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Diphtheria

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141. Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine Full Text available with Trip Pro

Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine In recipients primed with acellular pertussis diphtheria-tetanus combined vaccine (DTaP) an increased incidence of severe local reactions with extensive redness/swelling has been reported for each subsequent dose of diphtheria-tetanus based combination vaccine given as a booster. This has been (...) footpad swelling model assay indicated that the B-oligomer carbohydrate binding activity and possibly other factors were associated with intensified sensitization to local reaction following diphtheria toxoid booster.

2014 Human vaccines & immunotherapeutics

142. Diphtheria in the immunized with observations on a diphtheria-like disease associated with non-toxigenic strains of Corynebacterium diphtheriae Full Text available with Trip Pro

Diphtheria in the immunized with observations on a diphtheria-like disease associated with non-toxigenic strains of Corynebacterium diphtheriae 14880693 2004 02 15 2018 12 01 0022-1724 49 2-3 1951 Jun-Sep The Journal of hygiene J Hyg (Lond) Diphtheria in the immunized with observations on a diphtheria-like disease associated with nontoxigenic strains of Corynebacterium diphtheriae. 205-19 EDWARD D G DG ALLISON V D VD eng Journal Article England J Hyg (Lond) 0375374 0022-1724 OM Corynebacterium (...) diphtheriae Diphtheria prevention & control Humans Immunization Vaccination 5221:10964:98:113 CORYNEBACTERIUM DIPHTHERIAE DIPHTHERIA/prevention and control 1951 6 1 1951 6 1 0 1 1951 6 1 0 0 ppublish 14880693 PMC2235032 Bacteriol Rev. 1943 Mar;7(1):1-41 16350084 Am J Public Health Nations Health. 1947 May;37(5):543-8 18016523

1951 The Journal of hygiene

143. Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid Full Text available with Trip Pro

Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid 20789460 2011 04 04 2011 04 04 0007-1447 2 5298 1962 Jul 21 British medical journal Br Med J Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid. 149-51 eng Journal Article England Br Med J 0372673 0007

1962 British medical journal

144. A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria at Cambridge, 1903 Full Text available with Trip Pro

A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria at Cambridge, 1903 20474195 2010 06 22 2018 11 13 0022-1724 4 2 1904 Apr The Journal of hygiene J Hyg (Lond) A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria

1904 The Journal of hygiene

145. A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin Full Text available with Trip Pro

A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin 20755772 2011 03 29 2011 03 29 0007-1447 2 1815 1895 Oct 12 British medical journal Br Med J A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin. 907 Wright A E AE Semple D D eng

1895 British medical journal

146. Pathogenic properties of a Corynebacterium diphtheriae strain isolated from a case of osteomyelitis. Full Text available with Trip Pro

Pathogenic properties of a Corynebacterium diphtheriae strain isolated from a case of osteomyelitis. Corynebacterium diphtheriae is typically recognized as a colonizer of the upper respiratory tract (respiratory diphtheria) and the skin (cutaneous diphtheria). However, different strains of Corynebacteriumdiphtheriae can also cause invasive infections. In this study, the characterization of a non-toxigenic Corynebacteriumdiphtheriae strain (designated BR-INCA5015) isolated from osteomyelitis

2016 Journal of Medical Microbiology

147. More than 20 years after re-emerging in the 1990s, diphtheria remains a public health problem in Latvia. Full Text available with Trip Pro

More than 20 years after re-emerging in the 1990s, diphtheria remains a public health problem in Latvia. In 1994, the World Health Organization (WHO) declared the goal of eliminating diphtheria within the WHO European Region by the year 2000. However, in 1990 an epidemic emerged within the Russian Federation and spread to other countries, including Latvia, by 1994. We describe national surveillance and immunisation coverage data in Latvia from 1994 to 2014 and present historical data from 1946 (...) . We defined a laboratory-confirmed case as a clinical case in which toxin-producing Corynebacterium diphtheriae, C. ulcerans or C. pseudotuberculosis was isolated. From 1994 to 2014, 1,515 cases were reported, giving an average annual incidence of 3.2 cases per 100,000 inhabitants (range 0.1-14.8), with the highest incidence in age groups 5-19 and 40-49 years (4.4 and 4.3/100,000, respectively); 111 deaths were reported, 83.8% cases were laboratory-confirmed. Most cases occurred in unvaccinated

2016 Euro Surveillance

148. Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children: A cross-sectional study. Full Text available with Trip Pro

Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children: A cross-sectional study. Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation of vaccination programs. The primary schedule of diphtheria (...) and tetanus vaccinations is similar in various countries, with differences mainly in the number and timing of booster doses. The aim of the study was to assess diphtheria and tetanus antibody concentrations in a population of healthy children.Diphtheria and tetanus antibody levels were analyzed in a group of 324 children aged 18 to 180 months. All children were vaccinated in accordance with the Polish vaccination schedule.Specific antibody concentrations greater than 0.1 IU/mL were considered protective

2016 Medicine

149. Sex-differential effects on mortality of BCG and diphtheria-tetanus-pertussis vaccines in a rural area with high vaccination coverage: observational study from Senegal. (Abstract)

Sex-differential effects on mortality of BCG and diphtheria-tetanus-pertussis vaccines in a rural area with high vaccination coverage: observational study from Senegal. Diphtheria-tetanus-pertussis (DTP) may be associated with increased female mortality; the effect of co-administration with BCG is not known.Between 1989 and 1997, we examined female and male mortality rates in rural Senegal where 7824 infants received the first dose of DTP and inactivated polio vaccine (DTP-IPV) with BCG

2016 Transactions of the Royal Society of Tropical Medicine & Hygiene

150. Diphtheria: It is still prevalent!!! (Abstract)

Diphtheria: It is still prevalent!!! Diphtheria is a respiratory infectious disease of childhood. It is a fatal disease and may cause complications if not recognized early and treated properly. Despite availability of effective vaccination it continues to be reported from many parts of the world particularly developing countries.To assess the demographic and clinical characteristics of diphtheria patients, and the predictors of outcomes of respiratory diphtheria.A prospective analysis of 180 (...) patients with a clinical diagnosis of respiratory diphtheria admitted from 2011 to 2014 at a tertiary referral hospital. They were evaluated with respect to demographic details, immunization status, clinical features, complications and outcomes.Most common age group affected was children less than 5 years of age (87 cases, 48.33%). The peak incidence of diphtheria was seen in the months of September and October (111 cases, 62%). Majority of the patients were unimmunized (54%), followed by partially

2016 International Journal of Pediatric Otorhinolaryngology

151. A Phase 2, Randomized, Active-controlled, Observer-blinded Study to Assess the Immunogenicity, Tolerability, and Safety of Bivalent rLP2086, a Meningococcal Serogroup B Vaccine, Coadministered With Tetanus, Diphtheria and Acellular Pertussis Vaccine and S (Abstract)

A Phase 2, Randomized, Active-controlled, Observer-blinded Study to Assess the Immunogenicity, Tolerability, and Safety of Bivalent rLP2086, a Meningococcal Serogroup B Vaccine, Coadministered With Tetanus, Diphtheria and Acellular Pertussis Vaccine and S Bivalent rLP2086, targeting meningococcal serogroup B, will extend prevention of meningococcal disease beyond that provided by quadrivalent serogroup ACWY vaccines; coadministration with recommended vaccines may improve adherence to vaccine (...) schedules. This phase 2, randomized, active-controlled, observer-blinded study assessed whether immune responses induced by coadministration of Menactra (meningococcal A, C, Y and W-135 polysaccharide conjugate vaccine [MCV4]) and Adacel (tetanus toxoid, reduced diphtheria toxoid, acellular pertussis vaccine [Tdap]) with bivalent rLP2086 (Trumenba [meningococcal serogroup B vaccine], approved in the United States) were noninferior to MCV4 + Tdap or bivalent rLP2086 alone.Healthy adolescents aged 10

2016 The Pediatric infectious disease journal Controlled trial quality: uncertain

152. Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. Full Text available with Trip Pro

Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. Many adult immunization schedules recommend that tetanus and diphtheria vaccination be performed every 10 years. In light of current epidemiological trends of disease incidence and rates of vaccine-associated adverse events, the 10-year revaccination schedule has come into question.We performed cross-sectional analysis of serum antibody titers in 546 adult subjects stratified by age or sex (...) . All serological results were converted to international units after calibration with international serum standards.Approximately 97% of the population was seropositive to tetanus and diphtheria as defined by a protective serum antibody titer of ≥0.01 IU/mL. Mean antibody titers were 3.6 and 0.35 IU/mL against tetanus and diphtheria, respectively. Antibody responses to tetanus declined with an estimated half-life of 14 years (95% confidence interval, 11-17 years), whereas antibody responses

2016 Clinical Infectious Diseases

153. Impact of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccinations on Reported Pertussis Cases Among Those 11 to 18 Years of Age in an Era of Waning Pertussis Immunity: A Follow-up Analysis. Full Text available with Trip Pro

