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Diabetic Foot Ulcer

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2. Topical antimicrobial agents for treating foot ulcers in people with diabetes. (PubMed)

Topical antimicrobial agents for treating foot ulcers in people with diabetes. People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Topical antimicrobial therapy has been used on diabetic foot ulcers, either as a treatment for clinically infected wounds (...) , or to prevent infection in clinically uninfected wounds.To evaluate the effects of treatment with topical antimicrobial agents on: the resolution of signs and symptoms of infection; the healing of infected diabetic foot ulcers; and preventing infection and improving healing in clinically uninfected diabetic foot ulcers.We searched the Cochrane Wounds Specialised Register, CENTRAL, Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL Plus in August 2016. We

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2017 Cochrane

3. Pexiganan (Locilex) for mild foot infection in diabetic foot ulcers

Pexiganan (Locilex) for mild foot infection in diabetic foot ulcers Pexiganan (Locilex) for mild foot infection in diabetic foot ulcers Pexiganan (Locilex) for mild foot infection in diabetic foot ulcers NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Pexiganan (Locilex) for mild foot infection in diabetic foot ulcers. Birmingham: NIHR (...) Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' objectives Diabetes is a common life-long condition. People with diabetes have very high levels of glucose, a type of sugar, in their blood because their bodies do not make enough insulin or the insulin does not work properly. Diabetes can cause foot problems, such as infections and ulcers. Some people may have their feet amputated if the ulcer or infection is severe. Pexiganan is a new antibiotic cream for diabetic

2016 Health Technology Assessment (HTA) Database.

4. Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: a health technology assessment

Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: a health technology assessment Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: a health technology assessment Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: a health technology assessment Health Quality (...) Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: a health technology assessment. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 17(12). 2017 Authors

2018 Health Technology Assessment (HTA) Database.

5. Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: OHTAC recommendation

Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: OHTAC recommendation Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: OHTAC recommendation Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: OHTAC recommendation Health Quality Ontario Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Fibreglass total contact casting, removable cast walkers, and irremovable cast walkers to treat diabetic neuropathic foot ulcers: OHTAC recommendation. Toronto: Health Quality Ontario (HQO). 2017 Authors' conclusions The Ontario Health Technology Advisory Committee recommends that fibreglass total

2018 Health Technology Assessment (HTA) Database.

6. Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat Diabetic Neuropathic Foot Ulcers

Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat Diabetic Neuropathic Foot Ulcers Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat Diabetic Neuropathic Foot Ulcers - Health Quality Ontario (HQO) Let's make our health system healthier Open Menu Quick Links Search Search A A A Evidence to Improve Care Share: Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat (...) Diabetic Neuropathic Foot Ulcers Ontario Health Technology Advisory Committee Recommendation The Ontario Health Technology Advisory Committee (OHTAC) recommends that fibreglass total contact casting, removable cast walkers, and irremovable cast walkers be publicly funded in patients presenting with a neuropathic diabetic plantar foot ulcer. Diabetes can lead to nerve damage in the foot, causing the wasting of muscle and a loss of feeling. This, combined with increased pressure from shoes, a foot

2017 Health Quality Ontario

7. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers

Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers Public Comment: Held October 24 to November 14, 2016. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: OHTAC Recommendation ONTARIO HEALTH TECHNOLOGY ADVISORY COMMITTEE RECOMMENDATION ? The Ontario Health Technology Advisory Committee concludes that the current evidence is insufficient to assess the benefits of hyperbaric oxygen therapy in healing diabetic foot ulcers. Given the low quality of the available (...) Technology Advisory Committee decided the evidence was insufficient to make a recommendation to publicly fund or not fund hyperbaric oxygen therapy for treating diabetic foot ulcers. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: OHTAC Recommendation. May 2017; pp. 1–3 2 Decision Determinants for Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers Decision Criteria Subcriteria Decision Determinants Considerations Overall clinical benefit How likely is the health

2017 Health Quality Ontario

8. Expert panel report: The role of topical oxygen therapy in the management of diabetic foot ulcers

Expert panel report: The role of topical oxygen therapy in the management of diabetic foot ulcers

