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Desquamation

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21. Dementia, diarrhea, desquamating shellac-like dermatitis revealing late-onset cobalamin C deficiency (PubMed)

Dementia, diarrhea, desquamating shellac-like dermatitis revealing late-onset cobalamin C deficiency 29379858 2019 02 26 2352-5126 4 1 2018 Jan JAAD case reports JAAD Case Rep Dementia, diarrhea, desquamating shellac-like dermatitis revealing late-onset cobalamin C deficiency. 91-94 10.1016/j.jdcr.2017.09.016 Gilson Robert Christopher RC University of Texas Health Science Center, San Antonio, Texas. Wallis Luke L University of Texas Health Science Center, San Antonio, Texas. Yeh Jenny J (...) University of Texas Health Science Center, San Antonio, Texas. Gilson Robert T RT University of Texas Health Science Center, San Antonio, Texas. eng Case Reports 2017 12 20 United States JAAD Case Rep 101665210 2352-5126 MMA MMA, methylmalonic acid cobalamin C dermatitis desquamation homocystinuria methylmalonic acid nutritional deficiency 2018 1 31 6 0 2018 1 31 6 0 2018 1 31 6 1 epublish 29379858 10.1016/j.jdcr.2017.09.016 S2352-5126(17)30225-4 PMC5771731 Clin Dermatol. 2015 Jul-Aug;33(4):414-9

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2017 JAAD Case Reports

22. A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder (PubMed)

A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder A 60-year-old man presented with an 18-month history of gradually worsening cough and a 12-month history of dyspnea on exertion. High-resolution computed tomography showed bilateral uniform ground grass opacity in the lower lung fields, partially resolved by smoking cessation. A tentative diagnosis of desquamative interstitial pneumonia (DIP) was made. Video-assisted thoracic surgery

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2017 Respiratory Medicine Case Reports

23. Novel Pathogenic Variants in FOXP3 in Fetuses with Echogenic Bowel and Skin Desquamation Identified by Ultrasound (PubMed)

Novel Pathogenic Variants in FOXP3 in Fetuses with Echogenic Bowel and Skin Desquamation Identified by Ultrasound Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome is a rare, X-linked recessive disease that affects regulatory T cells (Tregs) resulting in diarrhea, enteropathy, eczema, and insulin-dependent diabetes mellitus. IPEX syndrome is caused by pathogenic alterations in FOXP3 located at Xp11.23. FOXP3 encodes a transcription factor that interacts with several

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2017 American journal of medical genetics. Part A

24. Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis (PubMed)

Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis Desquamative inflammatory vaginitis is a poorly understood chronic vaginitis with an unknown etiology. Symptoms of desquamative inflammatory vaginitis include copious yellowish discharge, vulvovaginal discomfort, and dyspareunia. Cervical ectropion, the presence of glandular columnar cells on the ectocervix, has not been reported as a cause of desquamative inflammatory vaginitis. Although cervical ectropion can be a normal (...) clinical finding, it has been reported to cause leukorrhea, metrorrhagia, dyspareunia, and vulvovaginal irritation. Patients with cervical ectropion and desquamative inflammatory vaginitis are frequently misdiagnosed with candidiasis or bacterial vaginosis and repeatedly treated without resolution of symptoms. We report the case of a 34-year-old woman with a 4-year history of profuse yellowish discharge and dyspareunia. Upon presentation, her symptoms and laboratory results met the criteria

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2017 Sexual Medicine

25. Erythrodermie desquamative (PubMed)

Erythrodermie desquamative Paraneoplastic dermatoses are a spectrum of cutaneous manifestations which may precede, coincide with or follow the diagnosis of cancer. Our study aims to remind clinicians that desquamative erythrodermia is a form of paraneoplastic dermatosis which may occur during hematologic malignancies. Hence the importance of a complete assessment to identify a neoplastic process in the presence of these clinical signs and especially when they are suspect.

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2017 The Pan African medical journal

26. Desquamative Interstitial Pneumonia Complicated with IgG4-related Lung Disease (PubMed)

Desquamative Interstitial Pneumonia Complicated with IgG4-related Lung Disease As an idiopathic interstitial pneumonia, desquamative interstitial pneumonia (DIP) is an uncommon form of interstitial lung disease and is considered to be a smoking- or dust inhalation-related interstitial pneumonia in the majority of cases. However, the details regarding immunoglobulin G4 (IgG4)-related lung disease remain unclear and controversial. We herein report the first case of DIP complicated with IgG4

