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Diffuse Hyperpigmentation

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1. Imatinib-induced diffuse hyperpigmentation of the oral mucosa, the skin, and the nails in a patient affected by chronic myeloid leukemia: report of a case and review of the literature. (PubMed)

Imatinib-induced diffuse hyperpigmentation of the oral mucosa, the skin, and the nails in a patient affected by chronic myeloid leukemia: report of a case and review of the literature. Imatinib mesylate is a tyrosine-kinase inhibitor used as the first-line treatment in chronic myeloid leukemia patients, but it is also indicated for other hematological diseases and solid tumors. Imatinib treatment is often associated with hypopigmentation, but only a few cases of hyperpigmentation are described (...) in literature.We are reporting the first case of imatinib-related hyperpigmentation involving the oral mucosa, skin, and nails in a patient affected by chronic myeloid leukemia and treated with imatinib since 2002. A review of all the available literature regarding the imatinib-related hyperpigmentation was performed, and one additional case was analyzed. Due to the possibility of a post-inflammatory hyperpigmentation, all cases of pigmentary changes previously characterized by a rash and/or pruritus

2018 International Journal of Dermatology

2. Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation (PubMed)

Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire (...) excluded. An objective causality assessment reveals that, the cutaneous hyperpigmentation was possibly associated with Polymyxin B therapy, though further studies may be needed to explain the underlying mechanism.

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2017 Journal of clinical and diagnostic research : JCDR

3. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2018 FP Notebook

4. Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection (PubMed)

Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors

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2016 IDCases

5. Palladium causes bizarre skin hyperpigmentation in long-term dihydrocodeinone 'Braun' abusers. (PubMed)

. Palladium skin content was assessed by X-ray fluorescence (XRF) spectrometry.Both patients showed generalized diffuse dark blue-grey hyperpigmentation of the skin. In both, an abnormal population of cells containing intracytoplasmic brownish granular material was identified in the papillary dermis by light microscopy. Electron microscopy revealed a dense and minimally structured material that predominantly accumulated in macrophages, fibroblasts and vascular endothelial cells. XRF analysis confirmed (...) elevated levels of palladium in the patient's skin in comparison to healthy controls.Long-term abuse of palladium-contaminated dihydrocodeinone ('Braun') results in excessive accumulation of granular material in various dermal cell types and causes generalized diffuse skin hyperpigmentation.© 2019 European Academy of Dermatology and Venereology.

2019 Journal of the European Academy of Dermatology and Venereology

6. Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. (PubMed)

Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: analysis of a cohort of 239 patients. Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker.To assess the association between pigmentation disorders and systemic involvement in patients with SSc.A total of 5 patterns of skin pigmentation disorders were defined: diffuse hyperpigmentation (...) ; hyperpigmentation of sun-exposed areas; hypopigmentation of the head, neck, and/or upper part of the chest; acral hypopigmentation; and diffuse hypopigmentation.A total of 239 patients were included; 88 patients (36.8%) had skin pigmentation disorders as follows: diffuse hyperpigmentation and hyperpigmentation of sun-exposed areas in 38.6% (n = 34) and 27.3% (n = 24) of patients, respectively; hypopigmentation of the face, neck, and/or chest in 10.2% of patients (n = 9); diffuse hypopigmentation in 12.5% (n

2018 Journal of American Academy of Dermatology

7. General hyperpigmentation induced by Grave's disease: A case report. (PubMed)

General hyperpigmentation induced by Grave's disease: A case report. Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease.A 42-year-old Chinese woman with accumulated general pigmentation of skin was admitted to our hospital in October 2017. On examination, hyperpigmentation was observed throughout the whole body, especially (...) on the extremities and the face.The patient has elevated levels of serum free thyroxine (FT4), free triiodothyronine (FT3), reduced levels of thyroid-stimulating hormone (TSH) and positive anti-TSH receptor antibody (TRAb). She presented with grade I goiter and a diffusely increased thyroid uptake to 18.5% in thyroid scan. Histopathological examination demonstrated melanin pigmentation in the pigmented skin area. The patient was diagnosed with hyperpigmentation induced by Grave's disease.The patient was treated

2018 Medicine

8. Dermatoscopic evaluation and histopathological correlation of acquired dermal macular hyperpigmentation. (PubMed)

Dermatoscopic evaluation and histopathological correlation of acquired dermal macular hyperpigmentation. Acquired dermal macular hyperpigmentation (ADMH) is a hypernym encompassing Riehl's melanosis, lichen planus pigmentosus, and ashy dermatoses that show significant clinicopathological overlap. We sought to describe the dermatoscopic features of ADMH and correlate them with histopathological findings.This was a prospective observational study performed in two phases. A detailed clinical (...) structures (15.7%). Four dermatoscopic grades of disease severity were identified: grade 1 - dotted; grade 2 - Chinese letter; grade 3 - reticulate; and grade 4 - diffuse. Density of melanin incontinence on histopathology correlated positively with size of pigment structures (r = 0.7, P < 0.000) and grades of disease severity (r = 0.75, P < 0.000) on dermatoscopy.Increasing grades of disease severity can be detected dermatoscopically, which correlate well with histopathological features. A carefully

2017 International Journal of Dermatology

9. An In Vivo Model for Postinflammatory Hyperpigmentation

An In Vivo Model for Postinflammatory Hyperpigmentation An In Vivo Model for Postinflammatory Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An In Vivo Model for Postinflammatory (...) Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02905903 Recruitment Status : Unknown Verified February 2017 by Iltefat Hamzavi, Henry Ford Health System. Recruitment status was: Recruiting First Posted : September 19, 2016 Last Update Posted : February 23, 2017 Sponsor: Henry Ford Health

