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61. An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across Disciplines (PubMed)

An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across Disciplines The idea of synergistic interactions between drugs and chemicals has been an important issue in the biomedical world for over a century. As complex diseases, especially cancer, are being treated with various drug cocktails, understanding the interactions among these drugs is increasingly vital to ensuring successful treatment regimens. However, the idea of synergy is not limited to only (...) the biomedical realm and these ideas have developed across many different disciplines, as well. In this review, we first discuss the various terminology surrounding the idea of synergy, providing a comprehensive list of terms defined across numerous disciplines. We then review the most common methodology for detection and quantification of synergy, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence. We also discuss advantages

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2017 Frontiers in pharmacology

62. Exponentially Modified Peak Functions in Biomedical Sciences and Related Disciplines (PubMed)

Exponentially Modified Peak Functions in Biomedical Sciences and Related Disciplines In many cases relevant to biomedicine, a variable time, which features a certain distribution, is required for objects of interest to pass from an initial to an intermediate state, out of which they exit at random to a final state. In such cases, the distribution of variable times between exiting the initial and entering the final state must conform to the convolution of the first distribution and a negative

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2017 Computational and mathematical methods in medicine

63. Medical Informatics as Academic and Scientific Discipline in Bosnia and Herzegovina – Twenty Five Years of Experiences from Faculty of Medicine, University of Sarajevo (PubMed)

Medical Informatics as Academic and Scientific Discipline in Bosnia and Herzegovina – Twenty Five Years of Experiences from Faculty of Medicine, University of Sarajevo 28883670 2018 11 13 0353-8109 25 2 2017 Jun Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH Acta Inform Med Medical Informatics as Academic and Scientific Discipline in Bosnia and Herzegovina - Twenty Five Years of Experiences

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2017 Acta Informatica Medica

64. What is medicinal chemistry? – Demystifying a rapidly evolving discipline! (PubMed)

What is medicinal chemistry? – Demystifying a rapidly evolving discipline! Medicinal chemistry is a scientific discipline that has progressed rapidly over the last few decades. Facilitated by the technological advancement, the early understanding of medicinal chemistry as "synthesizing bioactive molecules" has become the connecting bridge of a variety of related scientific disciplines. This opinion article will guide you through a brief evolution of this discipline and discuss what medicinal

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2017 Medchemcomm

65. Perception of educational environment among undergraduate students of health disciplines in an Iranian university (PubMed)

Perception of educational environment among undergraduate students of health disciplines in an Iranian university This paper seeks to determine the perception of Medical, Nursing and Midwifery students about their educational environment and compare their perceptions in terms of disciplines, demographic attributes and academic level.In this cross-sectional study, Medical, Nursing and Midwifery students in Islamic Azad University, Mashhad, Iran, were selected using stratified random sampling (...) ±8, 23.4±6, 18±5.5, 25.5±7.7 and 15.8±4, respectively. In the first four domains (p=0.000, F=27.35), (p=0.000, F=9.9), (p=0.000, F=18.5), (p=0.000, t=18.7) and for total scores (p=0.000, F=22.77), the three disciplines were significantly different. Also, there was a significant difference between mean total score (p=0.021, t=2.3) and scores of students' perception of learning (p=0.008, t=2.65) and social conditions (p=0.022, t=2.3) with respect to gender.According to these results, students tend

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2017 International Journal of Medical Education

66. The Influence of Mid-Event Deception on Psychophysiological Status and Pacing Can Persist across Consecutive Disciplines and Enhance Self-paced Multi-modal Endurance Performance (PubMed)

The Influence of Mid-Event Deception on Psychophysiological Status and Pacing Can Persist across Consecutive Disciplines and Enhance Self-paced Multi-modal Endurance Performance Purpose: To examine the effects of deceptively aggressive bike pacing on performance, pacing, and associated physiological and perceptual responses during simulated sprint-distance triathlon. Methods: Ten non-elite, competitive male triathletes completed three simulated sprint-distance triathlons (0.75 km swim, 500 kJ

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2017 Frontiers in physiology

