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Diphenhydramine

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81. [Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. (PubMed)

[Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. 4387505 1969 02 27 2006 11 15 0040-5957 23 5 1968 Sep-Oct Therapie Therapie [Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. 1037-48 Bordeleau J M JM Saint-Hilaire (...) J J Juretic F F Tetreault L L fre Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial Assomication hypnotique-antihistaminique. Evaluation comparative des propriétés hypnotiques du Mandrax, de la méthaqualone, du sécobarbital, de la diphenhydramine et du placebo chez le malade mental psychiatrique. France Therapie 0420544 0040-5957 0 Histamine H1 Antagonists 0 Hypnotics and Sedatives IM Adolescent Adult Drug Synergism Female Histamine H1

1969 Therapie

82. Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability. (Full text)

Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability. To see whether antihistamines could prevent and reverse histamine-induced pulmonary edema and increased lung vascular permeability, we compared the effects of a 4-h intravenous infusion of 4 mug/kg per min histamine phosphate on pulmonary hemodynamics, lung lymph flow, lymph and plasma protein content, arterial blood gases (...) , hematocrit, and lung water with the effects of an identical histamine infusion given during an infusion of diphenhydramine or metiamide on the same variables in unanesthetized sheep. Histamine caused lymph flow to increase from 6.0+/-0.5 to 27.0+/-5.5 (SEM) ml/h (P less than 0.05), lymph; plasma globulin concentration ratio to increase from 0.62+/-0.01 to 0.67+/-0.02 (P less than 0.05), left atrial pressure to fall from 1+/-1 to -3+/-1 cm H2O (P less than 0.05), and lung lymph clearance of eight protein

1976 Journal of Clinical Investigation PubMed

83. A rapid method for the determination of diphenhydramine in plasma (Full text)

A rapid method for the determination of diphenhydramine in plasma 22216532 2012 01 26 2018 11 13 0306-5251 3 6 1976 Dec British journal of clinical pharmacology Br J Clin Pharmacol A rapid method for the determination of diphenhydramine in plasma. 1062-4 Baugh R R Calvert R T RT eng Letter England Br J Clin Pharmacol 7503323 0306-5251 0 Histamine H1 Antagonists 8GTS82S83M Diphenhydramine IM Calibration Chromatography, Gas methods Diphenhydramine blood Histamine H1 Antagonists blood Humans 2012

1976 British journal of clinical pharmacology PubMed

84. Acute Diphenhydramine Hydrochloride Poisoning (Full text)

Acute Diphenhydramine Hydrochloride Poisoning 13051559 2003 05 01 2018 12 01 0007-1447 2 4826 1953 Jul 04 British medical journal Br Med J A case of acute diphenhydramine hydrochloride poisoning. 24 AARON F E FE eng Journal Article England Br Med J 0372673 0007-1447 0 Salts 8GTS82S83M Diphenhydramine OM Diphenhydramine poisoning Drug-Related Side Effects and Adverse Reactions Humans Salts 5324:22096:195 DIPHENHYDRAMINE/poisoning 1953 7 4 1953 7 4 0 1 1953 7 4 0 0 ppublish 13051559 PMC2028543 Br

1953 British medical journal PubMed

85. Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations (Full text)

Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations Histamine stimulated the isolated auricles and heart of the guinea-pig. The effect was best seen in auricles which had been previously depressed by treatment with reserpine. Ganglionic blocking drugs (hexamethonium and pempidine), applied to auricles which had been previously treated with reserpine, abolished the diphasic effect of nicotine (...) , but did not alter the response to histamine. Dichloroisoproterenol did not modify the stimulant action of histamine in isolated auricles, either before or after treatment with reserpine; nor did it alter the response of the isolated heart. Diphenhydramine reduced or blocked the stimulant action of histamine in auricles which had been previously treated with reserpine. The results support the hypothesis that histamine stimulates the myocardium by a direct action on specific receptors.

