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Diphenhydramine

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61. A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches. Full Text available with Trip Pro

A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches. We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches.In this emergency department (ED)-based randomized, double-blind study, we enrolled adults with nonmigraine (...) the same medication again.We included 120 patients in the analysis. The metoclopramide/diphenhydramine arm improved by a median of 5 (interquartile range 3, 7) scale units, whereas the ketorolac arm improved by a median of 3 (IQR 2, 6) (95% confidence interval [CI] for difference 0 to 3). Metoclopramide+diphenhydramine was superior to ketorolac for all 3 secondary outcomes: the number needed to treat for not requiring ED rescue medication was 3 (95% CI 2 to 6); for sustained headache freedom, 6 (95% CI

2013 Annals of Emergency Medicine Controlled trial quality: predicted high

62. Diphenhydramine

Diphenhydramine Diphenhydramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diphenhydramine Diphenhydramine Aka: Diphenhydramine (...) , Benadryl From Related Chapters II. Indications See for Allergy III. Dosing: Standard Adult: 25-50 mg PO/IV/IM q6h Child: 5 mg/kg/day divided qid (12.5 mg/5 ml) IV. Preparation: Diphenhydramine 1% (for Local Anesthesia) Dilute Diphenhydramine 5% in (1:4) Longer delay to onset of action than Shorter duration of action than Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Diphenhydramine." Click on the image (or right click) to open

2015 FP Notebook

63. Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Patients With Nausea

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Patients With Nausea Randomized Trial of the Effectiveness of Topical "ABH Gel" vs. Placebo in Cancer Patients With Nausea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) Update Posted : October 16, 2015 Sponsor: Virginia Commonwealth University Collaborator: National Cancer Institute (NCI) Information provided by (Responsible Party): Virginia Commonwealth University Study Details Study Description Go to Brief Summary: This randomized clinical trial studies ABH (lorazepam, diphenhydramine hydrochloride, and haloperidol) gel in patients with nausea. ABH gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting. The general purpose

2012 Clinical Trials

64. [Prophylactic effect of diphenhydramine on postoperative vomiting in children after laparoscopic surgery]. (Abstract)

[Prophylactic effect of diphenhydramine on postoperative vomiting in children after laparoscopic surgery]. Laparoscopic percutaneous extraperitoneal closure (LPEC), introduced as an alternative to a conventional open inguinal hernia repair in children, has shown a higher incidence of postoperative vomiting (POV). The aim of this study was to examine whether a prophylactic use of diphenhydramine can decrease the incidence of POV in children undergoing LPEC.We studied 60 girls between 1 and 6 (...) years of age with ASA physical status I or II undergoing LPEC. Patients were allocated to receive either diphenhydramine 1 mg x kg(-1) intravenously (n = 30) or placebo (n = 30) during the operation. Anesthesia was performed with air-oxygen-sevoflurane in combination with epidural anesthesia. Opioids were avoided throughout the perioperative period. The incidence of POV was recorded postoperatively.Demographic data were similar between the groups. The overall incidence of POV during the first 24

2012 Masui. The Japanese journal of anesthesiology Controlled trial quality: uncertain

65. A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. (Abstract)

A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. The study aimed to evaluate the effects of midazolam and diphenhydramine for the prevention of metoclopramide-induced akathisia.This randomized, double-blind, and controlled trial aimed to investigate coadministered midazolam vs diphenhydramine in the prophylaxis of metoclopramide-induced akathisia. Patients 18 to 65 years of age who presented to the emergency department with primary or secondary (...) complaints of nausea and/or moderate to severe vascular-type headache were eligible for this study. Patients were randomized to one of the fallowing 3 groups: (1) metoclopramide 10 mg + midazolam 1.5 mg; (2) metoclopramide 10 mg + diphenhydramine 20 mg; (3) metoclopramide 10 mg + placebo. Metoclopramide was administered as a 2-minute bolus infusion. Midazolam, diphenhydramine, and normal saline solution were administered as a 15-minute slow infusion. The whole procedure was observed; and akathisia

2012 American Journal of Emergency Medicine Controlled trial quality: predicted high

66. Acute Diphenhydramine Hydrochloride Poisoning Full Text available with Trip Pro

Acute Diphenhydramine Hydrochloride Poisoning 13051559 2003 05 01 2018 12 01 0007-1447 2 4826 1953 Jul 04 British medical journal Br Med J A case of acute diphenhydramine hydrochloride poisoning. 24 AARON F E FE eng Journal Article England Br Med J 0372673 0007-1447 0 Salts 8GTS82S83M Diphenhydramine OM Diphenhydramine poisoning Drug-Related Side Effects and Adverse Reactions Humans Salts 5324:22096:195 DIPHENHYDRAMINE/poisoning 1953 7 4 1953 7 4 0 1 1953 7 4 0 0 ppublish 13051559 PMC2028543 Br

