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Diphenhydramine

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81. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain (Morpheus II) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01280591 Recruitment Status : Completed First

2011 Clinical Trials

82. Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis

Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01293968 Recruitment Status : Completed First Posted : February 11, 2011 Results First Posted : June 20

2011 Clinical Trials

83. Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects (LoDi-Basel) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01321021 Recruitment Status : Completed First Posted : March 23, 2011 Last Update

2011 Clinical Trials

84. Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine

Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine (MalD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01289938 Recruitment Status : Terminated (To unsuccessful recruitment of rare UM-genotype. All other planned genotype groups are completed (EM, IM and PM).) First Posted

2011 Clinical Trials

85. A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery

A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01451762 Recruitment Status : Completed First Posted : October

2011 Clinical Trials

86. Case Files of the Medical Toxicology Fellowship at Drexel University: Rhabdomyolysis and Compartment Syndrome Following Acute Diphenhydramine Overdose Full Text available with Trip Pro

Case Files of the Medical Toxicology Fellowship at Drexel University: Rhabdomyolysis and Compartment Syndrome Following Acute Diphenhydramine Overdose 21656083 2011 11 30 2018 11 13 1937-6995 7 3 2011 Sep Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose. 213-9 10.1007/s13181-011-0157-3 (...) Vearrier David D Division of Medical Toxicology, Department of Emergency Medicine, Drexel University College of Medicine, Philadelphia, PA 19102, USA. david.vearrier@drexelmed.edu Curtis John A JA eng Case Reports Journal Article United States J Med Toxicol 101284598 1556-9039 0 Central Nervous System Depressants 0 Histamine H1 Antagonists 0 Xenobiotics 3K9958V90M Ethanol 8GTS82S83M Diphenhydramine IM Adult Blood Chemical Analysis Central Nervous System Depressants poisoning Compartment Syndromes

2011 Journal of Medical Toxicology

87. Evaluation of the subjective and reinforcing effects of diphenhydramine, levetiracetam, and valproic acid. (Abstract)

Evaluation of the subjective and reinforcing effects of diphenhydramine, levetiracetam, and valproic acid. Few unscheduled sedating medications have been evaluated for their subjective and reinforcing effects in humans. To increase the information available about unscheduled sedating medications and to evaluate the ability of human laboratory measures to discriminate between scheduled and unscheduled sedating drugs, 24 subjects with a history of experience with several classes of drugs of abuse (...) , including sedatives and/or alcohol, and who reported liking a test dose of pentobarbital 300 mg, were randomized to single doses of diphenhydramine 400 mg, levetiracetam 4000 mg, valproic acid 1500 mg, diazepam 30 mg or placebo in a double-blind, 5-way crossover study. On the Addiction Research Center Inventory-Morphine-Benzedrine Group and the Next Day Questionnaire measures 'Take Again' and 'Willing to Pay', diazepam produced a significantly greater effect than placebo; all three other active drugs

2011 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain

88. Motion sickness: comparison of metoclopramide and diphenhydramine to placebo. (Abstract)

Motion sickness: comparison of metoclopramide and diphenhydramine to placebo. This is an evaluation of the efficacy of metoclopramide (MTCP) or diphenhydramine (DPH) to relieve symptoms of motion sickness in patients being transported via ambulance in a mountainous setting.This is a prospective, randomized, double-blinded, placebo-controlled study of patients transported by ambulance in the Sierra Nevada mountains of Fresno County. Consenting patients who met the inclusion criteria were asked (...) groups.During ambulance transport in a mountainous setting, the administration of MTCP is superior to both DPH and placebo in the treatment of motion sickness. Diphenhydramine is not superior to placebo.

