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Desquamation

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41. Cellular Basis of Secondary Infections and Impaired Desquamation in Certain Inherited Ichthyoses. (PubMed)

Cellular Basis of Secondary Infections and Impaired Desquamation in Certain Inherited Ichthyoses. Secondary infections and impaired desquamation complicate certain inherited ichthyoses, but their cellular basis remains unknown. In healthy human epidermis, the antimicrobial peptides cathelicidin (LL-37) and human β-defensin 2 (HBD2), as well as the desquamatory protease kallikrein-related peptidase 7 (KLK7), are delivered to the stratum corneum (SC) interstices by lamellar body (LB (...) ) exocytosis.To assess whether abnormalities in the LB secretory system could account for increased risk of infections and impaired desquamation in inherited ichthyoses with known abnormalities in LB assembly (Harlequin ichthyosis [HI]), secretion (epidermolytic ichthyosis [EI]), or postsecretory proteolysis (Netherton syndrome [NS]).Samples from library material were taken from patients with HI, EI, NS, and other ichthyoses, but with a normal LB secretory system, and in healthy controls and were evaluated

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2015 JAMA dermatology (Chicago, Ill.)

42. A systematic review to investigate the effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients

A systematic review to investigate the effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients A systematic review to investigate the effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients A systematic review to investigate the effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients Kedge EM CRD summary This review found mixed evidence concerning use of hydrogels (...) and hydrocolloid dressings for moist desquamation in radiotherapy patients, despite being recommended by many guidelines. Improved patient comfort was sometimes seen. There was limited evidence to support other interventions. The author’s conclusions should be treated with caution as the evidence provided was very limited, heterogeneous and of questionable quality. Authors' objectives To evaluate the safety and effectiveness of interventions for moist desquamation in radiotherapy patients. Searching AMED

2009 DARE.

43. Treating breast cancer radiotherapy-induced moist desquamation with a traditional Chinese medicine formula: a case series pilot study. (PubMed)

Treating breast cancer radiotherapy-induced moist desquamation with a traditional Chinese medicine formula: a case series pilot study. Abstract Objective: A case series is presented to investigate the efficacy and safety of Erhegao for patients with breast cancer who have radiotherapy-induced moist desquamation.Eighteen women with breast cancer who received radiotherapy and developed moist desquamation were enrolled. Erhegao cream, a Traditional Chinese Medicine formula consisting of zinc oxide (...) powder, calamine powder, and lithospermum oil, was applied on areas of moist desquamation. Application was repeated once a day until healing. The primary end point for efficacy was the time to healing of the moist desquamation areas. A numerical rating scale was used to measure wound pain relief daily. Incidence of toxicity was also assessed.The average time to healing of the moist desquamation area was 13.56 days. The mean pain scores on the first, third, and seventh days were 5.22, 2.94, and 0.83

2014 Journal of Alternative and Complementary Medicine

44. Keratinocyte-Specific Mesotrypsin Contributes to Desquamation Process via Kallikrein Activation and LEKTI Degradation. (PubMed)

Keratinocyte-Specific Mesotrypsin Contributes to Desquamation Process via Kallikrein Activation and LEKTI Degradation. Kallikrein-related peptidases (KLKs) have critical roles in corneocyte desquamation and are regulated by lymphoepithelial Kazal-type inhibitor (LEKTI). However, it is unclear how these proteases are activated and how activated KLKs are released from LEKTI in the upper cornified layer. Recently, we reported cloning of a PRSS3 gene product, keratinocyte-specific mesotrypsin, from (...) a cDNA library. We hypothesized that mesotrypsin is involved in the desquamation process, and the aim of the present study was to test this idea by examining the effects of mesotrypsin on representative desquamation-related enzymes pro-KLK5 and pro-KLK7. Incubation of mesotrypsin and these zymogens resulted in generation of the active forms. KLK activities were effectively inhibited by recombinant LEKTI domains D2, D2-5, D2-6, D2-7, D5, D6, D6-9, D7, D7-9, and D10-15, whereas mesotrypsin activity

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2014 Journal of Investigative Dermatology

45. Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. (PubMed)

Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Safetac-based soft silicone dressings used in a management setting decrease the severity of radiation-induced acute skin reactions but do not affect moist desquamation rates. Here we investigate the prophylactic use of another Safetac product, Mepitel Film, on moist desquamation rates.A total of 80 breast cancer patients receiving (...) -treated skin which progressed to moist desquamation in 26% of patients (RTOG grades I: 28%; IIA: 46%; IIB: 18%; III: 8%). Only 44% of patients had a skin reaction under the Film, which did not progress to moist desquamation in any of the patients (RTOG grades I: 36%; IIA: 8%).Mepitel Film completely prevented moist desquamation and reduced skin reaction severity by 92% when used prophylactically in our cohort.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

2014 Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

46. Lung Tumors Masquerading as Desquamative Interstitial Pneumonia (DIP): Report of 7 Cases and Review of the Literature. (PubMed)

Lung Tumors Masquerading as Desquamative Interstitial Pneumonia (DIP): Report of 7 Cases and Review of the Literature. Malignant tumors in the lung (both primary and metastatic) rarely may be associated with markedly discohesive tumor cells, resulting in airspace filling reminiscent of "desquamative interstitial pneumonia" (DIP) on histopathology evaluation. A peculiar aspect of this growth pattern is the relatively bland appearance of the tumor cells, in many cases simulating benign alveolar

2014 American Journal of Surgical Pathology

47. Desquamative alveolar disease (desquamative interstitial pneumonia): case report (PubMed)

Desquamative alveolar disease (desquamative interstitial pneumonia): case report 5822250 1969 11 05 2018 11 13 0040-6376 24 2 1969 Mar Thorax Thorax Desquamative alveolar disease (desquamative interstitial pneumonia): case report. 186-91 Cruz E E Rodriguez J J Lisboa C C Ferretti R R eng Journal Article England Thorax 0417353 0040-6376 IM Humans Male Middle Aged Pulmonary Alveoli pathology Pulmonary Fibrosis diagnosis diagnostic imaging pathology Radiography Respiratory Function Tests Sputum

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1969 Thorax

48. Reflectance Confocal Microscopy As A New Tool In The In Vivo Evaluation Of Desquamative Gingivitis: Patterns In Mucous Membrane Pemphigoid, Pemphigus Vulgaris And Oral Lichen Planus. (PubMed)

Reflectance Confocal Microscopy As A New Tool In The In Vivo Evaluation Of Desquamative Gingivitis: Patterns In Mucous Membrane Pemphigoid, Pemphigus Vulgaris And Oral Lichen Planus. Desquamative gingivitis refers to a clinical manifestation associated with several mucocutaneous disorders. The most common are mucous membrane pemphigoid, pemphigus vulgaris and lichen planus. Their specific diagnosis is better established by histopathological and immunofluorescence evaluation.To examine cases (...) of desquamative gingivitis using reflectance confocal microscopy (RCM) and compare the findings with those of normal gingiva. To compare RCM findings in desquamative gingivitis with conventional histopathology of the biopsied lesions, in order to establish criteria for this noninvasive diagnostic technique.A total of 25 cases of suspected mucous membrane pemphigoid, pemphigus vulgaris and lichen planus were included. RCM was performed on the gingiva of a healthy person and on gingival lesions. All lesions

2012 British Journal of Dermatology

49. Impact of epidermal desquamation on tissue stores of iron. (PubMed)

Impact of epidermal desquamation on tissue stores of iron. Although several billion corneocytes are shed from human skin daily, metabolic studies from 50 years ago led to the conclusion that corneocyte desquamation had no measurable impact on systemic protein or iron status in humans.To measure iron content of internal organs after introducing local genetic changes in epidermis that alter iron metabolism in skin.Iron was measured in tissues and blood from groups of animals 7 weeks after weaning

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2012 Journal of dermatological science

50. Desquamation

Desquamation Desquamation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Desquamation Desquamation Aka: Desquamation , Scaling II (...) . Pathophysiology Rapid epithelial cell proliferation (outer epidermal layer) does not form Outermost layer now appears as scale III. Signs Desquamating layers of skin Sandpaper feel suggests solar keratosis IV. Causes: Examples See ( ) Drug eruption Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Desquamation." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database

