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Dermal Filler Injection

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161. Safety and Persistence of Non-Animal Stabilized Hyaluronic Acid Fillers for Nasolabial Folds Correction in 30 Indian Patients (PubMed)

Safety and Persistence of Non-Animal Stabilized Hyaluronic Acid Fillers for Nasolabial Folds Correction in 30 Indian Patients Correction of nasolabial creases through minimally invasive procedures is increasingly being sought by patients. Injecting non-animal stabilized hyaluronic acid filler is a highly effective method to achieve an optimal and persistent cosmetic resultTo evaluate the efficacy, persistence and safety of Restylane and Perlane (Q-Med, Sweden) for correction of nasolabial folds (...) like erythema at puncture site, needle marks and bruising were seen.Restylane and Perlane are safe and effective dermal fillers for correction of nasolabial creases and offer immediate effect.

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2010 Journal of cutaneous and aesthetic surgery

162. Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. (PubMed)

Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. Repeat treatments of nonpermanent dermal fillers are used in the long-term treatment of wrinkles and folds and to volumize. OBJECTIVE To determine the safety and effectiveness of a nonanimal-sourced hyaluronic acid (HA) (which uses a cohesive polydensified matrix (CPM) technology [CPMHA]) for the treatment of nasolabial folds (NLFs (...) a decrease from baseline on the Wrinkle Severity Rating Scale. The effects persisted in the majority (∼80%) of subjects without repeat treatment for at least one interval of 48 weeks. The study filler was well tolerated, with only one related AE (injection site bruising) reported. Little potential for immunogenic reactions was identified.This CPMHA is a well-tolerated and effective treatment for at least 48 weeks in the majority of subjects for the correction of moderate to severe NLFs with repeat

2010 Dermatologic Surgery

163. Buccal reaction to silicone cosmetic filler. (PubMed)

Buccal reaction to silicone cosmetic filler. Administering injections of dermal fillers has become a popular office procedure that is performed to restore facial volume, augment facial volume or both. Injectable silicone is a nonbiodegradable filler that was introduced 40 years ago. Adverse reactions can develop from its long-term presence in the body.The authors evaluated a 45-year-old woman who nine years previously had received bilateral silicone cosmetic filler injections in the malar (...) by a reaction to silicone. Differentiating it from facial cellulitis is essential. Practitioners should base their diagnoses of orofacial inflammatory swellings on patients' history of receiving injectable cosmetic filler.

2010 Journal of the American Dental Association

164. A Phase IIa Open-Label Dose-Escalation Pilot Study Using Allogeneic Human Dermal Fibroblasts for Nasolabial Folds. (PubMed)

A Phase IIa Open-Label Dose-Escalation Pilot Study Using Allogeneic Human Dermal Fibroblasts for Nasolabial Folds. The correction of soft tissue contour defects and dermal atrophy is a growing area driven by medical and aesthetic need. Deterioration of the skin's appearance occurs as a result of age and trauma, such as surgery, infections, and acne. Typically, imperfections are treated with volume-correcting fillers. This study evaluated allogeneic human dermal fibroblasts (HDFs (...) ) for the treatment of nasolabial folds as an alternative strategy to improve the structure, texture, and quality of the skin.In this phase IIa study, a suspension of allogeneic HDF (2 × 10(6) cells/mL or 2 × 10(7) cells/mL) was injected intradermally along the nasolabial fold; line severity was assessed using a photographic scale.Mean investigator satisfaction was 7.4 (range 4.7-9.5) at 12 weeks and 7.6 (range 4.4-9.8) at 24 weeks. Subject satisfaction scores were 7.0 (range 0.1-10.0) at 12 weeks and 7.8 (range

2010 Dermatologic Surgery

165. Safety of nonanimal stabilized hyaluronic acid dermal fillers in patients with skin of color: a randomized, evaluator-blinded comparative trial. (PubMed)

