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Digital Block

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101. Tumescent technique in digits: a subcutaneous single-injection digital block. (PubMed)

Tumescent technique in digits: a subcutaneous single-injection digital block. A modified subcutaneous single-injection approach to achieve digital block using a tumescent technique is described.A convenient sample of patients requiring digital anesthesia for minor surgical procedures on the fingers or thumb in the emergency and plastic departments were enrolled into the study. Digital nerve block was performed by injecting 1% lidocaine into the volar subcutaneous space at the proximal digit (...) to create a firm, turgid feel to the tissue, the so-called tumescent state. The volume of anesthetic was based on the size of the digit. All nerve blocks were performed by 1 surgeon. Successful digital anesthesia was defined as complete loss of pinprick sensation on both the dorsal and volar aspects of the digit and the ability to complete the anticipated minor surgical procedure without pain. All patients were followed for 1 month to assess for adverse events.Between August 2009 and January 2011, 123

2011 American Journal of Emergency Medicine

102. Comparing the Accuracy of Digital Radiography (DR), MDCT and CBCT in Detecting Vertical Root Fractures (VRF)

Comparing the Accuracy of Digital Radiography (DR), MDCT and CBCT in Detecting Vertical Root Fractures (VRF) UTCAT2320, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Comparing the Accuracy of Digital Radiography (DR), MDCT and CBCT in Detecting Vertical Root Fractures (VRF) Clinical Question What is the most accurate diagnostic imaging technique in detecting VRF in present or absent of gutta-percha root filling (...) Study type (level of evidence) #1) Da Silveira/2013 100 teeth In-Vitro analysis Key results In presence of gutta-percha CBCT was significantly higher than DR(P = 0.009), but MDCT was significantly higher than that of CBCT and DR(P Evidence Search Vertical root fracture AND CBCT Comments on The Evidence In these in-vitro studies, VRF was produced artificially and they used acrylic resin blocks to keep the fractured segments close to each other but, in In the clinical situation, tooth are surrounded

2012 UTHSCSA Dental School CAT Library

103. Management of residual pleural space after lung resection: fully controllable paralysis of the diaphragm through continuous phrenic nerve block (PubMed)

). Inclusion criteria were: digitally detected air flow >200 mL/min at post-op day 3, presence of empty pleural space at chest x-ray, absence of restrictive lung disease, absence of known arrhythmias. A 22G nerve-block catheter was place under ultrasound guidance in proximity to the phrenic nerve, between the sternocleidomastoid muscle and the anterior scalene muscle at the level of 6th cervical vertebra. Continuous infusion of ropivacaine 0.2% 3 mL/h was started. Fluoroscopy was used to confirm (...) Management of residual pleural space after lung resection: fully controllable paralysis of the diaphragm through continuous phrenic nerve block Residual pleural space after lung resection associated with air leak is a challenging issue, potentially causing serious complications. We report a new, postoperative technique to reduce the pleural space, inducing a controlled and reversible paralysis of the diaphragm.Ten patients were enrolled (7 lobectomies, 2 bilobectomy, 1 wedge resection

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2018 Journal of thoracic disease

104. FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment (PubMed)

FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment Bio-banked formalin-fixed paraffin-embedded (FFPE) tissues provide an excellent opportunity for translational genomic research. Historically matched blood has not always been collected as a source of germline DNA. This project aimed to establish if normal FFPE breast tissue could be used as an alternative to blood.Exome (...) were called using the MuTect software analysis tool and copy number abnormalities (CNA) were identified using CNVkit. Targeted sequencing and droplet digital PCR were used to validate somatic variants and CNA, respectively.Overlap of somatic variants and CNA called on tumour versus blood and tumour versus normal breast tissue was good. Agreement in somatic variant calling ranged from 76.9 to 93.6%. Variants with an allele frequency lower than 10% were more difficult to validate irrespective

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2018 Breast cancer research and treatment

