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Dermal Filler Injection

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141. Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area

the presence of any clinically significant bleeding disorder. Any medical condition (e.g., respiratory, cardiovascular, hepatic, neurological disease, or thyroid dysfunction) that would interfere with assessment of safety or efficacy or compromise the subject's ability to undergo study procedures or give informed consent. Treatment with radio frequency, laser procedures, chemical peels, or dermal fillers in the neck or chin area within 12 months before randomization. Treatment with botulinum toxin (...) Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2012 Clinical Trials

142. Use Of Three Commercial Preparations Of Injectable Hyaluronic Acid In Hands Rejuvenation

Drug: Emervel® Volume Lidocaine and Emervel® Deep Lidocaine Phase 4 Detailed Description: This is a single center, phase IV, randomized, investigator-blind study of three different hyaluronic dermal filler injections for volume enhancing in the dorsum of the hands. As an investigator-blind study, only the investigators are unaware of which dermal fillers were injected in the dorsum of each hand. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial (...) for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Subjects agreeing to take part of all procedures of the study (including pre-test, filler injection, photographs, etc.), after being fully informed on the objectives and nature of the investigations; Written Informed Consent; Treatment-naive patients for fillers in hands; Subjects of both genders over 18 years; Fitzpatrick skin phototypes I to VI; Subjects presenting a similar loss of fatty tissue on both hands, at least of 2

2012 Clinical Trials

143. Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo. Full Text available with Trip Pro

binding and mechanical forces, resulting in fibroblast shrinkage and reduced function, including collagen production. Here, we report that these age-related alterations are largely reversed by enhancing the structural support of the ECM. Injection of dermal filler, cross-linked hyaluronic acid, into the skin of individuals over 70 years of age stimulates fibroblasts to produce type I collagen. This stimulation is associated with localized increase in mechanical forces, indicated by fibroblast (...) elongation/spreading, and mediated by upregulation of type II TGF-β receptor and connective tissue growth factor. Interestingly, enhanced mechanical support of the ECM also stimulates fibroblast proliferation, expands vasculature, and increases epidermal thickness. Consistent with our observations in human skin, injection of filler into dermal equivalent cultures causes elongation of fibroblasts, coupled with type I collagen synthesis, which is dependent on the TGF-β signaling pathway. Thus, fibroblasts

2012 Journal of Investigative Dermatology

144. The use of a contact cooling device to reduce pain and ecchymosis associated with dermal filler injections. Full Text available with Trip Pro

The use of a contact cooling device to reduce pain and ecchymosis associated with dermal filler injections. Objectives. Consensus guidelines developed for the use of hyaluronic acid dermal fillers describe the use of cooling the skin to reduce patient discomfort during injection. The vasoconstrictive effects of cold may provide reduced ecchymosis and swelling at the site. However, the effect of applying ice or cooled air is unpredictable because these modalities do not deliver precise (...) injection, one hour, three hours, and next-day postinjection. Conclusion. The cooling system provided adequate pain management (both subjectively and objectively through blinded evaluations) during and after small gel particle hyaluronic acid dermal filler injections for the correction of moderate nasolabial folds. Furthermore, results demonstrate that the cooling system is associated with decreased ecchymosis. Future studies are needed comparing the use of topical anesthetics to a cooling system

2010 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

145. Characterization of physical properties and histologic evaluation of injectable Dermicol-p35 porcine-collagen dermal filler. (Abstract)

Characterization of physical properties and histologic evaluation of injectable Dermicol-p35 porcine-collagen dermal filler. Injectable dermal fillers have become important alternatives to traditional surgical procedures for the correction of facial wrinkles and restoration of facial volume. The physical properties of a dermal filler/volumizing agent, and the host tissue response to the agent, influence its clinical performance and patient outcomes.In this study, several key physical properties (...) of the new porcine collagen dermal filler Dermicol-P35 27G were measured and compared with those of commercially available hyaluronic acid-based dermal fillers. Furthermore, the in vivo properties of implanted Dermicol-P35 27G were evaluated by histologic and histopathologic methods.This study found that Dermicol-P35 27G provides a lower extrusion force profile and yield point compared with the hyaluronic acid-based dermal fillers tested. At 2 years, staining of punch biopsy specimens with hematoxylin

2010 Plastic and reconstructive surgery

146. Efficacy and durability of two hyaluronic acid-based fillers in the correction of nasolabial folds: results of a prospective, randomized, double-blind, actively controlled clinical pilot study. Full Text available with Trip Pro

