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Dermatofibroma

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1. Cellular Dermatofibroma: Clinicopathologic Review of 218 Cases of Cellular Dermatofibroma to Determine Clinical Recurrence Rate. (PubMed)

Cellular Dermatofibroma: Clinicopathologic Review of 218 Cases of Cellular Dermatofibroma to Determine Clinical Recurrence Rate. Cellular dermatofibromas, a variant of dermatofibroma, are reported to recur at rates of 26% to 50%.To determine whether there are distinct clinical or histological differences between cellular dermatofibromas that recur versus those that do not. To determine recurrence rates in a real-world clinical setting.A retrospective analysis of the medical records and skin (...) biopsies of cellular dermatofibroma in the University of Utah Health system between December 2011 and 2016. Clinical and dermatopathological features were evaluated to find distinct differences between the cellular dermatofibromas that recurred compared with those that did not.There were no significant differences in histology between the primary lesions in recurrent and nonrecurrent cases. One factor that seemed to be associated with a greater likelihood of recurrence was an initial lesion size

2019 Dermatologic Surgery

2. A retrospective review of 93 cases of cellular dermatofibromas. (PubMed)

A retrospective review of 93 cases of cellular dermatofibromas. Cellular dermatofibromas (CDF) are an uncommon variant of benign fibrous histiocytomas with propensity to recur and rarely metastasize as well as demonstrate histologic similarities to more dangerous lesions.The aim of this present study was to further describe the presentation and outcome of the cellular variant of benign fibrous histiocytomas so that it can be diagnosed and treated appropriately.A retrospective chart review (...) negative (19/21). Of patients, 33.33% had recurrences of their CDF (9/27). Two patients had three or more recurrences. One patient's death was attributed to the CDF.CDF have a high local recurrence rate and similarities to more dangerous and malignant lesions. Patients with cellular dermatofibromas present to many subspecialty services for diagnosis and should be treated aggressively.© 2019 The International Society of Dermatology.

2019 International Journal of Dermatology

3. Dermatopathological characteristics of dermatofibromas from dermatoscopic clues. (PubMed)

Dermatopathological characteristics of dermatofibromas from dermatoscopic clues. Several types of dermatofibroma (DF) have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far. We identify DFs with specific dermatoscopic structures and determine the respective dermatopathological correlates.Dermatoscopic and dermatopathologic correlation of 403 DFs were assessed. A pattern analysis algorithm was used

2019 International Journal of Dermatology

4. Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. (PubMed)

Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. Dermatofibromas are common benign skin lesions, the etiology of which is poorly understood. We identified two unrelated pedigrees in which there was autosomal dominant transmission of multiple dermatofibromas. Whole exome sequencing revealed a rare shared heterozygous missense variant in F13A1 gene encoding factor XIII subunit A, a transglutaminase involved in hemostasis

2019 Journal of Investigative Dermatology

5. Dermoscopy of lipidised dermatofibroma: A morphological study of 13 cases. (PubMed)

Dermoscopy of lipidised dermatofibroma: A morphological study of 13 cases. The aim of this study was to evaluate the morphological findings of lipidised dermatofibromas under dermoscopic observation.Dermoscopic examination of 13 cases of lipidised dermatofibromas was performed to evaluate specific dermoscopic criteria and patterns.The most frequently occurring dermoscopic features were as follows: (i) A yellowish homogenous pigmentation in all cases (100%); this pigmentation was total in 30.7 (...) %; (ii) White structures were seen in 46.1%, most of them were central white networks (38.4%); (iii) Pigment network was observed in 53.8%, most of them were peripheral delicate pigment networks (38.4%), but two cases showed an atypical pigment network; (iv) The presence of vascular structures was common (10 cases, 77%); (v) Regarding to dermoscopic patterns, five lipidised dermatofibromas (38.4%) showed a total yellowish homogeneous pattern; 38.4% an atypical pattern and 23.2% a 'central white

2018 Australasian Journal of Dermatology

6. Hemosiderotic dermatofibroma mimicking melanoma in a 12‐year‐old boy: a case report (PubMed)

Hemosiderotic dermatofibroma mimicking melanoma in a 12‐year‐old boy: a case report We report a case of hemosiderotic dermatofibroma presenting as a brown-black-colored nodule with peripheral extensions, which mimics melanoma. Histopathology showed completely benign features with no atypia or mitosis. Nodular extensions of childhood dermatofibromas may be related to the growth of the child not necessarily pointing to a malignant process.