105. A guide to analysis and reconstruction of serial block face scanning electron microscopy data (PubMed)

A guide to analysis and reconstruction of serial block face scanning electron microscopy data Serial block face scanning electron microscopy (SBF-SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can be obtained from the resulting image stacks but this presents a new challenge for researchers - how to computationally analyse and make best use of the large datasets (...) SBF-SEM data, although there are more options available than can be covered here. To showcase the programmes, datasets of skeletal muscle from foetal and adult guinea pigs are initially used with procedures subsequently applied to guinea pig cardiac tissue and locust brain. The tissue is processed using the heavy metal protocol developed specifically for SBF-SEM. Trimmed resin blocks are placed into a Zeiss Sigma SEM incorporating the Gatan 3View and the resulting image stacks are analysed

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2018 Journal of microscopy

106. Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery

Comparator: Local anesthesia with minimal sedation The comparison group. Performed by the operating surgeon. Procedure: Local anesthesia with minimal sedation The operating surgeon will perform a digital or wrist block to numb the surgical area prior to the surgery, instead of using a brachial plexus block. Outcome Measures Go to Primary Outcome Measures : Quality of Recovery 15 Questionnaire (QoR-15) [ Time Frame: At 24 hours post-surgery ] This psychometrically tested and validated 15-items (...) Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2018 Clinical Trials

107. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.

Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. (VRBLOC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03677323 Recruitment Status : Completed First Posted : September 19, 2018 Last

2018 Clinical Trials

108. Serratus Plane Block: A Cadaveric Study to Evaluate Optimal Injectate Spread. (PubMed)

Serratus Plane Block: A Cadaveric Study to Evaluate Optimal Injectate Spread. Although serratus plane block reportedly provides satisfactory analgesia for breast and thoracic surgeries, the optimal technique for consistent success has not been studied. The goal of this anatomical study was to evaluate the impact of volume, level, and site of injection on the extent of injectate spread that can influence anesthetic coverage.Ultrasound-guided dye injection and subsequent dissection were performed (...) in 39 cadaveric hemithoraces. Methylene blue was injected according to 1 of 4 injection protocols as follows: one 20-mL bolus, either superficial or deep to the serratus anterior muscle (SAM), at the fifth rib level (groups SUP-20 and DEEP-20, respectively), or two 20-mL boluses, either superior or deep to the SAM, one at the third rib and one at the fifth rib level (group SUP-40 and group DEEP-40, respectively). Following injection, dissection and 3-dimensional digitization were performed to map

2018 Regional Anesthesia and Pain Medicine

109. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing (PubMed)

HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection, but it is unclear what mechanisms govern latent HIV infection in vivo. To address this question, we developed a new panel of reverse transcription droplet digital polymerase chain reaction (RT-ddPCR) assays specific for different HIV transcripts that define distinct blocks (...) to transcription. We applied this panel of assays to CD4+ T cells freshly isolated from HIV-infected patients on suppressive antiretroviral therapy (ART) to quantify the degree to which different mechanisms inhibit HIV transcription. In addition, we measured the degree to which these transcriptional blocks could be reversed ex vivo by T cell activation (using anti-CD3/CD28 antibodies) or latency-reversing agents. We found that the main reversible block to HIV RNA transcription was not inhibition

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2018 Science translational medicine

110. An Indicator of Successful Peripheral Nerve Block

observer will photograph the reaction of the nail polish (i.e. color change) in both hands immediately after application of nail polish and at two minute intervals for 30 min after performing the block. Two blinded observers were reviewed the digital photographs. They were asked to compare the colors of nail polish in both hands and to score the difference based on a three-point scale (0: absolutely no difference, 1: I am not sure, 2: indisputable difference) Study Design Go to Layout table for study (...) An Indicator of Successful Peripheral Nerve Block An Indicator of Successful Peripheral Nerve Block - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Indicator of Successful Peripheral Nerve Block

2018 Clinical Trials

111. [Dose-response relationship of ropivacaine for epidural block in early herpes zoster guided by CT]. (PubMed)

[Dose-response relationship of ropivacaine for epidural block in early herpes zoster guided by CT]. Objective: To determine the dose-response relationship of ropivacaine for epidural block in early herpes zoster by CT guided. Methods: From January 2015 to February 2017, according to the principle of completely random digital table, 80 patients with early herpes zoster who were prepared for epidural block were divided into 4 groups(each group 20 patients): in group A the concentration (...) for epidural block in early herpes zoster was defined as positive when the NRS values was less than or equal to one.The ED(50), ED(95) and 95% confidence interval (CI) of ropivacaine for epidural block in early herpes zoster guided by CT were calculated by probit analysis. Results: The NRS values before treatment were 5.00(4.00, 6.00), 5.00(4.25, 6.00), 5.50(5.00, 6.00) and 5.00(4.00, 6.00), the difference was no significant(Z=2.576, P=0.462). The NRS values at 30 minutes decreased and the effective rate

