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Diabetic Dermopathy

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1. Diabetic Dermopathy

Diabetic Dermopathy Diabetic Dermopathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diabetic Dermopathy Diabetic Dermopathy Aka (...) : Diabetic Dermopathy , Skin Spots II. Epidemiology Most common skin finding in More common if comorbid More common in men III. Pathophysiology Skin due to hemosiderin deposition May be associated with IV. Symptoms None V. Signs Round hyperpigmented areas Initial: flat-topped, red and scaly s Later: Depressed below skin level Distribution Bilateral shins (most common) s Anterior thighs Lateral feet VI. Course Heal spontaneously May leave preciously involved skin with altered pigment VII. References Habif

2018 FP Notebook

2. A study on the association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes mellitus Full Text available with Trip Pro

A study on the association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes mellitus Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association.This study investigated association of diabetic (...) dermopathy with nephropathy and retinopathy in patients with type 2 diabetes referring specialty clinic of Shahrekord.This descriptive, cross-sectional study was conducted on 102 type 2 diabetes patients with dermopathy referring clinic constantly or as outpatient. Dermatological and ophthalmological examinations and examination for nephropathy were done for all patients. Demographic data and results of examinations and patients history, and biochemical tests were gathered and recorded by researcher

2016 Journal of nephropathology

3. Diabetic Dermopathy

Diabetic Dermopathy Diabetic Dermopathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diabetic Dermopathy Diabetic Dermopathy Aka (...) : Diabetic Dermopathy , Skin Spots II. Epidemiology Most common skin finding in More common if comorbid More common in men III. Pathophysiology Skin due to hemosiderin deposition May be associated with IV. Symptoms None V. Signs Round hyperpigmented areas Initial: flat-topped, red and scaly s Later: Depressed below skin level Distribution Bilateral shins (most common) s Anterior thighs Lateral feet VI. Course Heal spontaneously May leave preciously involved skin with altered pigment VII. References Habif

2015 FP Notebook

4. Cutaneous Manifestations of Diabetes Mellitus: A Review. (Abstract)

and diabetic dermopathy. Furthermore, antidiabetic therapies may provoke dermatologic adverse events. Treatment with insulin may evoke local reactions like lipohypertrophy, lipoatrophy and both instant and delayed type allergy. Erythema multiforme, leukocytoclastic vasculitis, drug eruptions, and photosensitivity have been described as adverse reactions to oral antidiabetics. The identification of lesions may be crucial for the first diagnosis and for proper therapy of diabetes. (...) Cutaneous Manifestations of Diabetes Mellitus: A Review. Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition

2017 American journal of clinical dermatology

5. Nephrogenic Fibrosing Dermopathy (Follow-up)

. Neuromuscular involvement in nephrogenic systemic fibrosis. J Clin Neuromuscul Dis . 2007 Dec. 9(2):297-302. . Sanchez-Ross M, Snyder R, Colome-Grimmer MI, Blumberg M, Huttenbach Y, Raimer S. Nephrogenic fibrosing dermopathy in a patient with systemic lupus erythematosus and acute lupus nephritis. Pediatr Dermatol . 2007 Sep-Oct. 24(5):E36-9. . Goddard DS, Magee CC, Lazar AJ, Miller DM. Nephrogenic fibrosing dermopathy with recurrence after allograft failure. J Am Acad Dermatol . 2007 May. 56(5 Suppl):S109 (...) Nephrogenic Fibrosing Dermopathy (Follow-up) Nephrogenic Systemic Fibrosis Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5Nzg4OS10cmVhdG1lbnQ

2014 eMedicine.com

6. Nephrogenic Fibrosing Dermopathy (Treatment)

. Neuromuscular involvement in nephrogenic systemic fibrosis. J Clin Neuromuscul Dis . 2007 Dec. 9(2):297-302. . Sanchez-Ross M, Snyder R, Colome-Grimmer MI, Blumberg M, Huttenbach Y, Raimer S. Nephrogenic fibrosing dermopathy in a patient with systemic lupus erythematosus and acute lupus nephritis. Pediatr Dermatol . 2007 Sep-Oct. 24(5):E36-9. . Goddard DS, Magee CC, Lazar AJ, Miller DM. Nephrogenic fibrosing dermopathy with recurrence after allograft failure. J Am Acad Dermatol . 2007 May. 56(5 Suppl):S109 (...) Nephrogenic Fibrosing Dermopathy (Treatment) Nephrogenic Systemic Fibrosis Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5Nzg4OS10cmVhdG1lbnQ

