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161. Delirium in Adult Cancer Patients: ESMO Clinical Practice Guidelines

anticholinergic activity, e.g. tricyclic antidepressants, diphenhydramine, promethazine, trihexyphenidyl, hyoscine butylbromide Other psychoactive: antipsychotics, antidepressants, levodopa, lithium Anti-infectives: cipro?oxacin, acyclovir, ganciclovir Histamine H2 blockers Omeprazole Immunomodulators: interferon, interleukins, ciclosporin Medication polypharmacy Otherstatusorpredisposingcomorbidities[5,39] Age> 70 years Pre-existing cognitive impairment, e.g. dementia History of delirium Hearing impairment

2018 European Society for Medical Oncology

162. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline

insomnia (versus no treatment) in adults. (WEAK) We suggest that clinicians not use trazodone as a treatment for sleep onset or sleep maintenance insomnia (versus no treatment) in adults. (WEAK) We suggest that clinicians not use tiagabine as a treatment for sleep onset or sleep maintenance insomnia (versus no treatment) in adults. (WEAK) We suggest that clinicians not use diphenhydramine as a treatment for sleep onset and sleep maintenance insomnia (versus no treatment) in adults. (WEAK) We suggest

2017 American Academy of Sleep Medicine

164. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold

to make cough less severe or resolve sooner (Ungraded Consensus-Based Statement). 2. In adult patients with cough due to the common cold, we suggest against the use of nonsteroidal anti- in?ammatory agents until they have been shown to make cough less severe or resolve sooner (Ungraded Consensus-Based Statement). 3. In pediatric patients (aged 1-18 years) with cough due to the common cold, we suggest honey may offer more relief for cough symptoms than no treatment, diphenhydramine, or placebo (...) broncho-pulmonary disease. Cochrane Database Syst Rev. 2013;(5):CD003124. 15. De Sutter AIM, Saraswat A, van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev. 2015;(11):CD009345. 16. Dicpinigaitis PV, Dhar S, Johnson A, Gayle Y, Brew J, Caparros- Wanderley W. Inhibition of cough re?ex sensitivity by diphenhydramine during acute viral respiratory tract infection. Int J Clin Pharm. 2015;37(3):471-474. 17. Kim SY, Chang YJ, Cho HM, Hwang YW, Moon YS. Non-steroidal anti-in?ammatory

2017 American College of Chest Physicians

167. CRACKCast E029 – Nausea and Vomiting

hyperaldosteronism 2) List commonly used antiemetics including their dose and their receptor site of action. Treatment pathophysiology: Because the CTZ is stimulated by dopamine & other neurotransmitters, most of the drugs to relieve N/V are: Dopamine D2 antagonists (metoclopramide / Maxeran) Serotonin receptor antagonists ( ondansetron / Zofran) Cholinergic & histamine receptors antagonists are in the lateral vestibular nucleus (diphenhydramine, scopolamine, dimenhydrinate) Cannabinoid receptors also inhibit (...) Prochlorperazine, haloperidol, promethazine s/e: dystonic reactions (4%), sedation, restlessness (16%) Treated: with diphenhydramine or benztropine Metoclopramide (prokinetic agent – increased gastric emptying) Has mild anticholinergic and antiserotonin effects Useful in GERD, gastroparesis s/e: tardive dyskinesia, drowsiness, diarrhea, Serotonin antagonists Ondansetron – s/e headaches and constipation/diarrhea Benzodiazepines: No literature to support their routine use for non-specific N/V in the ED Non-pharm

2017 CandiEM

168. Pharmacology and Substance Use

, morphine, etc.), sedatives and medications for anxiety and sleep (e.g., lorazepam, diazepam, diphenhydramine, etc.). Depressants have this slowing effect because they affect certain neurotransmitters that act as the brakes in the brain. ? Stimulants increase brain activity, especially in areas that are part of the reward system (see Figure 1). Because of this activity, stimulants lead to pleasurable and rewarding effects. They include drugs such as cocaine, methamphetamine, methylphenidate

2017 Canadian Centre on Substance Abuse

169. CRACKCast E070 – Oral Medicine

causes of oral ulcerations: Hand-foot-mouth / Herpetic stomatitis/ HIV / Syphilis / TB / Wegner’s / Scleroderma / Lupus / to name a few Symptomatic care Saline and Hydrogen peroxide rinses Mix of Benzocaine and diphenhydramine gel Rx for steroid – antibiotic ointments (Kenalog or orabase) F/U with GP to ensure resolution WiseCracks Case 1: Spot Diagnosis! 32yo male with obvious right sided deep space neck infection and chest pain, SOB and severe septic shock. Remember: Deep fascial layers of neck

2017 CandiEM

172. Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial (Abstract)

). Our objective was to determine if IV lidocaine provides significant pain relief and overall improvement in quality of life in the longer term (for up to four weeks).This single site randomized double-blind, crossover trial compared IV lidocaine infusion (5 mg·kg-1) with active placebo infusion containing diphenhydramine (50 mg) in patients with chronic neuropathic pain of peripheral nerve origin of at least six months duration. The primary outcome was average pain intensity reduction from IV

