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161. The duration of action of some cardiac glycosides and aglycones in the guinea-pig Full Text available with Trip Pro

The duration of action of some cardiac glycosides and aglycones in the guinea-pig A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea-pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one-fifth (...) of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin-3-one, digitoxin, 3-acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.

1959 British journal of pharmacology and chemotherapy

162. [Effect of cardiac glycosides on the duration of systole. A comparison between proscillaridin and strophanthin]. (Abstract)

[Effect of cardiac glycosides on the duration of systole. A comparison between proscillaridin and strophanthin]. 5103642 1971 07 13 2007 11 15 0036-7672 101 18 1971 May 08 Schweizerische medizinische Wochenschrift Schweiz Med Wochenschr [Effect of cardiac glycosides on the duration of systole. A comparison between proscillaridin and strophanthin]. 638-42 Heierli C C Schweizer W W Burkart F F ger Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Der Einfluss von

1971 Schweizerische Medizinische Wochenschrift Controlled trial quality: uncertain

163. The role of potassium in the inhibition by cardiac glycosides of (Na+-K+)-ATPase prepared from human heart [(proceedings)]. Full Text available with Trip Pro

The role of potassium in the inhibition by cardiac glycosides of (Na+-K+)-ATPase prepared from human heart [(proceedings)]. 136282 1977 01 29 2018 11 13 0007-1188 58 3 1976 Nov British journal of pharmacology Br. J. Pharmacol. The role of potassium in the inhibition by cardiac glycosides of (Na+-K+)-ATPase prepared from human heart [(proceedings)]. 413P-414P De Pover A A Godfraind T T eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Cardiac Glycosides EC 3.6.1.- Adenosine (...) Triphosphatases RWP5GA015D Potassium IM Adenosine Triphosphatases antagonists & inhibitors Cardiac Glycosides pharmacology Heart drug effects Humans In Vitro Techniques Myocardium enzymology Potassium pharmacology 1976 11 1 1976 11 1 0 1 1976 11 1 0 0 ppublish 136282 PMC1667536 Arch Int Pharmacodyn Ther. 1976 Jun;221(2):339-41 134678 Naunyn Schmiedebergs Arch Pharmacol. 1974;283(4):335-56 4278432 Bull Acad R Med Belg. 1972;12:403-48 4267374 Arzneimittelforschung. 1964 Oct;14:1073-7 14346985

1976 British journal of pharmacology

164. Kinetics of active sodium transport in rat proximal tubules and its variation by cardiac glycosides at zero net volume and ion fluxes. Evidence for a multisite sodium transport system. Full Text available with Trip Pro

Kinetics of active sodium transport in rat proximal tubules and its variation by cardiac glycosides at zero net volume and ion fluxes. Evidence for a multisite sodium transport system. 1. Transepithelial Na concentration difference, deltaCNa, across proximal tubules of rat kidney was measured at varying intraluminal Na concentrations (CNainfinity) under conditions of zero net volume and Na flux. Simultaneous stopped-flow intratubular and artificial peritubular capillary perfusion techniques (...) ) the relationship remained the same. The maximum deltaCNa was reduced by approximately 50% by cardiac glycoside inhibition whereas the half-saturation constant was essentially unchanged. These changes from the control represent simple non-competitive inhibition by the cardiac glycosides. 3. Absence of potential difference (p.d.) measurements precludes exact description of the relation between true active transport and substrate concentration but much evidence indicates that the apparently sigmoid relation

1976 The Journal of physiology

165. Structural complexes in the squid giant axon membrane sensitive to ionic concentrations and cardiac glycosides Full Text available with Trip Pro

Structural complexes in the squid giant axon membrane sensitive to ionic concentrations and cardiac glycosides Giant nerve fibers of squid Sepioteuthis sepioidea were incubated for 10 min in artificial sea water (ASW) under control conditions, in the absence of various ions, and in the presence of cardiac glycosides. The nerve fibers were fixed in OsO4 and embedded in Epon, and structural complexes along the axolemma were studied.

