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Dermatitis Herpetiformis

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21. Rituximab Treatment for Recalcitrant Dermatitis Herpetiformis. (PubMed)

Rituximab Treatment for Recalcitrant Dermatitis Herpetiformis. Dermatitis herpetiformis (DH) is an autoimmune blistering condition seen in the context of celiac disease. While typically managed by gluten-free diet and dapsone, treatment of DH refractory to standard treatments is not well defined.A man in his 80s with DH not controlled by gluten-free diet (with poor adherence), dapsone, and conventional immune-suppressing agents responded to treatment with rituximab according to the lymphoma

2016 JAMA dermatology (Chicago, Ill.)

22. The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis. (PubMed)

The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis. Mucosal-associated invariant T (MAIT) cells are a novel subset of innate-like T-cells that are enriched in mucosal tissues. Their presence in human skin has only recently been recognised. We describe the expression of skin-tropic molecules on human skin MAIT cells at steady state and investigate their contribution to various dermatoses with known T-cell involvement.To examine (...) the expression of skin-tropic molecules by MAIT cells at steady state, we performed a flow cytometric analysis of blood and skin samples from healthy donors. To investigate any potential wider contribution of MAIT cells to skin disease, we examined psoriasis, alopecia areata and dermatitis herpetiformis biopsies using immunofluorescent staining to identify the proportion of T-cells expressing MAIT cell surface markers.We found that MAIT cells constituted a small population of T-cells in normal human skin

2016 Australasian Journal of Dermatology

23. Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study. (PubMed)

Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study. Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. The burden of illness in untreated coeliac disease is known to be considerable, but corresponding evidence for DH is lacking. In this study the burden of DH was evaluated prospectively in 52 patients newly diagnosed with DH using a study questionnaire and a validated Psychological General Well-Being (PGWB

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2016 Acta Dermato-Venereologica

24. Dermatitis Herpetiformis

Dermatitis Herpetiformis Dermatitis Herpetiformis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermatitis Herpetiformis Dermatitis (...) Herpetiformis Aka: Dermatitis Herpetiformis From Related Chapters II. Epidemiology : Up to 39 cases per 100,000 Usual onset at 20 to 40 years Gender preponderance in men by 2:1 ratio Ethnicity Most commonly affects white patients Rarely affects black or asian patients III. Pathophysiology Idiopathic condition Usually associated with IV. Symptoms: Precede lesion onset by 8 to 12 hours Intense Skin burning V. Signs Grouping of lesions may occur (herpetiform-like) Altered pigmentation at sites of healed

2018 FP Notebook

25. Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis. (PubMed)

Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis. Recently, high prevalence of cryofibrinogenaemia has been observed in plasma of untreated dermatitis herpetiformis (DH) patients, and the pathological IgA and TG3 deposits in the papillary dermis were found to co-localize with fibrin and fibrinogen.To study the fibrinolytic potential in plasma of untreated, dapsone and or/gluten-free diet treated DH patients as well as the in vitro effect

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2016 Journal of dermatological science

26. Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease. (PubMed)

Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease. Dermatitis herpetiformis (DH) is an itchy blistering skin disease with predilection sites on elbows, knees, and buttocks. Diagnosis is confirmed by showing granular immunoglobulin A deposits in perilesional skin. DH is one manifestation of coeliac disease; the skin symptoms heal with gluten free diet (GFD) and relapse on gluten challenge. Of the first-degree relatives, 5% may be affected by either condition. Tissue (...) is increasing, whereas the opposite is true for DH. A female predominance is evident in coeliac disease, while DH may be more common in males. Coeliac disease carries the risk of small intestinal T-cell lymphoma; in DH B-cell lymphomas at any site may prevail. Adult coeliac disease carries a slightly increased elevated mortality risk, whereas in DH, the relative mortality rate is significantly decreased. Key messages Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease; both conditions

2016 Annals of Medicine

27. Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus? (PubMed)

Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus? Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up.We included all patients with confirmed PH followed from

2018 International Journal of Dermatology

28. Quality of Life and Gastrointestinal Symptoms in Long-Term Treated Dermatitis Herpetiformis Patients: A Cross-Sectional Study in Finland. (PubMed)

Quality of Life and Gastrointestinal Symptoms in Long-Term Treated Dermatitis Herpetiformis Patients: A Cross-Sectional Study in Finland. Dermatitis herpetiformis (DH) is a cutaneous manifestation of celiac disease. Both conditions are treated with a restrictive life-long gluten-free diet (GFD). Treated celiac disease patients have been shown to have more severe gastrointestinal symptoms and inferior quality of life compared with healthy controls, but evidence regarding quality of life in DH