1953 British medical journal

67. [Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. (Abstract)

[Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. 4387505 1969 02 27 2006 11 15 0040-5957 23 5 1968 Sep-Oct Therapie Therapie [Hypnotic-antihistaminic combination. Comparative evaluation of the hypnotic properties of Mandrax, methaqualone, secobarbital and diphenhydramine and placebo in psychiatric mental patients]. 1037-48 Bordeleau J M JM Saint-Hilaire (...) J J Juretic F F Tetreault L L fre Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial Assomication hypnotique-antihistaminique. Evaluation comparative des propriétés hypnotiques du Mandrax, de la méthaqualone, du sécobarbital, de la diphenhydramine et du placebo chez le malade mental psychiatrique. France Therapie 0420544 0040-5957 0 Histamine H1 Antagonists 0 Hypnotics and Sedatives IM Adolescent Adult Drug Synergism Female Histamine H1

1969 Therapie Controlled trial quality: uncertain

68. Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability. Full Text available with Trip Pro

Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability. To see whether antihistamines could prevent and reverse histamine-induced pulmonary edema and increased lung vascular permeability, we compared the effects of a 4-h intravenous infusion of 4 mug/kg per min histamine phosphate on pulmonary hemodynamics, lung lymph flow, lymph and plasma protein content, arterial blood gases (...) , hematocrit, and lung water with the effects of an identical histamine infusion given during an infusion of diphenhydramine or metiamide on the same variables in unanesthetized sheep. Histamine caused lymph flow to increase from 6.0+/-0.5 to 27.0+/-5.5 (SEM) ml/h (P less than 0.05), lymph; plasma globulin concentration ratio to increase from 0.62+/-0.01 to 0.67+/-0.02 (P less than 0.05), left atrial pressure to fall from 1+/-1 to -3+/-1 cm H2O (P less than 0.05), and lung lymph clearance of eight protein

1976 Journal of Clinical Investigation

69. A rapid method for the determination of diphenhydramine in plasma Full Text available with Trip Pro

A rapid method for the determination of diphenhydramine in plasma 22216532 2012 01 26 2018 11 13 0306-5251 3 6 1976 Dec British journal of clinical pharmacology Br J Clin Pharmacol A rapid method for the determination of diphenhydramine in plasma. 1062-4 Baugh R R Calvert R T RT eng Letter England Br J Clin Pharmacol 7503323 0306-5251 0 Histamine H1 Antagonists 8GTS82S83M Diphenhydramine IM Calibration Chromatography, Gas methods Diphenhydramine blood Histamine H1 Antagonists blood Humans 2012

1976 British journal of clinical pharmacology

70. The influence of diphenhydramine on the absorption of methaqualone in man Full Text available with Trip Pro

The influence of diphenhydramine on the absorption of methaqualone in man 1 The effects of diphenhydramine on the buccal absorption, in vivo absorption and the in vitro dissolution of methaqualone have been studied. 2 Diphenhydramine significantly reduced the buccal absorption of methaqualone and the effect was dose and pH dependent. In vivo, diphenhydramine did not alter the rate of absorption or the distribution of methaqualone in blood. In vitro, the presence of diphenhydramine increased (...) the rate of dissolution of methaqualone and the effect was more marked when the particle size was small. 3 The reasons for and the implications of these apparently contradictory results are discussed and it is concluded that any increased efficacy resulting from combining diphenhydramine with methaqualone cannot be due to increased plasma drug levels.

1974 British journal of clinical pharmacology

71. Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. Full Text available with Trip Pro

Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 4513854 1973 08 09 2018 11 13 0003-3006 20 3 1973 May-Jun Anesthesia progress Anesth Prog Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 76-82 Malamed S F SF eng Journal Article United States Anesth Prog 0043533 0003-3006 0 Anesthetics, Local 8GTS82S83M Diphenhydramine D Anesthesia, Dental Anesthetics, Local Diphenhydramine administration & dosage 1973 5 1 1973 5 1 0 1 1973 5 1 0 0 ppublish

1973 Anesthesia progress

72. Extrapyramidal Symptoms Associated with the Administration of Trifluoperazine: Report of a Case Treated with Diphenhydramine Full Text available with Trip Pro