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2018 Clinical Case Reports

7. Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas

Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03392935 Recruitment Status : Recruiting First Posted : January 8, 2018 Last Update Posted

2018 Clinical Trials

8. Rare experience of keloidal dermatofibroma of forehead (PubMed)

Rare experience of keloidal dermatofibroma of forehead Dermatofibromas most commonly occur on limbs and rarely occur on the face. Dermatofibroma occurring on the face is associated with unusual clinicopathologic features and a more aggressive clinical course in comparison to typical cases. Additionally, the most common subtype found in previous studies was benign fibrous histiocytoma, with the keloid type being very rare (about 1% of reported cases). The aim of this study was to present our (...) experience with a keloidal dermatofibroma of the face, which is usually missed clinically, and to discuss the treatment of a keloidal dermatofibroma in this location.

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2018 Archives of Craniofacial Surgery

9. Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone (PubMed)

Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone 30207570 2018 11 14 2148-5046 33 2 2018 Jun Archives of rheumatology Arch Rheumatol Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone. 236-237 10.5606/ArchRheumatol.2018.6569 An İsa İ Department of Dermatology, Medical Faculty of Dicle University, Diyarbakır, Turkey. Devran Gevher Özlem Ö Department of Dermatology

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2017 Archives of Rheumatology

10. Beyond classic dermoscopic patterns of dermatofibromas: a prospective research study (PubMed)

Beyond classic dermoscopic patterns of dermatofibromas: a prospective research study The usual stereotypical dermoscopic pattern associated with dermatofibromas is a pigment network and central white patch. However, this pattern may be difficult to diagnose in some variant cases. We aimed to describe dermoscopic patterns of dermatofibroma according to its histopathological subtypes, with special emphasis on new and rare dermoscopic features.This prospective study, which was conducted between (...) September 2015 and May 2016 in the Department of Dermatology, University Hospital Hassan II, Fez, Morocco, included 100 cases of dermatofibroma confirmed on clinical and histological grounds. Each lesion was scored for classic, previously reported, or new dermoscopic features.All our Moroccan patients had a dark skin phototype (Fitzpatrick scale types IV and V). A total of 14 morphological dermoscopic structures were distinguished, and 17 dermoscopic patterns were observed, with the most common pattern

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2017 Journal of medical case reports

11. Multiple Clustered Dermatofibromas Following Ustekinumab Treatment for Psoriasis Vulgaris (PubMed)

Multiple Clustered Dermatofibromas Following Ustekinumab Treatment for Psoriasis Vulgaris 29062570 2019 01 08 2019 01 08 2075-0528 17 3 2017 Aug Sultan Qaboos University medical journal Sultan Qaboos Univ Med J Multiple Clustered Dermatofibromas Following Ustekinumab Treatment for Psoriasis Vulgaris . e375-e377 10.18295/squmj.2017.17.03.025 Ruiz-Villaverde Ricardo R Department of Dermatology, Complejo Hospitalario de Granada, Jaén, Granada, Spain. Díaz-Martinez Miguel A MA Department

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2017 Sultan Qaboos University medical journal

12. Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy (PubMed)

Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination

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2016 Case reports in dermatology

13. Dermatofibroma of the Eyelid with Monster Cells. (PubMed)

Dermatofibroma of the Eyelid with Monster Cells. Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A recurrent lesion of the right lower eyelid developed in a 64-year-old woman. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted, and hyperchromatic nucleus. The presence of these cells does not signify a malignant transformation. The background cells were either histiocytoid (many were (...) adipophilin positive), spindled cells, or dendritiform cells without mitoses. Factor XIIIa, CD68, and CD163 immunostaining was positive, and a subpopulation of CD1a+ Langerhans cells was intermixed. Facial and eyelid dermatofibromas are more likely to recur and deserve wider, tumor-free surgical margins. Their microscopic differential diagnosis includes a cellular scar, peripheral nerve tumor, atypical fibrous xanthoma, and dermatofibrosarcoma protuberans.Copyright © 2016 Elsevier Inc. All rights reserved.

