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Dermal Filler Injection

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161. An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles. Full Text available with Trip Pro

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles. The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and this makes them an ideal material for dermal filling purposes. Hollow PCL spheres were developed by the Council for Scientific and Industrial Research (CSIR) to serve both (...) migrate into the ported particles. In vivo studies were conducted in BALB/c mice into whom particles were introduced at the level of the hypodermis. Mice injected with PCL particles (ported and non-ported; with or without MEFs) showed evidence of local inflammation and increased adipogenesis at the site of injection, as well as a systemic inflammatory response. These effects were also observed in mice that received apparently inert (polystyrene) particles. Ported PCL particles can therefore act

2018 PLoS ONE

162. Safety and Persistence of Non-Animal Stabilized Hyaluronic Acid Fillers for Nasolabial Folds Correction in 30 Indian Patients Full Text available with Trip Pro

Safety and Persistence of Non-Animal Stabilized Hyaluronic Acid Fillers for Nasolabial Folds Correction in 30 Indian Patients Correction of nasolabial creases through minimally invasive procedures is increasingly being sought by patients. Injecting non-animal stabilized hyaluronic acid filler is a highly effective method to achieve an optimal and persistent cosmetic resultTo evaluate the efficacy, persistence and safety of Restylane and Perlane (Q-Med, Sweden) for correction of nasolabial folds (...) like erythema at puncture site, needle marks and bruising were seen.Restylane and Perlane are safe and effective dermal fillers for correction of nasolabial creases and offer immediate effect.

2010 Journal of cutaneous and aesthetic surgery

163. Buccal reaction to silicone cosmetic filler. (Abstract)

Buccal reaction to silicone cosmetic filler. Administering injections of dermal fillers has become a popular office procedure that is performed to restore facial volume, augment facial volume or both. Injectable silicone is a nonbiodegradable filler that was introduced 40 years ago. Adverse reactions can develop from its long-term presence in the body.The authors evaluated a 45-year-old woman who nine years previously had received bilateral silicone cosmetic filler injections in the malar (...) by a reaction to silicone. Differentiating it from facial cellulitis is essential. Practitioners should base their diagnoses of orofacial inflammatory swellings on patients' history of receiving injectable cosmetic filler.

2010 Journal of the American Dental Association

164. Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. (Abstract)

Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. Repeat treatments of nonpermanent dermal fillers are used in the long-term treatment of wrinkles and folds and to volumize. OBJECTIVE To determine the safety and effectiveness of a nonanimal-sourced hyaluronic acid (HA) (which uses a cohesive polydensified matrix (CPM) technology [CPMHA]) for the treatment of nasolabial folds (NLFs (...) a decrease from baseline on the Wrinkle Severity Rating Scale. The effects persisted in the majority (∼80%) of subjects without repeat treatment for at least one interval of 48 weeks. The study filler was well tolerated, with only one related AE (injection site bruising) reported. Little potential for immunogenic reactions was identified.This CPMHA is a well-tolerated and effective treatment for at least 48 weeks in the majority of subjects for the correction of moderate to severe NLFs with repeat

2010 Dermatologic Surgery Controlled trial quality: uncertain

165. Transverse Facial Artery Perforators: Anatomical, Two- and Three-Dimensional Radiographic Study. (Abstract)

artery perforators could be as follows: (1) performing a lateral facial skin flap; (2) facial composite allotransplants; (3) face-lift procedures to improve skin perfusion; and (4) prevention of vessel injury in aesthetic procedures such as dermal filler injection or thread-lift techniques. (...) and their perfusion area.Fourteen hemifaces of fresh adult cadavers from the Department of Anatomy of Lyon University were harvested. Transverse facial artery perforators were identified, dissected, cannulated, and selectively injected with 1 ml of patent blue or contrast solution. Photography, microangiography, and computed tomography were performed. Perforator diameter and localization from the lateral canthus were measured. Exact topography and size of the perforasome were analyzed.Twenty-three transverse

