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Diphtheria

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181. Immunogenicity of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine compared to standard-dose diphtheria, tetanus, acellular pertussis when used as a pre-school booster in UK children: (PubMed)

Immunogenicity of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine compared to standard-dose diphtheria, tetanus, acellular pertussis when used as a pre-school booster in UK children: This serological follow up study assessed the kinetics of antibody response in children who previously participated in a single centre, open-label, randomised controlled trial of low-dose compared to standard-dose diphtheria booster preschool (...) vaccinations in the United Kingdom (UK). Children had previously been randomised to receive one of three combination vaccines: either a combined adsorbed tetanus, low-dose diphtheria, 5-component acellular pertussis and inactivated polio vaccine (IPV) (Tdap-IPV, Repevax(®); Sanofi Pasteur MSD); a combined adsorbed tetanus, low-dose diphtheria and 5-component acellular pertussis vaccine (Tdap, Covaxis(®); Sanofi Pasteur MSD) given concomitantly with oral polio vaccine (OPV); or a combined adsorbed standard

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2015 Vaccine

182. A Pilot Study: Factors Influencing Compliance With Tetanus–Diphtheria Vaccine in Katsina State, Northwestern Nigeria (PubMed)

A Pilot Study: Factors Influencing Compliance With Tetanus–Diphtheria Vaccine in Katsina State, Northwestern Nigeria Tetanus-diphtheria vaccine (Td+) coverage has been steadily declining in Katsina State, Nigeria. The pilot study was guided by The Andersen and Newman Framework of Health Services Utilization. The goal of the pilot study was to identify the Td+ vaccination coverage and identify any association between maternal residence, educational status, occupational status, access

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2018 Health services research and managerial epidemiology

183. Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway (PubMed)

Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway Diphtheria toxin (DTx) is a well-characterized bacterial toxin. However, the endocytic pathway of the mutant of DTx, CRM197, which is used as an immunological adjuvant, has not yet been fully explained. The aim of this study was to investigate the intracellular trafficking of CRM197-loaded endosomes.Human umbilical vein endothelial cells (HUVECs) were used in a cell culture. The effective

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2018 Northern clinics of Istanbul

184. Diphtheria outbreak in Thailand, 2012; seroprevalence of diphtheria antibodies among Thai adults and its implications for immunization programs. (PubMed)

Diphtheria outbreak in Thailand, 2012; seroprevalence of diphtheria antibodies among Thai adults and its implications for immunization programs. An age distribution shift in diphtheria cases during a 2012 outbreak in northeastern of Thailand suggests adults are increasingly at risk for infection in Thailand. Data regarding immunity against diphtheria among the adult Thai population is limited. We review a 2012 diphtheria outbreak in Thailand and conducted a nationwide seroepidemiological survey (...) to determine the prevalence of diphtheria antibodies among Thai adults in order to inform immunization programs. A total of 41 confirmed cases, 6 probable cases and 101 carriers of diphtheria were reported from northeastern and upper southern Thailand. The diphtheria outbreak in northeastern Thailand occurred among adults aged > or =15 years; sporadic cases occurred among children from upper southern Thailand. We conducted a seroepidemiological survey of 890 Thai adults from 4 age groups (20-29, 30-39, 40

2014 Southeast Asian Journal of Tropical Medicine and Public Health

186. Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine (PubMed)

Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine In recipients primed with acellular pertussis diphtheria-tetanus combined vaccine (DTaP) an increased incidence of severe local reactions with extensive redness/swelling has been reported for each subsequent dose of diphtheria-tetanus based combination vaccine given as a booster. This has been (...) footpad swelling model assay indicated that the B-oligomer carbohydrate binding activity and possibly other factors were associated with intensified sensitization to local reaction following diphtheria toxoid booster.