2015 FP Notebook

51. Retinoid Induces the Degradation of Corneodesmosomes and Downregulation of Corneodesmosomal Cadherins: Implications on the Mechanism of Retinoid-induced Desquamation (PubMed)

Retinoid Induces the Degradation of Corneodesmosomes and Downregulation of Corneodesmosomal Cadherins: Implications on the Mechanism of Retinoid-induced Desquamation Topical retinoids induce skin fragility. As corneodesmosomes are important adhesion structures in the epidermal cohesion, an effect of retinoids on corneodesmosomes has been suspected.The aim of this study was to investigate the effect of retinoid on the expression of corneodesmosomal components including desmoglein (DSG) 1 (...) at the mRNA and protein levels in keratinocytes that were cultured in both low- and high-calcium media. On the other hand, CDSN mRNA levels did not decrease in low-calcium media or increase in high-calcium media after RA treatment. KLK5 and KLK7 expression did not increase after RA treatment.Our results indicate that DSG1 and DSC1 downregulation by RA could be related to the increased degradation of corneodesmosomes and consequent desquamation induced by retinoids.

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2011 Annals of dermatology

52. Circumscribed palmo-plantar hypokeratosis: a disease of desquamation? Immunohistological study of five cases and literature review. (PubMed)

Circumscribed palmo-plantar hypokeratosis: a disease of desquamation? Immunohistological study of five cases and literature review. Circumscribed palmoplantar hypokeratosis (CPH) is a recently recognized, rarely reported dermatosis that shows characteristic clinicopathological features; however, its pathogenesis remains unknown.The aim of this study was to get further insight into the pathogenesis of CPH.An immunohistological study was performed on five cases of CPH to investigate (...) the expression of several epidermal proliferation and differentiation proteins, with emphasis on those involved in corneocyte desquamation [including corneodesmosin, kallikrein 5 and lympho-epithelial Kazal type inhibitor (LEKTI)].In three of five cases, a decreased expression of LEKTI, corneodesmosin and filaggrin was found, along with an increased expression of kallikrein 5 and keratin 6. The expression of several other antigens (including involucrin, Ki67, p63, CD138/syndecan I, EGF-R) did not present

2011 Journal of the European Academy of Dermatology and Venereology

53. Desquamative fibrosing alveolitis unresponsive to steroid or cytotoxic therapy. (PubMed)

Desquamative fibrosing alveolitis unresponsive to steroid or cytotoxic therapy. A case of desquamative fibrosing alveolitis beginning in early infancy is described. The disease was characterized by tachypnoea, hypoxia relieved by O2, absence of signs in the chest or clubbing, and radiological and physiological evidence of hyperinflation. The diagnosis was made by needle biopsy of the lung. Treatment with steroids and immunosuppression was without effect and the infant died at 9 months

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1975 Archives of Disease in Childhood

54. LARYNGOTRACHEITIS VIRUS IN CHICKENS : A MODEL FOR STUDY OF ACUTE NONFATAL DESQUAMATING RHINITIS (PubMed)

LARYNGOTRACHEITIS VIRUS IN CHICKENS : A MODEL FOR STUDY OF ACUTE NONFATAL DESQUAMATING RHINITIS Infectious laryngotracheitis can be produced in chickens as an experimental model of severe nonfatal rhinitis and sinusitis. Inoculated intranasally into unanesthetized baby chicks it remains limited to the nasal fossa, produces acute desquamation of all nasal epithelia, results in functional recovery of the respiratory epithelium, but leaves important residual abnormalities. From the earliest (...) recognizable lesions through 4(1/2) months' convalescence, the principal changes are as follows: 1. Initial lesions, or small syncytia of intranuclear "inclusions", first identifiable in the mucociliated cells of the shallowest portion of the epithelium at about 21 hr postinoculum (the inner surface of the maxillary conchal scroll). 2. Acute sloughing, (about 3 to 7 days), marked by: (a) spread of lesions from cell to cell via multinucleated "giant cells" which progressively slough and desquamate

