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Desquamation

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121. Lenvima - lenvatinib

dilatation and cortical necrosis), small intestine (distension in 13M/11F, duodenal inflammation, cystic dilatation of duodenal glands). Other changes found in bone marrow (hypocellularity), vagina (mucification), epididymides (desquamated seminiferous epithelial cells), pituitary (basophilic cell vacuolation), stomach (mucosal hyperplasia and inflammatory cell infiltration in glandular stomach, medial necrosis of arterioles and erosion), intestine (accumulation of foamy cells and neutrophils, crypt

2015 European Medicines Agency - EPARs

122. Docetaxel Hospira UK Limited - docetaxel

assessment report is attached. The CHMP endorsed this advice without changes. The CHMP endorsed the Risk Management Plan version 3.0 with the following content: Safety concerns Summary of safety concerns Important identified risks ? Myelosuppression and complications ? Severe hypersensitivity reactions ? Severe cutaneous reactions such as eruptions/desquamations, Stevens Johnson syndrome (SJN) and Toxic Epidermal Necrolysis (TEN) ? Severe fluid retention pleural effusion, pericardial effusion, ascites (...) minimisation measures Safety concern Routine risk minimisation measures Additional risk minimisation measures Myelosuppression and complications Proposed text in the SPC None Severe hypersensitivity reactions Proposed text in the SPC None Severe cutaneous reactions such as eruptions/desquamations, Stevens Johnson syndrome (SJN) and Toxic Epidermal Necrolysis (TEN) Proposed text in the SPC None Severe fluid retention pleural effusion, pericardial effusion, ascites Proposed text in the SPC None Severe

2015 European Medicines Agency - EPARs

123. Seborrhoeic dermatitis

to surrounding skin. Symmetrically distributed lesions — usually one or two body areas are affected but signs may be more widespread. Mild itching (in particular where the scalp is affected). The most commonly affected areas are the: Scalp — lesions can range from mild desquamation (dandruff) to thick brownish crusts adherent to skin and hair. Face (in particular the nasolabial folds, glabellar area, eyebrows, and behind the ears). The eyelids may be red, swollen and flaky (seborrhoeic blepharitis

2019 NICE Clinical Knowledge Summaries

124. Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant). Full Text available with Trip Pro

Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant). Lesions of herpes labialis are caused by the herpes simplex virus type 1 and cause pain and aesthetic compromise. It is characterized by the formation of small vesicles that coalesce and rupture forming extremely painful ulcers, that evolve to crusts, dry desquamations until their complete remission. Currently the treatment of these lesions is done with acyclovir. Although it diminishes

2020 Medicine

125. The matriptase-prostasin proteolytic cascade in dermatologic diseases. (Abstract)

The matriptase-prostasin proteolytic cascade in dermatologic diseases. The proper development and function of skin and hair are dependent on proteolytic activities. Specifically, the matriptase-prostasin cascade is a series of proteolytic reactions in the epidermis integral to normal regulation of desquamation. An increasing amount of research describing this pathway has recently become available, and the importance of this pathway is exhibited by the association of genetic defects

2020 Experimental Dermatology

126. Vulvar diseases: Conditions in adults and children. (Abstract)

may be less familiar with, such as plasma cell vulvitis, desquamative inflammatory vaginitis, vulvar aphthae, and low estrogen states. Nearly 1 in 6 women experience undiagnosed and untreated vulvovaginal discomfort at some point in their lives. Physicians who treat vulvar disorders will improve the quality of life of countless women.Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

2020 Journal of American Academy of Dermatology

129. Thyroid Cancer Treatment (PDQ®): Health Professional Version

). Adverse events occurred in 98.6% of patients treated with sorafenib and 87.6% of patients treated with placebo. The most common adverse events in the sorafenib group were hand-foot skin reactions (76.3%), diarrhea (68.6%), alopecia (67.1%), and rash or desquamation (50.2%). Most events were grade 1 or 2. Seven squamous cell carcinomas of the skin occurred in the sorafenib group. Lenvatinib Lenvatinib is an orally active, multitargeted tyrosine kinase inhibitor. Evidence (lenvatinib): A phase III (...) in the placebo group (HR, 0.56; 95% CI, 0.43–0.72; P < .001). Adverse events occurred in 98.6% of patients treated with sorafenib and 87.6% of patients treated with placebo. The most common adverse events in the sorafenib group were hand-foot skin reactions (76.3%), diarrhea (68.6%), alopecia (67.1%), and rash or desquamation (50.2%). Most events were grade 1 or 2. Seven squamous cell carcinomas of the skin occurred in the sorafenib group. Lenvatinib Lenvatinib is an orally active, multitargeted tyrosine

2018 PDQ - NCI's Comprehensive Cancer Database

130. Sore throat - acute

). Cervical lymphadenopathy. Polymorphous rash (a combination of morbilliform, scarlatiniform, urticariform, or erythema multiforme-like rash). Changes in the extremities (reddening of the palms and soles, desquamation of the skin, and oedema of the hands and feet). Oral mucositis secondary to radiotherapy or chemotherapy, which may become secondarily infected. For more information see the CKS topic on . Haematological disorders: Leukaemia: ulceration and haemorrhage of the mucous membrane of the pharynx