Impact of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccinations on Reported Pertussis Cases Among Those 11 to 18 Years of Age in an Era of Waning Pertussis Immunity: A Follow-up Analysis. There is accumulating literature on waning acellular pertussis vaccine-induced immunity, confirming the results of studies assessing the duration of protection of pertussis vaccines.To evaluate the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine's

2016 JAMA pediatrics

154. Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin. Full Text available with Trip Pro

Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin. Diphtheria antitoxin for therapeutic use is in limited supply. A potential source might be affinity-purified antibodies originally derived from plasma of adults who received a booster dose of a vaccine containing diphtheria toxoid. These antibodies might be useful for treating even severe cases of diphtheria.

2016 Emerging Infectious Diseases

155. Sex-differential non-vaccine specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination. Full Text available with Trip Pro

Sex-differential non-vaccine specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination. Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking

2016 Clinical Infectious Diseases Controlled trial quality: uncertain

156. Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents. Full Text available with Trip Pro

Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents. Concomitant administration of bivalent rLP2086 (Trumenba [Pfizer, Inc] and diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) was immunologically noninferior to DTaP/IPV and saline and was safe and well tolerated. Bivalent (...) the coadministration of Repevax (diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine [DTaP/IPV]) (Sanofi Pasteur MSD, Ltd) and bivalent rLP2086.Healthy adolescents aged ≥11 to <19 years received bivalent rLP2086 + DTaP/IPV or saline + DTaP/IPV at month 0 and bivalent rLP2086 or saline at months 2 and 6. The primary end point was the proportion of participants in whom prespecified levels of antibodies to DTaP/IPV were achieved 1 month after DTaP/IPV administration. Immune responses

2016 Journal of the Pediatric Infectious Diseases Society Controlled trial quality: uncertain

157. Effect of tetanus-diphtheria (Td) vaccine on immune response to hepatitis B vaccine in healthy individuals with insufficient immune response. Full Text available with Trip Pro

Effect of tetanus-diphtheria (Td) vaccine on immune response to hepatitis B vaccine in healthy individuals with insufficient immune response. Hepatitis B virus (HBV) fails to produce appropriate immune responses in some healthy individuals; thus, different strategies have been adopted to promote immune responses. The current study aimed at evaluating the efficacy of HBV vaccine coadministered with tetanus-diphtheria (Td) vaccine compared with HBV vaccine in healthy individuals through measuring

2016 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences Controlled trial quality: uncertain

159. Meningococcal Conjugate and tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccination Among HIV-Infected Youth. (Abstract)

Meningococcal Conjugate and tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccination Among HIV-Infected Youth. The meningococcal conjugate vaccine (MCV4) and the tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) were first recommended for adolescents in the US in 2005. The goal of our study was to determine MCV4 and Tdap vaccines coverage among perinatally and behaviorally HIV-infected adolescents in 2006 and to compare coverage estimates

2016 Pediatric Infectious Dsease Journal

160. Comparison of the Safety and Immunogenicity of a Novel Quadrivalent Meningococcal ACWY-Tetanus Toxoid Conjugate Vaccine and a Marketed Quadrivalent Meningococcal ACWY-Diphtheria Toxoid Conjugate Vaccine in Healthy Individuals 10-25 Years of Age. Full Text available with Trip Pro

Comparison of the Safety and Immunogenicity of a Novel Quadrivalent Meningococcal ACWY-Tetanus Toxoid Conjugate Vaccine and a Marketed Quadrivalent Meningococcal ACWY-Diphtheria Toxoid Conjugate Vaccine in Healthy Individuals 10-25 Years of Age. Universal immunization of adolescents against meningococcal disease with a quadrivalent meningococcal ACWY (MenACWY) conjugate vaccine is recommended in a number of countries.In a randomized, controlled, observer-blinded, multicenter trial, 1016 (...) participants, 10-25 years of age, were randomly allocated 1:1:1 to receive a single dose of 1 of 2 lots of an investigational tetanus toxoid-conjugated MenACWY vaccine (MenACWY-TT) or a marketed diphtheria toxoid-conjugated MenACWY vaccine (MenACWY-DT). The primary outcome was the noninferiority of the vaccine response after MenACWY-TT (lot A) compared with MenACWY-DT for all 4 serogroups. Vaccine response was defined as a postvaccination human serum bactericidal antibody (hSBA) titer against each

2016 Journal of the Pediatric Infectious Diseases Society Controlled trial quality: uncertain

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