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Diarrhea Secondary to Medications

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7301. Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome. (PubMed)

rate of adequate relief of IBS pain and discomfort. Secondary endpoints included 48-wk average satisfactory control rates of urgency, stool frequency, stool consistency, and bloating. Other efficacy endpoints were average monthly adequate relief and urgency control rates and impact of provided rescue medication.Alosetron-treated patients had significantly greater 48-wk average adequate relief (p= 0.01) and urgency control (p < 0.001) rates, regardless of rescue medication use, compared with placebo (...) Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome. To assess long-term safety and efficacy of alosetron in women with severe, chronic diarrhea-predominant IBS and in a subset having more frequent urgency (i.e., bowel urgency at least 10 of 14 days during screening).Randomized patients received either alosetron 1 mg (n = 351) or placebo (n = 363) twice daily during a 48-wk, double-blind study. The primary endpoint was the 48-wk average

2004 The American journal of gastroenterology Controlled trial quality: predicted high

7302. Knowledge and use of secondary contraception among patients requesting termination of pregnancy. (PubMed)

no medical advice. There was a range of knowledge of postcoital contraceptive methods. Knowledge of how to deal with forgotten pills, severe vomiting, severe diarrhea, and concurrent antibiotic treatment among the 422 patients who had ever used the combined pill also was variable. 19% of the 372 patients treated by general practitioners knew 4 correct answers, but 50% of the 50 patients in community family planning clinics answered correctly 4 times. Differences could not be explained by other (...) Knowledge and use of secondary contraception among patients requesting termination of pregnancy. 8461770 1993 05 05 2008 11 20 0959-8138 306 6877 1993 Feb 27 BMJ (Clinical research ed.) BMJ Knowledge and use of secondary contraception among patients requesting termination of pregnancy. 556-7 Bromham D R DR Fertility Control Unit, St James's University Hospital, Leeds. Cartmill R S RS eng Journal Article England BMJ 8900488 0959-8138 0 Contraceptives, Postcoital AIM IM J BMJ. 1993 Apr 3;306(6882

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1993 BMJ : British Medical Journal

7303. Vancomycin vs. Metronidazole in C. difficile Diarrhea: Vancomycin vs. metronidazole in C. difficile

. 98% (P=0.36) Severe disease: 76% vs. 97% (P=0.02; NNT 5) All: 84% vs. 97% (P=0.006; NNT 8) Relapse (recurrence of diarrhea by day 21 after initial cure) Mild disease: 8% vs. 5% (P=0.67) Severe disease: 21% vs. 10% (P=0.30) All: 14% vs. 7% (P=0.27) Secondary Outcomes Intolerance One patient from each group developed nausea/vomiting and was changed to the opposite group; both individuals achieved cure. Criticisms Performed before the NAP1/BI/027 strain emerged in the US Funding Sources (...) Vancomycin vs. Metronidazole in C. difficile Diarrhea: Vancomycin vs. metronidazole in C. difficile Vancomycin vs. Metronidazole in C. difficile Diarrhea - Wiki Journal Club Vancomycin vs. Metronidazole in C. difficile Diarrhea From Wiki Journal Club Jump to: , Zar FA, et al. "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity". Clinical Infectious Diseases . 2007. 45(3):302-7. • • Contents Clinical

2007 Wiki Journal Club

7304. Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis

to Primary Outcome Measures : Reduction of diarrhea as measured by NCI CTC version 2.0 weekly during pelvic radiotherapy [ Time Frame: Up to 2 years ] Secondary Outcome Measures : Reduction of patient-reported bowel dysfunction as assessed by the bowel function questionnaire weekly during radiotherapy, weekly for 4 weeks after radiotherapy, and 12 and 24 months after completion of radiotherapy [ Time Frame: Up to 2 years ] Toxicity as assessed by NCI CTC version 2.0 weekly during pelvic radiotherapy (...) Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2002 Clinical Trials

7305. A Study of Nitazoxanide in Patients With AIDS and Diarrhea Caused by Cryptosporidium

period prior to baseline. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Inability to tolerate oral medications. Life expectancy less than 3 months in the opinion of the investigator. Active CMV colitis, C. difficile colitis, giardiasis, salmonellosis, shigellosis, campylobacteriosis, inflammatory bowel disease, diarrhea secondary to another documented intestinal pathogen, or active or uncontrolled MAC disease, defined as symptomatic MAC (...) Volunteers: No Criteria Inclusion Criteria Patients must have: Documented HIV infection. Intestinal cryptosporidiosis. Willingness to undergo a 1 week washout phase of all anticryptosporidial medications and stabilization on a protocol directed, antidiarrheal regimen. Greater than or equal to 4 stools per day, on average, for a minimum of 21 out of 28 days prior to study entry, secondary to cryptosporidiosis. AS PER AMENDMENT 2/10/97: Four or more stools per day, on average, during the 5-day screening