2018 NICE Clinical Knowledge Summaries

131. Fungal skin infection - foot

contaminated with infectious desquamated skin scales, for example communal shower facilities, swimming pools, and saunas. Immunocompromised states — may lead to severe, resistant or extensive disease, for example spread to the dorsum of the feet. [ ; ; ] Prevalence How common is it? The prevalence of fungal foot infection increases with age [ ] . Infection is common in adolescents but rare in pre-pubertal children [ ]. It is the most common form of fungal skin infection in the post-puberty period

2018 NICE Clinical Knowledge Summaries

132. Gingivitis and periodontitis

, pain, and ulceration of both gingiva and oral mucosa. Gums are enlarged, red and painful. Desquamative gingivitis (which may be due to lichen planus, pemphigoid, or pemphigus), which is characterized by: White and erythematous or erosive areas on the whole of the gingiva and/or buccal mucosa. Full thickness inflammation of the gums (not just the margins). Bullae in oral mucosa. May be ulcerative. Sometimes bilateral. Skin may be involved in lichen planus (papular rash predominantly on the flexor (...) in toothpaste. Advise the person to leave a minimum of 30 minutes between using mouthwash and toothpaste. The mouth should be rinsed well with water between using toothpaste and mouthwashes containing chlorhexidine. Some people will require treatment by a dentist to remove staining. Transient altered taste and burning sensation of the tongue - usually improves with continued use. Mucosal irritation — if oral desquamation occurs, advise dilution of mouthwash with an equal volume of water before use. Rarely

2018 NICE Clinical Knowledge Summaries

133. Scarlet fever

, limbs, and extremities. The rash is characteristically red, generalized and punctate with a rough, sandpaper-like texture. The rash is particularly florid in the skin folds of the neck, axillae, groin, elbows, and knees (Pastia's lines). The skin (in particular at the tips of the digits) may peel (desquamate) after the rash resolves. Examination may also reveal: Strawberry tongue — initially the tongue is covered with a white coat through which red papillae may be seen. Later, the white covering

2018 NICE Clinical Knowledge Summaries

134. What is the clinical benefit of adjuvant whole brain radiotherapy following resection or stereotactic radiosurgery to the brain metastasis(es)?

. The EORTC randomised trial is the only trial which has measured this prospectively. Patients receiving WBRT had worse Health Related Quality of Life scores than the observation group. This was significant for physical functioning and fatigue at 8 weeks, global health status at 9 months, and cognitive functioning at 12 months after treatment. The commonest dose for adjuvant WBRT was 30Gy in 10 fractions. This dose was associated with mild acute toxicity (13% brisk skin erythema or dry desquamation, 10

2016 MHRA Drug Safety Update

135. Cutaneous Lupus Erythematosus (CLE), Treatment

trial by Kuhn and co-workers [38] included 30 patients with various CLE subtypes. Significant improvement was observed for edema and erythema of CLE lesions using 0.1% tacrolimus ointment compared to the vehicle, while no effect was seen on desquamation and hypertrophy as well as on subjective symptoms, such as dysesthesia. The best response was noted in the group of LET followed by SCLE patients as well as within facial lesions compared to other locations and in lesions lasting less than 6 months

2016 European Dermatology Forum

137. Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses. Full Text available with Trip Pro

with a high dose of 222-nm UVC to mammalian cells has not been determined. In this study, it was demonstrated that large numbers of CPD-expressing cells were induced in the epidermis of mice following treatment with a small amount of single exposure 254-nm UVC, and then less than half of these cells reduced within 24 h. Chronic 254-nm UVC irradiation was revealed to induce sunburn and desquamation in mouse skin. Histological analysis demonstrated that small numbers of CPD-expressing cells were detected

2018 PLoS ONE

138. Magnetic resonance imaging guided reirradiation of recurrent and second primary head and neck cancer Full Text available with Trip Pro

or hospitalizations. Complications included skin desquamation, odynophagia, otitis externa, keratitis and/or conjunctivitis, and 1 case of aspiration pneumonia.Our preliminary findings show that reirradiation with MRI guided radiation therapy results in effective disease control with relatively low morbidity for patients with recurrent and second primary cancers of the head and neck. The superior soft tissue resolution of the MRI scans that were used for planning and delivery has the potential to improve

2017 Advances in radiation oncology

139. Predictors of radiation-induced acute skin toxicity in breast cancer at a single institution: Role of fractionation and treatment volume Full Text available with Trip Pro

Predictors of radiation-induced acute skin toxicity in breast cancer at a single institution: Role of fractionation and treatment volume The associations among radiation fractionation, body mass index (BMI), and acute skin toxicity with adjuvant radiation for breast cancer is of increasing interest. This study evaluated the rate of grade ≥2 dermatitis and moist desquamation (MD) in patients with a high BMI who were treated to the breast or chest wall to understand the role of radiation target

2017 Advances in radiation oncology

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