2016 Clinical Trials

10. Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. (PubMed)

Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 (...) patients were enrolled and reviewed for clinical features and factors associated with PIH.The overall incidence of PIH was 20.3%. We demonstrated that patients with erythematous lentigines presented with PIH more frequently compared with those without erythematous lentigines. Among several coexisting conditions, facial diffuse dyschromia was significantly associated with PIH. Furthermore, PIH occurred more frequently in patients with invisible pores and velvety skin. However, age, sex, Fitzpatrick

2016 Journal of Dermatological Treatment

11. Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review (PubMed)

hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190 (...) reversal of hyperpigmentation at 12 weeks following parenteral cobalamin therapy. In all five cases with pyrexia, fever subsided after 24 to 72 hours following administration of parenteral cobalamin therapy.Cutaneous hyperpigmentation and cytopenia (s) are strongly associated with megaloblastic anemia. Knuckle pad hyperpigmentation is much more frequent than diffuse pigmentation of the palms and/or soles in such patents. A nonsignificant trend towards a greater degree of MA was found in cases

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2016 Mediterranean journal of hematology and infectious diseases

12. Hyperpigmentation

: Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related (...) Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka

2018 FP Notebook

13. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2015 FP Notebook

14. Sturge-Weber Syndrome Associated with Monolateral Ocular Melanocytosis, Iris Mammillations, and Diffuse Choroidal Haemangioma (PubMed)

Sturge-Weber Syndrome Associated with Monolateral Ocular Melanocytosis, Iris Mammillations, and Diffuse Choroidal Haemangioma We present the case of a 12-year-old boy with Sturge-Weber syndrome and ocular melanocytosis who presented with bilateral naevus flammeus of the face and hyperpigmentation of the right iris associated with ipsilateral iris mammillations. The patient had glaucoma and a diffuse choroidal haemangioma of the right eye. Optical coherence tomography of the anterior segment

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2017 Case reports in ophthalmology

15. Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream (PubMed)

Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells

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2016 Scientia pharmaceutica

16. A Novel Germline KIT Mutation (p.L576P) in a Family Presenting With Juvenile Onset of Multiple Gastrointestinal Stromal Tumors, Skin Hyperpigmentations, and Esophageal Stenosis. (PubMed)

A Novel Germline KIT Mutation (p.L576P) in a Family Presenting With Juvenile Onset of Multiple Gastrointestinal Stromal Tumors, Skin Hyperpigmentations, and Esophageal Stenosis. Familial gastrointestinal stromal tumor (GIST) syndrome is a rare autosomal dominant genetic disorder. We report on a kindred in which 3 family members carry a germline mutation (c.1727T>C, p.L576P) in exon 11 of the KIT gene. This mutation was not reported so far in familial GISTs. Apart from multiple GISTs in 2 (...) of the mutation carriers, all of them had multiple hyperpigmented skin macules and a history of achalasia-like stenosis of the esophagus in early childhood. In the index patient >100 tumors and a diffuse Cajal cell hyperplasia of the small bowel occurred. Sequencing of DNA extracted from tumor tissue of one of his GISTs revealed the KIT mutation in exon 11 (c.1727T>C). By array comparative genomic hybridization whole chromosomal gains 3, 5, 7, 9, 12, 15, and 18 were detected. In addition, we could identify

2013 American Journal of Surgical Pathology

17. Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings (PubMed)

protein.Here we report three siblings with FGD. The second in order of siblings presented at an age of 15 years with history of diffuse hyperpigmentation since childhood. Their parents were non consanguineous. The patients were hyperpigmented and taller compared with their parents. None of the siblings had ambiguous genitalia or neurological abnormalities. There was no history of tuberculosis in the family. Biochemical investigations revealed low serum cortisol (<1 μg/dl) and elevated plasma ACTH (>1250 pg (...) Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by glucocorticoid deficiency, high ACTH levels and normal mineralocorticoid levels. FGD is caused due to defects in adrenocorticotropic hormone (ACTH) signaling. The defect can be caused by mutations in genes encoding the ACTH receptor (melanocortin 2 receptor) or its accessory

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2012 Indian journal of endocrinology and metabolism

18. Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. (PubMed)

Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a disorder of pigmentation. Although several cases of PCZH have been reported, no clinicopathologic studies of the condition have been published in the English-language literature.The purpose of this study was to determine the clinical characteristics and histologic findings of PCZH.Between 1999 and 2009, 30 patients were diagnosed with PCZH (...) was observed in 13 of 30 cases.There was no significant difference in prevalence, age at onset, and duration of lesions between male and female patients with PCZH. The lesions corresponded to the lines of Blaschko and were localized rather than exhibiting diffuse patterns. A common feature of the histopathologic findings was higher melanin content in the lesions than in normal skin but with no significant difference in the number of melanocytes.© 2012 The International Society of Dermatology.

2012 International Journal of Dermatology

19. Hyperpigmentation

: Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related (...) Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka

2015 FP Notebook

20. Hyperpigmentation in human solar lentigo is promoted by heparanase-induced loss of heparan sulfate chains at the dermal-epidermal junction. (PubMed)

Hyperpigmentation in human solar lentigo is promoted by heparanase-induced loss of heparan sulfate chains at the dermal-epidermal junction. Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of heparan sulfate at the dermal-epidermal junction (DEJ), resulting in uncontrolled diffusion of heparan

2011 Journal of dermatological science

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