2018 Zhonghua yi xue za zhi Controlled trial quality: uncertain

112. Bupivacaine digital blocks: how long is the pain relief and temperature elevation? (PubMed)

Bupivacaine digital blocks: how long is the pain relief and temperature elevation? The goals of this study are threefold: (1) to determine what effect epinephrine has on the duration of bupivacaine finger block anesthesia; (2) to see whether the duration of action of bupivacaine on digital pain relief is the same duration as numbness to touch/pressure; and (3) to assess the fingertip temperature changes that result from bupivacaine digital blocks.The ring fingers of both hands of 44 volunteers (...) were randomized to injection of bupivacaine with or without 1:200,000 epinephrine. The durations of time for digits to return to normal pain, touch, pressure sensation, and fingertip temperature were measured and recorded.There were three main findings: (1) the pain block of bupivacaine lasts only half as long (15 hours) as the return to normal sensation (30 hours); (2) the effect of adding epinephrine to bupivacaine prolongs the duration of pain relief in a finger block for only an additional 1.5

2013 Plastic and reconstructive surgery Controlled trial quality: uncertain

113. Bupivacaine digital blocks: how long is the pain relief and temperature elevation? (PubMed)

Bupivacaine digital blocks: how long is the pain relief and temperature elevation? The goals of this study are threefold: (1) to determine what effect epinephrine has on the duration of bupivacaine finger block anesthesia; (2) to see whether the duration of action of bupivacaine on digital pain relief is the same duration as numbness to touch/pressure; and (3) to assess the fingertip temperature changes that result from bupivacaine digital blocks.The ring fingers of both hands of 44 volunteers (...) were randomized to injection of bupivacaine with or without 1:200,000 epinephrine. The durations of time for digits to return to normal pain, touch, pressure sensation, and fingertip temperature were measured and recorded.There were three main findings: (1) the pain block of bupivacaine lasts only half as long (15 hours) as the return to normal sensation (30 hours); (2) the effect of adding epinephrine to bupivacaine prolongs the duration of pain relief in a finger block for only an additional 1.5

2013 Plastic and reconstructive surgery Controlled trial quality: uncertain

114. Skin perfusion and pain evaluation with different local anaesthetics in a double blind randomized study following digital nerve block anaesthesia. (PubMed)

Skin perfusion and pain evaluation with different local anaesthetics in a double blind randomized study following digital nerve block anaesthesia. Supplementing a local anaesthetic with epinephrine has advantages in hand surgery: faster onset of anaesthesia, extended effect of anaesthetics with prolonged pain reduction, decreased bleeding into the operative field, and abandoned need for tourniquet. We hypothesized that the use of ropivacaine with epinephrine additive in digits allows good skin (...) perfusion rates with prolonged pain reduction.In this prospective, double-blinded, randomized study with 20 volunteers (80 fingers, without operation) the chronological course of changes in digit blood flow, post injection pain status and complication rates after two-injection dorsal technique anaesthetic block with ropivacaine (group 1: ropivacaine 0.75%, group 2: ropivacaine 0.75% and epinephrine 1 : 1.000.000, group 3: local tumescent anaesthesia 0.15% TLA: ropivacaine, lidocaine, saline solution

2013 Clinical hemorheology and microcirculation Controlled trial quality: uncertain

115. Alpha blocking versus no blocking prior to adrenalectomy for pheochromocytoma - a systematic review and meta-analysis

Alpha blocking versus no blocking prior to adrenalectomy for pheochromocytoma - a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital ruler software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case

2019 PROSPERO

116. Quasi noise-free digital holography (PubMed)

Quasi noise-free digital holography One of the main drawbacks of Digital Holography (DH) is the coherent nature of the light source, which severely corrupts the quality of holographic reconstructions. Although numerous techniques to reduce noise in DH have provided good results, holographic noise suppression remains a challenging task. We propose a novel framework that combines the concepts of encoding multiple uncorrelated digital holograms, block grouping and collaborative filtering