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2014 Human vaccines & immunotherapeutics

187. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. (PubMed)

Safety and immunogenicity of tetanus diphtheria and acellular pertussis (tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine could prevent infant pertussis.To evaluate the safety and immunogenicity of Tdap immunization during pregnancy and its effect on infant responses to diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine.Phase 1-2

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2014 JAMA

188. Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema (PubMed)

Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in some cases months or years later. Finding answers for these basic questions has been hampered by the lack of adequate animal models (...) . In the current study, we used Cre-lox mice that expressed the human diphtheria toxin receptor (DTR) driven by a lymphatic-specific promoter in order to noninvasively ablate the lymphatic system of the hind limb. Animals treated in this manner developed lymphedema that was indistinguishable from clinical lymphedema temporally, radiographically, and histologically. Using this model and clinical biopsy specimens, we show that the initial resolution of edema after injury is dependent on the formation

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2016 JCI insight

189. Diphtheria in the immunized with observations on a diphtheria-like disease associated with non-toxigenic strains of Corynebacterium diphtheriae (PubMed)

Diphtheria in the immunized with observations on a diphtheria-like disease associated with non-toxigenic strains of Corynebacterium diphtheriae 14880693 2004 02 15 2018 12 01 0022-1724 49 2-3 1951 Jun-Sep The Journal of hygiene J Hyg (Lond) Diphtheria in the immunized with observations on a diphtheria-like disease associated with nontoxigenic strains of Corynebacterium diphtheriae. 205-19 EDWARD D G DG ALLISON V D VD eng Journal Article England J Hyg (Lond) 0375374 0022-1724 OM Corynebacterium (...) diphtheriae Diphtheria prevention & control Humans Immunization Vaccination 5221:10964:98:113 CORYNEBACTERIUM DIPHTHERIAE DIPHTHERIA/prevention and control 1951 6 1 1951 6 1 0 1 1951 6 1 0 0 ppublish 14880693 PMC2235032 Bacteriol Rev. 1943 Mar;7(1):1-41 16350084 Am J Public Health Nations Health. 1947 May;37(5):543-8 18016523

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1951 The Journal of hygiene

190. Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid (PubMed)

Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid 20789460 2011 04 04 2011 04 04 0007-1447 2 5298 1962 Jul 21 British medical journal Br Med J Inefficiency of Purified Diphtheria Formol Toxoid in Primary Immunization Against Diphtheria: A Report to the Medical Research Council by its Committee on Diphtheria Toxoid. 149-51 eng Journal Article England Br Med J 0372673 0007

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1962 British medical journal

191. A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin (PubMed)

A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin 20755772 2011 03 29 2011 03 29 0007-1447 2 1815 1895 Oct 12 British medical journal Br Med J A Note on the Employment of Diphtheria Antitoxin as a Culture Medium for the Diphtheria Bacillus: And on some Practical Points in Connection with the Preparation of Diphtheria Antitoxin. 907 Wright A E AE Semple D D eng

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1895 British medical journal

192. A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria at Cambridge, 1903 (PubMed)

A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria at Cambridge, 1903 20474195 2010 06 22 2018 11 13 0022-1724 4 2 1904 Apr The Journal of hygiene J Hyg (Lond) A Study of the Virulence of the Diphtheria Bacilli isolated from 113 Persons, and of 11 Species of Diphtheria-like Organisms, together with the Measures taken to check an Outbreak of Diphtheria

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1904 The Journal of hygiene

193. Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects

Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02587520 Recruitment Status : Completed First Posted : October 27, 2015

2015 Clinical Trials

194. Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam

Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2015 Clinical Trials

195. Safety and immunogenicity of a single intramuscular dose of a tetanus-diphtheria toxoid (Td) vaccine (BR-TD-1001) in healthy Korean adult subjects. (PubMed)

Safety and immunogenicity of a single intramuscular dose of a tetanus-diphtheria toxoid (Td) vaccine (BR-TD-1001) in healthy Korean adult subjects. BR-TD-1001 was developed as a booster for the immunity maintenance of diphtheria and tetanus. The aim of this study was to evaluate the safety and immunogenicity of BR-TD-1001 (test vaccine) in comparison with placebo and an active comparator in healthy Korean adults. A randomized, double-blind, placebo-controlled, active comparator, phase I (...) different from those of the other treatment groups (P = 0.4974, 0.3061). No serious adverse event occurred, and no subject was withdrawn from the study for safety. The seroprotection rates against both tetanus and diphtheria at 4 weeks after vaccination were over 0.95. For anti-tetanus antibody, the geometric mean titer in the test group was significantly higher than those of the other groups (P = 0.0364, 0.0033). The geometric mean titer of anti-diphtheria antibody in the test group was significantly

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2015 Human vaccines & immunotherapeutics

196. Vaccine preventable diseases: MMR, Diphtheria, Tetanus, Pertussis, Polio, Hib - a systematic review

Vaccine preventable diseases: MMR, Diphtheria, Tetanus, Pertussis, Polio, Hib - a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2018 PROSPERO

