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Digital Clubbing

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1. A novel mutation in the HPGD gene results in the unusual phenotype of palmoplantar keratoderma with digital clubbing and hyperhidrosis (PubMed)

A novel mutation in the HPGD gene results in the unusual phenotype of palmoplantar keratoderma with digital clubbing and hyperhidrosis 30364714 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep A novel mutation in the HPGD gene results in the unusual phenotype of palmoplantar keratoderma with digital clubbing and hyperhidrosis. 950-952 10.1016/j.jdcr.2018.07.007 Stephan Carla C Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. Hanna Edith E (...) University Medical Center, New York, New York. eng Case Reports 2018 10 12 United States JAAD Case Rep 101665210 2352-5126 HPGD gene PPK, palmoplantar keratoderma digital clubbing hyperhidrosis palmoplantar keratoderma 2018 10 27 6 0 2018 10 27 6 0 2018 10 27 6 1 epublish 30364714 10.1016/j.jdcr.2018.07.007 S2352-5126(18)30188-7 PMC6197940 Clin Exp Rheumatol. 2010 Mar-Apr;28(2):153-7 20406614 Dermatology. 1997;194(3):302-5 9187857 Ann Dermatol Syphiligr (Paris). 1959 Nov-Dec;86:611-22 13806034 Acta Derm

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2018 JAAD Case Reports

2. Assessment of clubbing

Assessment of clubbing Assessment of clubbing - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of clubbing Last reviewed: February 2019 Last updated: August 2018 Summary An important nail sign of systemic disease linked with underlying pulmonary, cardiovascular, neoplastic, infectious, hepatobiliary, mediastinal, endocrine, and gastrointestinal disorders. Digital clubbing may also occur in isolation (e.g (...) ., familial clubbing, as an autosomal-dominant trait). Definition Clubbing is described as a bulbous uniform swelling of the soft tissue of the terminal phalanx of a digit, with subsequent loss of the normal angle between the nail and nail bed. The first stage of clubbing is a periungual erythema and a softening of the nail bed; this is followed by an increase in the Lovibond's angle (the angle between the proximal nail fold and the nail plate). Eventually the depth of the distal phalange increases

2018 BMJ Best Practice

3. Digital Clubbing

Digital Clubbing Digital Clubbing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Digital Clubbing Digital Clubbing Aka: Digital (...) Clubbing , Clubbing , Schamroth's Window Test , Schamroth's Sign , Digital Index , Lovibond Angle II. History First described by Hippocrates in 5th century B.C. III. Definition Bulbous digital deformity Watch-crystal deformity of IV. Pathophysiology Sign of ( ) Thickening of nail bed's soft tissue (especially proximally) Typically affects all fingers Results from abnormal microvasculature with increased blood flow to the microvasculature V. Signs: Schamroth's Window Test for Clubbing Oppose fingers

2018 FP Notebook

4. A rare cause of digital clubbing: pachydermoperiostosis (PubMed)

A rare cause of digital clubbing: pachydermoperiostosis 28270899 2018 02 15 2018 02 15 1937-8688 25 2016 The Pan African medical journal Pan Afr Med J A rare cause of digital clubbing: pachydermoperiostosis. 194 10.11604/pamj.2016.25.194.10890 Alaya Zeineb Z Department of Rheumatology, Farhat Hached Hospital, Faculty of Medicine of Sousse, Sousse, Tunisia. Osman Walid W Department of Orthopaedics, Sahloul Hospital, Faculty of Medicine of Sousse, Sousse, Tunisia. eng Case Reports Journal Article (...) 2016 11 25 Uganda Pan Afr Med J 101517926 0 Analgesics 0 Anti-Inflammatory Agents, Non-Steroidal IM Adult Analgesics therapeutic use Anti-Inflammatory Agents, Non-Steroidal therapeutic use Diagnosis, Differential Humans Male Osteoarthropathy, Primary Hypertrophic diagnosis diagnostic imaging drug therapy Radiography Pachydermoperiostosis digital clubbing thickening of the skin 2016 10 06 2016 10 16 2017 3 9 6 0 2017 3 9 6 0 2018 2 16 6 0 epublish 28270899 10.11604/pamj.2016.25.194.10890 PAMJ-25-194

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2016 The Pan African medical journal

5. Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease (PubMed)

Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data.We evaluated patients with ILD who visited the teaching hospital (...) at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1. We examined the association of clubbing with clinical data.Of 102 patients with ILD, we identified 17 (16.7%) with clubbing. The partial pressure of oxygen in arterial blood was lower (65.2 ± 5.9 mmHg versus 80.2 ± 3.1 mmHg; p=0.03), serum Krebs von den Lugen-6 (KL-6) levels were higher (1495.0 ± 277.4 U/mL versus

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2018 Canadian respiratory journal

6. Use of Mobile Devices, Social Media, and Crowdsourcing as Digital Strategies to Improve Emergency Cardiovascular Care

Use of Mobile Devices, Social Media, and Crowdsourcing as Digital Strategies to Improve Emergency Cardiovascular Care Use of Mobile Devices, Social Media, and Crowdsourcing as Digital Strategies to Improve Emergency Cardiovascular Care | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 (...) January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article Use of Mobile Devices, Social Media, and Crowdsourcing as Digital Strategies to Improve Emergency Cardiovascular Care A Scientific Statement From the American Heart Association , MD, PhD, FAHA, Chair , MD, MHSc , MD, FAHA , MPH, MSN, RN, FAHA , MD, MPH , MD, MS, MRCP , MD, FAHA , MD, FAHA , and MD MD, MSHP, FAHA, Vice ChairOn behalf

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2016 American Heart Association

7. Clubbing in patients with fibrotic interstitial lung diseases. (PubMed)

methods in patients with fibrotic ILDs. Additionally, we assessed the prevalence of clubbing in different fibrotic ILDs and related clubbing to disease severity and quality of life.Consecutive outpatients with fibrotic ILDs of two tertiary referral centers were included. Clubbing was assessed with the phalangeal depth ratio, the digital index, the Schamroth sign test, and by the treating physicians and investigator.We included 153 patients (100 men), mean age 65 (range 33-88), mean FVC 79% (25-145 (...) Clubbing in patients with fibrotic interstitial lung diseases. Clubbing is associated with poor prognosis and is variably present in patients with idiopathic pulmonary fibrosis (IPF), but is also seen in other fibrotic interstitial lung diseases (ILDs). Little is known about the best methodology to assess clubbing in ILDs and, hence, the prevalence and clinical utility and clinical significance of clubbing. We therefore aimed to evaluate the agreement between different clubbing assessment

2017 Respiratory medicine

8. High rates of retention and viral suppression in the scale-up of antiretroviral therapy adherence clubs in Cape Town, South Africa. (PubMed)

High rates of retention and viral suppression in the scale-up of antiretroviral therapy adherence clubs in Cape Town, South Africa. Increasingly, there is a need for health authority scale up of successfully piloted differentiated models of antiretroviral therapy (ART) delivery. However, there is a paucity of evidence on system-wide outcomes after scale-up. In the Cape Town health district, stable adult patients were referred to adherence clubs (ACs) - a group model of ART delivery with five (...) digitized registers and used competing risks regression and cross-sectional methods to estimate outcomes: mortality, transfers, loss to follow-up (LTFU) and viral load suppression (≤400 copies/mL). Predictors of LTFU and viral rebound were assessed using Cox proportional hazards models.Of the 3216 adults contributing 4019 person years of follow-up (89% in an AC, median 1.1 years), 70% were women. Retention was 95.2% (95% CI, 94.0-96.4) at 12 months and 89.3% (95% CI, 87.1-91.4) at 24 months after AC

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2017 Journal of the International AIDS Society

9. Learning Experimental Design through Targeted Student-Centric Journal Club with Screencasting (PubMed)

a journal club training exercise to address this need. Students were instructed on methods for interpreting scientific literature using a screencast, a digital recording of a slide presentation narrated by an instructor. Students subsequently examined a series of research publications with a focus on the experimental designs and data interpretation in a two-session group discussion journal club format. We have found this approach to be an efficient and productive method for engaging students in learning (...) Learning Experimental Design through Targeted Student-Centric Journal Club with Screencasting Knowledge and application of experimental design principles are essential components of scientific methodology, and experience with these skills is fundamental for participating in scientific research. However, undergraduates often enter the research laboratory with little training in designing and interpreting their own experiments. In the context of a research university laboratory, we designed

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2017 Journal of Undergraduate Neuroscience Education

