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Desquamation

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104. Management of Colorectal Carcinoma

, with/without swelling, blistering, moist desquamation or pain Medication Common and important side effects Comments Capecitabine • Diarrhoea, nausea, vomiting, mucositis, abdominal pain • Hand-foot syndrome • Fatigue/weakness • Hyperbilirubinaemia • Cardiotoxicity - uncommon but can be fatal • Use cautiously in patients with history of heart disease • Dose reduction is required in patients with moderate renal dysfunction • Monitor for hand-foot syndrome Fluorouracil (5-FU) • Gastrointestinal (diarrhoea

2017 Ministry of Health, Malaysia

105. Radiodermatitis

Radiodermatitis Radiodermatitis | ONS Hello [ Name ] ! Renew Membership: Hello [ Name ] ! Renew Membership: Menu Search Radiodermatitis is the integumentary system's response to exposure to ionizing radiation. Short-term skin responses can range from erythematous rash to development of desquamation and necrosis. Late effects can appear months to years after radiation treatment and include pigmentation changes, telangiectasia, photosensitivity, fibrosis, atrophy, and delayed wound healing

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2017 Oncology Nursing Society Putting Evidence into Practice (PEP)

106. Chlorhexidine mouthwash is useful short-term for people with mild gum disease

of rinsing. Other adverse effects The adverse effects most commonly reported in the included studies were taste disturbance/alteration (reported in 11 studies), effects on the oral mucosa including soreness, irritation, mild desquamation and mucosal ulceration/erosions (reported in 13 studies) and a general burning sensation or a burning tongue or both (reported in nine studies). AUTHORS' CONCLUSIONS: There is high-quality evidence from studies that reported the Loe and Silness Gingival Index

2018 NIHR Dissemination Centre

109. Radiation therapy for early Dupuytren's disease

in 50% (n=8, denominator not stated) of patients in a case series of 17 patients (treated with 21 Gy of radiation) that collected self-report questionnaire data. 5.2 Dry skin or redness was reported in 38% (76/198) of hands in a randomised controlled trial (RCT) of 129 patients treated with 30 Gy or 21 Gy of radiation within a 4-week follow-up. 5.3 Dry desquamation was reported in 5% (10/198) of hands and wet desquamation in 2% (3/198) of hands in the RCT of 129 patients treated with 30 Gy or 21 Gy (...) patients, with a mean follow-up of 35 months. 5.8 Overall, chronic toxicity events occurred in 16% (15/95) of hands treated with 30 Gy of radiation and in 11% (11/103) of hands treated with 21 Gy within 3 months and in 4% (4/95), and 5% (5/103) of hands treated with 30 Gy or 21 Gy respectively within 12 months of radiation therapy, in the RCT of 129 patients. Most of these events were skin dryness, increased desquamation, mild skin atrophy or slight subcutaneous fibrosis needing topical treatment (type

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

110. Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation. (PubMed)

Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation. In a recent study, we showed that long-term treatment with two different moisturizers affected TEWL in opposite directions. Therefore, we decided to examine the effect of these moisturizers on the cellular and molecular level. In a randomized controlled study on 20 volunteers, epidermal mRNA expression of genes essential for keratinocyte differentiation (...) and desquamation after a 7-week treatment with two moisturizers was analyzed. Treatment with one test moisturizer increased gene expression of involucrin, transglutaminase 1, kallikrein 5, and kallikrein 7, while the other moisturizer affected only expression of cyclin-dependent kinase inhibitor 1A. Thus, moisturizers are able to modify the skin barrier function and change the mRNA expression of certain epidermal genes. Since the type of influence depends on the composition of the moisturizer, these should

2009 Archives of dermatological research

111. Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis. (PubMed)

Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis. The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week

2009 Brazilian dental journal

112. Diffuse Cellular and Fibrosing Interstitial Pneumonitis With Desquamative Interstitial Pneumonitis-like Features Associated With Myeloid Neoplasia. (PubMed)

Diffuse Cellular and Fibrosing Interstitial Pneumonitis With Desquamative Interstitial Pneumonitis-like Features Associated With Myeloid Neoplasia. Patients with preleukemic myeloid neoplasia can develop nonhematologic disease. Five patients with the myelodysplastic syndrome presented with interstitial lung disease that heralded acute leukemia in 3. Chest radiographs showed diffuse interstitial opacities, and the lung biopsies showed diffuse cellular interstitial and fibrosing pneumonitis