1976 The Journal of cell biology

166. Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding. Full Text available with Trip Pro

Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding. The effects of ischemia on the canine myocardial (Na+ + K+)-ATPase complex were examined in terms of alterations in cardiac glycoside binding and enzymatic activity. Ability of the myocardial cell to bind tritiated ouabain in vivo was assessed after 1, 2, and 6 h of coronary occlusion followed by 45 min of reperfusion, and correlated with measurements of in vitro (Na+ + K+)-ATPase activity and in vitro (...) . In five dogs occluded for 1 h, (Na+ + K+)-ATPase activity in ischemic myocardium was unchanged from control levels. We conclude that reduced regional myocardial blood flow, local alterations in cellular milieu, and altered glycoside-binding properties of (Na+ + K+)-ATPase all participate in the reduction of cardiac glycoside binding observed after reperfusion of ischemic myocardium. In addition, after 2 or more hours of severe ischemia, myocardial (Na+ + K+)-ATPase catalytic activity is significantly

1976 Journal of Clinical Investigation

167. Studies on the localization of the cardiac glycoside receptor Full Text available with Trip Pro

Studies on the localization of the cardiac glycoside receptor The purpose of this study was to see whether the receptor for cardiac glycosides might be localized upon or within the plasma membrane of digitalis-sensitive cells. Ouabain and digoxin were joined covalently to several large protein molecules. These macromolecular conjugates are too large to enter intact cells; consequently, any pharmacologic or biochemical effects which they display should arise from interaction with a cell surface (...) active than the free glycosides. Careful chromatographic examination of the various conjugates revealed that they contained a small but persistent free cardiac glycoside contaminant. The amount of this species ranged from 0.1 to 1.0% of the total macromolecule-bound glycoside, and its presence fully explains the levels of biologic activity observed with the conjugates. To try to minimize steric factors which could interfere with glycoside-receptor interaction, digoxin and ouabain were also coupled

1972 Journal of Clinical Investigation

168. THE MEASUREMENT OF CARDIAC GLYCOSIDE CONCENTRATIONS Full Text available with Trip Pro

THE MEASUREMENT OF CARDIAC GLYCOSIDE CONCENTRATIONS 15215993 2018 11 13 0093-3546 1 2 1974 Cardiovascular diseases Cardiovasc Dis THE MEASUREMENT OF CARDIAC GLYCOSIDE CONCENTRATIONS. 114-119 Monroe Linda L The Section of Nuclear Medicine, Department of Radiology, Baylor College of Medicine, and The Nuclear Medicine Service of St. Luke's Episcopal-Texas Children's Hospitals, Houston, Texas 77025. Burdine John A. JA eng Journal Article United States Cardiovasc Dis 0414111 0093-3546 1974 1 1 2004

1974 Cardiovascular diseases

169. The time courses of the changes in contractile force and in transmembrane potentials induced by cardiac glycosides in guinea-pig papillary muscle Full Text available with Trip Pro

The time courses of the changes in contractile force and in transmembrane potentials induced by cardiac glycosides in guinea-pig papillary muscle 1. The effects of ouabain, digoxin, digoxigenin monodigitoxoside, digoxigenin bisdigitoxoside and digitoxigenin bisdigitoxoside on the force of contraction and on the transmembrane action potential were compared in isolated papillary muscles of guinea-pigs.2. All cardiac glycosides studied had a dose-dependent positive inotropic effect (...) and simultaneously shortened the duration of the action potential at all levels of repolarization from the start of drug action.3. In every instance, the reduction of the action potential duration developed more slowly than the increment in contractile force. However, the ratios between the two rates were independent of the concentrations used and seemed to be characteristic for the individual cardiac glycosides.4. All cardiac glycosides had a biphasic effect on the time-to-peak tension. An initial increase

1973 British journal of pharmacology

170. Effects of an Antibody to a Highly Purified Na+, K+-ATPase from Canine Renal Medulla: Separation of the “Holoenzyme Antibody” into Catalytic and Cardiac Glycoside Receptor-Specific Components Full Text available with Trip Pro

Effects of an Antibody to a Highly Purified Na+, K+-ATPase from Canine Renal Medulla: Separation of the “Holoenzyme Antibody” into Catalytic and Cardiac Glycoside Receptor-Specific Components An antiserum was prepared against a highly purified Na(+), K(+)-adenosine triphosphatase (ATP phosphohydrolase, EC 3.6.1.3). Purification and fractionation yielded two globulin components, one of which appears specific for a digitalis glycoside receptor site or binding conformation and the other

1974 Proceedings of the National Academy of Sciences of the United States of America

171. Metabolism of cardiac glycosides studied in the isolated perfused guinea-pig liver Full Text available with Trip Pro