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2017 Internal Medicine

27. Multiple Small Intestine Ulcers with Desquamation of the Fingers (PubMed)

Multiple Small Intestine Ulcers with Desquamation of the Fingers A 73-year-old female was admitted to our hospital with abdominal pain and diarrhea. Computed tomography detected distension of the small intestine. A palmar erythema, multiple oral ulcers, and desquamation of the fingers appeared after hospitalization. Small-bowel endoscopic images showed multiple ulcers. We attributed this case to infection with Yersinia pseudotuberculosis based on the changes in Y. pseudotuberculosis antibody

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2017 Case reports in gastroenterology

28. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) (PubMed)

Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) Cathepsin C (CTSC) is necessary for the activation of several serine proteases including neutrophil elastase (NE), cathepsin G and proteinase 3. GSK2793660 is an oral, irreversible inhibitor of CTSC that is hypothesized to provide an alternative route to achieve NE inhibition and was tested in a Phase I study.Single escalating oral doses of GSK2793660 from 0.5 to 20 mg or placebo were administered (...) of approximately 20% were observed for NE, cathepsin G and proteinase 3. Seven of 10 subjects receiving repeat doses of GSK2793660 manifested epidermal desquamation on palmar and plantar surfaces beginning 7-10 days after dosing commencement. There were no other clinically important safety findings.GSK2793660 inhibited CTSC activity but not the activity of downstream neutrophil serine proteases. The palmar-plantar epidermal desquamation suggests a previously unidentified role for CTSC or one of its target

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2017 British journal of clinical pharmacology

29. Coal Mine Dust Desquamative Chronic Interstitial Pneumonia: A Precursor of Dust-Related Diffuse Fibrosis and of Emphysema (PubMed)

Coal Mine Dust Desquamative Chronic Interstitial Pneumonia: A Precursor of Dust-Related Diffuse Fibrosis and of Emphysema Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention.To identify the precursor of dust-related diffuse fibrosis and emphysema.Birefringent silica/silicate particles were counted by standard microscope (...) . Fibrotic septa of centrilobular emphysema contained numerous silica/silicate particles while only a few were present in adjacent normal lung tissue. In coal miners who smoked, tobacco-associated interstitial fibrosis was replaced by fibrosis caused by silica/silicate particles.The presence of silica/silicate particles and anthracotic pigment-laden macrophages inside the alveoli with various degrees of interstitial fibrosis indicated a new disease: coal mine dust desquamative chronic interstitial

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2017 The international journal of occupational and environmental medicine

30. Early Desquamating Perineal Erythema in a Febrile Infant: A Characteristic Clinical Feature of Kawasaki Disease (PubMed)

Early Desquamating Perineal Erythema in a Febrile Infant: A Characteristic Clinical Feature of Kawasaki Disease Background: The occurrence of a distinctive perineal eruption that appears early in infants with Kawasaki disease (KD), the most relevant type of febrile vasculitis of childhood, has received little attention in pediatric reports. KD diagnosis is based on clinical criteria, which can be supported by laboratory abnormalities or positive echocardiography findings: difficulty (...) . The presence of early desquamating perineal erythema led to the consideration of KD diagnosis, confirmed by the echocardiographic assessment of right and left coronary artery dilatations with pericardial effusion on the fifth day of hospital stay. Conclusions: Diagnosis of KD represents a demanding challenge, mainly when the illness starts with an incomplete or nuanced presentation. An erythematous desquamating perineal rash is a valuable early clinical clue, which might facilitate a prompt diagnosis of KD

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2017 International journal of environmental research and public health

31. A practical clinical recording system for cases with desquamative gingivitis. (PubMed)

A practical clinical recording system for cases with desquamative gingivitis. 27639053 2018 07 30 2018 07 30 1365-2133 177 1 2017 07 The British journal of dermatology Br. J. Dermatol. A practical clinical recording system for cases of desquamative gingivitis. 299-301 10.1111/bjd.15075 Arduino P G PG Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy. Broccoletti R R Department of Surgical Sciences, Oral Medicine Section, CIR-Dental

2016 British Journal of Dermatology

32. Keratinizing desquamative squamous metaplasia in the kidney of a patient with complex spinal cord injury (PubMed)

Keratinizing desquamative squamous metaplasia in the kidney of a patient with complex spinal cord injury Keratinizing desquamative squamous metaplasia (KDSM) of the upper urinary tract was previously thought, but never proven, to represent a premalignant condition. However, no clear guidelines exist regarding the long-term management and follow up once this rare diagnosis has been made.Patients with spinal cord injury often develop a range of risk factors for malignancy of the urinary tract. We

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2016 The journal of spinal cord medicine

33. Candidal Infection of the Gingiva Mimicking Desquamative Gingivitis: A Case Report (PubMed)

Candidal Infection of the Gingiva Mimicking Desquamative Gingivitis: A Case Report There has been an increase in the occurrence of fungal infections in humans in the recent years due to the discrete use of broad spectrum antibiotics and immunosuppressive therapies. The genus candida is the most frequently found fungi in humans. Candida albicans is a mucosal microbiota although it can cause infections which can be mucosal or life threatening infections in susceptible individuals. Candidiasis (...) is the most common oral opportunistic fungal infection in humans. Candidiasis usually affects oral mucosa (buccal mucosa) and hard palate. Candidiasis affecting gingiva is not so common, but when it occurs, it is often misdiagnosed as desquamative gingivitis because of its clinical appearance. This paper discusses a case of Candidal infection of gingiva that mimics desquamative gingivitis.