2015 American journal of clinical dermatology

29. Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases (PubMed)

Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production

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2015 Mediators of inflammation

30. The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis (PubMed)

The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis A gluten-free diet (GFD) is currently the only available therapy for coeliac disease (CD).We aim to review the literature on the GFD, the gluten content in naturally gluten-free (GF) and commercially available GF food, standards and legislation concerning the gluten content of foods, and the vitamins and mineral content of a GFD.We carried out a PubMed search for the following terms: Gluten, GFD

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2015 United European gastroenterology journal

31. The diagnosis and treatment of dermatitis herpetiformis (PubMed)

The diagnosis and treatment of dermatitis herpetiformis Dermatitis herpetiformis (DH) is an inflammatory cutaneous disease with a chronic relapsing course, pruritic polymorphic lesions, and typical histopathological and immunopathological findings. According to several evidences, DH is considered the specific cutaneous manifestation of celiac disease, and the most recent guidelines of celiac disease have stated that, in celiac patients with a proven DH, a duodenal biopsy is unnecessary

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2015 Clinical, cosmetic and investigational dermatology

32. Unique characteristics in Japanese dermatitis herpetiformis. (PubMed)

Unique characteristics in Japanese dermatitis herpetiformis. 26119216 2016 12 13 2016 12 30 1365-2133 174 1 2016 Jan The British journal of dermatology Br. J. Dermatol. Unique characteristics in Japanese dermatitis herpetiformis. 180-3 10.1111/bjd.13965 Ohata C C Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0001, Japan. Ishii N N Department of Dermatology, Kurume University School (...) Dermatitis Herpetiformis ethnology immunology Female HLA-DQ Antigens immunology Humans Immunoglobulin A immunology Immunoglobulin G immunology Japan ethnology Male Middle Aged 2015 6 30 6 0 2015 6 30 6 0 2016 12 15 6 0 ppublish 26119216 10.1111/bjd.13965

2015 British Journal of Dermatology

33. Regulatory T cells as well as IL-10 are reduced in the skin of patients with dermatitis herpetiformis. (PubMed)

Regulatory T cells as well as IL-10 are reduced in the skin of patients with dermatitis herpetiformis. Dermatitis herpetiformis (DH) and celiac disease (CD) are considered as autoimmune diseases that share a defined trigger (gluten) and a common genetic background (HLA-DQ2/DQ8). However, the pathogenesis of DH is not fully understood and no data are available about the immune regulation in such a disease.The aim of this study was to assess if alterations in the pattern of the immune response

2015 Journal of dermatological science

34. Dermatitis Herpetiformis Refractory to Gluten-free Dietary Treatment. (PubMed)

Dermatitis Herpetiformis Refractory to Gluten-free Dietary Treatment. Dermatitis herpetiformis (DH) is a blistering skin disease, which is regarded as an extra-intestinal manifestation of coeliac disease. Refractory cases of coeliac disease, that do not respond to a gluten-free diet and which carry an increased risk of lymphoma, are well-known in coeliac disease. To determine whether refractory cases of DH with active rash and persistent small bowel atrophy occur we analysed our series of 403

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2015 Acta Dermato-Venereologica

35. Dermatitis Herpetiformis: Pathognomonic Transglutaminase IgA Deposits in the Skin and Excellent Prognosis on a Gluten-free Diet. (PubMed)

Dermatitis Herpetiformis: Pathognomonic Transglutaminase IgA Deposits in the Skin and Excellent Prognosis on a Gluten-free Diet. Dermatitis herpetiformis (DH) is an itchy, blistering skin disease with sites of predilection at the elbows, knees and buttocks. Although DH is mostly asymptomatic, all patients exhibit small bowel villous atrophy or at least coeliac-type inflammatory changes. Deposition of immunoglobulin A (IgA) in the papillary dermis is a key diagnostic feature of DH. Epidermal

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2015 Acta Dermato-Venereologica

