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Digital Block

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81. A real‐time digital bio‐imaging system to quantify cellular cytotoxicity as an alternative to the standard chromium‐51 release assay Full Text available with Trip Pro

A real‐time digital bio‐imaging system to quantify cellular cytotoxicity as an alternative to the standard chromium‐51 release assay Reliable measurement of cellular cytotoxicity is essential for the characterization of immune responses and for the monitoring of antibody treatment efficacy. Until now, the standard 51 Cr-release assay has remained the sole sensitive assay that measures cellular cytotoxicity. Alternative non-radioactive assays have been developed but they do not provide (...) developed classical natural killer cell assays in the presence or absence of blocking antibodies and antibody-dependent cell-mediated cytotoxicity. We show that in these assays, cell killing occurs within the first 2 hr with half maximum killing reached after 30 min. This technology has numerous applications such as natural killer and T-cell cytotoxicity assays and can be extended to cell survival and apoptosis measurement assays.© 2016 John Wiley & Sons Ltd.

2017 Immunology

82. Seeing elements by visible-light digital camera Full Text available with Trip Pro

Seeing elements by visible-light digital camera A visible-light digital camera is used for taking ordinary photos, but with new operational procedures it can measure the photon energy in the X-ray wavelength region and therefore see chemical elements. This report describes how one can observe X-rays by means of such an ordinary camera - The front cover of the camera is replaced by an opaque X-ray window to block visible light and to allow X-rays to pass; the camera takes many snap shots (called (...) single-photon-counting mode) to record every photon event individually; an integrated-filtering method is newly proposed to correctly retrieve the energy of photons from raw camera images. Finally, the retrieved X-ray energy-dispersive spectra show fine energy resolution and great accuracy in energy calibration, and therefore the visible-light digital camera can be applied to routine X-ray fluorescence measurement to analyze the element composition in unknown samples. In addition, the visible-light

2017 Scientific reports

83. SlowMo, a digital therapy targeting reasoning in paranoia, versus treatment as usual in the treatment of people who fear harm from others: study protocol for a randomised controlled trial Full Text available with Trip Pro

SlowMo, a digital therapy targeting reasoning in paranoia, versus treatment as usual in the treatment of people who fear harm from others: study protocol for a randomised controlled trial Paranoia is one of the most common symptoms of schizophrenia-spectrum disorders, and is associated with significant distress and disruption to the person's life. Developing more effective and accessible psychological interventions for paranoia is a clinical priority. Our research team has approached (...) this challenge in two main ways: firstly, by adopting an interventionist causal approach to increase effectiveness and secondly, by incorporating user-centred inclusive design methods to enhance accessibility and usability. Our resultant new digital intervention, SlowMo, intensively targets a reasoning style associated with paranoia, fast thinking, characterised by jumping to conclusions and belief inflexibility. It consists of an easy-to-use, enjoyable and memorable digital interface. An interactive web

2017 Trials Controlled trial quality: predicted high

84. Experimental measurement-device-independent quantum digital signatures Full Text available with Trip Pro

Experimental measurement-device-independent quantum digital signatures The development of quantum networks will be paramount towards practical and secure telecommunications. These networks will need to sign and distribute information between many parties with information-theoretic security, requiring both quantum digital signatures (QDS) and quantum key distribution (QKD). Here, we introduce and experimentally realise a quantum network architecture, where the nodes are fully connected using (...) a minimum amount of physical links. The central node of the network can act either as a totally untrusted relay, connecting the end users via the recently introduced measurement-device-independent (MDI)-QKD, or as a trusted recipient directly communicating with the end users via QKD. Using this network, we perform a proof-of-principle demonstration of QDS mediated by MDI-QKD. For that, we devised an efficient protocol to distil multiple signatures from the same block of data, thus reducing

2017 Nature communications

85. Efficacy of Digital Anesthesia: Comparison of Two Techniques Full Text available with Trip Pro

Efficacy of Digital Anesthesia: Comparison of Two Techniques Digital nerve block is commonly performed by care providers in medical fields. This study compares the blocks in terms of effectiveness of anesthesia and pain.Patients were divided into two groups. First group underwent digital block whereas 2nd group had transmetacarpal digital block. The subcutaneous ring block was performed by two injections of 3 ml of 2% lignocaine in a 3 ml syringe with a 26G needle at the level of phalangeal (...) /palmer crease. One prick was performed on either side of the finger base extending on dorsal and volar aspects of the digit. The transmetacarpal block received lignocaine identically at dorsal aspect of metacarpo-phalangeal joint. 1.5ml of the solution was injected in dorsal and 1.5ml in palmer side on either side of the finger. When sensation of needle was felt, 1ml of the solution was injected. Then the needle was withdrawn injecting another 1ml and finally the last 1ml was injected close

