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Desquamation

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2. Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report (Full text)

Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report Kawasaki disease (KD) is a vasculitis that mostly affects children under 5 years of age. This article presents a 2.5-year-old boy who presented with 6 days of fever, generalized maculopapular rash, bilateral non-exudative conjunctivitis, cracked lips, right cervical lymphadenopathy, erythematous extremities, and perianal desquamation. Laboratory studies showed leukocytosis and sterile pyuria. Because diagnosis (...) of KD was proved, oral acetylsalicylic acid with the anti-inflammatory dose and intravenous immunoglobulin were started for him. On the seventh day of admission time, he developed desquamation and erythema on the site of his right cervical lymphadenopathy as well as periungual scaling. About three weeks after starting the treatment, scaling of the cervical lymphadenopathy and periungual area stopped. Echocardiography was performed for him three times: at the time of diagnosis, four weeks, and 6

2017 Electronic physician PubMed

3. First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene. (PubMed)

First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene. Rubinstein-Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in patients with RSTS while there has been no report of desquamation so far (...) in any patients with RSTS. We report an unusual case of RSTS in an 8-year-old boy who presented with the typical facial and limb abnormalities of RSTS accompanied with apparent hirsutism and desquamation, but without apparent intellectual disability. Whole exome sequencing identified a novel mutation in the bromodomain of CREBBP (c.3503A>G, p.N1168S), which was further confirmed by targeted Sanger sequencing in comparison with healthy controls. Our findings expand the spectra of genetic mutations

2019 Clinical & Experimental Dermatology

4. A randomised clinical study comparing the effect of Steareth 30 and SLS containing toothpastes on oral epithelial integrity (desquamation). (Full text)

A randomised clinical study comparing the effect of Steareth 30 and SLS containing toothpastes on oral epithelial integrity (desquamation). To compare the clinical effect of toothpastes containing Steareth 30 and SLS (sodium lauryl sulphate) surfactants on oral epithelial integrity (desquamation) using a new Oral Mucosal Sloughing Index (OMSI).30 volunteers participated in a single centre, double-blind, randomised, crossover clinical study. After a lead-in, subjects were allocated to the first (...) test toothpaste, which was applied to the maxilla via a cap splint, followed by whole mouth brushing with the respective toothpaste and rinsing with the toothpaste slurry. Soft desquamation (lesion status) was assessed using a novel Oral Mucosal Sloughing Index (OMSI). Soft tissue status was measured at baseline (prior to test product use), 30 min following test product application and 4 days later following "at home" use of test toothpaste. After a wash out period, soft tissue assessment

2019 Journal of dentistry PubMed

5. Newborn with desquamating rash. (PubMed)

Newborn with desquamating rash. A 9-day-old boy was brought to the emergency department by his mother. The infant had been doing well until his most recent diaper change when his mother noticed a rash around the umbilicus, genitalia, and anus. The infant was born at term via spontaneous vaginal delivery. The pregnancy was uncomplicated; the infant's mother was group B strep negative. Following a routine postpartum course, the infant underwent an elective circumcision before hospital discharge

2019 Journal of Family Practice

6. Desquamative gingivitis: A review (Full text)

Desquamative gingivitis: A review Desquamative gingivitis (DG) is characterized by the erythematous gingiva, desquamation and erosion of the gingival epithelium, and blister formation. It is a common clinical manifestation in several diseases. Contact allergic reactions to various oral hygiene products and chemical agents have also been reported to represent as DG. The management of DG has been a major problem, largely because the etiology of the disease has been elusive. In this paper, we

2016 Journal of Istanbul University Faculty of Dentistry PubMed

7. Successful lung transplantation in an HIV seropositive patient with desquamative interstitial pneumonia: a case report. (Full text)

Successful lung transplantation in an HIV seropositive patient with desquamative interstitial pneumonia: a case report. Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the advent of highly active antiretroviral therapies (HAART); however, HIV remains a relative contraindication to lung transplantation. We describe, to our knowledge, the first (...) HIV seropositive lung transplant recipient in Canada. We also review the literature of previously reported cases of solid-organ transplantation in patients with HIV with a focus on immunosuppression considerations.A 48-year old man received a bilateral lung transplant for a diagnosis of desquamative interstitial pneumonia (DIP) attributed to cigarette and cannabis smoking. His control of HIV infection pre-transplant was excellent on HAART, and he had no other contraindications to lung