36. A Rare Bullous Variant of Dermatitis Herpetiformis. (PubMed)

A Rare Bullous Variant of Dermatitis Herpetiformis. 26042658 2016 12 13 2016 12 30 1365-2133 174 1 2016 Jan The British journal of dermatology Br. J. Dermatol. A rare bullous variant of dermatitis herpetiformis. 231-3 10.1111/bjd.13941 Griss J J Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. Stingl G G Division of Immunology, Allergy and Infectious Diseases, Department (...) Dermatitis Herpetiformis drug therapy pathology Dermatologic Agents therapeutic use Diagnosis, Differential Female Humans Immunoglobulin A metabolism Microscopy, Fluorescence Treatment Outcome 2015 6 5 6 0 2015 6 5 6 0 2016 12 15 6 0 ppublish 26042658 10.1111/bjd.13941

2015 British Journal of Dermatology

37. Transverse Myelitis Associated With an Itchy Rash and HyperCkemia: Neuromyelitis Optica Associated With Dermatitis Herpetiformis. (PubMed)

Transverse Myelitis Associated With an Itchy Rash and HyperCkemia: Neuromyelitis Optica Associated With Dermatitis Herpetiformis. Neuromyelitis optica is associated with severe neurodisability if not recognized and treated promptly. Several autoimmune disorders are associated with this condition and may vary in their presentation. It is essential that clinicians are aware of the uncommon presenting features of neuromyelitis optica and associated autoimmune conditions.A 53-year-old woman (...) presented with nausea and vomiting and was noted to have an asymptomatic elevated creatinine kinase level, which improved with conservative management. She had a history of iron-deficiency anemia due to long-standing celiac disease that was managed with a gluten-free diet. She then presented with recurrent transverse myelitis and a vesicobullous rash over her arms and feet that was pruritic and excoriating. Skin biopsy results confirmed a clinical diagnosis of dermatitis herpetiformis and antibody test

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2014 JAMA neurology

38. Dermatitis herpetiformis in children: a long-term follow-up study. (PubMed)

Dermatitis herpetiformis in children: a long-term follow-up study. 24720674 2015 07 14 2014 11 21 1365-2133 171 5 2014 Nov The British journal of dermatology Br. J. Dermatol. Dermatitis herpetiformis in children: a long-term follow-up study. 1242-3 10.1111/bjd.13047 Hervonen K K Department of Dermatology and, Tampere University Hospital, PO Box 2000, 33521, Tampere, Finland; School of Medicine and, University of Tampere, Tampere, Finland. Salmi T T TT Kurppa K K Kaukinen K K Collin P P Reunala (...) T T eng Letter Research Support, Non-U.S. Gov't 2014 08 31 England Br J Dermatol 0004041 0007-0963 0 Dermatologic Agents 8W5C518302 Dapsone IM Adolescent Celiac Disease complications diet therapy Child Child, Preschool Dapsone therapeutic use Dermatitis Herpetiformis diagnosis diet therapy drug therapy Dermatologic Agents therapeutic use Diet, Gluten-Free Female Follow-Up Studies Humans Male 2014 4 12 6 0 2014 4 12 6 0 2015 7 15 6 0 ppublish 24720674 10.1111/bjd.13047

2014 British Journal of Dermatology

39. Incidence and Prevalence of Celiac Disease and Dermatitis Herpetiformis in the UK Over Two Decades: Population-Based Study. (PubMed)

Incidence and Prevalence of Celiac Disease and Dermatitis Herpetiformis in the UK Over Two Decades: Population-Based Study. Few studies have quantified the incidence and prevalence of celiac disease (CD) and dermatitis herpetiformis (DH) nationally and regionally by time and age groups. Understanding this epidemiology is crucial for hypothesizing about causes and quantifying the burden of disease.Patients with CD or DH were identified in the Clinical Practice Research Datalink between 1990

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2014 American Journal of Gastroenterology

40. IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis: a significant but not complete response to a gluten-free diet treatment. (PubMed)

IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis: a significant but not complete response to a gluten-free diet treatment. 25196300 2016 01 04 2015 04 01 1365-2133 172 4 2015 Apr The British journal of dermatology Br. J. Dermatol. IgA antiepidermal transglutaminase antibodies in dermatitis herpetiformis: a significant but not complete response to a gluten-free diet treatment. 1139-41 10.1111/bjd.13387 Reunala T T Department of Dermatology, Tampere University Hospital (...) Biomarkers metabolism Celiac Disease diet therapy immunology Dermatitis Herpetiformis diet therapy etiology immunology Diet, Gluten-Free Female GTP-Binding Proteins immunology Humans Immunoglobulin A metabolism Male Transglutaminases immunology 2014 9 9 6 0 2014 9 10 6 0 2016 1 5 6 0 ppublish 25196300 10.1111/bjd.13387

2014 British Journal of Dermatology

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