Extrapyramidal Symptoms Associated with the Administration of Trifluoperazine: Report of a Case Treated with Diphenhydramine 13891541 1998 11 01 2018 12 01 0008-4409 85 1961 Dec 30 Canadian Medical Association journal Can Med Assoc J Extrapyramidal symptoms associated with the administration of trifluoperazine: report of a case treated with diphenhydramine. 1459 FANNING W J WJ eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Tranquilizing Agents 214IZI85K3 Trifluoperazine (...) 8GTS82S83M Diphenhydramine OM Basal Ganglia Diseases Diphenhydramine therapy Disease Extrapyramidal Tracts Tranquilizing Agents toxicity Trifluoperazine DIPHENHYDRAMINE/therapy EXTRAPYRAMIDAL TRACTS/diseases TRANQUILIZING AGENTS/toxicology 1961 12 30 1961 12 30 0 1 1961 12 30 0 0 ppublish 13891541 PMC1848744 Dis Nerv Syst. 1959 Jan;20(1):24-6 13609517 N Engl J Med. 1960 Feb 18;262:353-4 13843192

1961 Canadian Medical Association Journal

73. Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations Full Text available with Trip Pro

Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations Histamine stimulated the isolated auricles and heart of the guinea-pig. The effect was best seen in auricles which had been previously depressed by treatment with reserpine. Ganglionic blocking drugs (hexamethonium and pempidine), applied to auricles which had been previously treated with reserpine, abolished the diphasic effect of nicotine (...) , but did not alter the response to histamine. Dichloroisoproterenol did not modify the stimulant action of histamine in isolated auricles, either before or after treatment with reserpine; nor did it alter the response of the isolated heart. Diphenhydramine reduced or blocked the stimulant action of histamine in auricles which had been previously treated with reserpine. The results support the hypothesis that histamine stimulates the myocardium by a direct action on specific receptors.

1960 British journal of pharmacology and chemotherapy

74. Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. (Abstract)

Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings (...) , whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.

1978 European journal of clinical pharmacology

75. Hypnotic activity of diphenhydramine, methapyrilene, and placebo. (Abstract)

Hypnotic activity of diphenhydramine, methapyrilene, and placebo. In a double-blind controlled study, an oral dose of diphenhydramine hydrochloride (12.5, 25, or 50 mg), methapyrilene fumarate (36, 72, or 144 mg), or placebo was administered to 1295 post-partum patients if they complained of, or anticipated, a sleep problem. Hypnotic activity was assessed clinically by subjective and objective techniques. Methapyrilene and diphenhydramine, at all doses, were found to be effective hypnotics

1978 Journal of clinical pharmacology

76. A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. (Abstract)

A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough. Lotussin and linctus diphenhydramine were compared for efficacy and patient preference in fifty patients suffering from post-infective cough. The trial was a single-blind randomized crossover one which was subjected to sequential analysis based on patient preferences. Under the conditions of the trial there appeared to be a significant difference in favour of Lotussin (p less than 0-01).

1977 The Journal of international medical research Controlled trial quality: uncertain

77. Methamphetamine and diphenhydramine effects on the rate of cognitive processing. (Abstract)

Methamphetamine and diphenhydramine effects on the rate of cognitive processing. Three cognitive tasks in which performance depends primarily on the rate of cognitive processing were given to 24 male subjects before and after oral doses of methamphetamine (10 mg), diphenhydramine hydrochloride (100 mg), and placebo. Each subject was tested on Monday, Wednesday, and Friday of one week with drug orders balanced across subjects. Compared with placebo and diphenhydramine, methamphetamine increased (...) , diphenhydramine caused subjects no experience geophysical time as passing more slowly, but the drug had no significant effects on the visual search or divided-attention tasks. This suggests that time perception is more likely to be altered by diphenhydramine than is performance on tasks requiring short periods of rapid cognitive processing.

1978 Psychopharmacology Controlled trial quality: uncertain

78. Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. Full Text available with Trip Pro

Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. 21945608 2011 12 12 2018 11 13 1097-6825 128 5 2011 Nov The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. 1127-8 10.1016/j.jaci.2011.08.026 Park Joon H JH Godbold James H JH Chung Danna D Sampson Hugh A HA Wang Julie J eng RR026134 RR NCRR NIH HHS United States (...) Allergy Clin Immunol 1275002 0091-6749 0 Anti-Allergic Agents 0 Hypnotics and Sedatives 8GTS82S83M Diphenhydramine YO7261ME24 Cetirizine AIM IM Acute Disease Adolescent Anti-Allergic Agents therapeutic use Cetirizine therapeutic use Child Child, Preschool Diphenhydramine therapeutic use Food Hypersensitivity drug therapy Humans Hypnotics and Sedatives Young Adult 2011 03 30 2011 08 19 2011 08 31 2011 9 28 6 0 2011 9 29 6 0 2011 12 14 6 0 ppublish 21945608 S0091-6749(11)01392-3 10.1016/j.jaci

2011 The Journal of allergy and clinical immunology Controlled trial quality: uncertain

79. Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain (Morpheus/DPH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01495858 Recruitment Status

2011 Clinical Trials

80. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain (Morpheus II) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01280591 Recruitment Status : Completed First

2011 Clinical Trials

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