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Direct Coombs

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1. Direct Coombs

Direct Coombs Direct Coombs Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Coombs Direct Coombs Aka: Direct Coombs , Direct (...) Antiglobulin Test , DAT From Related Chapters II. Normal Negative III. Positive ( ) Medications ( ) s s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Direct Coombs." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Alzheimer's Disease (C0002395) Definition (MEDLINEPLUS) Alzheimer's disease (AD) is the most common form of among older people. Dementia

2018 FP Notebook

2. Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review. (PubMed)

Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review. We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells were opsonized with antibody. Three principal reasons account for the absence of a positive direct antiglobulin test in these cases: a) IgG sensitization below the threshold (...) of detection by the commercial antiglobulin reagent, b) low affinity IgG, removed by preparatory washes not conducted at 4°C or at low ionic strength, and c) red cell sensitization by IgA alone, or rarely (monomeric) IgM alone, but not accompanied by complement fixation, and thus not detectable by a commercial antiglobulin reagent that contains anti-IgG and anti-C3. In cases in which the phenotype is compatible with warm-antibody type, autoimmune hemolytic anemia and the direct antiglobulin test

2014 Blood cells, molecules & diseases

3. Coombs

. Coombs Reagent Anti-Human Globulin Binds to human IgG and C3 Complement Produced in rabbits by III. Direct Coombs Question Is IgG or complement bound to ? Technique Start with patient's s Add Anti-human globulin antibodies (Coombs Reagent) Positive Agglutination indicates coated RBCs Example of use Are maternal antibodies bound to fetal RBCs? IV. Indirect Coombs Question Is against present in serum? Technique Start with patient's serum Add Anti-human globulin antibodies (Coombs Reagent) Add Indicator (...) non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells. Definition (NCI) Hemagglutination test in which Coombs' reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking

2018 FP Notebook

4. Direct Coombs

Direct Coombs Direct Coombs Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Coombs Direct Coombs Aka: Direct Coombs , Direct (...) Antiglobulin Test , DAT From Related Chapters II. Normal Negative III. Positive ( ) Medications ( ) s s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Direct Coombs." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Alzheimer's Disease (C0002395) Definition (MEDLINEPLUS) Alzheimer's disease (AD) is the most common form of among older people. Dementia

2015 FP Notebook

5. Evaluation of the Use of Gel Card System for Assessment of Direct Coombs Test: Weighing the Pros and Cons (PubMed)

Evaluation of the Use of Gel Card System for Assessment of Direct Coombs Test: Weighing the Pros and Cons A positive direct Coombs test (DCT) is the hallmark of diagnosis of immune hemolytic anemias. The reagent used for the test is the Antihuman globulin (AHG), which may be either 'Polyspecific' or 'Monospecific'. The advent of the Gel card systems has made the procedure and interpretation of DCT simpler. Aim of this study is to evaluate three of the various techniques used for the performance

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2011 Indian Journal of Hematology & Blood Transfusion

6. Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity. (PubMed)

Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity. Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less common. Erthyrocytes were never found sensitized

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1979 Clinical and experimental immunology

7. Positive Direct Coombs Test Induced by Phenylhydrazine (PubMed)

Positive Direct Coombs Test Induced by Phenylhydrazine 13211826 2003 05 01 2018 12 01 0021-9738 33 12 1954 Dec The Journal of clinical investigation J. Clin. Invest. Positive direct Coombs test induced by phenylhydrazine. 1700-11 MUIRHEAD E E EE GROVES M M BRYAN S S eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Phenylhydrazines 064F424C9K phenylhydrazine OM Coombs Test Hemagglutination Humans Phenylhydrazines 5527:23606:210 HEMAGGLUTINATION 1954 12 1 1954 12 1 0 1 1954 12

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1954 Journal of Clinical Investigation

8. Changing incidence of positive direct Coombs test in inbred NZB-BL mice. (PubMed)

Changing incidence of positive direct Coombs test in inbred NZB-BL mice. 5722882 1969 01 23 2018 11 13 0022-2593 5 2 1968 Jun Journal of medical genetics J. Med. Genet. Changing incidence of positive direct Coombs test in inbred NZB-BL mice. 129-33 Barnes R D RD Tuffrey M M Holliday J J eng Journal Article England J Med Genet 2985087R 0022-2593 0 Autoantibodies IM Animals Autoantibodies analysis Autoimmune Diseases genetics Coombs Test Female Inbreeding Male Selection, Genetic Sex 1968 6 1 1968

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1968 Journal of Medical Genetics