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2016 Journal of clinical and diagnostic research : JCDR

34. Desquamation

Desquamation Desquamation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Desquamation Desquamation Aka: Desquamation , Scaling II (...) . Pathophysiology Rapid epithelial cell proliferation (outer epidermal layer) does not form Outermost layer now appears as scale III. Signs Desquamating layers of skin Sandpaper feel suggests solar keratosis IV. Causes: Examples See ( ) Drug eruption Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Desquamation." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database

2018 FP Notebook

35. Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. (PubMed)

Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. Epidermal homeostasis is maintained through the balance between keratinocyte proliferation, differentiation and desquamation; however, human skin equivalent (HSE) models are known to differentiate excessively. In native tissue, proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 cleave the extracellular components of corneodesmosomes (...) ; proteins corneodesmosin, desmocollin 1 and desmoglein 1, loosening the cellular connections and enabling desquamation. The actions of KLK7 are tightly controlled by protease inhibitors, skin-derived antileucoproteinase (SKALP) and lymphoepithelial Kazal-type-related inhibitor (LEKTI), which also inhibits KLK5, localizing protease activity to the stratum corneum.To investigate the mechanisms that inhibit the desquamation cascade in HSE models.Human skin tissue and HSE models were investigated using gene

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2016 British Journal of Dermatology

36. Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast (PubMed)

Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast Erosive oral lichen planus and desquamative gingivitis are uncommon but severe debilitating variants of oral lichen planus. Treatment of these presentations is difficult and challenging.A 44-year-old woman was referred to the dermatology clinic with chronic painful lichen planus-related gingivitis and buccal erosions. She has failed multiple treatments including topical clobetasol

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2016 Journal of dermatological case reports

37. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis (PubMed)

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis Harlequin Ichthyosis is a severe skin disease caused by mutations in the human gene encoding ABCA12. Here, we characterize a novel mutation in intron 29 of the mouse Abca12 gene that leads to the loss of a 5' splice donor site and truncation of the Abca12 RNA transcript. Homozygous mutants of this smooth skin or smsk allele die perinatally with shiny (...) of multilamellar structures in the stratum corneum, but also proteolytic enzymes that are required for normal desquamation. Smsk mutant mice recapitulate many of the pathological features of HI and can be used to explore novel topical therapies against a potentially lethal and debilitating neonatal disease.

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2016 PloS one

38. Severe desquamation in Kawasaki disease: Is it somehow protective? (PubMed)

Severe desquamation in Kawasaki disease: Is it somehow protective? Kawasaki disease is a common vasculitis that typically affects children between one and five years of age. We report a 12-year-old boy who presented following a presumed diagnosis of pharyngitis associated with nondesquamating skin rash and conjunctivitis. Despite treatment with amoxicillin for seven days his fever persisted for ten days and then remitted. Two weeks later, he developed full thickness extensive desquamation (...) of his palms and soles that mandated a visit to emergency department in our tertiary health centre. Physical examination revealed full thickness desquamation of his palms and soles with absence of erythema or swelling and he had unremarkable systemic examination. Laboratory tests showed thrombocytosis and high erythrocytes sedimentation rate. Throat culture and Anti-streptolysin-O titer were negative. Aspirin, anti-platelets dose, was initiated. Echocardiography was performed in the first visit

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2017 Sudanese journal of paediatrics

39. Desquamative gingivitis: a systematic review of possible treatments

Desquamative gingivitis: a systematic review of possible treatments Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures

2018 PROSPERO

40. Near fatal desquamative interstitial pneumonia with bilateral recurrent tension pneumothorax. (PubMed)

Near fatal desquamative interstitial pneumonia with bilateral recurrent tension pneumothorax. Desquamative interstitial pneumonia (DIP) is an uncommon form of interstitial lung disease demonstrating good response to corticosteroid therapy and favorable prognosis. In rare cases, patients with DIP fail to respond to corticosteroid therapy, and may progress to end-stage fibrotic lung disease with respiratory failure. For such patients, well defined treatment regimen does not exist until now. We

2015 Sarcoidosis, Vasculitis, and Diffuse Lung Diseases

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