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Diphenhydramine

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101. Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis

Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis - Full Text View (...) - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From

2010 Clinical Trials

102. Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01204255 Recruitment Status : Completed First Posted : September 17, 2010 Results First Posted : August 5, 2011 Last Update Posted : November 17, 2017

2010 Clinical Trials

103. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition

Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01053338 Recruitment Status : Completed First Posted : January 21, 2010

2010 Clinical Trials

104. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition

Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01053208 Recruitment Status : Completed First Posted

2010 Clinical Trials

105. Rapid urine drug screens: diphenhydramine and methadone cross-reactivity. (PubMed)

Rapid urine drug screens: diphenhydramine and methadone cross-reactivity. Rapid urine screens to detect drugs of abuse are often used in pediatric emergency departments (PEDs). A positive result may lead to further clinical testing, social evaluation, and increased stress/inconvenience. A PED patient with suspected diphenhydramine (DPH) ingestion had a positive methadone result on the rapid urine drug screen, One Step Multi-Drug, Multi-Line Screen Test Device (ACON Laboratories, San Diego

2010 Pediatric Emergency Care

106. Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial (PubMed)

Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial A randomized, controlled, crossover clinical study compared 14-night treatment with 15 mg temazepam, 50 mg diphenhydramine, and placebo in elderly individuals with insomnia (mean age, 73.9 years; range, 70-89 years). Primary outcome measures were subjective assessments of sleep recorded on sleep diaries. Secondary measures were the morning-after psychomotor impairment (...) were seen with diphenhydramine treatment compared with placebo on the number of awakenings only (mean, 1.7 +/- 1.1 vs 2.0 +/- 1.2; P < 0.05). Numbers of adverse events reported were similar after all treatments, although there was 1 fall during temazepam treatment. Findings indicate that temazepam is more effective than diphenhydramine when compared with placebo at the doses tested, although this advantage is mitigated by the risk of falls associated with temazepam use. The choice of agent to use

2008 EvidenceUpdates

107. Cough (acute): antimicrobial prescribing

reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 11 of 36Summary of the e Summary of the evidence vidence Self-care Hone Honey y Honey significantly reduced the frequency and severity of cough at 1 day follow-up compared with placebo, no treatment or an antihistamine (diphenhydramine) by about 0.5 to 2 points on a carer-reported 7-point Likert scale in children and young people with an acute cough caused by an upper respiratory tract infection (...) ), but not compared with no treatment or dextromethorphan (low quality evidence). Honey had no significant effect on children's or parents' sleep quality compared with placebo or dextromethorphan, but was significantly better compared with no treatment or diphenhydramine (by about 0.5 to 1 point on a 7-point Likert scale; low to moderate quality evidence). There was no data on the effect of honey on cough duration because follow-up was for 1 day only. There was no significant difference in gastrointestinal side

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

108. Insomnia

may be considered as an adjunct to ongoing behavioral treatment of insomnia. o First-line: doxepin (preferred), melatonin (alternative) o Second-line: trazodone o First-line in the elderly: ramelteon, melatonin • The following pharmacologic treatments are not recommended for insomnia: o Benzodiazepines and Z-drugs o Diphenhydramine (Benadryl) • Changes in sleep patterns, such as difficulty in sleep initiation and reductions in total sleep time and sleep efficiency, are a normal part of the aging (...) , weight gain Doxepin Antidepressant 10 min 80 min HRME Limit < 6 mg if aged = 65 years. Trazodone Antidepressant 10 min 80 min Orthostatic hypotension Diphenhydramine OTC – antihistamine No change 11 min HRME Limit use to 2–3 days. May impair physical or mental abilities Doxylamine OTC – antihistamine Not available Not available HRME Limit use to 2–3 days. May impair physical or mental abilities Temazepam Benzodiazepine 4 15 min 33 min Risk of next-day impairment, unawareness of activities during

2019 Kaiser Permanente Clinical Guidelines

109. Management of Cancer Medication-Related Infusion Reactions

medications • Route of administration • Drug formulation • Patient factors Additional Considerations • Consider a non-sedating H1-receptor antagonist (e.g. cetirizine 10 mg) in patients with comorbidities where diphenhydramine may be contraindicated. 12,13 Key prophylactic recommendations by medication 1.2 Taxanes: Anticancer Medication Prevention Strategy Paclitaxel every 3 weeks 7,14–24 (Recommendation 1.1) • Dexamethasone 20 mg PO 12- and 6- hours prior to paclitaxel OR Dexamethasone 20 mg IV 30-60 (...) minutes prior to paclitaxel. • Diphenhydramine 25-50 mg IV/PO 30-60 minutes prior to paclitaxel. • Ranitidine 50 mg IV or Famotidine 20 mg IV 30-60 minutes prior to paclitaxel. Management of Cancer Medication-Related Infusion Reactions 10 Anticancer Medication Prevention Strategy Weekly Paclitaxel 7,17,18,22,23,25,26 (Recommendation 1.2, Recommendation 1.3) To be given 30-60 minutes prior to paclitaxel: • Dexamethasone 10 mg IV. • Diphenhydramine 25-50 mg IV/PO. • Ranitidine 50 mg IV or Famotidine 20

2019 Cancer Care Ontario

110. Trastuzumab (Ogivri) - breast cancer or stomach cancer

be used to reduce risk of occurrence of these events. The majority of these events occur during or within 2.5 hours of the start of the first infusion. Should an infusion reaction occur the infusion should be discontinued or the rate of infusion slowed and the patient should be monitored until resolution of all observed symptoms (see section 4.2). These symptoms can be treated with an analgesic/antipyretic such as meperidine or paracetamol, or an antihistamine such as diphenhydramine. The majority