2014 eMedicine.com

7. Nephrogenic Fibrosing Dermopathy (Overview)

):149-50. . Keyrouz S, Rudnicki SA. Neuromuscular involvement in nephrogenic systemic fibrosis. J Clin Neuromuscul Dis . 2007 Dec. 9(2):297-302. . Sanchez-Ross M, Snyder R, Colome-Grimmer MI, Blumberg M, Huttenbach Y, Raimer S. Nephrogenic fibrosing dermopathy in a patient with systemic lupus erythematosus and acute lupus nephritis. Pediatr Dermatol . 2007 Sep-Oct. 24(5):E36-9. . Goddard DS, Magee CC, Lazar AJ, Miller DM. Nephrogenic fibrosing dermopathy with recurrence after allograft failure. J Am (...) Nephrogenic Fibrosing Dermopathy (Overview) Nephrogenic Systemic Fibrosis: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5Nzg4OS1vdmVydmlldw== processing > Nephrogenic

2014 eMedicine.com

8. Nephrogenic Fibrosing Dermopathy (Diagnosis)

):149-50. . Keyrouz S, Rudnicki SA. Neuromuscular involvement in nephrogenic systemic fibrosis. J Clin Neuromuscul Dis . 2007 Dec. 9(2):297-302. . Sanchez-Ross M, Snyder R, Colome-Grimmer MI, Blumberg M, Huttenbach Y, Raimer S. Nephrogenic fibrosing dermopathy in a patient with systemic lupus erythematosus and acute lupus nephritis. Pediatr Dermatol . 2007 Sep-Oct. 24(5):E36-9. . Goddard DS, Magee CC, Lazar AJ, Miller DM. Nephrogenic fibrosing dermopathy with recurrence after allograft failure. J Am (...) Nephrogenic Fibrosing Dermopathy (Diagnosis) Nephrogenic Systemic Fibrosis: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5Nzg4OS1vdmVydmlldw== processing > Nephrogenic

2014 eMedicine.com

9. Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells. (Abstract)

Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells. Patients suffering from type II diabetes develop several skin manifestations including cutaneous infections, diabetic dermopathy, diabetic bullae and acanthosis nigricans. Diabetic micro- and macroangiopathy as well as diabetic neuropathy are believed to play a crucial role in the development of diabetic skin disorders. A reduced cutaneous nerve fibre (...) density was reported in diabetic subjects, which subsequently leads to impaired sensory nerve functions. Using an innervated skin model, we investigated the impact of human diabetic dermal fibroblasts and keratinocytes on porcine sensory neurons. Diabetic skin cells showed a reduced capacity to induce neurite outgrowth due to a decreased support with neurotrophic factors, such as NGF. Furthermore, diabetic keratinocytes displayed insulin resistance and increased expression of pro-inflammatory

2016 Experimental Dermatology

10. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. (Abstract)

Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD (...) ). These conditions possibly relate to underlying diabetogenic mechanisms. Our aim was to determine whether skin signs are feasible as cutaneous markers for the prediabetic or diabetic state.Data were collected from the databases PubMed, Embase and Cochrane. Articles were excluded if the populations presented with comorbidities or received treatment with drugs affecting the skin. Also, animal studies, studies with poor methodology and pilot studies were excluded.Among the 34 included original articles

2016 Danish medical journal

11. Skin blood flow abnormalities in diabetic dermopathy. (Abstract)

Skin blood flow abnormalities in diabetic dermopathy. Diabetic dermopathy is the most common specific cutaneous finding in diabetes.Using laser Doppler technology, we tested the hypothesis that diabetic dermopathy arises from abnormal local skin blood flow.We measured cutaneous blood flow in patients with type 1 diabetes without dermopathy and compared values with those in a control group of patients with type 1 diabetes without diabetic dermopathy and in a nondiabetic group. We measured at 3 (...) separate sites on the pretibial area on the legs of each participant, at dermopathy lesions, and at a number of standard sites on the upper and lower extremities.We studied 25 patients with diabetes and diabetic dermopathy, average age 51 ± 2 years, mean duration of diabetes 28 ± 3 years. In all, 58 patients with type 1 diabetes without diabetic dermopathy served as control patients, average age 41 ± 2 years, mean duration of diabetes 23 ± 2 years. There were 67 nondiabetic control subjects, average