197. IMMUNOGENICITY AND SAFETY OF QUINVAXEM® (DIPHTHERIA, TETANUS, WHOLE-CELL PERTUSSIS, HEPATITIS B AND HAEMOPHILUS INFLUENZAE TYPE B VACCINE) GIVEN TO VIETNAMESE INFANTS AT 2 TO 4 MONTHS OF AGE. (PubMed)

IMMUNOGENICITY AND SAFETY OF QUINVAXEM® (DIPHTHERIA, TETANUS, WHOLE-CELL PERTUSSIS, HEPATITIS B AND HAEMOPHILUS INFLUENZAE TYPE B VACCINE) GIVEN TO VIETNAMESE INFANTS AT 2 TO 4 MONTHS OF AGE. Vietnam plans to replace the routine childhood diphtheria, pertussis and tetanus combination (DPT) vaccine with a pentavalent vaccine. The present study was performed to assess the immunogenicity and safety of the combined diphtheria, tetanus, whole-cell pertussis, hepatitis B (HepB), and Haemophilus (...) influenzae type b (Hib) (DTwP-HepB-Hib) Quinvaxem® vaccine in children. A total of 131 infants received the Quinvaxem® vaccine at 2, 3 and 4 months. Antibody levels were measured at baseline, at one month after the third injection and one year after the first injection. Seroprotection rates were high for each vaccine antigen at one month after the third dose: 93.1% for diphtheria, 98.5% for tetanus, 99.2% for pertussis (seroconversion rate), 93.1% for HepB, and 100% for Hib (anti-PRP ≥ 0.15 µg/ml

2015 Southeast Asian Journal of Tropical Medicine and Public Health

198. Seroprevalence and Determinants of Immunity to Diphtheria for Children Living in Two Districts of Contrasting Incidence During an Outbreak in East Java, Indonesia. (PubMed)

Seroprevalence and Determinants of Immunity to Diphtheria for Children Living in Two Districts of Contrasting Incidence During an Outbreak in East Java, Indonesia. In 2012, an ongoing outbreak of diphtheria in Indonesia was focused in the province of East Java. There was a need to assess vaccine coverage and immunity gaps in children.We conducted a cross-sectional seroprevalence and vaccine coverage survey of children 1-15 years of age in 2 districts of East Java: one of high incidence (...) (on the island of Madura) and one of low incidence (on the mainland). From each district, we sampled 150 children (10 children per year of age). Sera and throat swabs were taken to determine immunity and carriage status. Immunity was defined as ≥0.1 international unit/mL of antibody to diphtheria toxin.A total of 297 children were selected to participate in the study. Coverage of three doses of combined vaccine for diphtheria, tetanus and pertussis was significantly lower (P < 0.001) in the high incidence

2015 Pediatric Infectious Dsease Journal

199. Colonisation with toxigenic Corynebacterium diphtheriae in a Scottish burns patient, June 2015. (PubMed)

Colonisation with toxigenic Corynebacterium diphtheriae in a Scottish burns patient, June 2015. On 12 June 2015, Corynebacterium diphtheriae was identified in a skin swab from a burns patient in Scotland. The isolate was confirmed to be genotypically and phenotypically toxigenic. Multilocus sequence typing of three patient isolates yielded sequence type ST 125. The patient was clinically well. We summarise findings of this case, and results of close contact identification and screening: 12 (...) family and close contacts and 32 hospital staff have been found negative for C. diphtheriae.

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2015 Euro Surveillance

200. Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment with a Long-Acting Parathyroid Hormone Analog. (PubMed)

Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment with a Long-Acting Parathyroid Hormone Analog. Hypoparathyroidism (HP) arises most commonly from parathyroid (PT) gland damage associated with neck surgery, and is typically treated with oral calcium and active vitamin D. Such treatment effectively increases levels of serum calcium (sCa), but also brings risk of hypercalciuria and renal damage. There is thus considerable interest in using PTH or PTH (...) analogs to treat HP. To facilitate study of this disease and the assessment of new treatment options, we developed two mouse models of acquired HP, and used them to assess efficacy of PTH(1-34) as well as a long-acting PTH analog (LA-PTH) in regulating blood calcium levels. In one model, we used PTHcre-iDTR mice in which the diphtheria toxin (DT) receptor (DTR) is selectively expressed in PT glands, such that systemic DT administration selectively ablates parathyroid cells. For the second model, we

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2015 Journal of Bone and Mineral Research

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