, NASHA dermal fillers are safe for the correction of moderate to severe facial folds and wrinkles, with no immunogenicity or keloid formation and only mild to moderate AEs occurring around the injection site. (...) Safety of nonanimal stabilized hyaluronic acid dermal fillers in patients with skin of color: a randomized, evaluator-blinded comparative trial. Nonanimal stabilized hyaluronic acid (NASHA) dermal fillers have been used in the United States since 2003 for the treatment of moderate to severe facial wrinkles and folds, such as nasolabial folds. Previous trials with NASHA dermal fillers have included small numbers of patients with pigmented skin.This randomized, evaluator-blinded, split-face trial

2009 Dermatologic Surgery

166. A systematic review of permanent and semipermanent dermal fillers for HIV-associated facial lipoatrophy. (PubMed)

A systematic review of permanent and semipermanent dermal fillers for HIV-associated facial lipoatrophy. The objective of this study was to assess the safety and efficacy of injectable semipermanent and permanent dermal fillers, compared to other facial augmentation techniques, for the management of facial lipoatrophy as a result of highly active antiretroviral therapy (HAART) for HIV infection through a systematic review of the literature. A systematic search strategy was used to retrieve (...) relevant studies. Inclusion of articles was by the application of a predetermined protocol, independent assessment by two reviewers, and a final consensus decision. One randomized controlled trial (RCT), one pseudo-RCT, two nonrandomized comparative studies, and seven case series were included for review. Injections with permanent and semipermanent dermal fillers improved subjective ratings of appearance and resulted in high patient satisfaction. Although short-term safety appeared favorable

2009 AIDS patient care and STDs

167. Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

Filler, Belotero®, After Mid-to-Deep Dermal Implantation for Correction of Moderate to Severe Facial Wrinkles Study Start Date : December 2006 Actual Primary Completion Date : July 2007 Actual Study Completion Date : December 2008 Arms and Interventions Go to Arm Intervention/treatment Experimental: Belotero Device: Belotero Belotero, injectable hyaluronic acid gel device, implanted into the nasolabial fold in the Treatment Phase of the study (multiple injections of 0.1 to 0.2 mL, up to a maximum (...) Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®. Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2009 Clinical Trials

168. Evaluation of Radiesse® Dermal Filler for Hand Rejuvenation

): Merz North America, Inc. Study Details Study Description Go to Brief Summary: The purpose of this study is to assess the safety and effectiveness of Radiesse® Injectable Dermal Filler for hand treatment. Condition or disease Intervention/treatment Phase Aging Hands Device: Radiesse Injectable Dermal Filler Not Applicable Detailed Description: This is a prospective, randomized, masked, controlled study to investigate the effectiveness of Radiesse® Dermal Filler for hand treatment (...) and Interventions Go to Arm Intervention/treatment Experimental: Radiesse Injectable Dermal Filler Device: Radiesse Injectable Dermal Filler Device: Radiesse Injectable Dermal Filler Calcium hydroxylapatite particles suspended in an aqueous-based gel carrier Active Comparator: Delayed Treatment Cross over to treatment with Radiesse Injectable Dermal Filler at 3 Months Device: Radiesse Injectable Dermal Filler Calcium hydroxylapatite particles suspended in an aqueous-based gel carrier Outcome Measures Go

2009 Clinical Trials

169. Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft

into the opposite side of the face that Belotero® Soft was administered for facial wrinkles, such as nasolabial folds. Device: Belotero Soft Dermal Filler Active Comparator: CosmoDerm1 Device: CosmoDerm1 CosmoDerm1 is a single use syringe, injected into the mid dermal layer. Outcome Measures Go to Primary Outcome Measures : The severity of the facial wrinkle [ Time Frame: 2 weeks and 4 weeks ] Secondary Outcome Measures : Investigator and subject assessments [ Time Frame: 2 weeks and 4 weeks ] Eligibility (...) Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2009 Clinical Trials