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1967 The Journal of experimental medicine

55. Morphology and pathogenesis of desquamative interstitial pneumonitis. (PubMed)

Morphology and pathogenesis of desquamative interstitial pneumonitis. Thirty human lung biopsy specimens have been diagnoses as desquamative interstitial pneumonitis. Six cases had intraalveolar lesions, believed to be early, while 20 had advanced disease characterised by intraalveolar cellular clumps, alveolar wall fibrosis, distortion, and loss of pulmonary parenchyma. Electron microscopy, high resolution light microscopy, and cytological examination have shown that the characteristic clumps

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1977 Thorax

56. "Blue bodies" in a case of cryptogenic fibrosing alveolitis (desquamative type) an ultra-structural study. (PubMed)

"Blue bodies" in a case of cryptogenic fibrosing alveolitis (desquamative type) an ultra-structural study. A patient with cryptogenic fibrosing alveolitis, with both mural and desquamative features, had two lung biopsies at the times of coronary artery surgery. These lung specimens were studied, using light and electron microscopy, with immunofluorescence techniques and electron microanalysis. In addition to the typical changes of cryptogenic fibrosing alveolitis previously reported, we found

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1978 Thorax

57. Relapse of fibrosing alveolitis (desquamative interstitial pneumonia) after twelve years. (PubMed)

Relapse of fibrosing alveolitis (desquamative interstitial pneumonia) after twelve years. 515990 1980 02 28 2018 11 13 0040-6376 34 5 1979 Oct Thorax Thorax Relapse of fibrosing alveolitis (desquamative interstitial pneumonia) after twelve years. 677-9 Hunter A M AM Lamb D D eng Case Reports Journal Article England Thorax 0417353 0040-6376 9PHQ9Y1OLM Prednisolone IM Adult Female Humans Lung pathology Prednisolone therapeutic use Pulmonary Fibrosis drug therapy pathology Recurrence 1979 10 1

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1979 Thorax

58. A case of desquamative interstitial pneumonia. (PubMed)

A case of desquamative interstitial pneumonia. 5439331 1970 06 01 2018 11 13 0008-4409 102 7 1970 Apr 11 Canadian Medical Association journal Can Med Assoc J A case of desquamative interstitial pneumonia. 736-9 Stewart K R KR Rona G G Lillie J B JB eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 VB0R961HZT Prednisone AIM IM Adult Biopsy Bronchitis diagnosis Cough etiology Diagnosis, Differential Follow-Up Studies Humans Lung pathology Male Pneumoconiosis diagnosis Prednisone

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1970 Canadian Medical Association Journal

59. Desquamative interstitial pneumonia. An electron microscopic study. (PubMed)

Desquamative interstitial pneumonia. An electron microscopic study. 5459746 1970 11 06 2018 11 13 0002-9440 60 3 1970 Sep The American journal of pathology Am. J. Pathol. Desquamative interstitial pneumonia. An electron microscopic study. 347-70 Farr G H GH Harley R A RA Hennigar G R GR eng Journal Article United States Am J Pathol 0370502 0002-9440 VB0R961HZT Prednisone AIM IM Biopsy Cyanosis Dyspnea Humans Macrophages Male Microscopy, Electron Middle Aged Osteoarthropathy, Secondary

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1970 The American journal of pathology

60. Electron microscopy of desquamative interstitial pneumonia (PubMed)

Electron microscopy of desquamative interstitial pneumonia 5821622 1969 11 05 2018 11 13 0040-6376 24 2 1969 Mar Thorax Thorax Electron microscopy of desquamative interstitial pneumonia. 192-208 Shortland J R JR Darke C S CS Crane W A WA eng Journal Article England Thorax 0417353 0040-6376 0 Aerosols 9PHQ9Y1OLM Prednisolone IM Adult Aerosols Female Humans Lung physiopathology Male Microscopy, Electron Prednisolone therapeutic use Pulmonary Alveoli pathology Pulmonary Fibrosis diagnosis

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1969 Thorax

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