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Dermatitis Herpetiformis

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181. Eosinophilic Dermatoses: Recognition and Management. (Abstract)

of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. We review clinicopathologic features and management of diseases belonging to each group, particularly: (1) pemphigus herpetiformis and atopic dermatitis as prototypes of the epidermal group; (2) bullous pemphigoid as prototypic eosinophilic dermatosis

2020 American journal of clinical dermatology

182. Update on the use of dapsone in dermatology. (Abstract)

of eosinophil peroxidase on mast cells and down-regulating neutrophil-mediated inflammatory responses. This allows for its use in the treatment of a wide variety of inflammatory and infectious skin conditions. Currently in dermatology, the US Food and Drug Administration (FDA)-approved indications for dapsone are leprosy, dermatitis herpetiformis, and acne vulgaris. However, it proved itself as an adjunctive therapeutic agent to many other skin disorders. In this review, we discuss existing evidence

2020 International Journal of Dermatology

183. Urticaria

lasts beyond 24 hours. For more information, see the CKS topic on . Chronic pruritus — no weals are present (but can be mistaken if urticarial symptoms occur at night and are not seen). Erythema multiforme minor — the lesions are usually fixed and have a 'target' appearance (often people have a prodromal illness). Insect bite or sting — these tend to be smaller papules and typically last beyond 24 hours. For more information, see the CKS topic on . Pemphigoid (bullous) and dermatitis herpetiformis (...) [ ]. Differential diagnosis Differential diagnosis Differential diagnoses of urticaria include: Atopic eczema — lesions are usually accompanied by a greater degree of surrounding xerosis and erythema, and the rash typically lasts beyond 24 hours. For more information, see the CKS topic on . Contact dermatitis — eczematous rash, at any site related to a topical allergen, in a person of any age. Lesions tend to be more confluent and irritated in nature compared with urticarial lesions, and the rash typically

2018 NICE Clinical Knowledge Summaries

184. Diarrhoea - adult's assessment

disease; previous gastrointestinal surgery with risk of stricture — consider small intestinal bacterial overgrowth (SIBO). Rashes (for example pyoderma gangrenosum or erythema nodosum in inflammatory bowel disease; hyperpigmentation in Addison's disease; dermatitis herpetiformis in coeliac disease). Assess for features that indicate a diagnosis of irritable bowel syndrome. For more information see the CKS topic on . Perform an abdominal examination, looking for distension, an abdominal mass

2018 NICE Clinical Knowledge Summaries

185. Chickenpox

to dermatomes). For more information, see the CKS topic on . Hand, foot, and mouth disease (caused by Coxsackie virus). Other infections, such as: Impetigo. Scabies. Syphilis. Meningococcaemia (can be confused with haemorrhagic varicella). Toxic shock syndrome. Skin disorders, such as: Guttate psoriasis. Drug eruption. Insect bites. Papular urticaria. Erythema multiforme. Stevens–Johnson syndrome. Henoch–Schönlein purpura. Dermatitis herpetiformis. Basis for recommendation Basis for recommendation

2018 NICE Clinical Knowledge Summaries

186. Diagnosis of Celiac Disease

transglutaminase (tTG) is an enzyme involved in the cross-linking of certain proteins. This test is included in the algorithms of all recent guidelines. Other tests may be ordered for individuals who are IgA deficient. Endomysial antibodies, IgA The endomysium is the thin connective-tissue layer covering individual muscle fibers. Endomysial antibodies (EmA) develop when the intestinal lining is damaged. Most patients with active celiac disease and many others with dermatitis herpetiformis have anti-EmA IgA

2016 Effective Health Care Program (AHRQ)

187. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders

be associated with CD. Anemia, most commonly as a result of iron deficiency, has been reported in 12% to 69% of newly diagnosed patients (15–18) and appears more prevalent in celiac patients with an atrophic mucosa compared with those with mild enteropathy (19). Linear growth failure as an isolated initial presentation of CD is well described and can be found in up to 10% of children undergoing investigation for short stature (20,21). Dermatitis herpetiformis (DH) is considered a skin presen- tation of CD (...) dermatitis X Fatigue X X X Headache/migraine X X X Foggy mind X X Angioedema X Anaphylaxis X Respiratory Asthma X Cough X Postnasal drip, throat clearing, rhinitis X DH¼ dermatitis herpetiformis; NCGS¼ nonceliac gluten sensitivity; WA¼ wheat allergy. JPGN Volume 63, Number 1, July 2016 NASPGHAN Clinical Report on Gluten-related Disorders 157 Copyright © ESPGHAL and NASPGHAN. All rights reserved. mineral density appear better able to correct this deficiency after starting the GFD, recovery