9. L.E. cells and positive direct Coombs' test induced by methyldopa. (PubMed)

L.E. cells and positive direct Coombs' test induced by methyldopa. 4174403 1968 10 01 2018 11 13 0008-4409 99 6 1968 Aug 10 Canadian Medical Association journal Can Med Assoc J L.E. cells and positive direct Coombs' test induced by methyldopa. 277-80 Harth M M eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Autoantibodies 56LH93261Y Methyldopa AIM IM Aged Antibody Formation Autoantibodies Coombs Test Humans Male Methyldopa adverse effects Neutrophils 1968 8 10 1968 8

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1968 Canadian Medical Association Journal

10. Positive direct Coombs' test without hemolytic anemia, attributed to penicillin therapy. (PubMed)

Positive direct Coombs' test without hemolytic anemia, attributed to penicillin therapy. 4175465 1968 11 01 2018 11 13 0008-4409 99 7 1968 Aug 17 Canadian Medical Association journal Can Med Assoc J Positive direct Coombs' test without hemolytic anemia, attributed to penicillin therapy. 321-6 Roy R B RB Doris L L Beanlands D S DS eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Antibodies, Anti-Idiotypic 0 Haptoglobins 0 Hemoglobins 0 Penicillins 0 gamma-Globulins 60-24-2 (...) Mercaptoethanol Q42T66VG0C Penicillin G AIM IM Adult Anemia, Hemolytic diagnosis Antibodies, Anti-Idiotypic Coombs Test Female Haptoglobins Hemagglutination Inhibition Tests Hemoglobins Humans Mercaptoethanol pharmacology Penicillin G pharmacology Penicillins therapeutic use Reticulocytes gamma-Globulins analysis 1968 8 17 1968 8 17 0 1 1968 8 17 0 0 ppublish 4175465 PMC1924412 Am J Clin Pathol. 1965 Dec;44(6):648-53 5846021 N Engl J Med. 1966 Jan 27;274(4):171-8 4159252 N Engl J Med. 1966 Jan 27;274(4):178

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1968 Canadian Medical Association Journal

11. The direct antiglobulin (Coombs) test in megaloblastic anaemia (PubMed)

The direct antiglobulin (Coombs) test in megaloblastic anaemia Folic acid deficiency with the picture of a megaloblastic bone marrow may develop in haemolytic anaemia, and, on the other hand, both vitamin B(12) and folic acid deficiency may produce signs of haemolysis. As the correct interpretation of a positive antiglobulin reaction associated with megaloblastic erythropoiesis is particularly important, the effect of deficiency of vitamin B(12) and folic acid on the results of the test

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1965 Journal of Clinical Pathology

12. Assessment Effects After Direct Acting Antiviral in Chronic Hepatitis c Virus Patients

Assessment Effects After Direct Acting Antiviral in Chronic Hepatitis c Virus Patients Assessment Effects After Direct Acting Antiviral in Chronic Hepatitis c Virus Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Assessment Effects After Direct Acting Antiviral in Chronic Hepatitis c Virus Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03163849 Recruitment Status : Not yet recruiting First Posted : May

2017 Clinical Trials

13. Coombs

. Coombs Reagent Anti-Human Globulin Binds to human IgG and C3 Complement Produced in rabbits by III. Direct Coombs Question Is IgG or complement bound to ? Technique Start with patient's s Add Anti-human globulin antibodies (Coombs Reagent) Positive Agglutination indicates coated RBCs Example of use Are maternal antibodies bound to fetal RBCs? IV. Indirect Coombs Question Is against present in serum? Technique Start with patient's serum Add Anti-human globulin antibodies (Coombs Reagent) Add Indicator (...) non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells. Definition (NCI) Hemagglutination test in which Coombs' reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking

2015 FP Notebook

14. Hour-Specific Bilirubin Nomogram in Infants With ABO Incompatibility and Direct Coombs-Positive Results. (PubMed)

Hour-Specific Bilirubin Nomogram in Infants With ABO Incompatibility and Direct Coombs-Positive Results. To determine the usefulness of the hour-specific Bhutani et al bilirubin nomogram when applied to infants with Coombs-positive test results.Retrospective chart review.Term nursery and neonatal intensive care unit of a university-affiliated hospital.All infants with A+ or B+ blood type born in our center from September 1, 2006, through August 31, 2008, to mothers with O+ blood.Proportion (...) of infants with Coombs-positive results from the nomogram zones who required phototherapy and comparison of the percentage of infants with Coombs-positive results in each zone with the percentage of those with Coombs-negative results in each zone.A total of 240 infants with Coombs-positive and 460 with Coombs-negative results having a gestational age of 35 weeks or older were evaluated. Sensitivity and specificity of data for infants with direct Coombs-positive results in zone 4 (high risk; 74.2