2019 Wounds UK

9. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: OHTAC recommendation

Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: OHTAC recommendation Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: OHTAC recommendation Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: OHTAC recommendation Ontario Health Technology Advisory Committee (OHTAC) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Ontario Health Technology Advisory Committee (OHTAC). Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: OHTAC recommendation. Toronto: Health Quality Ontario (HQO). 2017 Authors' conclusions The Ontario Health Technology Advisory Committee accepted the findings of the health technology assessment conducted by Health Quality Ontario. There is a large degree of uncertainty in both the clinical and economic evidence for hyperbaric oxygen therapy, meaning

2017 Health Technology Assessment (HTA) Database.

10. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment

Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 17(5). 2017 Authors' conclusions For patients with diabetic foot ulcers, there is a substantial daily burden of care and emotional weight associated with the condition. The worrisome possibility of amputation leads patients to carefully monitor and care for their feet

2017 Health Technology Assessment (HTA) Database.

11. Hyperbaric oxygen therapy for diabetes-related foot ulcers: a review of reviews

Hyperbaric oxygen therapy for diabetes-related foot ulcers: a review of reviews Hyperbaric oxygen therapy for diabetes-related foot ulcers: a review of reviews Hyperbaric oxygen therapy for diabetes-related foot ulcers: a review of reviews HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Hyperbaric oxygen therapy for diabetes-related foot (...) ulcers: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Rationale: Diabetes mellitus can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of wounds to heal. Hyperbaric oxygen therapy (HBOT) has been proposed as a treatment adjunct to wound care to improve oxygenation and promote healing when a diabetic patient has chronic foot ulcers despite standard wound therapy alone. Technology

2017 Health Technology Assessment (HTA) Database.

12. Comparative effectiveness of skin substitutes for chronic foot ulcers in adults with diabetes mellitus: a review of reviews

Comparative effectiveness of skin substitutes for chronic foot ulcers in adults with diabetes mellitus: a review of reviews Comparative effectiveness of skin substitutes for chronic foot ulcers in adults with diabetes mellitus: a review of reviews Comparative effectiveness of skin substitutes for chronic foot ulcers in adults with diabetes mellitus: a review of reviews HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Comparative effectiveness of skin substitutes for chronic foot ulcers in adults with diabetes mellitus: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Diabetes can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Reasons are multifactorial and may include

2017 Health Technology Assessment (HTA) Database.

13. Skin grafting and tissue replacement for treating foot ulcers in people with diabetes. (PubMed)

Skin grafting and tissue replacement for treating foot ulcers in people with diabetes. Foot ulceration is a major problem in people with diabetes and is the leading cause of hospitalisation and limb amputations. Skin grafts and tissue replacements can be used to reconstruct skin defects for people with diabetic foot ulcers in addition to providing them with standard care. Skin substitutes can consist of bioengineered or artificial skin, autografts (taken from the patient), allografts (taken (...) that were used in the trials increased the healing rate of foot ulcers in patients with diabetes compared to standard care (risk ratio (RR) 1.55, 95% confidence interval (CI) 1.30 to 1.85, low quality of evidence). However, the strength of effect was variable depending on the specific product that was used (e.g. EpiFix® RR 11.08, 95% CI 1.69 to 72.82 and OrCel® RR 1.75, 95% CI 0.61 to 5.05). Based on the four included studies that directly compared two products, no specific type of skin graft or tissue

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2016 Cochrane

14. Intensive versus conventional glycaemic control for treating diabetic foot ulcers. (PubMed)

Intensive versus conventional glycaemic control for treating diabetic foot ulcers. The estimated likelihood of lower limb amputation is 10 to 30 times higher amongst people with diabetes compared to those without diabetes. Of all non-traumatic amputations in people with diabetes, 85% are preceded by a foot ulcer. Foot ulceration associated with diabetes (diabetic foot ulcers) is caused by the interplay of several factors, most notably diabetic peripheral neuropathy (DPN), peripheral arterial (...) disease (PAD) and changes in foot structure. These factors have been linked to chronic hyperglycaemia (high levels of glucose in the blood) and the altered metabolic state of diabetes. Control of hyperglycaemia may be important in the healing of ulcers.To assess the effects of intensive glycaemic control compared to conventional control on the outcome of foot ulcers in people with type 1 and type 2 diabetes.In December 2015 we searched: The Cochrane Wounds Specialised Register; The Cochrane Central

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2016 Cochrane

15. Racial factors and inpatient outcomes among patients with diabetes hospitalized with foot ulcers and foot infections, 2003-2014. (PubMed)