Metabolism of cardiac glycosides studied in the isolated perfused guinea-pig liver 1. Metabolic degradation of tritiated ouabain, digoxin, and digitoxin has been investigated quantitatively using the isolated perfused guinea-pig liver. The cardiac glycosides and their metabolites have been extracted from the plasma, liver, and bile by different solvents and identified as far as possible by radio-chromatographic analysis.2. The total metabolic activity in the experimental system was localized (...) in the liver.3. The hydrophilic glycoside ouabain could not penetrate into the metabolically active compartment of the liver and was, therefore, not degraded. The more lipophilic compound digitoxin, however, was completely degraded due to its high affinity for the metabolically active sites. The unchanged digitoxin cannot enter the aqueous bile fluid in contrast to its more hydrophilic metabolites.4. The only detectable metabolic degradation of digoxin was a conjugation with glucuronic and/or sulphuric

1971 British journal of pharmacology

172. Plasma concentration, uptake by liver, and biliary excretion of tritiated cardiac glycosides in the isolated perfused guinea-pig liver Full Text available with Trip Pro

Plasma concentration, uptake by liver, and biliary excretion of tritiated cardiac glycosides in the isolated perfused guinea-pig liver 1. Investigations were carried out on isolated perfused guinea-pig livers. Different doses of tritiated ouabain, digoxin, and digitoxin were added to the perfusion medium and the subsequent plasma elimination, hepatic uptake, and biliary excretion quantitatively measured. After the perfusion, extracts of liver, bile and plasma were subjected to thin layer (...) was excreted with the bile within 4 hours. At the end of the perfusion almost all the identifiable substances in plasma and bile were polar metabolites, as shown by thin layer radiochromatography.4. Digoxin behaved similarly to digitoxin.5. The findings led to the following hypothesis: uptake of cardiac glycosides into the liver cells occurs by a passive diffusion process and is related to their lipid solubility. On the other hand excretion in the bile occurs in general if polar metabolites are formed

1971 British journal of pharmacology

173. Accumulation of radioactive cardiac glycosides by various brain regions in relation to the dysrhythmogenic effect. Full Text available with Trip Pro

Accumulation of radioactive cardiac glycosides by various brain regions in relation to the dysrhythmogenic effect. Ouabain was administered at a loading dose of 3 mug/kg followed by an infusion at a rate of 1 mug/kg-1 min-1 in order to produce severe dysrhythmia in dogs within 60 minutes. Similarly, digitoxin at a loading dose of 9 mug/kg followed by an infusion at a rate of 3 mug kg-1 min-1 was administered to compare its effect with that of ouabain. 2 During the 60 min experimental period (...) and digitoxin to give high tissue to plasma ratios. However, various neural areas of the brain (cerebellum, mesencephalon, hypothalamus, pons, and medulla) showed no preferential localization or uptake of these two glycosides. 4 Concentration of ouabain and digitoxin by the choroid plexus does not seem to affect the ionic composition of the CSF. 5 It was concluded that sampling the large areas of neural tissue above could provide no evidence for local accumulation of digitalis glycosides that might account

1977 British journal of pharmacology

174. Thyroid-induced alterations in myocardial sodium-potassium-activated adenosine triphosphatase, monovalent cation active transport, and cardiac glycoside binding. Full Text available with Trip Pro

Thyroid-induced alterations in myocardial sodium-potassium-activated adenosine triphosphatase, monovalent cation active transport, and cardiac glycoside binding. The effects of thyroid hormone on guinea pig myocardial NaK-ATPase activity, transmembrane monovalent cation active transport, and cardiac glycoside binding were were examined. NaK-ATPase activities of left atrial and left ventricular homogenates of control and triiodothyronine (T3)-treated animals were determined, and compared

1977 Journal of Clinical Investigation

175. Binding of the cardiac glycoside ouabain to intact cells Full Text available with Trip Pro

Binding of the cardiac glycoside ouabain to intact cells 1. Measurements were made of the binding of [(3)H]ouabain to a variety of cell types.2. Two components of binding could usually be distinguished: a component that saturated at low glycoside concentrations and a component that increased up to the highest ouabain concentrations examined.3. Detailed studies with HeLa cells and kidney slices from guinea-pigs showed that the saturable component is probably associated with inhibition of the Na (...) pump. The main evidence for this is (a) at low concentrations of ouabain there is a close correspondence between the concentration of ouabain giving half-maximum binding and the concentration giving half-maximum inhibition of the Na pump; (b) at low glycoside concentrations, binding precedes inhibition of the Na pump; (c) the rate of binding is very sensitive to external K ions, being highest in the absence of K; (d) binding is reversible and the release of ouabain is associated with reactivation

1972 The Journal of physiology

176. Inhibition of the sodium pump in squid axons by cardiac glycosides: dependence on extracellular ions and metabolism Full Text available with Trip Pro