170. EVOLENCE® Assessment of Recovery Time and Impact of Dermal Filler Selection: The E-ART™ Study

Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: EVOLENCE® Assessment of Recovery Time and Impact of Dermal Filler Selection: The E-ART™ Study Study Start Date : January 2008 Actual Primary Completion Date : June 2008 Actual Study Completion Date : August 2008 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: aging Device: collagen (EVOLENCE) injectable collagen Other Name (...) EVOLENCE® Assessment of Recovery Time and Impact of Dermal Filler Selection: The E-ARTâ„¢ Study EVOLENCE® Assessment of Recovery Time and Impact of Dermal Filler Selection: The E-ART™ Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2009 Clinical Trials

171. Treatment of injectable soft tissue filler complications. (PubMed)

Treatment of injectable soft tissue filler complications. Increasing use of dermal fillers, especially with the U.S. introduction of long-term and permanent fillers, is expected to increase the number of complications seen after treatment with these materials.To provide physicians with an overview for treatment of dermal filler complications.Complications of dermal filler use can be treated successfully based on a firm understanding of the mechanisms and limitations of filler action and wound (...) healing. Complications can be classified as immediate, early, or delayed onset; available treatment options are presented.Short- and long-term dermal fillers are increasingly becoming popular treatment options for signs of facial aging. Complications, although not common, can be treated effectively and excellent outcomes achieved.

2009 Dermatologic Surgery

173. A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines

/treatment and/or had the procedure at least 6 months prior to entering the study A patient that has previously been treated with botulinum toxin in the perioral or lateral canthal areas within the past six months A patient that has previously been treated with dermal filler in the perioral or lateral canthal areas within the past year A patient that with a history of allergic reaction to a dermal filler or lidocaine A patient that with a history of a permanent filler to the perioral or lateral canthal (...) A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines A Clinical Study Evaluaing the Efficacy, Safety, and Patient Satisfaction of Injectable Hylaronic Acid With 0.3% Lidocain Hydrochloride, Prevelle Silk, for Superficial, Vertical Perioral Lines and Superficial, Horizontal, Lateral Canthal Lines - Full Text

2010 Clinical Trials

174. Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement

light, radio frequency, dermabrasion, moderate or greater depth chemical peel, or other ablative procedures), tissue augmentation with dermal fillers or fat injections, or mesotherapy] anywhere in the face or neck, or BOTOX® Cosmetic injections in the lower face (below the orbital rim), within 6 months prior to entry in the study or be planning to undergo any of these procedures at any time during the study. Note: Prior treatment with Hyaluronic Acid fillers and/or collage is allowed, provided (...) Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2010 Clinical Trials

175. Comparison of Safety and Efficacy of a Metallic Cannula Versus a Standard Needle to Inject Hyaluronic Acid for Nasolabial Fold

investigator injected 1ml of dermal filler - hyaluronic acid (Restylane®, Q-Med, Uppsala, Sweden) - for each subject. The injected amount was 0,5ml for the right nasolabial fold and 0,5ml for the left nasolabial fold. The sides will be randomized. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 25 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Investigator) Primary (...) Purpose: Treatment Official Title: Double-blind, Randomized and Controlled Clinical Trial to Compare Safety and Efficacy of a Metallic Cannula vs a Standard Needle for the Injection of Hyaluronic Acid Gel Dermal Filler (Restylane®) to Treat Nasolabial Folds Study Start Date : July 2009 Actual Primary Completion Date : January 2010 Actual Study Completion Date : March 2010 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment

2010 Clinical Trials

176. Clinical indications, image acquisition and data interpretation for white blood cells and anti-granulocyte monoclonal antibody scintigraphy

activity) thus avoiding any operator bias [1]. This method alsoallows to correctly detect a true increase of uptakeinsuspectedregionsovertime,animportantcriteriaof positivity for bone infections and for most soft tissue infec- tions.Themethodhasbeenrecentlyvalidatedinamulticentre European study [69, 70] as being highly accurate for osteo- myelitis,prostheticjointinfections,diabeticfootosteomyelitis and some soft tissue infections (such as dermal filler infec- tions, endocarditis, abscesses, brain (...) devices for WBC labelling (Leukokit® and WBC Marker kit®) [9], functioning as disposable mini-isola- tors, has enormously facilitated the labelling procedure that, however, remains time consuming and requires with- drawing 30–40 ml of blood from patient. Once injected i.v. in the patient, radiolabelled WBC migrate rapidly to the lungs and, if not damaged, proceed to liver, spleen and the reticulo-endothelial system, including bone marrow. Approximately 1 h after injection, labeled cells further

2018 European Association of Nuclear Medicine

177. Needle and syringe programmes

to their use in the general population through needle and syringe programmes seeking information after clients reported injecting these types of drugs (Evans-Brown et al. 2009). It is not known how many people in the United Kingdom use drugs such as botulinum toxin or dermal fillers to reduce the appearance of wrinkles and lines but a number of factors suggest that Needle and syringe programmes (PH52) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms (...) Recommendation 1 Consult with and involve users, practitioners and the local community 8 Recommendation 2 Collate and analyse data on injecting drug use 9 Recommendation 3 Commission both generic and targeted services to meet local need 10 Recommendation 4 Monitor services 11 Recommendation 5 Develop a policy for young people who inject drugs 11 Recommendation 6 Provide a mix of services 13 Recommendation 7 Provide people with the right type of equipment and advice 14 Recommendation 8 Provide community

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

178. Guidelines for the use of local anesthesia in office-based dermatologic surgery

-based procedures, such as skin biopsy, small excisions, and filler and botulinum toxin injections The use of topical anesthetic agents is recommended to lessen the pain of injection and reduce the dose of infiltration anesthesia needed for larger procedures Topical lidocaine is safe for use on pregnant or nursing women, but there is insufficient evidence to recommend use of other topical anesthetics Elective procedures and those not of urgent medical necessity requiring topical lidocaine in pregnant (...) . and Alster, T.S. The S-Caine peel: a novel topical anesthetic for cutaneous laser surgery. Dermatol Surg . 2002 ; 28 : 999–1003 | | | , x 14 Kilmer, S.L., Chotzen, V., Zelickson, B.D. et al. Full-face laser resurfacing using a supplemented topical anesthesia protocol. Arch Dermatol . 2003 ; 139 : 1279–1283 | | | In the opinion of the expert panel, topical anesthesia is also helpful to enhance patient comfort during injections of subcutaneous filler and botulinum toxin. In cases where infiltration

2016 American Academy of Dermatology

179. The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz? (PubMed)

The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz? Lip augmentation procedures have increased drastically in the last years as patients seek to enhance the shape and size of their lips with dermal fillers. One of the main concerns faced with these procedures is the pain inflicted through injections. On the other hand, many different techniques have been introduced for the reduction of pain while performing office-based minimal invasive (...) procedures.This study aims to determine the analgesic effect of vibration anesthesia during lip augmentation procedures and to evaluate its overall effect on the comfort of patients.A split-lip study was designed in a randomized fashion for 25 lip augmentation patients who received hyaluronic acid fillers with or without with a concurrent vibration stimulus on either half of their lips. Patients were asked to score the pain that they felt during lip injections on a scale from 0 to 10 (0 being no pain and 10

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2018 Aesthetic surgery journal

180. An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles. (PubMed)

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles. The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and this makes them an ideal material for dermal filling purposes. Hollow PCL spheres were developed by the Council for Scientific and Industrial Research (CSIR) to serve both (...) migrate into the ported particles. In vivo studies were conducted in BALB/c mice into whom particles were introduced at the level of the hypodermis. Mice injected with PCL particles (ported and non-ported; with or without MEFs) showed evidence of local inflammation and increased adipogenesis at the site of injection, as well as a systemic inflammatory response. These effects were also observed in mice that received apparently inert (polystyrene) particles. Ported PCL particles can therefore act

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2018 PLoS ONE

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