67. Personality Measures Link Slower Binocular Rivalry Switch Rates to Higher Levels of Self-Discipline (PubMed)

Personality Measures Link Slower Binocular Rivalry Switch Rates to Higher Levels of Self-Discipline In this paper we investigated the relation between personality and the rate of perceptual alternations during binocular rivalry. Studies have demonstrated that slower rivalry alternations are associated with a range of clinical conditions. It is less clear whether rivalry dynamics similarly co-vary with individual differences in psychological traits seen across non-clinical population. We (...) assessed rivalry rates in a non-clinical population (n = 149) and found slower rivalry alternations were positively related r(149) = 0.20, p = 0.01 to industriousness, a trait characterized by a high level of self-discipline using the Big Five Aspect Scales (BFAS). Switch rates were also negatively related r(149) = -0.20, p = 0.01 to cognitive disorganization, a schizotypy trait capturing schizophrenia-like symptoms of disorganization using the Oxford-Liverpool Inventory of feelings and Experiences (O

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2017 Frontiers in psychology

68. Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites (PubMed)

Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites Genetic variants in drug targets and metabolizing enzymes often have important functional implications, including altering the efficacy and toxicity of drugs. Identifying single nucleotide variants (SNVs) that contribute to differences in drug response and understanding their underlying mechanisms

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2017 Bioinformatics

69. A Review of Living Collections with Special Emphasis on Sustainability and Its Impact on Research Across Multiple Disciplines (PubMed)

A Review of Living Collections with Special Emphasis on Sustainability and Its Impact on Research Across Multiple Disciplines Formal living collections have unique characteristics that distinguish them from other types of biorepositories. Comprising diverse resources, microbe culture collections, crop and biodiversity plant germplasm collections, and animal germplasm repositories are commonly allied with specific research communities or stakeholder groups. Among living collections, microbial

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2017 Biopreservation and biobanking

70. Waiting can be an optimal conservation strategy, even in a crisis discipline (PubMed)

Waiting can be an optimal conservation strategy, even in a crisis discipline Biodiversity conservation projects confront immediate and escalating threats with limited funding. Conservation theory suggests that the best response to the species extinction crisis is to spend money as soon as it becomes available, and this is often an explicit constraint placed on funding. We use a general dynamic model of a conservation landscape to show that this decision to "front-load" project spending can

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2017 Proceedings of the National Academy of Sciences of the United States of America

71. Identifying economics’ place amongst academic disciplines: a science or a social science? (PubMed)

Identifying economics’ place amongst academic disciplines: a science or a social science? Different academic disciplines exhibit different styles, including styles in journal titles. Using data from the 2014 Research Excellence Framework (REF) in the UK we are able to identify the stylistic trends of different disciplines using 155,552 journal titles across all disciplines. Cluster analysis is then used to group the different disciplines together. The resulting identification fits the social

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2017 Scientometrics

72. The Grand Challenges for Evolutionary Psychology: Survival Challenges for a Discipline (PubMed)

The Grand Challenges for Evolutionary Psychology: Survival Challenges for a Discipline 29021773 2018 11 13 1664-1078 8 2017 Frontiers in psychology Front Psychol The Grand Challenges for Evolutionary Psychology: Survival Challenges for a Discipline. 1727 10.3389/fpsyg.2017.01727 Jonason Peter K PK School of Social Sciences and Psychology, Western Sydney University, Penrith, NSW, Australia. eng Editorial 2017 09 27 Switzerland Front Psychol 101550902 1664-1078 evolutionary psychology life

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2017 Frontiers in psychology

73. Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists (PubMed)

Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists Radiation biology is a highly interdisciplinary field at the interface of biology, physics, and medicine. It is characterized by rapid advances in biological and technical knowledge. The potential for using these advances to optimize medical care, radiation protection, and related fields

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2017 Frontiers in oncology

74. Le poumon d’une discipline (PubMed)

Le poumon d’une discipline 29025812 2017 12 19 1715-5258 63 10 2017 Oct Canadian family physician Medecin de famille canadien Can Fam Physician 814 White David D fre Journal Article Le poumon d’une discipline. Canada Can Fam Physician 0120300 0008-350X 2017 10 14 6 0 2017 10 14 6 0 2017 10 14 6 1 ppublish 29025812 63/10/814 PMC5638483

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2017 Canadian Family Physician