2019 European Medicines Agency - EPARs

111. Pharmacological management of migraine

for complete headache relief when compared to metoclopramide. 29 Both prochlorperazine 10 mg and metoclopramide 20 mg (both coadministered with diphenhydramine and given intravenously) were found to be effective for pain relief at one hour for patients with acute migraine, as recorded on the NRS scale. At two hours the NRS for pain after treatment with prochlorperazine was 6.4 from a baseline NRS of 8.4, and for metoclopramide 5.9 from a baseline NRS of 8.8. The overall difference was 0.6 (95% CI -0.6

2018 SIGN

112. Honey for acute cough in children. (PubMed)

assessed two studies as at high risk of performance and detection bias; three studies as at unclear risk of attrition bias; and three studies as at unclear risk of other bias.Studies compared honey with dextromethorphan, diphenhydramine, salbutamol, bromelin (an enzyme from the Bromeliaceae (pineapple) family), no treatment, and placebo. Five studies used 7-point Likert scales to measure symptomatic relief of cough; one used an unclear 5-point scale. In all studies, low score indicated better cough (...) studies; 149 children; low-certainty evidence). Honey may be better than diphenhydramine in reducing cough frequency (MD -0.57, 95% CI -0.90 to -0.24; 1 study; 80 children; low-certainty evidence).Giving honey for up to three days is probably more effective in relieving cough symptoms compared with placebo or salbutamol. Beyond three days honey probably had no advantage over salbutamol or placebo in reducing cough severity, bothersome cough, and impact of cough on sleep for parents and children

2018 Cochrane

113. Transfusion reaction

-associated sepsis, and circulatory overload, should be considered in the differential diagnosis. Acute haemolytic transfusion reactions are most often the result of clerical error. Identification is critical because of the high probability of a second patient receiving the wrong blood product at the same time. Treatment depends upon the type of transfusion reaction. Although pretransfusion prophylactic paracetamol and diphenhydramine are often routinely administered, there is little evidence to support

2018 BMJ Best Practice

114. Methocarbamol

of diphenhydramine, lorazepam and methocarbamol : evaluation of abuse liability. 1501118 1992 09 11 1992 09 11 2015 11 19 0022-3565 262 2 1992 Aug The Journal of pharmacology and experimental therapeutics J. Pharmacol. Exp. Ther. Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol : evaluation of abuse liability. 707-20 The effects of orally administered placebo, diphenhydramine, lorazepam, methocarbamol and placebo were studied (...) in volunteers with histories of recreational (...) substance abuse including sedative/hypnotics. Placebo, diphenhydramine (100, 200 and 400 mg), lorazepam (1 and 4 mg) and methocarbamol (2.25 and 9 g) were tested in a randomized, double-blind crossover study using 14 subjects. Psychomotor and cognitive performance and subject- and observer-rated responses were measured daily before and for 5.5 hr after drug administration. The results showed that each of the drugs exhibited a different profile of effects 1992 Follow us: © 2019 Trip Database Ltd. company

2018 Trip Latest and Greatest

116. Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache

Class II 33-35 and 10 Class 388 III 36-45 studies. 389 In a Class II study published by Friedman et al, 33 the authors compared outcomes among ED patients with 390 migraine who received intravenous hydromorphone versus those who received intravenous prochlorperazine and 391 diphenhydramine. This was a double-blinded study that was halted by the data monitoring committee after 392 enrollment of 127 patients because of clear benefit in the nonopioid arm of the study. The primary outcome 393 included

2019 American College of Emergency Physicians

117. Tisagenlecleucel (Kymriah) - diffuse large B-cell lymphoma (DLBCL)

be pre- medicated with paracetamol and diphenhydramine (or another H1 antihistamine) approximately 30 to 60 minutes before tisagenlecleucel infusion. Tisagenlecleucel must be administered in a qualified treatment centre, and should be initiated under the direction of and supervised by a healthcare professional experienced in the treatment of haematological malignancies and trained for administration and management of patients treated with tisagenlecleucel. A minimum of four doses of tocilizumab (...) was a single intravenous infusion of 5.0 × 10 8 viable tisagenlecleucel transduced cells (acceptable dose range was 1.0 to 5.0 x 10 8 viable tisagenlecleucel transduced cells). Patients were given premedication with paracetamol and diphenhydramine or another H1 antihistamine every six hours as needed. 2 The primary outcome was overall response rate (ORR), defined as a best overall response of complete or partial response until progressive disease or start of new anticancer therapy. Response was assessed

2019 Scottish Medicines Consortium

120. Axicabtagene ciloleucel (Yescarta) - relapsed or refractory diffuse large B cell lymphoma (DLBCL) and primary mediastinal large B cell lymphoma (PMBCL)

, and third day before infusion of axicabtagene ciloleucel. Pre-medication: Paracetamol 500mg to 1,000mg given orally and diphenhydramine 12.5mg intravenous or oral (or equivalent) approximately one hour before axicabtagene ciloleucel infusion is recommended. Axicabtagene ciloleucel must be administered in a qualified clinical setting. Axicabtagene ciloleucel should be initiated under the direction of and supervised by a healthcare professional experienced in the treatment of haematological malignancies

2019 Scottish Medicines Consortium

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