2016 Survey of Ophthalmology

14. Dermatofibroma

Dermatofibroma Dermatofibroma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermatofibroma Dermatofibroma Aka: Dermatofibroma (...) , Solitary histiocytoma , Sclerosing Hemangioma , Nodulus Cutaneous , Fitzpatrick's Sign From Related Chapters II. Epidemiology Males predominate (3:1 ratio) Age of onset 20-50 years old III. Pathophysiology Idiopathic, benign, fibroblast proliferation IV. Causes Idiopathic benign skin tumor Fibrous reaction to local irritation Local Viral infection Underlying condition (>15 Dermatofibromas) Immunocompromised patient V. Symptoms Asymptomatic in most cases Lesions may be pruritic or tender VI. Signs

2018 FP Notebook

15. Signet Ring Dermatofibroma, a Rare and Confusing Variant (PubMed)

Signet Ring Dermatofibroma, a Rare and Confusing Variant Dermatofibroma is a common cutaneous benign fibrohistiocytic tumour, which is usually diagnosed without difficulty. In this report we demonstrated a signet ring variant of dermatofibroma as a rare variant of this common neoplasm together with the possible differential diagnosis.The presence of signet cells in cutaneous neoplasm does not necessarily means malignancy. Signet ring dermatofibroma is a rare variant eliciting differential

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2015 Journal of clinical and diagnostic research : JCDR

16. Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: a retrospective analysis of 200 lesions. (PubMed)

Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: a retrospective analysis of 200 lesions. Dermatology literature lacks a study investigating both histopathological and dermatoscopic features of dermatofibroma.To analyse histopathological, dermatoscopic and digital microscopic features of dermatofibromas.Two hundred dermatofibromas and 190 patients were included and retrospectively evaluated. Nine histopathological and ten dermatoscopic patterns were (...) used to classify the lesions. We identified four different types of dermatofibroma in digital microscopy.The mean age of the patients was 42.18 ± 13.72 years. Dermatofibroma was more common in females (67%) and the male to female ratio was 1:1.97. The most common location was leg (41%). The most frequent histopathological variant was fibrocollagenous type (49%). Grenz zone was the most common histopathological finding (89%). The most frequent digital microscopic type was type 1 (63%).We found

2015 Journal of the European Academy of Dermatology and Venereology

17. A case of perforating dermatofibroma with floret-like giant cells. (PubMed)

A case of perforating dermatofibroma with floret-like giant cells. Dermatofibromas are slow-growing solitary nodules, composed mostly of a dermal proliferation of spindle cells and epithelioid cells. Some dermatofibromas present with multinucleated giant cells, such as Touton, foreign body, and osteoclast-like cells. We report a case of dermatofibroma containing both Touton giant cells and floret-type cells. A 12-year-old boy presented with a 6-mm, firm, nontender, dusky-red to greyish dermal (...) dermis were mainly floret-type multinucleated giant cells with star-shaped cytoplasmic projections, associated with some Touton giant cells. To our knowledge, this is the first report of a perforating dermatofibroma with floret-type multinucleated giant cells. © 2014 British Association of Dermatologists.

2014 Clinical & Experimental Dermatology

18. Multiple clustered dermatofibroma presenting in a segmental distribution. (PubMed)

Multiple clustered dermatofibroma presenting in a segmental distribution. Multiple dermatofibromas is a rare entity consisting of more than fifteen lesions. Multiple clustered dermatofibroma is a distinct variant of multiple dermatofibromas and is defined as a well-demarcated plaque composed of individual dermatofibromas. We report a 16-year-old boy with multiple clustered dermatofibroma in a segmental distribution, which has previously not been reported in the literature. © 2014

2014 Australasian Journal of Dermatology

19. Dermatofibroma (Diagnosis)

Dermatofibroma (Diagnosis) Dermatofibroma: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1Njc0Mi1vdmVydmlldw== processing > Dermatofibroma Updated: Jun 04, 2018 Author (...) : Joseph C Pierson, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatofibroma Overview Background Dermatofibroma (superficial benign fibrous histiocytoma) is a common cutaneous nodule of unknown etiology that occurs more often in women. Dermatofibroma frequently develops on the extremities (mostly the lower legs) and is usually asymptomatic, although pruritus and tenderness can be present. It is actually the most common painful skin tumor. [ ] A number

2014 eMedicine.com

20. Dermatofibroma (Overview)

Dermatofibroma (Overview) Dermatofibroma: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1Njc0Mi1vdmVydmlldw== processing > Dermatofibroma Updated: Jun 04, 2018 Author (...) : Joseph C Pierson, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatofibroma Overview Background Dermatofibroma (superficial benign fibrous histiocytoma) is a common cutaneous nodule of unknown etiology that occurs more often in women. Dermatofibroma frequently develops on the extremities (mostly the lower legs) and is usually asymptomatic, although pruritus and tenderness can be present. It is actually the most common painful skin tumor. [ ] A number

2014 eMedicine.com

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