2019 EvidenceUpdates

173. Immune (idiopathic) thrombocytopenic purpura: rituximab

rituximab's licensed indications. Severe infusion-related reactions with a fatal outcome have been reported in post-marketing use. Premedication with an anti-pyretic and an antihistamine (for example, paracetamol and diphenhydramine) should always be given before administration of intravenous rituximab. In addition, premedication with a glucocorticoid should be given (except in people with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who are receiving rituximab in combination

2014 National Institute for Health and Clinical Excellence - Advice

174. Intravenous Fluid for the Treatment of Emergency Department Patients With Migraine Headache: A Randomized Controlled Trial (Abstract)

(fluid group) or saline solution at 10 mL/hour for 1 hour (control group). All patients received intravenous prochlorperazine and diphenhydramine at the start of fluid administration. Participants and outcome assessors were blinded; nurses administering the intervention were not. Outcomes were assessed at 60 and 120 minutes, and 48 hours. The primary outcome was the difference in the verbal pain rating (on a scale of 0 to 10) between 0 and 60 minutes. Key secondary outcomes included additional

2019 EvidenceUpdates

175. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Full Text available with Trip Pro

as well as diphenhydramine and lorazepam. The gel was not significantly better than placebo in this small study; however haloperidol is reported not to be absorbed significantly when applied topically, therefore the trial does not address the issue of whether haloperidol is effective or well-tolerated when administered by other routes (e.g. by mouth, subcutaneously or intravenously). We identified one ongoing trial of haloperidol for the management of nausea and vomiting in patients with cancer

2015 Cochrane

176. Sipuleucel-T - Benefit assessment according to §35a Social Code Book V (dossier assessment)

and antihistamine (e.g. diphenhydramine) ? ADT: surgical or medical castration with LH-RH agonists ? steroids; bisphosphonates were allowed if treatment had been started 28 days before the start of the study and the dose remained stable ? supportive care: transfusion of blood and blood products, antibiotics, antiemetics D9901 Sipuleucel-T IV 3 x approx. 30 min infusion at an interval of approx. 2 weeks (week 0, 2 and 4) Dose: total sipuleucel-T that could be prepared from a single leukapheresis procedure (...) , at least 3 x 10 6 CD54+ cells, activated with PAP-GM-CSF Sham treatment IV 3 x approx. 30 min infusion at an interval of approx. 2 weeks (week 0, 2 and 4) Dose per infusion: approx. 1/3 of inactive APCs that could be prepared from a single leukapheresis procedure Concomitant treatment: ? leukapheresis procedure 2–3 days before each infusion ? before infusion: acetaminophen and antihistamine (e.g. diphenhydramine) ? ADT: surgical or medical castration with LH-RH agonists ? steroids; bisphosphonates were

2015 Institute for Quality and Efficiency in Healthcare (IQWiG)

177. Oral versus Intravenous Administration of Pre-Chemotherapy Symptom Control Medications: Safety and Guidelines

administration of one medication for chemotherapy symptom control; one evidence-based guideline was identified regarding administration of pre-chemotherapy symptom control medications. Tags antineoplastic agents, chemotherapy, dexamethasone, dexasone, diphenhydramine, diphenylhydramine, metoclopramide, ondansetron, ranitidine, reglan, zantac, zofran, chemo-therapy, pre-chemo, pre-chemotherapy, prechemo, prechemotherapy Files Rapid Response Summary of Abstracts Published : March 11, 2016 Follow us: © 2019

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

178. Constipation in older adults: Stepwise approach to keep things moving

) Anticholinergic drugs: antipsychotic drugs, benztropine, oxybutynin Anti-Parkinson drugs: amantadine, bromocriptine, pramipexole Anticonvulsant drugs: gabapentin, phenytoin, pregabalin Antidepressant drugs: tricyclic antidepressants, paroxetine Antidiarrheal drugs: diphenoxylate, loperamide Antiemetic drugs: dimenhydrinate, ondansetron, prochlorperazine, promethazine, scopolamine Antihistamine drugs: diphenhydramine, hydroxyzine Antihypertensive drugs: α-adrenergic agonists (eg, clonidine), β-blockers

2016 RxFiles

180. Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines

frequent: bronchospasm, hypertension and hypoxia. Premedication 1h before every infu- sion: i.v. corticosteroid [(methyl)- prednisolone 100mg, or equivalent], oral antipyretics (para- cetamol 650–1000mg) and oral or i.v. antihistamine (diphenhydramine 25–50mg or equivalent). Following the second infusion, the dose of i.v. corticosteroid may be reduced [(methyl)prednisolone 60mg]. Post-infusion medication: oral corticosteroid [20mg (methyl)pred- nisolone or equivalent] on each of the 2 days following (...) : oral paracetamol 1g, oral or i.v. antihist- amine (e.g. diphenhydramine 50mg or cetirizine 10mg), i.v. corti- costeroid (prednisolone: in previ- ously untreated or relapsed CLL 50mg and in refractory CLL 100mg). If the patient does not experience an IR in the ?rst and second infusion, corticosteroid may be reduced or omitted. Before ninth infusion (?rst monthly infusion), full dose of premedication agents. If no IR, prednisolone may be reduced to 50mg. [IV, B] Grade 1/2: stop or slow the infusion

2017 European Society for Medical Oncology

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