1999 Clinical Trials

7306. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. (PubMed)

opportunistic infection (n = 4), and (3) idiopathic AIDS enteropathy with no identified source of infection (n = 3) or an untreatable opportunistic infection other than C. parvum (n = 1). All patients were treated with bovine immunoglobulin concentrate for 21 consecutive days. Patients in cohort 1 were randomized to receive the medication in powder or capsule forms, whereas all patients in cohorts 2 and 3 received the powder form. The primary end point was change in mean daily stool weight. Secondary end (...) movements per day at study entry, to 5.4 +/- 0.7 during treatment (p = 0.04), and 5.4 +/- 0.9 during observation (p = 0.12). Patients who received bovine immunoglobulin concentrate in capsule form and patients without C. parvum (cohort 3) showed no improvement. No serious side effects were observed, and the medication was well tolerated. Thus, bovine colostrum immunoglobulin concentrate, in powder form, appears promising in the treatment of severe diarrhea caused by C. parvum. The optimal dosage

1996 Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association Controlled trial quality: uncertain

7307. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. (PubMed)

, Staphylococcus aureus, and yeasts) analyses were studied in fecal samples. The metabolic activity of the gut microflora was assessed by analysis of fecal urease, beta-glucosidase, and beta-glucuronidase activities. The primary outcome measure was diarrhea during the first 2 weeks after the beginning of the antimicrobial treatment, because this period most likely reflects the effects of antimicrobial use. Secondary outcome measures were the activities of fecal urease, beta-glucuronidase, and beta (...) Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Antimicrobial treatment may disturb the colonization resistance of gastrointestinal microflora, which may induce clinical symptoms, most commonly diarrhea. The severity of antibiotic-associated diarrhea may range from a brief, self-limiting disease to devastating diarrhea with electrolyte disturbances, dehydration, crampy abdominal pain, pseudomembranous colitis

1999 Pediatrics Controlled trial quality: predicted high

7308. A multicenter randomized controlled trial of a liquid loperamide product versus placebo in the treatment of acute diarrhea in children. (PubMed)

diarrhea were enrolled. Children were randomly assigned to treatment with loperamide HCl 0.5 mg/5 mL (n = 130) or placebo (n = 128). The first dose of loperamide consisted of either 1.0 mg (children 2 through 5 years of age) or 2.0 mg (children 6 through 11 years of age) of study medication under the observation of study personnel. This was followed by 1 mg after each unformed stool, with a total daily dose of up to 3.0 mg in the children 2-5 years of age, 4.0 mg in the children 6-8 years of age (...) A multicenter randomized controlled trial of a liquid loperamide product versus placebo in the treatment of acute diarrhea in children. This randomized, double-blind, placebo-controlled trial of 48 hours' duration conducted in 13 primary care ambulatory practices in the United States and Mexico was used to compare the efficacy and safety of loperamide with placebo for the treatment of acute diarrhea in children aged 2 through 11 years. Two hundred fifty-eight children with acute nonspecific

1999 Clinical pediatrics Controlled trial quality: predicted high

7309. [Effect of racecadotril in the management of acute diarrhea in infants and children]. (PubMed)

with rehydration alone in children aged three months to three years who had acute diarrhoea and were evaluated in the emergency department (ED). The primary end point was the number of medical exams during the week after starting treatment. Secondary end points were the number of stools during the first 48 hours, the duration of the diarrhoea and the weight on day 7.One hundred and sixty-six children were alternatively randomized to the treated and the control groups. There was no difference for age, degree (...) [Effect of racecadotril in the management of acute diarrhea in infants and children]. The treatment of diarrhoea relies on the maintenance or restoration of hydration with maintenance of an adequate nutritional intake. Racecadotril has been shown to reduce the stools output during acute diarrhoea. The present work was aimed at measuring the number of emergency department visits for acute diarrhoea either the children received racecadotril or not.Racecadotril and rehydration were compared

2002 Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie Controlled trial quality: uncertain

7310. Teaching treatment of mild, acute diarrhea and secondary dehydration to homeless parents. (PubMed)

Teaching treatment of mild, acute diarrhea and secondary dehydration to homeless parents. Homeless people in America are at risk for numerous health hazards. Diarrhea and consequent dehydration commonly affect homeless infants and children. Dehydration, if not treated, can quickly become a medical emergency. If, however, signs of diarrhea and dehydration are recognized and treated early, medical complications may be avoided. Fortunately, some homeless people now have access to shelter (...) facilities that provide health education and services. Education is a fundamental tool in the prevention of disease. For homeless children sick with diarrhea, an educated parent may mean the difference between life and death. Therefore, an educational program was developed to help homeless parents recognize and treat mild, acute diarrhea and secondary dehydration. Participants were urged to treat mild diarrhea at home with oral rehydration therapy, thus preventing expensive medical treatment

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1987 Public Health Reports

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