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141. Axxent electronic brachytherapy system for early stage breast cancer

events such as rib fracture, infection, fat necrosis or desquamation did not occur. Strengths: Prospective study Limitations: Case series; small sample size; single centre; included patients with DCIS which is not a recommended criteria for treatment with SD-IORT; longer follow-up would allow recurrence to be fully assessed. Syed 2016 243 patients Prospective case series Multicentre (n=17) US Follow-up: 16.5 months (median) Xoft Axxent electronic brachytherapy system. Single dose of 20 Gy (n=242), 21

2016 National Institute for Health and Clinical Excellence - Advice

142. Gingivitis and periodontitis

, pain, and ulceration of both gingiva and oral mucosa. Gums are enlarged, red and painful. Desquamative gingivitis (which may be due to lichen planus, pemphigoid, or pemphigus), which is characterized by: White and erythematous or erosive areas on the whole of the gingiva and/or buccal mucosa. Full thickness inflammation of the gums (not just the margins). Bullae in oral mucosa. May be ulcerative. Sometimes bilateral. Skin may be involved in lichen planus (papular rash predominantly on the flexor (...) in toothpaste. Advise the person to leave a minimum of 30 minutes between using mouthwash and toothpaste. The mouth should be rinsed well with water between using toothpaste and mouthwashes containing chlorhexidine. Some people will require treatment by a dentist to remove staining. Transient altered taste and burning sensation of the tongue - usually improves with continued use. Mucosal irritation — if oral desquamation occurs, advise dilution of mouthwash with an equal volume of water before use. Rarely

2017 NICE Clinical Knowledge Summaries

145. Frankly my dear, I do give a damn

sandpaper-like texture, a pathognomic feature You may also notice sparing around the perioral area (circumoral pallor), linear areas of pigmentation in skin creases (Pastia lines) and, after 7-10 days, desquamation of the face and hands Scarlet Fever can also cause a strawberry tongue Q4. What causes the Rash? Answer and interpretation The streptococci release a pyrogenic exotoxin toxin. Q5. What is the prodrome? Answer and interpretation It usually evolves from tonsillar or pharyngeal infection (...) , septicaemia, myocarditis, acute rheumatic fever and post streptococcal glomerulonephritis. Q9. What other conditions look similar? Answer and interpretation also presents with a fever (for at least 5 days), strawberry tongue, a rash, late desquamation and cervical lymphadentitis. However there tends to be one dominant cervical lymph node > 1.5cm, red eyes due to non-suppurative conjunctivitis and bright red, cracked lips. may also produce a strawberry tongue, but lacks the perioral sparring and sandpaper

2017 Life in the Fast Lane Blog

146. Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice. (PubMed)

expression of matrix metalloprotease 13 was increased by UVA irradiation and significantly suppressed by dietary astaxanthin. In addition, HPLC-PDA analysis confirmed that dietary astaxanthin reached not only the dermis but also the epidermis. Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis.

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2017 PLoS ONE

147. Infliximab for chronic cutaneous sarcoidosis: a subset analysis from a double-blind randomized clinical trial. (PubMed)

/kg) or placebo over 24 weeks. Of 138 patients, the subset analysis evaluated 17 patients with chronic facial and another 9 patients with nonfacial skin involvement. The SASI evaluated lesions for degree of erythema, desquamation, induration, and percentage of area involved. Facial and nonfacial lesions were scored in a blinded manner.Among 5 placebo-treated and 12 infliximab-treated patients, an improvement was observed with infliximab versus placebo in change from baseline to weeks 12 and 24 (...) in desquamation (P<0.005) and induration (P<0.01) at week 24. Erythema, percentage of area involved and the evaluation of paired photographs did not reveal significant differences.Sample size; more extensive disease in placebo patients; chronic therapy upon enrollment; lung as primary organ of sarcoidosis involvement; limited investigator experience with SASI.Infliximab appears to be a beneficial treatment for chronic cutaneous sarcoidosis. The SASI scoring system demonstrated significant improvement versus