Inhibition of the sodium pump in squid axons by cardiac glycosides: dependence on extracellular ions and metabolism 1. The rate of inhibition of the Na pump by ouabain was examined both by direct measurement of the rate of decline of the Na efflux and by the binding of [(3)H]ouabain.2. The onset of inhibition of the Na efflux was concentration-dependent; but did not follow simple first order kinetics. The time course of inhibition was roughly exponential although in about 30% of the axons

1972 The Journal of physiology

177. Sodium-dependent cardiac glycoside binding: experimental evidence and hypothesis. Full Text available with Trip Pro

Sodium-dependent cardiac glycoside binding: experimental evidence and hypothesis. 1 The influence of increasing Na+ concentrations on the binding of digitoxin, digoxin and ouabain was examined in a Na+-K+-ATPase preparation of guinea-pig hearts. 2 Two distinct processes seem to be involved in this interaction: one binding process was activated at low Na+ concentrations. The maximum binding capacities were different and the K0.5 values were nearly identical for the cardiac glycosides studied. 3 (...) In contrast, the second binding process was activated at appreciably higher Na+ concentrations, the maximum binding capacities were almost identical and the K0.5 values were different for the cardiac glycosides studied. 4 On the basis of these results attempts are made to explain the well known differences in the myocardial accumulation of cardiac glycosides.

1978 British journal of pharmacology

178. Effects of Cardiac Glycosides on Renal Tubular Transport of Calcium, Magnesium, Inorganic Phosphate, and Glucose in the Dog Full Text available with Trip Pro

Sodium, Dietary 0 Strophanthins 3OWL53L36A Mannitol 73K4184T59 Digoxin 9NEZ333N27 Sodium I38ZP9992A Magnesium IY9XDZ35W2 Glucose SY7Q814VUP Calcium OM Biological Transport Blood Calcium Cardiac Glycosides Digoxin Dogs Glucose Kidney Tubules Magnesium Mannitol Pharmacology Phosphates Research Sodium Sodium, Dietary Strophanthins Urine BIOLOGICAL TRANSPORT BLOOD CALCIUM CARDIAC GLYCOSIDES DIGOXIN DOGS EXPERIMENTAL LAB STUDY GLUCOSE KIDNEY TUBULES MAGNESIUM MANNITOL PHARMACOLOGY PHOSPHATES SODIUM (...) Effects of Cardiac Glycosides on Renal Tubular Transport of Calcium, Magnesium, Inorganic Phosphate, and Glucose in the Dog 14328390 1996 12 01 2018 12 01 0021-9738 44 1965 Jul The Journal of clinical investigation J. Clin. Invest. EFFECTS OF CARDIAC GLYCOSIDES ON RENAL TUBULAR TRANSPORT OF CALCIUM, MAGNESIUM, INORGANIC PHOSPHATE, AND GLUCOSE IN THE DOG. 1132-43 KUPFER S S KOSOVSKY J D JD eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Cardiac Glycosides 0 Phosphates 0

1965 Journal of Clinical Investigation

179. Effect of intravenous cardiac glycosides on the aqueous humour dynamics of the cat. Full Text available with Trip Pro

Effect of intravenous cardiac glycosides on the aqueous humour dynamics of the cat. 5957150 1967 03 22 2018 11 13 0007-1161 50 12 1966 Dec The British journal of ophthalmology Br J Ophthalmol Effect of intravenous cardiac glycosides on the aqueous humour dynamics of the cat. 701-4 Warner D M DM Drance S M SM eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Cardiac Glycosides IM Animals Aqueous Humor drug effects Cardiac Glycosides pharmacology Cats 1966 12 1 1966 12 1 0 1 1966 12

1966 The British journal of ophthalmology

180. Nature of the Schwann Cell Electrical Potential : Effects of the external ionic concentrations and a cardiac glycoside Full Text available with Trip Pro

Nature of the Schwann Cell Electrical Potential : Effects of the external ionic concentrations and a cardiac glycoside The effects on the Schwann cell electrical potential of external ionic concentrations and of K-strophanthoside were investigated. Increasing (K)(o) depolarized the cell. The potential is related to the logarithm of (K)(o) in a quasi-linear fashion. The linear portion of the curve has a slope of 45 mv/ten-fold change in (K)(o). Diminutions of (Na)(o) and (Cl)(o) produced only (...) of potassium, and to a cardiac glycoside-sensitive ion transport process.

1968 The Journal of general physiology

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