2009 American Journal of Surgical Pathology

113. Epidemiology of desquamative gingivitis: evaluation of 125 patients and review of the literature. (PubMed)

Epidemiology of desquamative gingivitis: evaluation of 125 patients and review of the literature. Desquamative gingivitis (DG) is a descriptive term used to indicate epithelial desquamation, erythema, erosions, and/or vesiculobullous lesions of the gingiva. DG is commonly associated with several mucocutaneous disorders and systemic conditions that may carry a poor prognosis and high morbidity; however, there are no clear data concerning the frequency of these disease associations.We

2009 International Journal of Dermatology

114. PERIUNGUAL DESQUAMATION IN PATIENTS WITH KAWASAKI DISEASE. (PubMed)

PERIUNGUAL DESQUAMATION IN PATIENTS WITH KAWASAKI DISEASE. Periungual desquamation is one of the clinical signs included in the Kawasaki disease (KD) case definition that manifests after the acute febrile phase of the illness. This clinical sign is sometimes used to diagnose cases that were initially missed. We conducted a retrospective review to determine the frequency with which periungual desquamation is associated with KD.

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2009 Pediatric Infectious Dsease Journal

115. Apoptosis and Desquamation of Urothelial Cells in Tissue Remodeling During Rat Postnatal Development (PubMed)

Apoptosis and Desquamation of Urothelial Cells in Tissue Remodeling During Rat Postnatal Development Postnatal rat urothelium was studied from day 0 to day 14, when intense cell loss as part of tissue remodeling was expected. The morphological and biochemical characteristics of urothelial cells in the tissue and released cells were investigated by light and electron microscopy, by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, by annexin V/propidium iodide (...) assay, and by immunofluorescent detection of active caspases and tight-junction protein occludin. Intense apoptosis and massive desquamation were detected between postnatal days 7 and 10. During this period, active caspases and TUNEL-positive cells were found in the urothelium. Disassembled cell-cell junctions were detected between cells. The majority of desquamated cells expressed no apoptotic cell morphology, but were active caspase positive and TUNEL positive. Ann+/PI- apoptotic bodies

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2009 Journal of Histochemistry and Cytochemistry

116. Early and Late Onset Side Effects of Photodynamic Therapy (PubMed)

Early and Late Onset Side Effects of Photodynamic Therapy Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently

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2018 Biomedicines

117. Fever in under 5s: assessment and initial management

disease in children with fever that has lasted longer than 5 days and who have 4 of the following 5 features: bilateral conjunctival injection change in mucous membranes in the upper respiratory tract (for example, injected pharynx, dry cracked lips or strawberry tongue) change in the extremities (for example, oedema, erythema or desquamation) polymorphous rash cervical lymphadenopathy Be aware that, in rare cases, incomplete/atypical Kawasaki disease may be diagnosed with fewer features. [2007] [2007

2013 National Institute for Health and Clinical Excellence - Clinical Guidelines

118. Thyroid Cancer Treatment (PDQ®): Health Professional Version

). Adverse events occurred in 98.6% of patients treated with sorafenib and 87.6% of patients treated with placebo. The most common adverse events in the sorafenib group were hand-foot skin reactions (76.3%), diarrhea (68.6%), alopecia (67.1%), and rash or desquamation (50.2%). Most events were grade 1 or 2. Seven squamous cell carcinomas of the skin occurred in the sorafenib group. Lenvatinib Lenvatinib is an orally active, multitargeted tyrosine kinase inhibitor. Evidence (lenvatinib): A phase III (...) in the placebo group (HR, 0.56; 95% CI, 0.43–0.72; P < .001). Adverse events occurred in 98.6% of patients treated with sorafenib and 87.6% of patients treated with placebo. The most common adverse events in the sorafenib group were hand-foot skin reactions (76.3%), diarrhea (68.6%), alopecia (67.1%), and rash or desquamation (50.2%). Most events were grade 1 or 2. Seven squamous cell carcinomas of the skin occurred in the sorafenib group. Lenvatinib Lenvatinib is an orally active, multitargeted tyrosine

2018 PDQ - NCI's Comprehensive Cancer Database

120. Chlorhexidine mouthrinse: Reduced plaque and gingivitis when used as adjunct to mechanical oral hygiene procedures

in extrinsic tooth staining in participants using chlorhexidine mouthrinse at 4 to 6 weeks. SMD = 1.07 (95%CI; 0.80 to 1.34). There was also seen at 7 to 12 weeks and 6 months. Other adverse effects 11 studies reported taste disturbance/alteration 13 studies noted effects on the oral mucosa including soreness, irritation, mild desquamation and mucosal ulceration/erosions 9 studies reported general burning sensation or a burning tongue or both Conclusions The authors concluded:- There is high-quality

2017 The Dental Elf

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