10. College-aged women in the United States that play overhand throwing sports have masculine digit ratios. (PubMed)

, 103 varsity athletes, and 78 club sport athletes to test 8 hypotheses about the relationship between digit ratio and the athletic behavior of college-age women in the USA. Using independent samples t-tests, we found no significant differences between the digit ratios of women that (1) were athletes and non-athletes, (2) were varsity or club sport athletes, (3) had played or were currently playing individual or team sports, (4) played contact and non-contact sports, (5) played sports involving (...) College-aged women in the United States that play overhand throwing sports have masculine digit ratios. Athletic prowess in both males and females is negatively correlated with the ratio between the lengths of the second and fourth fingers (2D:4D), a correlate of prenatal testosterone exposure. Because multiple lines of evidence suggest that prenatal testosterone exposure is associated with sports interest, motivation, and athletic performance we measured the digit ratios of 77 non-athletes

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2018 PLoS ONE

11. Diagnosis of digital clubbing by high-frequency ultrasound imaging. (PubMed)

Diagnosis of digital clubbing by high-frequency ultrasound imaging. Current methods to diagnose clubbing have drawbacks. This study was done to test a novel and convenient method for the diagnosis of digital clubbing using high-frequency ultrasound.Index fingers from a healthy control group without digital clubbing and a patient group with digital clubbing were examined by ultrasound. The morphology of the clubbing fingers was observed. The soft tissue depth under the nail (SDUN (...) than IPDs in the patient group, while in the healthy control group, DPDs were smaller than IPDs. The mean DPD/IPD ratio was 0.86 ± 0.04 cm in the control group and 1.077 ± 0.11 cm in the patient group (P < 0.05).We present a new, easy, convenient method for the diagnosis of digital clubbing using ultrasound. We also discovered a new parameter for the diagnosis of clubbing fingers and identification of pseudodigital clubbing, the SDUN. The increased SDUN might be taken as an early sign of digital

2013 International Journal of Dermatology

12. Can an evidence-based book club intervention delivered via a tablet computer improve physical activity in middle-aged women? (PubMed)

Can an evidence-based book club intervention delivered via a tablet computer improve physical activity in middle-aged women? Fewer than 50% of middle-aged women participate in regular physical activity (PA). Innovative approaches that engage women who may not otherwise participate in PA programs are warranted. The purpose of this study was to explore the acceptability and feasibility of a 12-week tablet-based book club for improving middle-aged women's PA.Thirty women (35-64 years of age) were (...) randomized to the Fit Minded Tablet (n=15) and the Standard Fit Minded (i.e., face-to-face intervention) (n=15) groups. The Fit Minded Tablet was adapted from the Standard Fit Minded, a previously tested, theory-based book club intervention using books as a platform for discussion and group support to help women adopt regular PA. Both interventions met weekly for 3 months, for a total of 12 sessions. Tablet group participants accessed materials (e.g., e-books, workbook, live/recorded videoconferencing

2016 Telemedicine journal and e-health : the official journal of the American Telemedicine Association

13. Ultrasonographic‐based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: A retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong (PubMed)

Ultrasonographic‐based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: A retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, but predictive ultrasonographic features have not been reported.To determine ultrasonographic features of forelimb SDFT (...) injury at initial presentation in Thoroughbred racehorses that could predict a successful return to racing (completing ≥5 races).Retrospective cohort study.Digitised ultrasonographic images of 469 horses with forelimb SDFT injuries from the Hong Kong Jockey Club (2003-2014) were evaluated, using a previously validated ultrasonographic scoring system. Six ultrasonographic parameters were evaluated (type and extent of the injury, location, echogenicity, cross-sectional area and longitudinal fibre

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2018 Equine veterinary journal

14. Digital Clubbing

Digital Clubbing Digital Clubbing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Digital Clubbing Digital Clubbing Aka: Digital (...) Clubbing , Clubbing , Schamroth's Window Test , Schamroth's Sign , Digital Index , Lovibond Angle II. History First described by Hippocrates in 5th century B.C. III. Definition Bulbous digital deformity Watch-crystal deformity of IV. Pathophysiology Sign of ( ) Thickening of nail bed's soft tissue (especially proximally) Typically affects all fingers Results from abnormal microvasculature with increased blood flow to the microvasculature V. Signs: Schamroth's Window Test for Clubbing Oppose fingers

2015 FP Notebook

15. Primary hypertrophic osteoarthropathy with digital clubbing and palmoplantar hyperhidrosis caused by 15-PGHD/HPGD loss-of-function mutations. (PubMed)