2016 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

188. Celiac Disease

from normal mucosa to subtotal/total villous atrophy in patients with celiac disease. The modified Marsh classification is widely used in clinical practice [73,76]. Another simpler classification has been proposed in order to minimize intraobserver variability [77]. Table 5 Modified Marsh classification of gluten-induced small-intestinal damage [73,76] Stage 0 Pre-infiltrative mucosa; up to 30% of patients with dermatitis herpetiformis (DH) or gluten ataxia have small-intestinal biopsy specimens (...) and they should be followed up and the original biopsy reviewed. The majority of potential celiac disease patients later develop celiac disease. ? In addition, 30% of patients with dermatitis herpetiformis who have positive serology findings have normal histology. However, a GFD is recommended even with negative histology, as it restores positive serology and skin lesions. ? Asymptomatic individuals with titers just at the cut-off level (borderline) should be retested after 3–6 months on a normal diet

2016 World Gastroenterology Organisation

189. Management of scabies

Differential diagnosis Scabies frequently imitates other skin diseases. It is important to have a high degree of suspicion to recognise symptoms and signs of scabies. Differential diagnosis for scabies include: Impetigo, folliculitis, papular urticarial, atopic dermatitis, contact dermatitis, dermatitis herpetiformis, psoriasis, seborrhoeic dermatitis, pytiriasis rosea, secondary syphilis and lymphoma and pseudolymphoma (if scabies presents with nodules). Complications Secondary bacterial infection due

2016 British Association for Sexual Health and HIV

190. Review of Autoimmune Blistering Diseases: the Pemphigoid diseases. (Abstract)

Review of Autoimmune Blistering Diseases: the Pemphigoid diseases. Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub-epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides

2019 Journal of the European Academy of Dermatology and Venereology

191. Aphthous ulcer

— suspect if the person has unexplained gastrointestinal symptoms, chronic diarrhoea, unexplained iron deficiency anaemia, or a skin rash consistent with dermatitis herpetiformis. Crohn's disease — suspect if the person has bloody diarrhoea, weight loss, labial or facial swelling, and occasionally, joint manifestations. Be aware than symptoms can be highly variable. Ulcerative colitis — suspect if the person has left-sided abdominal pain and bloody diarrhoea. Behçet's syndrome — suspect if the person (...) lidocaine include: Allergic reactions. Ulceration. Dermatitis. [ ] Contraindications and cautions Contraindications and cautions Do not prescribe lidocaine to people with: Hypersensitivity to anaesthetics of the amide-type. Porphyria — lidocaine has been shown to be porphyrinogenic in animals. Prescribe lidocaine with caution to people with: Hepatic impairment — due to increased risk of adverse effects. Severe renal impairment — due to increased risk of accumulation of lidocaine and its active

2017 NICE Clinical Knowledge Summaries

192. Scabies

of elderly people, which often starts with pruritus and an urticaria-like rash, although this may occasionally be eczematous. Later, large, tense blisters develop. Contact dermatitis — suggested by a rash that develops within following contact with an allergen/irritant. For more information, see the CKS topic on . Dermatitis herpetiformis — a rare, chronic, recurrent, papulovesicular disease. It is symmetrical and consists of erythematous, urticarial, papular, or vesicular lesions located on the extensor (...) , hyperpigmented/purpuric lesions with surfaces that are scaly, excoriated, and possibly crusted, caused by scratching due to intense localised itchiness. Lesions range from small papules to hard globular nodules 1–3 cm in diameter. Seborrhoeic dermatitis — suggested by red, flaky, greasy areas of skin, which are commonly found on the scalp (dandruff), nasolabial folds, eyebrows, behind the ears, and on the upper chest. For more information, see the CKS topic on . Systemic lupus erythematosus (SLE) — suggested

2017 NICE Clinical Knowledge Summaries

193. FreeStyle Libre Glucose Monitoring System in Pediatric Populations

application sites that could interfere with device placement or the accuracy of interstitial glucose measurements. Such conditions include, but are not limited to extensive psoriasis, recent burns or severe sunburn, extensive eczema, extensive scarring, dermatitis herpetiformis, skin lesions, redness, infection or edema. Subject is currently participating in another clinical trial. Subject has had significant blood loss within 112 days (3.7 months) prior to the beginning of the study activities subjects

