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Diphenhydramine

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182. Strensiq - asfotase alfa

of diphenhydramine or dexamethasone SC reduced the reactions but did not completely alleviate the acute response. There was no evidence detected of a complement-based aetiology. A single IV injection of asfotase alfa at dose levels of 30 and 88 mg/kg produced immediate but transient and reversible effects (abnormal gait and reduced mobility, reduced extensor thrust reflex, altered landing foot splay and lower grip strength) on the general behaviour of male rats. Paw swelling and redness, decreased body

2015 European Medicines Agency - EPARs

188. Gabapentin for Adults with Neuropathic Pain

to 18). RR (95% CI) for one or more adverse events was 1.64 (1.15 to 2.32), favoring placebo. Fibromyalgia (FBM) One systematic review 6 included one RCT (parallel group, N = 150) comparing the effect of gabapentin (2400 mg) with active placebo (diphenhydramine) in patients with FBM. Statistically significant pain relief (assessed as = 30% pain reduction over baseline) was achieved with gabapentin (daily dose 2400 mg) compared to placebo over 12 weeks with RR (95% CI) of 1.6 (1.1 to 2.4 (...) in each RCT SMD (95% CI) a Pain reduction 3 20 4.38 (3.24 to 5.19 38 0.10 (-0.50 to 0.69) b 14 1.27 (0.12 to 2.42 a Results are reported for each individual RCT b In this RCT the placebo was an active placebo (diphenhydramine) Adverse events with gabapentin compared with placebo for SCI (results from I RCT with 20 patients) Outcome OR (95% CI) Dizziness 3.35 (0.32 to 35.36 Edema 8.20 (0.40 to 169.90) Headache 1.00 (0.06 to17.18) Sedation 8.20 (0.40 to 169.90 Weakness 3.00 (0.51 to 17.74) Gabapentin

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

190. Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis

Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis - Full Text View (...) - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From

2010 Clinical Trials

191. Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers

Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01119222 Recruitment Status : Completed First Posted : May 7, 2010 Results

2010 Clinical Trials

192. Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01118273 Recruitment Status : Completed First Posted : May 6, 2010 Results First Posted : June 17, 2014 Last Update Posted : June 8, 2015 Sponsor: Bayer Information provided

2010 Clinical Trials

193. Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01204255 Recruitment Status : Completed First Posted : September 17, 2010 Results First Posted : August 5, 2011 Last Update Posted : November 17, 2017

2010 Clinical Trials

194. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition

Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01053338 Recruitment Status : Completed First Posted : January 21, 2010

2010 Clinical Trials

195. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition

Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01053208 Recruitment Status : Completed First Posted

2010 Clinical Trials

196. Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. (Abstract)

Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. The objective of this study was to determine if sex influences the pharmacokinetics and hemodynamics of the CYP2D6 substrate metoprolol and its interaction with diphenhydramine (CYP2D6 inhibitor) in healthy young participants with high (extensive metabolizer [EM]) or low (poor metabolizer [PM]) CYP2D6 activities. A prespecified comparative analysis of data from 2 sequential clinical trials (...) that included 16 EM and 4 PM women and 10 EM and 6 PM men was performed. The participants in the 2 trials were administered a single oral dose of 100 mg metoprolol in the presence of steady-state diphenhydramine or placebo. Serial plasma and urine samples were obtained for 48 hours, and hemodynamic data was obtained for 12 hours after metoprolol. In the placebo arm, EM and PM women had 62% and 59% higher S-metoprolol AUC(0-infinity) and 26% and 71% lower CL/F, respectively, compared to men with the same

2010 Journal of clinical pharmacology Controlled trial quality: uncertain

197. Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. Full Text available with Trip Pro

Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. Subarachnoid (SA) morphine, highly effective for the management of pain after a cesarean delivery, is associated with a significant incidence of pruritus in up to 80% of patients. No previous study has compared the effectiveness of ondansetron (5-HT(3) antagonist) vs. diphenhydramine (H(1) receptor blocker) for the treatment of this side effect.In this randomized, double-blind (...) study, 113 patients with a pruritus score 3 or 4 (1=absent; 2=mild, no treatment required; 3=moderate pruritus, treatment required; and 4=severe pruritus) after SA morphine 0.2 mg were assigned to group ondansetron, which received 4 mg intravenously (i.v.) ondansetron, and group diphenhydramine, which received 25 mg i.v. diphenhydramine. Patients who continued to have pruritus > or =3, 30 min after the study drug were considered treatment failures and were treated with naloxone 0.04 mg i.v

2010 Acta Anaesthesiologica Scandinavica Controlled trial quality: uncertain

198. Rapid urine drug screens: diphenhydramine and methadone cross-reactivity. (Abstract)

Rapid urine drug screens: diphenhydramine and methadone cross-reactivity. Rapid urine screens to detect drugs of abuse are often used in pediatric emergency departments (PEDs). A positive result may lead to further clinical testing, social evaluation, and increased stress/inconvenience. A PED patient with suspected diphenhydramine (DPH) ingestion had a positive methadone result on the rapid urine drug screen, One Step Multi-Drug, Multi-Line Screen Test Device (ACON Laboratories, San Diego

2010 Pediatric Emergency Care

199. Reduction of the infarct size by simultaneous administration of l-histidine and diphenhydramine in ischaemic rat brains. (Abstract)

Reduction of the infarct size by simultaneous administration of l-histidine and diphenhydramine in ischaemic rat brains. While diphenhydramine is a histamine H(1) receptor antagonist, the agent has been shown to inhibit histamine-N-methyltransferase, a histamine inactivating enzyme in the brain. Since an increase in the brain concentration of histamine ameliorates reperfusion injury after cerebral ischaemia, effects of postischaemic administration of diphenhydramine were evaluated in rats (...) % confidence intervals, n=6). Administration of l-histidine (1000mg/kg, intraperitoneal) immediately after reperfusion did not affect the infarct size. Simultaneous administration of diphenhydramine (20mg/kg, intraperitoneal) with l-histidine reduced the infarct size to 25% and 21% of that in the control group, respectively. The combination therapy completely reduced ischaemia-induced brain oedema.Because histamine H(1) action does not influence ischaemic brain damage, elevation of the central histamine

2010 Resuscitation

200. Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. (Abstract)

Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia.during the period July 2007 to August 2008, 200 women scheduled for abdominal total (...) hysterectomy were randomised to one of four postoperative, patient-controlled analgesia regimens: group 1, morphine 1 mg ml; group 2, morphine 1 mg ml with metoclopramide 0.5 mg ml; group 3, morphine 1 mg ml with diphenhydramine 0.6 mg ml; and group 4, morphine 1 mg ml with metoclopramide 0.5 mg ml and diphenhydramine 0.6 mg ml. Dexamethasone 4 mg was administered to all patients in all groups after anaesthesia induction as a prophylactic antiemetic medication, and prochlorperazine 5 mg was administered

2010 European Journal of Anaesthesiology Controlled trial quality: uncertain

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