2017 World journal of plastic surgery Controlled trial quality: uncertain

86. In Vitro Comparison of Diagnostic Accuracy of DIAGNOdent and Digital Radiography for Detection of Secondary Proximal Caries Adjacent to Composite Restorations Full Text available with Trip Pro

teeth with carious lesions and 30 sound teeth were randomly selected. Class II cavities were prepared in all teeth and carious dentin was intentionally left in the gingival floor of cavities in 30 carious teeth. All cavities were restored with composite resin. The teeth were mounted in wax blocks (three teeth per block) and examined for caries using (DIAGNOdent kaVo Dental, Biberach, Germany). Digital radiographs using DIGORA photostimulable phosphor (PSP) plates (Soredex Corporation, Helsinki (...) In Vitro Comparison of Diagnostic Accuracy of DIAGNOdent and Digital Radiography for Detection of Secondary Proximal Caries Adjacent to Composite Restorations Introduction: Early detection of secondary proximal caries is critical for the preservation of tooth vitality. This study sought to assess and compare the diagnostic accuracy of DIAGNOdent and digital radiography for detection of secondary proximal caries adjacent to composite restorations. Methods: Sixty extracted molars including 30

2017 Journal of lasers in medical sciences

87. Diagnostic Value of Conventional and Digital Radiography for Detection of Cavitated and Non-Cavitated Proximal Caries Full Text available with Trip Pro

Diagnostic Value of Conventional and Digital Radiography for Detection of Cavitated and Non-Cavitated Proximal Caries This study aimed to assess the diagnostic value of conventional and digital radiography for detection of cavitated and non-cavitated proximal caries.Fifty extracted human premolars and molars were mounted in a silicone block. Charge-coupled device (CCD) and photostimulable phosphor plate (PSP) receptors and intra-oral films were exposed with 60 and 70 kVp with parallel technique (...) the highest sensitivity for enamel lesions, but the difference among receptors was not statistically significant (P>0.05). Sensitivity of all three receptors for detection of non-cavitated lesions was lower than that for cavitated lesions; PSP with 60 kVp and 0.07s exposure time had higher sensitivity and lower patient radiation dose for detection of cavitated and non-cavitated lesions, but the difference was not significant (P>0.05).Digital radiography using PSP receptor with 70 kVp is recommended

2017 Journal of dentistry (Tehran, Iran)

88. Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology

Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03067506 Recruitment Status : Completed First Posted : March 1, 2017 Results First Posted : January 10, 2019 Last

2017 Clinical Trials

89. Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology

Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology (HealthPals) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03167996 Recruitment Status : Completed First Posted : May 30, 2017 Last Update Posted : February 15

2017 Clinical Trials

90. [Dose-response relationship of ropivacaine for epidural block in early herpes zoster guided by CT]. (Abstract)

[Dose-response relationship of ropivacaine for epidural block in early herpes zoster guided by CT]. Objective: To determine the dose-response relationship of ropivacaine for epidural block in early herpes zoster by CT guided. Methods: From January 2015 to February 2017, according to the principle of completely random digital table, 80 patients with early herpes zoster who were prepared for epidural block were divided into 4 groups(each group 20 patients): in group A the concentration (...) for epidural block in early herpes zoster was defined as positive when the NRS values was less than or equal to one.The ED(50), ED(95) and 95% confidence interval (CI) of ropivacaine for epidural block in early herpes zoster guided by CT were calculated by probit analysis. Results: The NRS values before treatment were 5.00(4.00, 6.00), 5.00(4.25, 6.00), 5.50(5.00, 6.00) and 5.00(4.00, 6.00), the difference was no significant(Z=2.576, P=0.462). The NRS values at 30 minutes decreased and the effective rate

2018 Zhonghua yi xue za zhi Controlled trial quality: uncertain

91. Management of residual pleural space after lung resection: fully controllable paralysis of the diaphragm through continuous phrenic nerve block Full Text available with Trip Pro

). Inclusion criteria were: digitally detected air flow >200 mL/min at post-op day 3, presence of empty pleural space at chest x-ray, absence of restrictive lung disease, absence of known arrhythmias. A 22G nerve-block catheter was place under ultrasound guidance in proximity to the phrenic nerve, between the sternocleidomastoid muscle and the anterior scalene muscle at the level of 6th cervical vertebra. Continuous infusion of ropivacaine 0.2% 3 mL/h was started. Fluoroscopy was used to confirm (...) Management of residual pleural space after lung resection: fully controllable paralysis of the diaphragm through continuous phrenic nerve block Residual pleural space after lung resection associated with air leak is a challenging issue, potentially causing serious complications. We report a new, postoperative technique to reduce the pleural space, inducing a controlled and reversible paralysis of the diaphragm.Ten patients were enrolled (7 lobectomies, 2 bilobectomy, 1 wedge resection