2019 Plastic and reconstructive surgery

166. The case of the eyelid silicone granulomas. (Abstract)

. The patient ultimately underwent a blepharoplasty for improvement of the swelling. Histopathology suggested silicone granulomas of the upper and lower eyelid. This case illustrates the importance of keeping foreign body granulomas on the differential for all patients with a history of facial dermal filler injections. Although hyaluronic acid is the most common dermal filler, providers should suspect the use of other dermal fillers including those not FDA approved particularly when common conservative (...) The case of the eyelid silicone granulomas. Foreign body granulomas can develop even several years after autologous fat or filler injection. In some instances the foreign body granulomas have been found at sites other than the original injection site. We present a case of a 48-year-old male with reported "hyaluronic acid fillers" injected into his upper and lower eyelids several years prior. He subsequently developed periorbital swelling with negative allergic and rheumatologic workup

2019 American Journal of Otolaryngology

167. Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound. Full Text available with Trip Pro

Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound. Injectable hyaluronic acid fillers have been widely applied in the clinical treatment of facial wrinkles. However, further information and clinical evidence concerning dermal changes and hyaluronic acid filler longevity after injection and diffusion pattern are limited.The authors evaluated the longevity and diffusion pattern of two hyaluronic acid fillers (...) generated by different cross-linking technologies used in the treatment of nasolabial folds using high-frequency ultrasound. Forty-one subjects were treated with Restylane 2 and the remaining 41 were treated with Dermalax DEEP. Wrinkle severity rating scale score and high-frequency ultrasound evaluation of nasolabial folds were performed before and after the injection of hyaluronic acid filler. The ultrasound images were acquired and analyzed to determine dermal thickness and the shape and distribution

2019 Plastic and reconstructive surgery

168. Cellulite: Patient Selection and Combination Treatments for Optimal Results-A Review and Our Experience. (Abstract)

a more algorithmic approach to comprehensively address a condition that affects so many women.A review of the literature surrounding treatment options for cellulite and the authors' experience in this area are provided.This review summarizes available treatment options for cellulite, including topical agents, controlled subcision, energy-based devices, dermal fillers, and new injectable medications. Furthermore, the various ways that these treatments can be combined in an algorithmic and sequential

2019 Dermatologic Surgery

169. Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement

light, radio frequency, dermabrasion, moderate or greater depth chemical peel, or other ablative procedures), tissue augmentation with dermal fillers or fat injections, or mesotherapy] anywhere in the face or neck, or BOTOX® Cosmetic injections in the lower face (below the orbital rim), within 6 months prior to entry in the study or be planning to undergo any of these procedures at any time during the study. Note: Prior treatment with Hyaluronic Acid fillers and/or collage is allowed, provided (...) Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2010 Clinical Trials

170. A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines

/treatment and/or had the procedure at least 6 months prior to entering the study A patient that has previously been treated with botulinum toxin in the perioral or lateral canthal areas within the past six months A patient that has previously been treated with dermal filler in the perioral or lateral canthal areas within the past year A patient that with a history of allergic reaction to a dermal filler or lidocaine A patient that with a history of a permanent filler to the perioral or lateral canthal (...) A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines - Full Text

2010 Clinical Trials

171. Comparison of Safety and Efficacy of a Metallic Cannula Versus a Standard Needle to Inject Hyaluronic Acid for Nasolabial Fold

investigator injected 1ml of dermal filler - hyaluronic acid (Restylane®, Q-Med, Uppsala, Sweden) - for each subject. The injected amount was 0,5ml for the right nasolabial fold and 0,5ml for the left nasolabial fold. The sides will be randomized. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 25 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Investigator) Primary (...) Purpose: Treatment Official Title: Double-blind, Randomized and Controlled Clinical Trial to Compare Safety and Efficacy of a Metallic Cannula vs a Standard Needle for the Injection of Hyaluronic Acid Gel Dermal Filler (Restylane®) to Treat Nasolabial Folds Study Start Date : July 2009 Actual Primary Completion Date : January 2010 Actual Study Completion Date : March 2010 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment

2010 Clinical Trials

172. Comparative Study of UMA Jeunesse Classic (Abstract)

Comparative Study of UMA Jeunesse Classic The emergence of hyaluronic acid dermal fillers with lidocaine has transformed the minimally invasive treatment of wrinkles, lines and folds of the face. Patients can be treated quickly, painlessly and without the need for large doses of lidocaine. Therefore, it is important to scientifically evaluate the merits of lidocaine-containing products over those without.The two products, with (UJU) and without lidocaine (UJ), were randomly injected (...) into nasolabial folds of 75 healthy volunteers with varying skin types in a split face study, age ranging 26-60 years. Only 73 subjects completed the follow-up. There were 68 females and 5 males with medium-to-deep nasolabial folds. All subjects were randomly injected with the two products on one or the other side of the face. Patients were followed up for 9 months.Both products achieved significant improvement in the wrinkle severity score. Overall results were slightly better with UJU due to ease

2018 Aesthetic plastic surgery Controlled trial quality: uncertain

173. PicoWayâ„¢ 730 Resolve Fusion for Benign Pigmented Lesions and Wrinkles

surgery, light, laser, ultrasound or radiofrequency treatments Willing to abstain from use of prescription cosmetic products for treatment of benign pigmented lesions or wrinkles in the laser treatment areas for the duration of the study including injections of neurotoxins or dermal fillers, skin lightening creams, and wrinkle creams Willingness to adhere to study treatment and follow-up visit schedules Exclusion Criteria Pregnant, planning pregnancy or breast feeding Allergy to topical or injectable (...) lidocaine or similar medications Allergy to topical steroid or similar medications Unprotected sun exposure in the six weeks prior to enrollment, or active tan in the laser treatment area History of melanoma in the intended treatment area History of keloid or hypertrophic scar formation Use of topical or systemic retinoid therapy during the past six (6) months Use of neurotoxins in the intended treatment area within the past three (3) months or throughout the duration of the study Use of dermal fillers

2018 Clinical Trials

174. Pilot Study to Evaluate the Safety and the Efficacy of the Modified Matrix Obtained by the AmeaCell® Device and Intended for the Filling of Wrinkles on the Face.

Estimated Study Completion Date : October 2019 Arms and Interventions Go to Arm Intervention/treatment Experimental: Modified matrix obtained by the AmeaCell® device Device: AmeaCell Lipoaspirate obtained from liposuction is treated by the AmeaCell® device in order to obtain de modified matrix which contains cellular phase and matrix phase. The modified matrix is injected in the same patient as facial wrinkles filler. Outcome Measures Go to Primary Outcome Measures : Incidence of the Adverse Event(s (...) procedure (laser, photo modulation, intense pulsed light, radio frequency, dermabrasion, chemical peel or other ablative procedures) within 12 months at least prior to enrolment or subject who is planning this type of procedure during the study Subject who has received semi-permanent dermal fillers or permanent facial implants or who is planning to do this type of implant during the study Subject having history of formation of hypertrophic scars or keloids Subject having a skin disease or skin

2018 Clinical Trials

175. A 52-week Clinical Investigation of Princess® VOLUME PLUS Lidocaine in Subjects With Midface Volume Deficit

Intervention/treatment Midface Volume Deficit Device: Dermal filler for midface deficit Detailed Description: This non-interventional study will evaluate subjects treated with Princess VOLUME PLUS Lidocaine for midface volume deficit augmentation. A touch-up treatment will be allowed, on discretion of the treating investigator, if the initial treatment didn't provide optimal correction. The effectiveness parameters will be evaluated based on a validated scale for midface volume deficit scale and confirmed (...) Study Start Date : March 28, 2018 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : June 2019 Resource links provided by the National Library of Medicine available for: Groups and Cohorts Go to Group/Cohort Intervention/treatment Dermal filler for midface deficit There will be one group in this study, the actual treatment group. Device: Dermal filler for midface deficit During this procedure the device (a dermal filler) will be deep intradermal, subcutaneous

2018 Clinical Trials

176. Use of AAM for Correction of Age Related Volume Deficits in the Face

within 6 months of study entry. A subject that is unwilling to forego cosmetic facial treatments for the duration of the study A subject that has received Sculptra in the treatment area A subject that has received dermal filler in the treatment area within 2 years prior to randomization A subject that has previously undergone mid-face cosmetic plastic surgery, tissue grafting, or tissue augmentation with silicone, semi-permanent fillers or fat A subject that has previously undergone laser resurfacing (...) by (Responsible Party): Musculoskeletal Transplant Foundation Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate Allograft Adipose Matrix (AAM) in the face of people with age-related volume deficit - fat loss. AAM is a tissue used to correct fat loss. Participation in this study requires injections for placing AAM in the bilateral pre-jowl and malar areas of the face. The research will tell whether AAM is effective in maintaining mid-face fullness and whether