Primary hypertrophic osteoarthropathy with digital clubbing and palmoplantar hyperhidrosis caused by 15-PGHD/HPGD loss-of-function mutations. Digital clubbing is the most prominent feature in primary (PHO) and secondary (pulmonary) hypertrophic osteoarthropathy (HO). Homozygous and compound heterozygous germline mutations in the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene encoding the major prostaglandin PGE2 catabolizing enzyme have been recently described in familial PHO cases. Elevated (...) ; however, therapeutic strategies have not been reported to date. Naproxen treatment in one of our mutation-positive patients resulted in alleviation of pain caused by periostosis and arthritis as well as reduction in substantially elevated prostaglandin levels, while no significant effects on digital clubbing, hyperhidrosis and pachyderma were observed. Further experience with nonsteroidal anti-inflammatory drugs in PHO is awaited.© 2011 John Wiley & Sons A/S.

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2011 Experimental Dermatology

16. Tripe Palms, Digital Clubbing and Jaccoud's-type Arthropathy: A Quiz. (PubMed)

Tripe Palms, Digital Clubbing and Jaccoud's-type Arthropathy: A Quiz. 21369678 2011 08 26 2012 01 02 1651-2057 91 3 2011 May Acta dermato-venereologica Acta Derm. Venereol. Tripe Palms, digital clubbing and Jaccoud's-type arthropathy: a quiz. Pachydermatoglyphy in an apparently cancer-free smoker. 380, 384 10.2340/00015555-0930 Ben Hmida Myriam M Department of Dermatology, La Rabta Hospital, Jabbari, Bab Saadoun, Tunis, Tunisia. Zaraa Ines I Mrabet Dalia D Cherif Jouda J Chelly Ines I Zitouna

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2011 Acta Dermato-Venereologica

17. Quantitation of digital clubbing by shadowgram technique. (PubMed)

Quantitation of digital clubbing by shadowgram technique. Finger clubbing was quantified from the magnified silhouette of the right index finger in controls and patients with clubbing, using a simple shadowgram technique. There was good correlation between clinical assessment and measurement of both the profile angle and the hyponychial angle. The hyponychial angle appeared to be a more accurate indicator of clubbing than the profile angle.

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1979 Archives of Disease in Childhood

18. Hereditary Clubbing of Digits in Two Families (PubMed)

Hereditary Clubbing of Digits in Two Families 20786524 2011 04 04 2018 11 13 0007-1447 1 4438 1946 Jan 26 British medical journal Br Med J Hereditary Clubbing of Digits in Two Families. 128-9 Davis E E eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1946 1 26 0 0 1946 1 26 0 1 ppublish 20786524 PMC2058112 Can Med Assoc J. 1936 Feb;34(2):145-9 20320148

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1946 British medical journal

19. CALORIMETRIC STUDY OF THE DIGITAL BLOOD FLOW IN CLUBBED FINGERS (PubMed)

CALORIMETRIC STUDY OF THE DIGITAL BLOOD FLOW IN CLUBBED FINGERS 14063016 1996 12 01 2018 12 01 0007-0769 25 1963 Sep British heart journal Br Heart J CALORIMETRIC STUDY OF THE DIGITAL BLOOD FLOW IN CLUBBED FINGERS. 677-83 ARAB M M MM eng Journal Article England Br Heart J 0370634 0007-0769 OM Blood Circulation Heart Defects, Congenital Hemodynamics Humans Hyperplasia Hypertrophy Osteoarthropathy, Secondary Hypertrophic BLOOD CIRCULATION HEART DEFECTS, CONGENITAL HYPERTROPHY AND HYPERPLASIA

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1963 British Heart Journal

20. LATS activity, exophthalmos and digital clubbing associated with myxoedema. (PubMed)

LATS activity, exophthalmos and digital clubbing associated with myxoedema. 5655219 1968 08 02 2018 11 13 0032-5473 44 511 1968 May Postgraduate medical journal Postgrad Med J LATS activity, exophthalmos and digital clubbing associated with myxoedema. 426-8 Beighton P P eng Case Reports Journal Article England Postgrad Med J 0234135 0032-5473 9034-48-4 Long-Acting Thyroid Stimulator IM Aged Exophthalmos Female Humans Long-Acting Thyroid Stimulator metabolism Myxedema Osteoarthropathy, Secondary

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1968 Postgraduate medical journal

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