1960 British journal of pharmacology and chemotherapy PubMed

86. Extrapyramidal Symptoms Associated with the Administration of Trifluoperazine: Report of a Case Treated with Diphenhydramine (Full text)

Extrapyramidal Symptoms Associated with the Administration of Trifluoperazine: Report of a Case Treated with Diphenhydramine 13891541 1998 11 01 2018 12 01 0008-4409 85 1961 Dec 30 Canadian Medical Association journal Can Med Assoc J Extrapyramidal symptoms associated with the administration of trifluoperazine: report of a case treated with diphenhydramine. 1459 FANNING W J WJ eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Tranquilizing Agents 214IZI85K3 Trifluoperazine (...) 8GTS82S83M Diphenhydramine OM Basal Ganglia Diseases Diphenhydramine therapy Disease Extrapyramidal Tracts Tranquilizing Agents toxicity Trifluoperazine DIPHENHYDRAMINE/therapy EXTRAPYRAMIDAL TRACTS/diseases TRANQUILIZING AGENTS/toxicology 1961 12 30 1961 12 30 0 1 1961 12 30 0 0 ppublish 13891541 PMC1848744 Dis Nerv Syst. 1959 Jan;20(1):24-6 13609517 N Engl J Med. 1960 Feb 18;262:353-4 13843192

1961 Canadian Medical Association Journal PubMed

87. Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. (Full text)

Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 4513854 1973 08 09 2018 11 13 0003-3006 20 3 1973 May-Jun Anesthesia progress Anesth Prog Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 76-82 Malamed S F SF eng Journal Article United States Anesth Prog 0043533 0003-3006 0 Anesthetics, Local 8GTS82S83M Diphenhydramine D Anesthesia, Dental Anesthetics, Local Diphenhydramine administration & dosage 1973 5 1 1973 5 1 0 1 1973 5 1 0 0 ppublish

1973 Anesthesia progress PubMed

88. The influence of diphenhydramine on the absorption of methaqualone in man (Full text)

The influence of diphenhydramine on the absorption of methaqualone in man 1 The effects of diphenhydramine on the buccal absorption, in vivo absorption and the in vitro dissolution of methaqualone have been studied. 2 Diphenhydramine significantly reduced the buccal absorption of methaqualone and the effect was dose and pH dependent. In vivo, diphenhydramine did not alter the rate of absorption or the distribution of methaqualone in blood. In vitro, the presence of diphenhydramine increased (...) the rate of dissolution of methaqualone and the effect was more marked when the particle size was small. 3 The reasons for and the implications of these apparently contradictory results are discussed and it is concluded that any increased efficacy resulting from combining diphenhydramine with methaqualone cannot be due to increased plasma drug levels.

1974 British journal of clinical pharmacology PubMed

89. Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. (PubMed)

Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings (...) , whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.

1978 European journal of clinical pharmacology

90. Hypnotic activity of diphenhydramine, methapyrilene, and placebo. (PubMed)

Hypnotic activity of diphenhydramine, methapyrilene, and placebo. In a double-blind controlled study, an oral dose of diphenhydramine hydrochloride (12.5, 25, or 50 mg), methapyrilene fumarate (36, 72, or 144 mg), or placebo was administered to 1295 post-partum patients if they complained of, or anticipated, a sleep problem. Hypnotic activity was assessed clinically by subjective and objective techniques. Methapyrilene and diphenhydramine, at all doses, were found to be effective hypnotics

1978 Journal of clinical pharmacology

91. Methamphetamine and diphenhydramine effects on the rate of cognitive processing. (PubMed)

Methamphetamine and diphenhydramine effects on the rate of cognitive processing. Three cognitive tasks in which performance depends primarily on the rate of cognitive processing were given to 24 male subjects before and after oral doses of methamphetamine (10 mg), diphenhydramine hydrochloride (100 mg), and placebo. Each subject was tested on Monday, Wednesday, and Friday of one week with drug orders balanced across subjects. Compared with placebo and diphenhydramine, methamphetamine increased (...) , diphenhydramine caused subjects no experience geophysical time as passing more slowly, but the drug had no significant effects on the visual search or divided-attention tasks. This suggests that time perception is more likely to be altered by diphenhydramine than is performance on tasks requiring short periods of rapid cognitive processing.

1978 Psychopharmacology

92. A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. (PubMed)

A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. Lotussin and linctus diphenhydramine were compared for efficacy and patient preference in fifty patients suffering from post-infective cough. The trial was a single-blind randomized crossover one which was subjected to sequential analysis based on patient preferences. Under the conditions of the trial there appeared to be a significant difference in favour of Lotussin (p less than 0-01).