2018 Journal of thoracic disease

92. FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment Full Text available with Trip Pro

FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment Bio-banked formalin-fixed paraffin-embedded (FFPE) tissues provide an excellent opportunity for translational genomic research. Historically matched blood has not always been collected as a source of germline DNA. This project aimed to establish if normal FFPE breast tissue could be used as an alternative to blood.Exome (...) were called using the MuTect software analysis tool and copy number abnormalities (CNA) were identified using CNVkit. Targeted sequencing and droplet digital PCR were used to validate somatic variants and CNA, respectively.Overlap of somatic variants and CNA called on tumour versus blood and tumour versus normal breast tissue was good. Agreement in somatic variant calling ranged from 76.9 to 93.6%. Variants with an allele frequency lower than 10% were more difficult to validate irrespective

2018 Breast cancer research and treatment

93. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing Full Text available with Trip Pro

HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection, but it is unclear what mechanisms govern latent HIV infection in vivo. To address this question, we developed a new panel of reverse transcription droplet digital polymerase chain reaction (RT-ddPCR) assays specific for different HIV transcripts that define distinct blocks (...) to transcription. We applied this panel of assays to CD4+ T cells freshly isolated from HIV-infected patients on suppressive antiretroviral therapy (ART) to quantify the degree to which different mechanisms inhibit HIV transcription. In addition, we measured the degree to which these transcriptional blocks could be reversed ex vivo by T cell activation (using anti-CD3/CD28 antibodies) or latency-reversing agents. We found that the main reversible block to HIV RNA transcription was not inhibition

2018 Science translational medicine

94. Serratus Plane Block: A Cadaveric Study to Evaluate Optimal Injectate Spread. (Abstract)

Serratus Plane Block: A Cadaveric Study to Evaluate Optimal Injectate Spread. Although serratus plane block reportedly provides satisfactory analgesia for breast and thoracic surgeries, the optimal technique for consistent success has not been studied. The goal of this anatomical study was to evaluate the impact of volume, level, and site of injection on the extent of injectate spread that can influence anesthetic coverage.Ultrasound-guided dye injection and subsequent dissection were performed (...) in 39 cadaveric hemithoraces. Methylene blue was injected according to 1 of 4 injection protocols as follows: one 20-mL bolus, either superficial or deep to the serratus anterior muscle (SAM), at the fifth rib level (groups SUP-20 and DEEP-20, respectively), or two 20-mL boluses, either superior or deep to the SAM, one at the third rib and one at the fifth rib level (group SUP-40 and group DEEP-40, respectively). Following injection, dissection and 3-dimensional digitization were performed to map

2018 Regional Anesthesia and Pain Medicine

95. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.

Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block. (VRBLOC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03677323 Recruitment Status : Completed First Posted : September 19, 2018 Last

2018 Clinical Trials

96. Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery

Comparator: Local anesthesia with minimal sedation The comparison group. Performed by the operating surgeon. Procedure: Local anesthesia with minimal sedation The operating surgeon will perform a digital or wrist block to numb the surgical area prior to the surgery, instead of using a brachial plexus block. Outcome Measures Go to Primary Outcome Measures : Quality of Recovery 15 Questionnaire (QoR-15) [ Time Frame: At 24 hours post-surgery ] This psychometrically tested and validated 15-items (...) Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2018 Clinical Trials

97. A guide to analysis and reconstruction of serial block face scanning electron microscopy data Full Text available with Trip Pro

A guide to analysis and reconstruction of serial block face scanning electron microscopy data Serial block face scanning electron microscopy (SBF-SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can be obtained from the resulting image stacks but this presents a new challenge for researchers - how to computationally analyse and make best use of the large datasets (...) SBF-SEM data, although there are more options available than can be covered here. To showcase the programmes, datasets of skeletal muscle from foetal and adult guinea pigs are initially used with procedures subsequently applied to guinea pig cardiac tissue and locust brain. The tissue is processed using the heavy metal protocol developed specifically for SBF-SEM. Trimmed resin blocks are placed into a Zeiss Sigma SEM incorporating the Gatan 3View and the resulting image stacks are analysed

2018 Journal of microscopy

98. An Indicator of Successful Peripheral Nerve Block

observer will photograph the reaction of the nail polish (i.e. color change) in both hands immediately after application of nail polish and at two minute intervals for 30 min after performing the block. Two blinded observers were reviewed the digital photographs. They were asked to compare the colors of nail polish in both hands and to score the difference based on a three-point scale (0: absolutely no difference, 1: I am not sure, 2: indisputable difference) Study Design Go to Layout table for study (...) An Indicator of Successful Peripheral Nerve Block An Indicator of Successful Peripheral Nerve Block - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Indicator of Successful Peripheral Nerve Block

2018 Clinical Trials

99. The effect of ultrasound-guided erector spinae plane block on post-surgical pain: a meta-analysis of randomized controlled trials

The effect of ultrasound-guided erector spinae plane block on post-surgical pain: a meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record (...) . Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital

2020 PROSPERO

100. The efficacy and safety of dexmedetomidine combined with local anesthetics in lower limbs nerves block: a systematic review and meta-analysis of randomized controlled trials

The efficacy and safety of dexmedetomidine combined with local anesthetics in lower limbs nerves block: a systematic review and meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability (...) will extract data from graphs using digital ruler software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used

2020 PROSPERO

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