2011 Prehospital and disaster medicine Controlled trial quality: uncertain

89. Safety Trial of Naproxen Sodium/ Diphenhydramine

Safety Trial of Naproxen Sodium/ Diphenhydramine Safety Trial of Naproxen Sodium/ Diphenhydramine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety Trial of Naproxen Sodium/ Diphenhydramine (MUST (...) : The purpose of this trial is to see how safe the combination of naproxen sodium 440 mg and diphenhydramine hydrochloride (DPH) 50 mg (the investigational product) is compared to placebo (capsules containing no drug) when taken for 10 days. Condition or disease Intervention/treatment Phase Pain Drug: Naproxen sodium 440 mg/DPH 50 mg (BAY98-7111) Drug: Placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 326 participants

2011 Clinical Trials

90. Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery. (Abstract)

Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery. Pruritus is the most common side effect of epidural morphine analgesia. Diphenhydramine is a widely used agent for the treatment of urticarial pruritus. Nalbuphine is a mixed opioid agonist-antagonist and has been reported to be effective in treating opioid-induced pruritus. We compared the effectiveness of intramuscular diphenhydramine and nalbuphine (...) for the prevention of epidural morphine-induced pruritus after cesarean section.One hundred and fifty, American Society of Anesthesiologists physical status I or II, women undergoing cesarean section with epidural anesthesia were randomly assigned to three groups. Group S, group D, and group N received intramuscular normal saline (1 ml; n = 50), diphenhydramine (30 mg/1 ml; n = 50), and nalbuphine (10 mg/1 ml; n = 50), respectively, after delivery of the baby. The occurrence and the severity of pruritus were

2011 Chang Gung medical journal Controlled trial quality: uncertain

91. Cough (acute): antimicrobial prescribing

reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 11 of 36Summary of the e Summary of the evidence vidence Self-care Hone Honey y Honey significantly reduced the frequency and severity of cough at 1 day follow-up compared with placebo, no treatment or an antihistamine (diphenhydramine) by about 0.5 to 2 points on a carer-reported 7-point Likert scale in children and young people with an acute cough caused by an upper respiratory tract infection (...) ), but not compared with no treatment or dextromethorphan (low quality evidence). Honey had no significant effect on children's or parents' sleep quality compared with placebo or dextromethorphan, but was significantly better compared with no treatment or diphenhydramine (by about 0.5 to 1 point on a 7-point Likert scale; low to moderate quality evidence). There was no data on the effect of honey on cough duration because follow-up was for 1 day only. There was no significant difference in gastrointestinal side

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

92. Management of Poisoning

with overdose of tricyclic antidepressants, certain phenothiazines (e.g. mesoridazine and thoridazine), diphenhydramine and other agents with anticholinergic properties (pg 121). Grade D, Level 3 D Urine analysis/microscopy and serum creatinine kinase: rhabdomyolysis in anti-cholinergic toxicity can occur secondary to prolonged seizures or may be atraumatic in doxylamine and diphenhydramine poisoning (pg 122). Grade D, Level 3 D Serum drug levels of anticholinergic agents are not helpful or readily (...) 140). Grade D, Level 3 D For drug-induced dystonia in the adult, give IV benztropine 1-2 mg or diphenhydramine 50 mg IV/IM over 2 minutes. For that in the child, give diphenhydramine 1 mg/kg/dose IV over 2 minutes (maximum 5 mg/kg/day or 50 mg/m2/day) (pg 140). Grade D, Level 3 D Perform continuous cardiac monitoring. Monitor antimuscarinic effects, and check creatine kinase (CK) levels in patients with prolonged agitation, excessive rigidity or coma. In patients with neurologic symptoms, monitor

2020 Ministry of Health, Singapore

93. Polatuzumab vedotin in combination with bendamustine and rituximab for the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are not candidates for haematopoietic stem cell transplant

premedication was planned with oral acetamino- phen/paracetamol and diphenhydramine before administration of polatuzumab vedotin and rituximab (administration of corticosteroids is permitted at the discretion of the treating physician). In addition, tumour lysis syndrome prophylaxis prior to treatment initiation (ad- equate hydration and allopurinol) was recommended in patients with high tumour burden and considered by the investigator to be at high risk. Primary end- point Randomised Phase II stage