75. Lifeblood of a discipline (PubMed)

Lifeblood of a discipline 29025811 2018 06 14 2018 11 13 1715-5258 63 10 2017 10 Canadian family physician Medecin de famille canadien Can Fam Physician Lifeblood of a discipline. 813 White David D eng Journal Article Canada Can Fam Physician 0120300 0008-350X IM Biomedical Research standards Canada Family Practice standards Humans 2017 10 14 6 0 2017 10 14 6 0 2018 6 15 6 0 ppublish 29025811 63/10/813 PMC5638482 Can Fam Physician. 2004 Sep;50:1189-91, 1197-9 15508359 Can Fam Physician. 2007

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2017 Canadian Family Physician

76. Prof. Anwen Liu: promoting knowledge in medicine and discipline construction, bring benefits to patients (PubMed)

Prof. Anwen Liu: promoting knowledge in medicine and discipline construction, bring benefits to patients 29057106 2017 12 19 2072-1439 9 Suppl 11 2017 Oct Journal of thoracic disease J Thorac Dis Prof. Anwen Liu: promoting knowledge in medicine and discipline construction, bring benefits to patients. S1190-S1194 10.21037/jtd.2017.09.147 Wang Molly M Ma Lynn L eng News China J Thorac Dis 101533916 2072-1439 Conflicts of Interest: The authors have no conflicts of interest to declare. 2017 10 24 6

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2017 Journal of thoracic disease

77. Implications of not matching to a first-choice discipline: a family medicine perspective (PubMed)

Implications of not matching to a first-choice discipline: a family medicine perspective Family medicine is often selected as an alternate career choice by medical students who do not match to their first choice discipline. Consequently, family medicine residency programs accept and train some residents who prepared for and intended a career in another specialty. The implications of this warrant investigation.Graduates (2006-2011) of Albertan family medicine residency programs were surveyed (...) to examine differences between physicians who indicated family medicine was their first choice discipline and those who indicated that it was not their first choice. Survey questions targeted practice location, preparedness for practice, perceptions of family medicine, lifestyle satisfaction, and well-being. Principal components analysis was used to examine the factor structure of our survey items and ANOVA and Chi square were used to compare mean scores and proportions, respectively.The overall response

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2017 Canadian medical education journal

78. Intramyocellular lipids of muscle type in athletes of different sport disciplines (PubMed)

Intramyocellular lipids of muscle type in athletes of different sport disciplines The present study used magnetic resonance spectroscopy (1H-MRS) to examine quantitative differences in intramyocellular lipid (IMCL) contents in various muscle types at rest for individual athletes from different sport disciplines. Five groups consisting of sprinters, alpine skiers, cross-country skiers, endurance runners and untrained healthy male subjects volunteered for this study. Data were acquired using 1H

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2017 Open access journal of sports medicine

79. Mapping the Growing Discipline of Dissemination and Implementation Science in Health (PubMed)

Mapping the Growing Discipline of Dissemination and Implementation Science in Health The field of dissemination and implementation (D&I) research in health has grown considerably in the past decade. Despite the potential for advancing the science, limited research has focused on mapping the field.We administered an online survey to individuals in the D&I field to assess participants' demographics and expertise, as well as engagement with journals and conferences, publications, and grants

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2017 Scientometrics

80. Ramanomics: New Omics Disciplines Using Micro Raman Spectrometry with Biomolecular Component Analysis for Molecular Profiling of Biological Structures (PubMed)

Ramanomics: New Omics Disciplines Using Micro Raman Spectrometry with Biomolecular Component Analysis for Molecular Profiling of Biological Structures Modern instrumentation for Raman microspectroscopy and current techniques in analysis of spectral data provide new opportunities to study molecular interactions and dynamics at subcellular levels in biological systems. Implementation of biomolecular component analysis (BCA) to microRaman spectrometry provides basis for the emergence of Ramanomics (...) , a new biosensing discipline with unprecedented capabilities to measure concentrations of distinct biomolecular groups in live cells and organelles. Here we review the combined use of microRaman-BCA techniques to probe absolute concentrations of proteins, DNA, RNA and lipids in single organelles of live cells. Assessing biomolecular concentration profiles of organelles at the single cell level provides a physiologically relevant set of biomarkers for cellular heterogeneity. In addition, changes

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2017 Biosensors

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