2016 Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders

148. Effects of Rusanda Spa balneotherapy combined with calcipotriol on plaque psoriasis. (PubMed)

reduction of 58.44%, and the second group of 34.78%. The therapeutic efficacy of mineral waters and peloids combined with calcipotriol showed to be significantly higher in regard to monotherapy with calcipotriol (p < 0.05). In regard to clinical symptoms, the best results were obtained in the reduction of desquamation (p < 0.001).The results of our study show that in the treatment of plaque-type psoriasis, topical calcipotriol combined with Spa Rusanda balineotherapy is more effective than topical

2016 Vojnosanitetski pregled

149. Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns (PubMed)

practice, we also observed the phenomenon that several viable cryopreserved alloskin or fresh pigskin grafts used as temporary coverage on subcutaneous tissue wounds had long-term survival after repeated desquamation. The macroscopic and histological results of one typical case were also analyzed.In this study, the first three TESGSTW operations were performed at 2-3, 5-8, and 11-16 days post-injury. The operation areas were 30.3 ± 7.9 % total body surface area (TBSA), 19.0 ± 6.0 % TBSA, and 12.0 ± 1.7

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2016 Burns & trauma

150. Acute Otitis Externa

can damage the external ear by causing acute and late skin reactions involving the pinna, external canal, and periauricular region. Acute events include erythema, desquamation, or ulceration of the auricle and ear canal, thus leading to pain and otorrhea. Late skin changes include atrophy, necrosis or ulceration, external otitis, and external canal stenosis. Damage to the epithelium of sebaceous and apocrine glands can diminish cerumen production. Management of AOE in patients after radiotherapy

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2014 American Academy of Otolaryngology - Head and Neck Surgery

151. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and The North American Menopause Society

, warming gels, lubricants, vaginal moisturizers, topical antimycotics); vulvovaginal dermatoses (eg, lichen sclerosus, erosive lichen planus, mucous membrane pemphigoid, plasma cell vulvitis); hypertonic pelvic floor muscle dysfunc- tion (levator ani spasm); desquamative inflammatory vaginitis; painful blad- der syndrome/interstitial cystitis; vulvodynia/vestibulodynia; and pudendal neuralgia. Menopause, Vol. 21, No. 10, 2014 1067 GENITOURINARY SYNDROME OF MENOPAUSE Copyright © 2014 The North American

2014 The North American Menopause Society

153. Mycoster (ciclopirox) - seborrhoeic dermatitis of the scalp

evaluation of seborrhoeic dermatitis status: 0: none; complete absence of signs or symptoms 1: mild; minor presence of signs or symptoms 2: mild plus; mild but evident 3: moderate; easily observable 4: pronounced; obvious 5: severe; extreme - Overall evaluation of the change in seborrhoeic dermatitis (0 to 5); - Itching score (0 to 5); - Desquamation score (0 to 5); - Inflammation score (0 to 5); - Sum of itching, desquamation and inflammation scores (0 to 15). 8.1.1 Study 301: A study of the efficacy (...) or female patients aged 18 to 88 years with stable or worsening seborrhoeic dermatitis of the scalp, with a score greater than or equal to 3 in the majority of cases (70% or more) on the “seborrhoeic dermatitis status”, “inflammation” and “desquamation” scales. Patients with psoriasis, asthma or diabetes were not included in the study. Population and treatments: Segment A A total of 1,000 patients were selected and 949 were randomised (2:2:1 ratio) to receive either 1 or 2 applications per week

2014 Haute Autorite de sante

154. British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease)

- ing in all cases and relapse in only two patients with genital disease over a mean 3-year follow-up period. 96 In a retrospective review of nine patients with digital SCC in situ, lesions were immersed in a water bath and treated with photon irradiation. The total median radiation dose delivered was 50 Gy (range 25–66 Gy) in 25-Gy fractions (range 2– 3 Gy). All lesions were locally controlled, with a median fol- low-up of 25 months with only mild-to-moderate erythema, desquamation or oedema

