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102. Thyroid Cancer

receiving sorafenib during the DECISION trial [96]: hand-and-foot skin reactions, diarrhoea, alopaecia, rash or desquamation, fatigue, weight loss and hypertension were the most common. Serum TSH levels exceeding 0.5 µIU/mL were observed in 33.3% patients (69/207) in the sorafenib arm. TSH increases are a recognised AE of sorafenib and other MKIs, and levels should be checked monthly to ensure that suppression is maintained. Serious AEs were documented in 37.2% (77/207) of the sorafenib-treated

2019 European Society for Medical Oncology

103. Use of Silver Diamine Fluoride for Dental Caries Management in Children and Adolescents, Including Those with Special Health Care Needs

if allowed to come in contact with skin). Skin pigmentation is temporary since the silver does not penetrate the dermis. Desquamation of the skin with pigmentation occurs when keratinocytes are shed over a period of 14 days. 25 Silver diamine fluoride also perma- nently stains most surfaces (e.g., counters, clothing) with which it comes into contact. Guideline implementation. This guideline will be pub- lished in the AAPD’s Reference Manual and the journal, Pediatric Dentistry. Social media, news items

2017 American Academy of Pediatric Dentistry

104. Axxent electronic brachytherapy system for early stage breast cancer

events such as rib fracture, infection, fat necrosis or desquamation did not occur. Strengths: Prospective study Limitations: Case series; small sample size; single centre; included patients with DCIS which is not a recommended criteria for treatment with SD-IORT; longer follow-up would allow recurrence to be fully assessed. Syed 2016 243 patients Prospective case series Multicentre (n=17) US Follow-up: 16.5 months (median) Xoft Axxent electronic brachytherapy system. Single dose of 20 Gy (n=242), 21

2016 National Institute for Health and Clinical Excellence - Advice

105. Management of Colorectal Carcinoma

, with/without swelling, blistering, moist desquamation or pain Medication Common and important side effects Comments Capecitabine • Diarrhoea, nausea, vomiting, mucositis, abdominal pain • Hand-foot syndrome • Fatigue/weakness • Hyperbilirubinaemia • Cardiotoxicity - uncommon but can be fatal • Use cautiously in patients with history of heart disease • Dose reduction is required in patients with moderate renal dysfunction • Monitor for hand-foot syndrome Fluorouracil (5-FU) • Gastrointestinal (diarrhoea

2017 Ministry of Health, Malaysia

106. CRACKCast E130 – Viruses

, malaise, sore throat, and profuse vomiting and diarrhea. After 5 to 7 days, patients can progress to develop the hemorrhagic manifestations, which include spontaneous bleeding, ecchymosis, and petechiae. It is also common for patients to not develop any hemorrhagic complications. An erythematous maculopapular rash can occur during that time that eventually desquamates. Patients can become hypovolemic and develop severe metabolic derangements secondary to fluid losses via the gastrointestinal tract

2017 CandiEM

107. CrackCAST E129 – Bacteria

”* Probable TSS: Labs/cultures -ve and ⅘ of the clinical criteria Confirmed TSS: Labs/cultures -ve and 5/5 of the clinical criteria present Clinical criteria: High fever Diffuse Rash Desquamation Hypotension >3 systems involved. Lab criteria: Body cultures -ve (except bloods may show staph. aureus) Rise in titre to RMSF, rubeola, leptospirosis Management: Resuscitation! Often large volumes needed for to combat distributive shock 10-15 L/day! Airway management and oxygenation Source control / culture

2017 CandiEM

108. CRACKCast E120 – Dermatologic presentations

are a useful alternative to older sedating ones to control pruritus and histamine-mediated rashes while allowing the patient to remain active. Scabies infestations should be diagnosed clinically and treated expeditiously even without definitive proof of the infestation. Medication reactions are common and may results from any medication, typically within 4 to 21 days after taking the medication. Rashes that are associated with mucosal lesions, blisters, or desquamating skin are often caused by significant (...) ) [12] Describe the presentation and management of Staphylococcal Scalded Skin Syndrome and TSS Staphylococcal Scalded Skin Syndrome This is a dx in kids < 6 yrs. caused by an infection with phage group 2 exotoxin-producing The illness begins with erythema and crusting around the mouth. The erythema then spreads down the body, followed by bulla formation and desquamation. Mucous membranes are usually typically involved . After desquamation occurs, the lesions dry up quickly, with clinical resolution

2017 CandiEM

109. Radiodermatitis

Radiodermatitis Radiodermatitis | ONS Hello [ Name ] ! Renew Membership: Hello [ Name ] ! Renew Membership: Menu Search Radiodermatitis is the integumentary system's response to exposure to ionizing radiation. Short-term skin responses can range from erythematous rash to development of desquamation and necrosis. Late effects can appear months to years after radiation treatment and include pigmentation changes, telangiectasia, photosensitivity, fibrosis, atrophy, and delayed wound healing

2017 Oncology Nursing Society Putting Evidence into Practice (PEP)

111. Lymphangioleiomyomatosis Diagnosis and Management Part II: An Official ATS/JRS Clinical Practice Guideline

were blinded to clinical and histopathological information. Clinicians included thoracic radiologists (7–9),pulmonologists(9),and pulmonary fellows (9). Diseases included LAM (7–9), pulmonary Langerhans cell histiocytosis (7–9), emphysema (7–9), usual interstitial pneumonia (8), lymphoid interstitial pneumonia (8, 9), desquamative interstitial pneumonia (8), Birt-Hogg-Dub´ e syndrome (9), amyloidosis (9), hypersensitivity pneumonitis (9), nonspeci?c Table 3. Interpretation of Strong and Conditional