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2016 Light, science & applications

117. Digital Technology Use Among Individuals with Schizophrenia: Results of an Online Survey (PubMed)

Digital Technology Use Among Individuals with Schizophrenia: Results of an Online Survey Despite growing interest in the use of digital technology by individuals with schizophrenia, little is known about how these individual relate to, own, and use technology in their daily life and in the context of their symptoms.The goal of this study is to better characterize technology use in those with schizophrenia.A Web-based survey of individuals' use of and attitudes toward technology for those 18 (...) . The respondents reported that Web-based technology helped with support from family and friends, as well as in gathering information. Many respondents used Web-based technology to help identify coping strategies (24% very often or often) including music to help block or manage voices (42%), while others used technology to set alarms/reminders for medication management (28%). Younger respondents in particular anticipated the role of technology growing over time with respect to their recovery.Survey respondents

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2016 JMIR mental health

118. Diagnostic Accuracy of CBCT with Different Voxel Sizes and Intraoral Digital Radiography for Detection of Periapical Bone Lesions: An Ex-Vivo Study (PubMed)

blocks, each with two posterior teeth. A no-defect control group was also included. Digital PA radiographs with PSP plates and CBCT scans with 200, 250 and 300μ voxel sizes were obtained. Four observers evaluated the possibility of lesion detection using a 5-point scale. Sensitivity, specificity, positive predictive value (PPV) and negative predicative value (NPV) were analyzed using one-way ANOVA and Tamhane's post hoc test. Kappa and weighted kappa statistics were applied to assess intraobserver (...) Diagnostic Accuracy of CBCT with Different Voxel Sizes and Intraoral Digital Radiography for Detection of Periapical Bone Lesions: An Ex-Vivo Study This study sought to assess the diagnostic accuracy of cone beam computed tomography (CBCT) with different voxel sizes and intraoral digital radiography with photostimulable phosphor (PSP) plate for detection of periapical (PA) bone lesions.In this ex vivo diagnostic study, one-millimeter defects were created in the alveolar sockets of 15 bone

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2016 Journal of dentistry (Tehran, Iran)

119. An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides (PubMed)

An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides Mice are used for modelling the biology of many human diseases, including colorectal cancer (CRC). Mouse models recapitulate many aspects of human disease and are invaluable tools for studying the biology, treatment and prevention of CRC. Unlike humans, many mouse models develop lesions primarily in the small intestine, which necessitates removal and examination of this organ in order to evaluate (...) treatment efficacy. Commonly, the small intestine is visually examined for gross lesions and then selectively embedded in paraffin blocks for further microscopic analysis. Unfortunately, this method suffers from inherent bias toward counting large lesions and simultaneously missing smaller lesions. Even more, this method leaves no permanent record of diagnosed and measured lesions. We evaluated inter-observer variability in a mouse model of CRC using visual examination, and directly compared the visual

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2016 PloS one

120. Effects on image quality of a 2D antiscatter grid in x-ray digital breast tomosynthesis: Initial experience using the dual modality (x-ray and molecular) breast tomosynthesis scanner (PubMed)

Effects on image quality of a 2D antiscatter grid in x-ray digital breast tomosynthesis: Initial experience using the dual modality (x-ray and molecular) breast tomosynthesis scanner Radiation scattered from the breast in digital breast tomosynthesis (DBT) causes image degradation, including loss of contrast between cancerous and background tissue. Unlike in 2-dimensional (2D) mammography, an antiscatter grid cannot readily be used in DBT because changing alignment between the tube and detector (...) of a DMT scan under conditions of fixed radiation dose.Two 2D focused prototype grids with 80 cm focal length were tested, one stack-laminated from copper (Cu) and one cast from a tungsten-polymer (W-poly). They were reciprocated using a motion scheme designed to maximize transmission of primary x-ray photons. Grid-in and grid-out scatter-to-primary ratios (SPRs) were measured for rectangular blocks of material simulating 30%, 50%, and 70% glandular tissue compositions. For assessment of changes

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2016 Medical physics

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