2018 Clinical Trials

194. PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site

of the preparation, application on cornea, wounds or mucosal Membrane. PI: hyperthyroid disease, intolerance to any of the compounds, iodine allergy, 2 weeks prior to radio- iodine treatment, Dermatitis herpetiformis Duhring, application on cornea, wounds or mucosal membranes) Emergency surgical Intervention Patients refusing General consent for use of personal data Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2018 Clinical Trials

195. Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm Full Text available with Trip Pro

, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background. Indeed there is a strong evidence that a selective activation of innate immunity may be the trigger for NCGS inflammatory response. The most commonly autoimmune disorders associated to NCGS are Hashimoto thyroiditis, dermatitis herpetiformis, psoriasis and rheumatologic diseases. The predominance of Hashimoto thyroiditis represents an interesting finding, since

2018 World Journal of Gastroenterology

196. Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients Full Text available with Trip Pro

I diabetes and dermatitis herpetiformis in 11%, respectively. At logistic regression, factors associated with AD were a positive 1st-degree family history of AD (OR 3.7, 95% CI 1.93-7), a body mass index ≥ 25 kg/m2 at CD diagnosis (OR 2.95%, CI 1.1-3.8), and long standing presentation signs/symptoms before CD diagnosis (>10 years) (OR 2.1, 95% CI 1.1-3.7). Analysis on age-gender-matched patients confirmed these results.CD patients with family history of AD, overweight at CD diagnosis

2018 Gastroenterology research and practice

197. Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats Full Text available with Trip Pro

Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Ascorbic acid is an antioxidant and reducing agent that scavenges the free radicals produced

2018 Clinical and experimental emergency medicine

198. Does the Disinfection of the Subcutaneous Tissue Reduce the Contamination of the Operative Field by P. Acnes During Primary Shoulder Surgery?

of the shoulder Antibiotherapy in the 2 weeks preceding the intervention Infiltration of cortisone in the 6 months preceding the intervention Iodinated contrast medium allergy or cefuroxime Allergy to the povidone iodine complex or other contraindication to Betadine namely: Hypersensitivity to the active ingredient, iodine or povidone iodine complex, or to any of the excipients according to the composition. Hyperthyroidism and other overt thyroid diseases. Dermatitis herpetiformis of Duhring. Before and after

2018 Clinical Trials

199. Cholinergic Urticaria

-, delayed pressure-, aquagenic-, or contact-urticaria These diseases are allowed a comorbidities, if cholinergic urticaria is the dominating form of chronic urticaria Any other severe skin disease associated with chronic itching that might confound the study evaluations and results (e.g. atopic dermatitis, bullous pemphigoid, dermatitis herpetiformis, senile pruritus etc.) Previous treatment with omalizumab within 3 months prior to screening. History of anaphylactic shock. Contacts and Locations Go (...) with Dupilumab has been shown to reduce clinically significant exacerbations and to improve skin symptom control as well as quality of life in moderate to severe atopic dermatitis patients and in moderate to severe asthma patients. It has been approval by EMA for the treatment of atopic dermatitis patients in September 2017. Dupilumab is a novel monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling and was previously found to be effective in atopic dermatitis and asthma

2018 Clinical Trials

200. Dupilumab in Chronic Spontaneous Urticaria

urticaria. Other diseases with symptoms of urticaria or angioedema, including urticarial vasculitis, erythema multiforme, cutaneous mastocytosis (urticaria pigmentosa), and hereditary or acquired angioedema (e.g., due to C1 inhibitor deficiency) Any other skin disease associated with chronic itching that might confound the study evaluations and results (e.g., atopic dermatitis, bullous pemphigoid, dermatitis herpetiformis, etc.) Previous exposure to omalizumab in last 3 months History of anaphylactic (...) : Placebo Phase 2 Detailed Description: Treatment with Dupilumab has been shown to reduce clinically significant exacerbations and to improve skin symptom control as well as quality of life in moderate to severe atopic dermatitis patients and in moderate to severe asthma patients. It has been approval by European Medicines Agency (EMA) for the treatment of atopic dermatitis patients in September 2017. Dupilumab is a novel monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13

2018 Clinical Trials

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