2017 American Thoracic Society

112. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

2. Bilateral bulbar conjunctival injection without exudate 3. Rash: maculopapular, diffuse erythroderma, or erythema multiforme-like 4. Erythema and edema of the hands and feet in acute phase and/or periungual desquamation in subacute phase 5. Cervical lymphadenopathy (≥1.5 cm diameter), usually unilateral A careful history may reveal that ≥1 principal clinical features were present during the illness but resolved by the time of presentation. Patients who lack full clinical features of classic (...) , jaundice Gallbladder hydrops Pancreatitis Nervous system Extreme irritability Aseptic meningitis (pleocytosis of cerebrospinal fluid) Facial nerve palsy Sensorineural hearing loss Genitourinary Urethritis/meatitis, hydrocele Other Desquamating rash in groin Retropharyngeal phlegmon Anterior uveitis by slit lamp examination Erythema and induration at BCG inoculation site The differential diagnosis includes other infectious and noninfectious conditions, including the following: Measles Other viral

2017 American Heart Association

113. AIUM Practice Parameter for the Performance of Physiologic Evaluation of Extremity Arteries

? ?to ? ?the ? ?skin ? ?in ? ?an ? ?area ? ?of ? ?questionable ? ?viability. ? 17 ? ? ?The ? ?usual ? ?locations ? ?on ? ?the ? ?lower extremities ? ?are ? ?on ? ?the ? ?foot, ? ?ankle, ? ?and ? ?calf, ? ?with ? ?a ? ?reference ? ?point ? ?on ? ?the ? ?chest. ? ? ??After ? ?the desquamated ? ?cells ? ?are ? ?cleaned ? ?from ? ?the ? ?skin, ? ?a ? ?coupling ? ?solution ? ?such ? ?as ? ?distilled ? ?water ? ?is applied ? ?to ? ?the ? ?skin, ? ?and ? ?the ? ?tcP ?O ?2 ? ??sensor ? ?is ? ?affixed

2017 American Institute of Ultrasound in Medicine

116. Phase III Study of Silver Leaf Nylon Dressing vs Standard Care for Reduction of Inframammary Moist Desquamation in Patients Undergoing Adjuvant Whole Breast Radiation Therapy. (Abstract)

Phase III Study of Silver Leaf Nylon Dressing vs Standard Care for Reduction of Inframammary Moist Desquamation in Patients Undergoing Adjuvant Whole Breast Radiation Therapy. The primary objective of this study was to assess silver leaf nylon dressings as a prophylactic measure in reducing inframammary fold radiation induced dermatitis in women receiving adjuvant whole breast radiotherapy compared with standard skin care. A secondary objective was to assess if the dressing influenced breast (...) was for anthracycline chemotherapy and fractionation scheme. Digital photos of the inframammary region were taken at one week before, the last day of whole breast radiotherapy, and one week after treatment completion. Three observers blinded to treatment arm assessed the images for the presence of moist desquamation and the Radiation Therapy Oncology Group (RTOG) skin toxicity score. Patients completed questionnaires comprising visual analogue scales for pain, itching and burning sensation, and questions regarding

2010 Journal of Medical Imaging and Radiation Sciences Controlled trial quality: uncertain

117. Fever in under 5s: assessment and initial management

disease in children with fever that has lasted longer than 5 days and who have 4 of the following 5 features: bilateral conjunctival injection change in mucous membranes in the upper respiratory tract (for example, injected pharynx, dry cracked lips or strawberry tongue) change in the extremities (for example, oedema, erythema or desquamation) polymorphous rash cervical lymphadenopathy Be aware that, in rare cases, incomplete/atypical Kawasaki disease may be diagnosed with fewer features. [2007] [2007

2013 National Institute for Health and Clinical Excellence - Clinical Guidelines

118. Early and Late Onset Side Effects of Photodynamic Therapy Full Text available with Trip Pro

Early and Late Onset Side Effects of Photodynamic Therapy Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently

2018 Biomedicines

119. Lenvima - lenvatinib

dilatation and cortical necrosis), small intestine (distension in 13M/11F, duodenal inflammation, cystic dilatation of duodenal glands). Other changes found in bone marrow (hypocellularity), vagina (mucification), epididymides (desquamated seminiferous epithelial cells), pituitary (basophilic cell vacuolation), stomach (mucosal hyperplasia and inflammatory cell infiltration in glandular stomach, medial necrosis of arterioles and erosion), intestine (accumulation of foamy cells and neutrophils, crypt

2015 European Medicines Agency - EPARs

120. Docetaxel Hospira UK Limited - docetaxel

assessment report is attached. The CHMP endorsed this advice without changes. The CHMP endorsed the Risk Management Plan version 3.0 with the following content: Safety concerns Summary of safety concerns Important identified risks ? Myelosuppression and complications ? Severe hypersensitivity reactions ? Severe cutaneous reactions such as eruptions/desquamations, Stevens Johnson syndrome (SJN) and Toxic Epidermal Necrolysis (TEN) ? Severe fluid retention pleural effusion, pericardial effusion, ascites (...) minimisation measures Safety concern Routine risk minimisation measures Additional risk minimisation measures Myelosuppression and complications Proposed text in the SPC None Severe hypersensitivity reactions Proposed text in the SPC None Severe cutaneous reactions such as eruptions/desquamations, Stevens Johnson syndrome (SJN) and Toxic Epidermal Necrolysis (TEN) Proposed text in the SPC None Severe fluid retention pleural effusion, pericardial effusion, ascites Proposed text in the SPC None Severe

2015 European Medicines Agency - EPARs

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