2014 British Association of Dermatologists

155. Kawasaki disease. The importance of prompt recognition and early referral

to weight-bear. In the sub- acute phase of Kawasaki disease (from about day 10 onward), there may be desquamation of the fingers and toes • polymorphous skin rash – usually begins in the nappy area (where there may be desquamation early in the disease) and spreads to involve the trunk, extremities and face. Rash may be maculopapular, annular or scarlatiniform. non- blanching or vesicular rashes are not usually seen • cervical lymphadenopathy – often unilateral and large, with node size >1.5 cm (...) disease? Fever Kawasaki disease should be suspected in any child with a persistent fever with no other likely explanation. The pyrexia associated with Kawasaki disease is typically high (often greater than 39°c), remittent and unresponsive to antibiotic therapy, and usually also unresponsive to antipyretics. This pattern of fever may help to distinguish Kawasaki disease from a common viral exanthem. Skin manifestations Rash and peeling (desquamation) of the nappy area rash is common in the acute phase

2014 Clinical Practice Guidelines Portal

157. Efficacy of a polyphenolic extract from silver fir ( (PubMed)

culture. 61 patients with mild psoriasis met the inclusion criteria and were willing to comply with protocol requirements, were enrolled in the study. The severity of the disease was measured by psoriasis area severity index (PASI). Treatment efficacy was evaluated by assessing erythema (E, 0 to 4-point scale), desquamation (D, 0 to 4-point scale) and induration (I, 0 to 4-point scale) of lesions before and after the treatment. All patients enrolled in the study had symmetrical psoriasis plaques

2018 Die Pharmazie

158. Effect of prophylactic cefalexin treatment on the development of bacterial infection in acute radiation-induced dermatitis in dogs: a blinded randomized controlled prospective clinical trial. (PubMed)

cytological evaluation were performed at first onset of moist desquamation and one week following completion of radiation therapy. Skin toxicity grading and owner quality of life (QoL) questionnaires were performed weekly. The rate of infection, multidrug resistance status, toxicity severity and QoL between cohorts were compared.Staphylococcus schleiferi and S. pseudintermedius were the most frequent bacterial agents isolated in both cohorts. There was no significant difference in prevalence of bacterial (...) infection or overall QoL between cohorts at either time point; however, multidrug-resistant infections were significantly increased in cohort A versus cohort B. Clinician- and client-perceived severity of toxicity was significantly greater and median duration of moist desquamation was significantly longer in cohort A than cohort B.Prophylactic use of cefalexin for management of canine ARID is not recommended.© 2017 ESVD and ACVD.

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2018 Veterinary dermatology

159. Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial). (PubMed)

the severity of the skin reactions significantly differed between the two groups (P = 0.004), with a larger percentage of patients experiencing RTOG grade 2 or higher (e.g., moist desquamation) in the placebo group (30% vs. 6.7%, for the placebo and laser group, resp.). The objective RISRAS score confirmed these results. In addition, the Skindex-16 and RISRAS subjective score demonstrated that the patients' quality of life was significantly better in the LT than in the control group.The results

2018 Lasers in surgery and medicine

160. Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients. (PubMed)

-lumpectomy was performed (TRANSDERMIS trial). Patients were randomized to receive PBM (808 nm CW/905 nm pulsed, 168 mW/cm2, spot size 19.6 cm2, fluence 4 J/cm2) or placebo treatments from the first day of RT (2×/week). Biophysical skin measurements were collected to assess the skin pigmentation and barrier function. Measurements were collected at the first day of RT, a RT dose of 40 Gray (Gy), and the end of RT (66 Gy).The incidence of moist desquamation was significantly higher in the control than (...) in the PBMT group at the end of RT (30 vs. 7%, respectively, odds ratio = 6, p = 0.004). The biophysical skin measures showed that the mean percentage change from the baseline transepidermal water loss (TEWL), erythema, and melanin values was significantly higher in the control than in the PBMT group at the end of RT (ps < 0.05). Logistic regression analysis revealed that the risk on moist desquamation was significantly increased for patients with a large (> 800 cc) breast volume (odds ratio = 4, p

2018 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

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