diseases provide a general framework

2003 American Journal of Human Genetics

12518. Paediatric sleep disorders: the need for multidisciplinary sleep clinics. (Abstract)

Paediatric sleep disorders: the need for multidisciplinary sleep clinics. The field of sleep disorders (SD) medicine crosses the boundaries of many medical specialties and disciplines. This paper aims to highlight the importance of a multidisciplinary approach to the assessment and treatment of SD in children, with particular reference to sleep-disordered breathing (SDB). The link between SDB and other SD (e.g. various parasomnias, sleep-related anxiety) illustrates the need for a holistic

2003 International Journal of Pediatric Otorhinolaryngology

12519. Concept mapping: a tool to bridge the disciplinary divide. (Abstract)

physiology and transformed it into a knowledge framework that builds capacity. The concept map highlights relationships between concepts and across disciplines, connecting the competencies to enable meaningful learning so that a learner can adapt their knowledge to multiple settings, incorporate new learning, and generate new knowledge to grow the interdisciplinary field of women's health. The on-line format allows access from multiple sites and courses, and allows the curricula to grow organically over

2002 American Journal of Obstetrics and Gynecology

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