2020 EUnetHTA

94. Insomnia

may be considered as an adjunct to ongoing behavioral treatment of insomnia. o First-line: doxepin (preferred), melatonin (alternative) o Second-line: trazodone o First-line in the elderly: ramelteon, melatonin • The following pharmacologic treatments are not recommended for insomnia: o Benzodiazepines and Z-drugs o Diphenhydramine (Benadryl) • Changes in sleep patterns, such as difficulty in sleep initiation and reductions in total sleep time and sleep efficiency, are a normal part of the aging (...) , weight gain Doxepin Antidepressant 10 min 80 min HRME Limit < 6 mg if aged = 65 years. Trazodone Antidepressant 10 min 80 min Orthostatic hypotension Diphenhydramine OTC – antihistamine No change 11 min HRME Limit use to 2–3 days. May impair physical or mental abilities Doxylamine OTC – antihistamine Not available Not available HRME Limit use to 2–3 days. May impair physical or mental abilities Temazepam Benzodiazepine 4 15 min 33 min Risk of next-day impairment, unawareness of activities during

2019 Kaiser Permanente Clinical Guidelines

96. Management of Cancer Medication-Related Infusion Reactions

medications • Route of administration • Drug formulation • Patient factors Additional Considerations • Consider a non-sedating H1-receptor antagonist (e.g. cetirizine 10 mg) in patients with comorbidities where diphenhydramine may be contraindicated. 12,13 Key prophylactic recommendations by medication 1.2 Taxanes: Anticancer Medication Prevention Strategy Paclitaxel every 3 weeks 7,14–24 (Recommendation 1.1) • Dexamethasone 20 mg PO 12- and 6- hours prior to paclitaxel OR Dexamethasone 20 mg IV 30-60 (...) minutes prior to paclitaxel. • Diphenhydramine 25-50 mg IV/PO 30-60 minutes prior to paclitaxel. • Ranitidine 50 mg IV or Famotidine 20 mg IV 30-60 minutes prior to paclitaxel. Management of Cancer Medication-Related Infusion Reactions 10 Anticancer Medication Prevention Strategy Weekly Paclitaxel 7,17,18,22,23,25,26 (Recommendation 1.2, Recommendation 1.3) To be given 30-60 minutes prior to paclitaxel: • Dexamethasone 10 mg IV. • Diphenhydramine 25-50 mg IV/PO. • Ranitidine 50 mg IV or Famotidine 20

2019 Cancer Care Ontario

97. Trastuzumab (Ogivri) - breast cancer or stomach cancer

be used to reduce risk of occurrence of these events. The majority of these events occur during or within 2.5 hours of the start of the first infusion. Should an infusion reaction occur the infusion should be discontinued or the rate of infusion slowed and the patient should be monitored until resolution of all observed symptoms (see section 4.2). These symptoms can be treated with an analgesic/antipyretic such as meperidine or paracetamol, or an antihistamine such as diphenhydramine. The majority

2019 European Medicines Agency - EPARs

99. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

should not be prescribed until they have been shown to make cough less 237 severe or resolve sooner (Ungraded Consensus-Based Statement). 11 238 39. For children with acute cough, we suggest that honey may offer more relief for cough 239 symptoms than no treatment, diphenhydramine, or placebo, but it is not better than 240 dextromethorphan (Ungraded Consensus-Based Statement). 11 241 40. For children with acute cough, we suggest avoiding using codeine-containing 242 medications because

2020 American College of Chest Physicians

100. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

, erythromycin, clarithromycin Quinolones - Cipro?oxacin, levo?oxacin, moxi?oxacin Trimethoprim-sulfamethoxazole Penicillins - Amoxicillin, amoxicillin-clavulanate, ampicillin Tetracycline - Doxycycline, minocycline Cephalosporins - Cefuroxime, cefepime Acetylcysteine Antihistamine (brompheniramine, chlorpheniramine, diphenhydramine, loratadine, fexofenadine, cetirizine) oral or inhaled Expectorant (guaifenesin) Cough suppressant (codeine, dextromethorphan) Decongestant (phenylephrine, pseudoephedrine

2020 American College of Chest Physicians

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