1977 The Journal of international medical research

93. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01118273 Recruitment Status : Completed First Posted : May 6, 2010 Results First Posted : June 17, 2014 Last Update Posted : June 8, 2015 Sponsor: Bayer Information provided

2010 Clinical Trials

94. Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers

Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01119222 Recruitment Status : Completed First Posted : May 7, 2010 Results

2010 Clinical Trials

95. Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. (PubMed)

Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. Subarachnoid (SA) morphine, highly effective for the management of pain after a cesarean delivery, is associated with a significant incidence of pruritus in up to 80% of patients. No previous study has compared the effectiveness of ondansetron (5-HT(3) antagonist) vs. diphenhydramine (H(1) receptor blocker) for the treatment of this side effect.In this randomized, double-blind (...) study, 113 patients with a pruritus score 3 or 4 (1=absent; 2=mild, no treatment required; 3=moderate pruritus, treatment required; and 4=severe pruritus) after SA morphine 0.2 mg were assigned to group ondansetron, which received 4 mg intravenously (i.v.) ondansetron, and group diphenhydramine, which received 25 mg i.v. diphenhydramine. Patients who continued to have pruritus > or =3, 30 min after the study drug were considered treatment failures and were treated with naloxone 0.04 mg i.v

2010 Acta Anaesthesiologica Scandinavica

96. Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. (PubMed)

Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. The objective of this study was to determine if sex influences the pharmacokinetics and hemodynamics of the CYP2D6 substrate metoprolol and its interaction with diphenhydramine (CYP2D6 inhibitor) in healthy young participants with high (extensive metabolizer [EM]) or low (poor metabolizer [PM]) CYP2D6 activities. A prespecified comparative analysis of data from 2 sequential clinical trials (...) that included 16 EM and 4 PM women and 10 EM and 6 PM men was performed. The participants in the 2 trials were administered a single oral dose of 100 mg metoprolol in the presence of steady-state diphenhydramine or placebo. Serial plasma and urine samples were obtained for 48 hours, and hemodynamic data was obtained for 12 hours after metoprolol. In the placebo arm, EM and PM women had 62% and 59% higher S-metoprolol AUC(0-infinity) and 26% and 71% lower CL/F, respectively, compared to men with the same

2010 Journal of clinical pharmacology

97. Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. (Full text)

Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia.during the period July 2007 to August 2008, 200 women scheduled for abdominal total (...) hysterectomy were randomised to one of four postoperative, patient-controlled analgesia regimens: group 1, morphine 1 mg ml; group 2, morphine 1 mg ml with metoclopramide 0.5 mg ml; group 3, morphine 1 mg ml with diphenhydramine 0.6 mg ml; and group 4, morphine 1 mg ml with metoclopramide 0.5 mg ml and diphenhydramine 0.6 mg ml. Dexamethasone 4 mg was administered to all patients in all groups after anaesthesia induction as a prophylactic antiemetic medication, and prochlorperazine 5 mg was administered

2010 European Journal of Anaesthesiology PubMed

98. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. (PubMed)

A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. Coughing is a prevalent symptom of upper respiratory infections (URIs) that cause disturbance in the sleep of children and their parents. There is as yet no reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world. The aim of this study is to compare

2010 Journal of Alternative and Complementary Medicine

99. Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. (PubMed)

Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. Antihistamines often are self-administered at night as over-the-counter (OTC) sleep aids, but their next-day residual sedative effect has never been evaluated using a reliable quantitative method such as positron emission tomography (PET). We performed a double-blind, placebo-controlled, crossover study in which we evaluated (...) the residual effect the next day after nighttime administration of diphenhydramine, a commonly used OTC sleep aid, in terms of brain H₁ receptor occupancy (H₁RO) measured using ¹¹C-doxepin-PET. We also compared the results of diphenhydramine with those of bepotastine, a second-generation antihistamine. Eight healthy adult male subjects underwent PET measurement the morning (11:00) after random oral administration of diphenhydramine (50 mg), bepotastine (10 mg), or placebo the night before (23:00). Binding

2010 Journal of Clinical Psychopharmacology

100. Reduction of the infarct size by simultaneous administration of l-histidine and diphenhydramine in ischaemic rat brains. (PubMed)

Reduction of the infarct size by simultaneous administration of l-histidine and diphenhydramine in ischaemic rat brains. While diphenhydramine is a histamine H(1) receptor antagonist, the agent has been shown to inhibit histamine-N-methyltransferase, a histamine inactivating enzyme in the brain. Since an increase in the brain concentration of histamine ameliorates reperfusion injury after cerebral ischaemia, effects of postischaemic administration of diphenhydramine were evaluated in rats (...) % confidence intervals, n=6). Administration of l-histidine (1000mg/kg, intraperitoneal) immediately after reperfusion did not affect the infarct size. Simultaneous administration of diphenhydramine (20mg/kg, intraperitoneal) with l-histidine reduced the infarct size to 25% and 21% of that in the control group, respectively. The combination therapy completely reduced ischaemia-induced brain oedema.Because histamine H(1) action does not influence ischaemic brain damage, elevation of the central histamine

2010 Resuscitation

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