2018 BMC pulmonary medicine PubMed

8. Desquamative Lesion of the Nose and Lip (Full text)

Desquamative Lesion of the Nose and Lip 29468006 2018 11 13 1999-768X 33 1 2018 Jan Oman medical journal Oman Med J Desquamative Lesion of the Nose and Lip. 80-81 10.5001/omj.2018.16 Bajpai Manas M Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur, India. eng Journal Article Oman Oman Med J 101526350 1999-768X 2018 2 23 6 0 2018 2 23 6 0 2018 2 23 6 1 ppublish 29468006 10.5001/omj.2018.16 OMJ-D-17-00126 PMC5798802 Arch Dermatol. 1995 May;131(5):617-8 7741556 N Engl J

2018 Oman medical journal PubMed

9. Smoking Relapse Causing an Acute Exacerbation of Desquamative Interstitial Pneumonia with Pleural Effusions and Mediastinal Adenopathies (Full text)

Smoking Relapse Causing an Acute Exacerbation of Desquamative Interstitial Pneumonia with Pleural Effusions and Mediastinal Adenopathies Desquamative interstitial pneumonia (DIP) is a rare interstitial pneumonia often caused by smoking. DIP is typically regarded as a chronic disease, but acute DIP exacerbations can occur, and some have resulted in death. Factors that can provoke a DIP exacerbation are not well described in the literature. We present a case of a 58-year-old male with DIP, who

2018 Case reports in pulmonology PubMed

10. A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation

A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03598881 Recruitment Status : Completed First Posted : July 25, 2018 Last Update Posted : July 25, 2018 Sponsor: Unilever R&D Collaborator: University

2018 Clinical Trials

11. Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial. (PubMed)

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial. The aim of this randomized, parallel-design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative

2018 International journal of dental hygiene

12. Oral Lichenoid Lesion Manifesting as Desquamative Gingivitis: Unlikely Association? Case Report (Full text)

Oral Lichenoid Lesion Manifesting as Desquamative Gingivitis: Unlikely Association? Case Report The aim of this report is to present a clinical case of oral lichenoid lesions associated with amalgam restorations with the presence of desquamative gingivitis for a nine months follow up period.The histopathologic characteristics and direct immunofluorescence were compatible with Oral Lichenoid Lesion (LLO). Diagnosis was based on a synthesis of all available information, including medical history (...) , clinical examination, histopathology and the results of specific tests, such as the patch test, which confirmed allergy to thimerosal, an organic compound of mercury.The replacement of amalgam restorations has brought improvements to the instrument, as evidenced by the disappearance of desquamative gingivitis, aspect erythematosus and erosive lesions. The fading does not complete the same, however, indicates the need to continue has been under continuous observation, the patient, having in view

2018 The open dentistry journal PubMed

13. Continuous Dark Chocolate Consumption Affects Human Facial Skin Surface by Stimulating Corneocyte Desquamation and Promoting Bacterial Colonization (Full text)

Continuous Dark Chocolate Consumption Affects Human Facial Skin Surface by Stimulating Corneocyte Desquamation and Promoting Bacterial Colonization Background: Nutrition can influence skin health. Dark chocolate possesses health promoting properties, but its consumption can exacerbate acne vulgaris in young people. Objective: We evaluated effects of continuous dark chocolate intake on morphological characteristics of the residual skin surface components (RSSCs) collected from the facial skin (...) of young and middle-aged men. Methods: RSSC samples were taken from 17 young and 16 middle-aged men before and after a four-week consumption period of dark chocolate (10g per day). Lipid droplet size, corneocyte desquamation, and microbial presence levels were measured in the collected RSSC. The project was registered as ISRCTN89815519 in the ISRCTN registry (https://www.isrctn.com/). Results: Chocolate consumption caused a significant increase in corneocyte desquamation only in the group of young men

2018 The Journal of clinical and aesthetic dermatology PubMed

14. Activography reveals aberrant proteolysis in desquamating diseases of differing backgrounds. (Full text)

Activography reveals aberrant proteolysis in desquamating diseases of differing backgrounds. The role of epidermal proteolysis in overdesquamation was revealed in Netherton syndrome, a rare ichthyosis due to genetic deficiency of the LEKTI inhibitor of serine proteases. Recently, we developed activography, a new histochemical method, to spatially localize and semiquantitatively assess proteolytic activities using activity-based probes. Activography provides specificity and versatility compared (...) to in situ zymography, the only available method to determine enzymatic activities in tissue biopsies. Here, activography was validated in skin biopsies obtained from an array of distinct disorders and compared with in situ zymography. Activography provides a methodological advancement due to its simplicity and specificity and can be readily adapted as a routine diagnostic assay. Interestingly, the levels of epidermal proteolysis correlated with the degree of desquamation independent of skin pathology

