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161. Daily Fractionation of External Beam Accelerated Partial Breast Irradiation to 40 Gy Is Well Tolerated and Locally Effective. (Abstract)

after radiation therapy, including grade 2 erythema in 2 patients (1.8%) and skin color changes in 4 patients (3.8%). Only 2 instances of grade 3 toxicity were reported, including 1 patient with acute moist desquamation after radiation therapy and another with fibrosis at 2 years. Planning target volume and breast V20 were significantly predictive of skin/subcutaneous toxicity, with evidence that limiting breast V20 to <45% may improve tolerability. Overall, 3 breast cancer recurrences arose: 1

2019 Biology and Physics

162. Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. Full Text available with Trip Pro

the next 3 days, he developed pinhead-sized, non-follicular pustules on his diffusely erythematous skin. Histological findings of the pustular lesion showed spongiform subcorneal pustules with perivascular inflammatory cells. Approximately 8 days after taking praziquantel, the pustules resolved with desquamation. He became afebrile on day 9 and his laboratory parameters returned to normal levels on day 16. He was diagnosed with AGEP caused by praziquantel. Physicians need to be aware that praziquantel

2019 American Journal of Tropical Medicine & Hygiene

163. Kawasaki disease complicating bilateral facial nerve palsy and giant coronary artery aneurysms: A case report. Full Text available with Trip Pro

described a 7-month-old infant who suffered from bilateral infranuclear facial nerve palsy (FNP) and multiple coronary artery aneurysms (CAAs) in parallel with KD. The patient had an intermittent fever for 18 days and had a medical history of bilateral conjunctival injection, strawberry tongue, reddened lips, and perianal excoriation. Physical examinations revealed fever (38.5°C), fingertips desquamation of the skin, and left cervical lymphadenopathies.The diagnosis of KD is based on the presence

2019 Medicine

164. The peculiarities of Kawasaki disease at the extremes of age: Two case reports. Full Text available with Trip Pro

-inflammatory drugs. In the 2nd day of admission, he presented severe desquamation of hands and soles.Both cases were diagnosed with KD. The echocardiography showed no cardiac impairment in the infant, while in the older patient it revealed mild dilation of the left coronary artery.Both patients received intravenously immunoglobulin and pulsed methylprednisolone.The evolution was favorable in both cases, but in the infant, the C-reactive protein levels persisted mildly elevated for approximately 2 months

2019 Medicine

165. Differences between congenital-syphilis presenting as sepsis and neonatal sepsis: A case-control study. Full Text available with Trip Pro

two groups as below, including rash, palmoplantar desquamation, abdominal distension, splenomegaly, hepatomegaly, etc. And, at the aspect of Hb, PLT, WBC, CRP, ALT, AST, these differences occurred in the different groups. It is obvious that the prognosis of children with syphilis is worse. According to a comparison between the different outcomes in the CS, the worse outcome subgroup of patients is significantly younger and have more severely impaired liver function.Because of the high mortality

2019 Medicine

167. Fortacin - lidocaine / prilocaine

in a 28 day repeated dose toxicity study after the dermal application of the drug to rats (study Nº 459140). The topical use of the product was associated with mild/moderate desquamation, signs of erythema and eschar; however, the applied doses were higher than those proposed clinically and there were no CHMP assessment report EMA/685541/2013 Page 28/126 signs of antigenicity or immunotoxicity. No further studies to address the local tolerance of PSD502 were needed. Other toxicity studies No other

2013 European Medicines Agency - EPARs

170. Cancer Pain (PDQ®): Health Professional Version

in the infusion rate. Chemical phlebitis may result from chemotherapy or nonchemotherapy infusions such as potassium chloride and hyperosmolar solutions.[ ] Vesicant extravasation may cause intense pain followed by desquamation and ulceration.[ ] Doxorubicin may result in the venous flare reaction, which includes local urticaria, pain, or stinging.[ ] Some chemotherapy agents such as vinorelbine may cause pain at the tumor site.[ ] Treatment-related mucositis Severe mucositis often occurs as a consequence

2017 PDQ - NCI's Comprehensive Cancer Database

171. Aphthous ulcer

— apply up to 12 sprays twice daily to affected areas. [ ] Adverse effects Adverse effects Adverse effects of chlorhexidine use include: Mucosal irritation — if desquamation occurs, discontinue treatment or advise dilution of mouthwash with an equal volume of water. Parotid gland swelling. Reversible brown staining of teeth or dentures. Taste disturbance. Tongue discolouration. [ ] Contraindications and cautions Contraindications and cautions Do not prescribe chlorhexidine mouthwash, dental gel

2017 NICE Clinical Knowledge Summaries

172. Zyclara - imiquimod

). In rats significantly decreased body weight and increased spleen weight were observed at 0.5 and 2.5 mg/kg, and local skin irritation (severe erythema, slight to moderate oedema, desquamation and scabbing) more severe than that seen in humans was observed. Histopathological examination revealed epidermal inflammation with epidermal ulceration and hyperkeratosis. There was no good dose/response relationship and a No Observed Effect Level (NOEL) was not established. In treated mice spleen weight