2018 Clinical Trials

177. Late Presentation of Infected Silicone Granulomas in the Lower Limb Full Text available with Trip Pro

Late Presentation of Infected Silicone Granulomas in the Lower Limb Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation.Two cases presented with pain, oedema, and erythema at the site of previous silicone filler injection (...) , following a considerable delay after the last injection (range 4-7 years). We collected data on their biochemistry, haematology, histology, microbiology, and imaging at the time of presentation.Complications included prolonged cellulitis with recurrent abscesses at sites of previous silicone dermal filler injection. Histology revealed infiltration of chronic inflammatory cells suggestive of silicone granuloma in both cases. Patients were reluctant to divulge use of cosmetic fillers or failed

2018 Clinical medicine insights. Arthritis and musculoskeletal disorders

178. Cohesive Polydensified Matrix Hyaluronic Acid for the Treatment of Etched-In Fine Facial Lines: A 6-Month, Open-Label Clinical Trial. (Abstract)

areas showed clinically meaningful and statistically significant improvements in average clinician rating scale scores at all study visits (p < .001 vs baseline). Most subjects reported maintained improvement from baseline of 50% or more throughout the 26-week study. Injection site reactions were mild and resolved without intervention.Cohesive polydensified matrix hyaluronic acid dermal filler treatment was well tolerated and provided consistent and durable improvement in the appearance of a diverse (...) Cohesive Polydensified Matrix Hyaluronic Acid for the Treatment of Etched-In Fine Facial Lines: A 6-Month, Open-Label Clinical Trial. Available hyaluronic acid dermal fillers have unique biophysical properties that influence their clinical utility, longevity, and aesthetic outcomes.To evaluate the effectiveness and durability of a cohesive polydensified matrix hyaluronic acid dermal filler (CPM-HA) for the treatment of etched-in fine facial lines.Subjects with etched-in fine lines

2018 Dermatologic Surgery

179. Role of Nonsurgical Chin Augmentation in Full Face Rejuvenation: A Review and Our Experience. (Abstract)

Role of Nonsurgical Chin Augmentation in Full Face Rejuvenation: A Review and Our Experience. The chin is a critical component to the perception of facial attractiveness. Dermal fillers offer a nonsurgical, temporary method of correcting mild to moderate chin retrusion and resorption. Thus far, discussion of this procedure has been largely limited to the plastic surgery and otolaryngology literature.To review pertinent aspects of anatomy, patient evaluation, injection technique, concomitant (...) therapies, and complications in chin augmentation using injectable fillers.A brief review of the literature surrounding chin augmentation using injectable fillers, as well as the authors' experience in this area, is provided.Chin augmentation using injectable fillers can be performed effectively and safely with adequate background knowledge of the regional anatomy and appropriate patient selection. The authors discuss both injection techniques in the published literature and their own approach

2018 Dermatologic Surgery

180. Safety and Effectiveness of THIODERM STRONG in the Correction of Nasolabial Folds

in the Correction of Nasolabial Folds. Actual Study Start Date : July 10, 2018 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : March 2020 Arms and Interventions Go to Arm Intervention/treatment Experimental: THIODERM STRONG THIODERM STRONG injected into the upper arm (cohort 1) THIODERM STRONG injected into nasolabial folds (cohort 2) Device: THIODERM STRONG Soft tissue filler containing crosslinked hyaluronic acid and Na-hyaluronate, supplemented with lidocaine hydrochloride (...) is longer Any dependency of the subject to the investigator or investigation site, or subjects who are employees or relatives of the investigator Subjects whose participation in clinical investigations is prohibited by the Austrian Medical Devices Act Facial plastic surgery, tissue augmentation with silicone, fat or another non-absorbable substance in the area of device application (cohort 2) Implantation of facial dermal fillers in the treatment area in the preceding 12 months (cohort 2) Skin

2018 Clinical Trials

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