2011 Journal of American Academy of Dermatology

12. Spectrum of cutaneous manifestations of type 1 diabetes mellitus in 500 south Asian patients. (Abstract)

%), were the most common findings, followed by limited joint mobility (LJM) (16·8%), xerosis (15·8%) and scleroderma-like skin changes (10%). Patients having long-duration DM (> 4·4 years) were significantly more likely to have lipohypertrophy (P = 0·000), LJM (P = 0·000), scleroderma-like skin changes (P = 0·000), diabetic dermopathy (P = 0·000), acanthosis nigricans (P = 0·005) and skin tags (P = 0·002). Lipohypertrophy, LJM and scleroderma-like skin changes also showed significant correlation (...) Spectrum of cutaneous manifestations of type 1 diabetes mellitus in 500 south Asian patients. Data on cutaneous manifestations of type 1 diabetes mellitus (DM) is scarce.To study the spectrum of dermatoses in patients with type 1 DM and the effects of disease duration and long-term glucose control on these cutaneous manifestations.After prior consent, clinical examination and relevant investigations were done in 500 subjects with type 1 DM enrolled between July 2011 and June 2012. Statistical

2014 British Journal of Dermatology

13. Relationship between skin diseases and extracutaneous complications of diabetes mellitus: clinical analysis of 750 patients. (Abstract)

Relationship between skin diseases and extracutaneous complications of diabetes mellitus: clinical analysis of 750 patients. The relationship between skin diseases and extracutaneous complications in diabetes mellitus (DM) is unclear.We aimed to investigate the relationship between skin disorders and diabetic neuropathy, nephropathy, and retinopathy in patients with DM.A total of 750 patients with DM were prospectively enrolled. Demographic and clinical features, skin disorders, glycosylated (...) in patients with nephropathy than in those without nephropathy. Cutaneous infections, diabetic foot, rubeosis faciei, and diabetic dermopathy were more common in patients with neuropathy. Fungal infections, diabetic foot, rubeosis faciei, diabetic dermopathy, and pigmented purpuric dermatitis were more frequent in patients with retinopathy. Patients with HbA1c ≥8 mmol/mL had more skin disorders than those with HbA1c <8 mmol/mL (P < 0.05 for all).Skin disorders may be clues to the presence of associated

2014 American journal of clinical dermatology

14. Bullous Disease of Diabetes (Overview)

of diabetes [ ] and reports of amputation due to infection. [ ] Previous References Kurdi AT. Bullosis diabeticorum. Lancet . 2013 Nov 30. 382(9907):e31. . . Bustan RS, Wasim D, Yderstræde KB, Bygum A. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Dan Med J . 2017 Jan. 64(1): . . Taylor SP, Dunn K. Bullosis diabeticorum. J Gen Intern Med . 2017 Feb. 32(2):220. . . Brzezinski P, Chiriac AE, Pinteala T, Foia L, Chiriac A. Diabetic dermopathy (...) Bullous Disease of Diabetes (Overview) Bullous Disease of Diabetes: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MjIzNS1vdmVydmlldw== processing > Bullous

2014 eMedicine.com

15. Bullous Disease of Diabetes (Follow-up)

review. Dan Med J . 2017 Jan. 64(1): . . Taylor SP, Dunn K. Bullosis diabeticorum. J Gen Intern Med . 2017 Feb. 32(2):220. . . Brzezinski P, Chiriac AE, Pinteala T, Foia L, Chiriac A. Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient. Pak J Med Sci . 2015 Sep-Oct. 31(5):1275-6. . . Michael MJ, Mefford JM, Lahham S, Chandwani CE. Bullosis diabeticorum. West J Emerg Med . 2016 Mar. 17(2):188. . . Kramer DW. Early or warning signs of impending gangrene (...) Bullous Disease of Diabetes (Follow-up) Bullous Disease of Diabetes Treatment & Management: Approach Considerations, Aspiration and Debridement Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