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2010 Archives of Pediatrics & Adolescent Medicine

15. Systematic review of the test accuracy of the direct antiglobulin (Coombs') test for hemolysis in newborns as compared to the End-Tidal Carbon Monoxide Concentration (ETCOc)

Systematic review of the test accuracy of the direct antiglobulin (Coombs') test for hemolysis in newborns as compared to the End-Tidal Carbon Monoxide Concentration (ETCOc) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2014 PROSPERO

16. Coombs test

Coombs test Coombs test - Wikipedia Coombs test From Wikipedia, the free encyclopedia This article needs additional citations for . Please help by . Unsourced material may be challenged and removed. Find sources: – · · · · ( October 2015 ) ( ) Coombs test A Coombs test (also known as antiglobulin test or AGT ) is either of two used in and . The two Coombs tests are the direct Coombs test ( DCT , also known as direct antiglobulin test or DAT ), and the indirect Coombs test (also known (...) as indirect antiglobulin test or IAT ) The direct Coombs test is used to test for —that is, a condition where the immune system breaks down , leading to . The direct Coombs test is used to detect antibodies or attached to the surface of red blood cells. To perform the test, a blood sample is taken and the red blood cells are washed (removing the patient's own plasma and unbound antibodies from the red blood cells) and then incubated with anti-human globulin ("Coombs reagent"). If the red cells

2012 Wikipedia

17. Levodopa and positive direct antiglobulin tests. (PubMed)

Levodopa and positive direct antiglobulin tests. 1234499 1977 01 29 2018 11 13 0306-5251 2 2 1975 Apr British journal of clinical pharmacology Br J Clin Pharmacol Levodopa and positive direct antiglobulin tests. 173 Moir D C DC Wood A J AJ Davidson J F JF eng Letter England Br J Clin Pharmacol 7503323 0306-5251 0 Autoantibodies 46627O600J Levodopa IM Autoantibodies Coombs Test Humans Levodopa immunology 1975 4 1 1975 4 1 0 1 1975 4 1 0 0 ppublish 1234499 PMC1402506 N Engl J Med. 1972 Jun 29;286

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1975 British journal of clinical pharmacology

18. Neonatal jaundice

cephalhaematoma hypertonia high-pitched cry retrocollis opisthotonus perinatal asphyxia macrosomia plethora hypotonia lethargy East Asian American-Indian maternal diabetes oxytocin in labour low birth weight decreased gestational age decreased caloric intake and weight loss breastfeeding delayed cord clamping (2-3 minutes) Diagnostic investigations transcutaneous bilirubinometer total serum bilirubin direct Coombs' test direct serum bilirubin haematocrit FBC reticulocyte count peripheral blood smear blood

2019 BMJ Best Practice

19. Improving outdoor air quality and health: review of interventions

13 Transport. Road transport policies can lower emissions from existing vehicles or reduce long-term emissions from the vehicle fleet. The latter include interventions that reduce demand for more polluting forms of transport and interventions that promote vehicles that have low exhaust emissions. Local authorities have less direct influence over aviation, maritime and railway interventions, where local action can be supported by national policy interventions and operators taking action. Industry (...) HFO Heavy Fuel Oil HIA Health Impact Assessment HMT HM Treasury HOT High Occupancy Toll HOV High Occupancy Vehicle IARC International Agency for Research on Cancer IAQM Institute of Air Quality Management IED Directive on Industrial Emissions (2010/75/EU) IER Integrated Exposure-Response function Review of interventions to improve outdoor air quality and public health 18 Term Explanation IGCB Interdepartmental Group on Costs and Benefits IHD Ischaemic Heart Disease IMD Index of Multiple

2019 Public Health England

20. Extended Stay Centers: Patient characteristics and appropriate procedures

eligible for ASC procedures. The ESCs may be a useful option for patients who: • Need extra time for managing pain or bodily functions, • Do not have a caregiver at home, or • May require extended travel time to return home after a surgical procedure. Evidence Summary Because of limited U.S. experience with ESCs or similar settings, no direct evidence exists regarding the effect these facilities may have on the safety and appropriateness of surgeries in an ambulatory setting. Existing data is either (...) (licensed as convalescent centers), Connecticut, and Illinois. At least two other states have considered legislation to create RCCs, including Florida (Smernoff, 2017) and Washington (Washington State Senate Committee on Ways & Means, 2016). Methodological Approach Because of limited U.S. experience with ESCs or similar settings, no direct evidence exists regarding the effect these facilities may have on the safety and appropriateness of surgeries in such a setting. Existing data is either

2019 Oregon Health Evidence Review Commission

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