Racial factors and inpatient outcomes among patients with diabetes hospitalized with foot ulcers and foot infections, 2003-2014. In patients with diabetes, foot amputations among Black patients have been historically higher compared with White patients. Using the National Inpatient Sample database, we sought to determine if disparities in foot amputations and resource utilization have improved over time. We hypothesized there would be improvements and reduced differences in foot amputations (...) between the two races as quality of care and access to healthcare has improved.Patients over 18 years old with a principal diagnosis of diabetic foot complications and secondary diagnosis of Diabetes Mellitus were selected. We compared the primary outcome of foot amputations between Black and White patients. Adjusted rates, odds ratios (aOR) and trends of foot amputations among Black and White patients were studied. Healthcare utilization was measured via length of hospital stay (LOS). Of 262,924

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2019 PLoS ONE

16. Skin grafts may help heal diabetic foot ulcers and reduce amputations

Skin grafts may help heal diabetic foot ulcers and reduce amputations Skin grafts may help heal diabetic foot ulcers and reduce amputations Discover Portal Discover Portal Skin grafts may help heal diabetic foot ulcers and reduce amputations Published on 19 April 2016 doi: Skin grafts and tissue replacement products can help heal diabetic foot ulcers in some cases, and may also slightly reduce the numbers of future amputations. Foot ulcers are common and can be hard to treat, but failure (...) to heal them carries high risk for amputation and mortality. This review showed skin grafts or tissue replacement moderately increased the healing rate of the most amenable diabetic foot ulcers in people with diabetes – that is, in those who had sufficient blood flow in their feet. Two trials reported slightly fewer amputations in people with diabetes compared to usual care at 12 weeks. The review identified the most relevant trial evidence available. These trials showed some limitations. For example

2019 NIHR Dissemination Centre

17. Diabetic Foot Ulcers: Prevention

Diabetic Foot Ulcers: Prevention Diabetic Foot Ulcers: Prevention | National Guideline Clearinghouse success fail JUL Aug 12 2017 2018 2019 02 Oct 2017 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group is 100% composed of volunteers and interested parties, and has (...) have an account? The AHRQ National Guideline Clearinghouse (NGC, guideline.gov) Web site will not be available after July 16, 2018 because federal funding through AHRQ will no longer be available to support the NGC as of that date. For additional information, read our . Guideline Synthesis Diabetic Foot Ulcers: Prevention Guidelines Being Compared: International Working Group on the Diabetic Foot (IWGDF) IWGDF guidance on the prevention of foot ulcers in at-risk patients with diabetes. 2016 Jan 01

2017 National Guideline Clearinghouse (partial archive)

18. Diabetic Foot Ulcers: Wound Management

Diabetic Foot Ulcers: Wound Management Diabetic Foot Ulcers: Wound Management | National Guideline Clearinghouse success fail JUL Aug 12 2017 2018 2019 02 Oct 2017 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group is 100% composed of volunteers and interested (...) * Remember Me Don't have an account? The AHRQ National Guideline Clearinghouse (NGC, guideline.gov) Web site will not be available after July 16, 2018 because federal funding through AHRQ will no longer be available to support the NGC as of that date. For additional information, read our . Guideline Synthesis Diabetic Foot Ulcers: Wound Management Guidelines Being Compared: International Working Group on the Diabetic Foot (IWGDF) IWGDF guidance on use of interventions to enhance the healing of chronic

2017 National Guideline Clearinghouse (partial archive)

19. CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England. (PubMed)

CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England. To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU).Multicentre, prospective, cross-sectional study.Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards across England.Inclusion criteria: consenting (...) patients aged ≥18 years; diabetes mellitus; suspected infected DFU.clinically inappropriate to take either sample.Wound swab obtained using Levine's technique; tissue samples collected using a sterile dermal curette or scalpel.Coprimary: reported presence, and number, of pathogens per sample; prevalence of resistance to antimicrobials among likely pathogens. Secondary: recommended change in antibiotic therapy based on blinded clinical review; adverse events; sampling costs.400 consenting patients (79

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2018 BMJ open

20. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound (...) healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting.All patients presenting to our multidisciplinary DFU clinic from June 2012 to July 2017 were enrolled in a prospective database. A Cox proportional hazards model accounting for patients' sociodemographics, comorbidities, medication profiles, and wound characteristics was used to assess the association between WIfI classification and likelihood of wound healing at 1 year.There were 310 DFU

2018 EvidenceUpdates

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