16. Bullous Disease of Diabetes (Treatment)

review. Dan Med J . 2017 Jan. 64(1): . . Taylor SP, Dunn K. Bullosis diabeticorum. J Gen Intern Med . 2017 Feb. 32(2):220. . . Brzezinski P, Chiriac AE, Pinteala T, Foia L, Chiriac A. Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient. Pak J Med Sci . 2015 Sep-Oct. 31(5):1275-6. . . Michael MJ, Mefford JM, Lahham S, Chandwani CE. Bullosis diabeticorum. West J Emerg Med . 2016 Mar. 17(2):188. . . Kramer DW. Early or warning signs of impending gangrene (...) Bullous Disease of Diabetes (Treatment) Bullous Disease of Diabetes Treatment & Management: Approach Considerations, Aspiration and Debridement Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

17. Bullous Disease of Diabetes (Diagnosis)

of diabetes [ ] and reports of amputation due to infection. [ ] Previous References Kurdi AT. Bullosis diabeticorum. Lancet . 2013 Nov 30. 382(9907):e31. . . Bustan RS, Wasim D, Yderstræde KB, Bygum A. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Dan Med J . 2017 Jan. 64(1): . . Taylor SP, Dunn K. Bullosis diabeticorum. J Gen Intern Med . 2017 Feb. 32(2):220. . . Brzezinski P, Chiriac AE, Pinteala T, Foia L, Chiriac A. Diabetic dermopathy (...) Bullous Disease of Diabetes (Diagnosis) Bullous Disease of Diabetes: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MjIzNS1vdmVydmlldw== processing > Bullous

2014 eMedicine.com

18. Clinical Assessment of a Novel Microprobe Array Continuous Glucose Monitor for Type 1 Diabetes

and 4: Inclusion Criteria: Adults over 18 years of age. Diagnosed with Type 1 diabetes for greater than 1 year. HbA1c less than or equal to 9.0 % (75 mmol/mol). Registered with a General Practitioner. Exclusion criteria: History of diabetic dermopathy or pre-existing skin condition History of upper limb neuropathy or radiculopathy Pregnant or planning pregnancy in next 12 months Breastfeeding Enrolled in other clinical trials uncontrolled concurrent illness physical or visual impairment preventing (...) Clinical Assessment of a Novel Microprobe Array Continuous Glucose Monitor for Type 1 Diabetes Clinical Assessment of a Novel Microprobe Array Continuous Glucose Monitor for Type 1 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2013 Clinical Trials

19. Graves' disease

Graves' disease Graves' disease - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Graves' disease Last reviewed: February 2019 Last updated: April 2018 Summary Most common cause of hyperthyroidism in countries with sufficient iodine intake. Caused by TSH receptor antibodies. Extrathyroidal manifestations include orbitopathy, pretibial myxoedema (thyroid dermopathy), or acropachy, which do not occur with other causes (...) secondary to orbitopathy or elephantiasis secondary to dermopathy. Definition Graves' disease is an autoimmune thyroid condition associated with hyperthyroidism. Associated orbitopathy occurs in around 25% of cases and is usually mild; Tanda ML, Piantanida E, Liparulo L, et al. Prevalence and natural history of Graves' orbitopathy in a large series of patients with newly diagnosed graves' hyperthyroidism seen at a single center. J Clin Endocrinol Metab. 2013 Apr;98(4):1443-9. https://academic.oup.com

2018 BMJ Best Practice

20. ACR–ASNR–SPR Practice Parameter for the Performance and Interpretation of Magnetic Resonance Imaging (MRI) of the Brain

1998;8:881-900. 12. Srinivasan A, Goyal M, Al Azri F, Lum C. State-of-the-art imaging of acute stroke. Radiographics 2006;26 Suppl 1:S75-95. 13. Sunshine JL, Tarr RW, Lanzieri CF, Landis DM, Selman WR, Lewin JS. Hyperacute stroke: ultrafast MR imaging to triage patients prior to therapy. Radiology 1999;212:325-332. 14. Au R, Massaro JM, Wolf PA, et al. Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study. Arch Neurol 2006;63:246-250. 15 (...) . Magn Reson Imaging Clin N Am 1995;3:509-528. 22. Wang WC, Gallagher DM, Pegelow CH, et al. Multicenter comparison of magnetic resonance imaging and transcranial Doppler ultrasonography in the evaluation of the central nervous system in children with sickle cell disease. J Pediatr Hematol Oncol 2000;22:335-339. 23. Barkovich AJ. The encephalopathic neonate: choosing the proper imaging technique. AJNR 1997;18:1816- 1820. 24. Griffiths PD, Russell SA, Mason G, Morris J, Fanou E, Reeves MJ. The use

2019 American Society of Neuroradiology

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