2018 Experimental Dermatology PubMed

15. Peeling Skin Disorders: A Paradigm for Skin Desquamation. (PubMed)

Peeling Skin Disorders: A Paradigm for Skin Desquamation. Epidermal desquamation is the highly regulated process of invisible shedding of corneocytes from the outermost layers of the stratum corneum. This occurs through the interplay between proteases and their inhibitors that control the degradation of corneodesmosomes. Skin peeling refers to exaggerated visible superficial desquamation and can occur in inherited and acquired conditions. The illumination of the molecular basis of genetic (...) disorders with skin peeling sheds light on the biological mechanisms of epidermal desquamation and skin barrier homeostasis. Proteins that are mutated in peeling skin disorders are components of corneodesmosomes (CDSN, DSG1) or protease inhibitors (LEKTI, CSTA, CAST, or SERPIN8). FLG2 emerged as a new player that regulates epidermal desquamation, as demonstrated by the phenotype observed in patients reported by 2 independent groups.Copyright © 2018 The Author. Published by Elsevier Inc. All rights

2018 Journal of Investigative Dermatology

16. Desquamative gingivitis: Clinical findings and diseases. (PubMed)

Desquamative gingivitis: Clinical findings and diseases. Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive

2018 Journal of American Academy of Dermatology

17. Desquamative gingivitis: Diagnosis and treatment. (PubMed)

Desquamative gingivitis: Diagnosis and treatment. Desquamative gingivitis is a clinical finding with several potential etiologies, and therefore histologic examination should be performed to confirm the diagnosis before the implementation of systemic therapy. The best methods for obtaining a mucosal biopsy specimen are discussed to aid the dermatologist in approaching these patients, and indications for additional testing, such as immunofluorescence studies, are reviewed. Desquamative

2018 Journal of American Academy of Dermatology

18. Is Neutrophilic Desquamative Erythroderma a Form of Acute Generalized Exanthematous Pustulosis? (PubMed)

Is Neutrophilic Desquamative Erythroderma a Form of Acute Generalized Exanthematous Pustulosis? 29224230 2018 06 07 1468-3083 32 6 2018 Jun Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Is neutrophilic desquamative erythroderma a form of acute generalized exanthematous pustulosis? e230-e232 10.1111/jdv.14751 Weins A B AB http://orcid.org/0000-0002-0982-7122 Department of Dermatology and Allergy Biederstein, Technical University of Munich

2017 Journal of the European Academy of Dermatology and Venereology

19. Complementary effect of hydroquinone and retinoic acid on corneocyte desquamation with their combination use. (PubMed)

Complementary effect of hydroquinone and retinoic acid on corneocyte desquamation with their combination use. Retinoic acid (RA) enhances skin-lightening capabilities of hydroquinone (HQ), at least in part, by facilitating desquamation which leads to increase penetration of HQ. The desquamation also affects skin irritation levels. The mechanism of RA-induced desquamation, however, has not been completely explored and no such data has been available for HQ uses.To examine the role of HQ, RA (...) skin epidermal protein were determined using time-course real-time PCR, Western blotting, ELISA, and immunofluorescence staining.HQ increased but RA decreased the synthesis of CDSN and DSC1. HQ reduced corneodesmosome degradation by the upregulation of SPINK5/LEKTI, whereas RA showed opposite results without upregulation of SPINK5/LEKTI. The combination of HQ and RA was close to the sum of the individual components.HQ reduced corneocyte desquamation. However, RA enhanced desquamation

2017 Journal of dermatological science

20. Desquamative interstitial pneumonia complicated by diffuse alveolar haemorrhage (Full text)

Desquamative interstitial pneumonia complicated by diffuse alveolar haemorrhage We report a rare case of desquamative interstitial pneumonia (DIP) with diffuse alveolar haemorrhage (DAH). A 56-year-old man diagnosed with DIP by surgical lung biopsy 2 years ago was admitted to our hospital because of severe acute respiratory failure. The DIP had progressed despite smoking cessation. On admission, the patient appeared extremely ill, and physical examination revealed respiratory distress

2017 Respirology case reports PubMed

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