2012 European Medicines Agency - EPARs

174. Sorafenib in treatment of patients with advanced hepatocellular carcinoma: a systematic review

/desquamation (four trials). Authors' conclusions Sorafenib-based therapy benefited patients with advanced hepatocellular carcinoma. Sorafenib was less effective for patients with extrahepatic spread, with normal alpha-fetoprotein level level and with elevated level of bilirubin. CRD commentary The review addressed a clear question and was supported by appropriate inclusion criteria. Relevant data sources were searched but it was unclear whether language restrictions were applied and unpublished studies (...) be interpreted with caution. Implications of the review for practice and research Practice : The authors stated that more reasonable administration of sorafenib be adopted during clinical practice based on these results to tailor a more-cost effective sorafenib therapeutic strategy. Also clinicians should pay more attention to sorefenib-based treatment related adverse reactions such as hand-foot skin reaction, diarrhoea, fatigue, and rash/desquamation. Research : The authors stated that further studies were

2012 DARE.

175. Bacterial Sepsis following Pregnancy

syndrome (STSS) 17,26 1. Fever > /= 39.9°C A. Isolation of group A Streptococcus from: 2. Rash: diffuse macular erythema 1. normally sterile site: blood, cerebrospinal fluid, peritoneal fluid, tissue biopsy 3. Desquamation: 10–14 days after onset of illness, 2. non-sterile site: throat, vagina, sputum especially palms and soles 4. Hypotension: systolic BP 176µ mol/l renal: creatinine twice the upper limit of normal coagulopathy – platelets 38ºC) Hypothermia (core temperature 90 beats/minute

2012 Royal College of Obstetricians and Gynaecologists

176. Bacterial Sepsis in Pregnancy

Streptococcal toxic shock syndrome 12,24 1. Fever > /= 39.9°C A. Isolation of beta-haemolytic group A Streptococcus from: 2. Rash – diffuse macular erythroderma 1. normally sterile site – blood, CSF, peritoneal fluid, tissue biopsy 3. Desquamation – 10 to 14 days after onset of illness, 2. non-sterile site – throat, vagina, sputum especially palms and soles 4. Hypotension – systolic BP 176µmol/l ? Renal – creatinine twice the upper limit of normal ? Coagulopathy – platelets < 100 x 10 9 /l or disseminated (...) intravascular ? Hepatic – total bilirubin twice the upper limit of normal coagulation ? Haematological – platelets < /= 100 x 10 9 /l ? Liver involvement – alanine transaminase or aspartame ? Central nervous system – disorientation or alterations in transaminase or bilirubin levels twice the normal upper limit for age consciousness without focal neurological signs ? Acute respiratory distress syndrome ? Generalised erythematous macular rash (present in 10%) – may desquamate ? Soft tissue necrosis including

2012 Royal College of Obstetricians and Gynaecologists

177. Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial). (Abstract)

the severity of the skin reactions significantly differed between the two groups (P = 0.004), with a larger percentage of patients experiencing RTOG grade 2 or higher (e.g., moist desquamation) in the placebo group (30% vs. 6.7%, for the placebo and laser group, resp.). The objective RISRAS score confirmed these results. In addition, the Skindex-16 and RISRAS subjective score demonstrated that the patients' quality of life was significantly better in the LT than in the control group.The results

2018 Lasers in surgery and medicine Controlled trial quality: uncertain

178. Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients. (Abstract)

-lumpectomy was performed (TRANSDERMIS trial). Patients were randomized to receive PBM (808 nm CW/905 nm pulsed, 168 mW/cm2, spot size 19.6 cm2, fluence 4 J/cm2) or placebo treatments from the first day of RT (2×/week). Biophysical skin measurements were collected to assess the skin pigmentation and barrier function. Measurements were collected at the first day of RT, a RT dose of 40 Gray (Gy), and the end of RT (66 Gy).The incidence of moist desquamation was significantly higher in the control than (...) in the PBMT group at the end of RT (30 vs. 7%, respectively, odds ratio = 6, p = 0.004). The biophysical skin measures showed that the mean percentage change from the baseline transepidermal water loss (TEWL), erythema, and melanin values was significantly higher in the control than in the PBMT group at the end of RT (ps < 0.05). Logistic regression analysis revealed that the risk on moist desquamation was significantly increased for patients with a large (> 800 cc) breast volume (odds ratio = 4, p

2018 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Controlled trial quality: uncertain

179. Efficacy of a polyphenolic extract from silver fir ( (Abstract)

culture. 61 patients with mild psoriasis met the inclusion criteria and were willing to comply with protocol requirements, were enrolled in the study. The severity of the disease was measured by psoriasis area severity index (PASI). Treatment efficacy was evaluated by assessing erythema (E, 0 to 4-point scale), desquamation (D, 0 to 4-point scale) and induration (I, 0 to 4-point scale) of lesions before and after the treatment. All patients enrolled in the study had symmetrical psoriasis plaques

2018 Die Pharmazie Controlled trial quality: predicted high

180. Assessment of the efficacy of a new complex antisensitive skin cream. (Abstract)

of facial skin including dryness, roughness, desquamation, and erythema was assessed. Subject self-assessment questionnaires, digital photography and noninvasive bioinstrumentation of hydration, transepidermal water loss, lipid index, skin texture, and wettability were also included in the study.Products were well tolerated. For all parameters studied, no significant difference was observed between test and control creams. Results showed that test cream provided a statistically significant improvement

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

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