Efficacy and durability of two hyaluronic acid-based fillers in the correction of nasolabial folds: results of a prospective, randomized, double-blind, actively controlled clinical pilot study. This pilot study compared a monophasic hyaluronic acid dermal filler with a biphasic filler for the correction of nasolabial folds.Participant- and assessor-blinded, randomized clinical trial involving participants with moderate to severe nasolabial folds. Split-face design comparing a monophase (...) hyaluronic acid (HA) filler (mono-HA) with a biphasic HA filler (bi-HA). Injection with touch-up after 1 month. Wrinkle improvement was measured before and after injection and after 1, 2, 4, and 7 months, using the Wrinkle Severity Rating Scale and the Global Aesthetic Improvement Scale as outcome criteria. An optional treatment was offered at the end of the study, with participants allowed to choose one of the products.Evaluation of efficacy and safety of both products.Both products showed immediate

2011 Dermatologic Surgery Controlled trial quality: uncertain

147. Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

, or thyroid dysfunction) that would interfere with assessment of safety or efficacy or compromise the subject's ability to undergo study procedures or provide informed consent. Treatment with radio frequency, laser procedures, chemical peels, or dermal fillers in the neck or chin area within 12 months before randomization, or botulinum toxin injections in the neck or chin area within 6 months before randomization. History of sensitivity to any components of the study material or to topical or local (...) Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2011 Clinical Trials

148. A Study to Assess Injection Comfort of Two Formulations of ATX-101

area, including but not limited to creams or ointments used to treat dermatologic conditions (e.g., steroids, capsaicin, retinoids, fluorouracil) within 7 days prior to Baseline. Treatment with radio frequency, laser procedures, chemical peel, or dermal fillers in the neck or chin area within 12 months before dosing or botulinum toxin injections within 6 months prior to Baseline. Previous enrollment into this trial or treatment with ATX-101 or agents containing deoxycholate. Treatment (...) A Study to Assess Injection Comfort of Two Formulations of ATX-101 A Study to Assess Injection Comfort of Two Formulations of ATX-101 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Assess

2011 Clinical Trials

149. Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

, or thyroid dysfunction) that would interfere with assessment of safety or efficacy or compromise the subject's ability to undergo study procedures or provide informed consent. Treatment with radio frequency, laser procedures, chemical peels, or dermal fillers in the neck or chin area within 12 months before randomization, or botulinum toxin injections in the neck or chin area within 6 months before randomization. History of sensitivity to any components of the study material or to topical or local (...) Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2011 Clinical Trials

150. Novel hyaluronic acid dermal filler: dermal gel extra physical properties and clinical outcomes. Full Text available with Trip Pro

injection pain (p<.001) with DGE treatment. Most adverse events were mild to moderate skin reactions.DGE is a firm HA gel that required significantly less volume and fewer touch-ups to provide equivalent efficacy to NASHA for NLF correction; both dermal gels were well tolerated. DGE will provide a comfortable and cost-effective dermal filler option for clinicians and patients.© 2010 by the American Society for Dermatologic Surgery, Inc. (...) Novel hyaluronic acid dermal filler: dermal gel extra physical properties and clinical outcomes. Dermal gel extra (DGE) is a new, tightly cross-linked hyaluronic acid (HA)-based dermal filler containing lidocaine engineered to resist gel deformation and degradation.To develop a firmer gel product (DGE) and compare the efficacy and safety of DGE with nonanimal stabilized HA (NASHA) for correction of nasolabial folds (NLFs).DGE physical properties were characterized, and 140 subjects

2010 Dermatologic Surgery Controlled trial quality: uncertain

151. Injectable Filler for Cheek Flattening

Injectable Filler for Cheek Flattening Injectable Filler for Cheek Flattening - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Injectable Filler for Cheek Flattening The safety and scientific validity (...) who have had prior exposure to any calcium hydroxylapatite, or any other filler, injection for any purpose in the 12 months preceding study enrollment through the duration of the study (excluding study drug). Subjects who have had a prior cosmetic procedure to improve malar eminence deficiency (i.e., rhytidectomy, lower eyelid surgery, cheek implants, CO2/erbium laser resurfacing, Thermage/Thermacool radiofrequency treatment) or who have visible scars that may affect evaluation of response

2010 Clinical Trials

152. Global Management of Facial Rejuvenation With a New Range of Hyaluronic Acid Dermal Fillers

: The range of fillers tested in this study includes 5 different hyaluronic acid dermal fillers: Emervel Touch, Emervel Classic, Emervel Deep, Emervel Volume and Emervel Lips. The study will last 6 month. Injections will be performed at baseline. If necessary, the investigator will perform touch-up injections at the following visit (3 weeks later). Investigator and subject satisfaction will be collected through questionnaires. Study Design Go to Layout table for study information Study Type (...) for: Arms and Interventions Go to Arm Intervention/treatment Experimental: hyaluronic acid Device: hyaluronic acid dermal fillers 1 injection per indication and 1 touch-up injection if necessary Other Name: Facial wrinkles Outcome Measures Go to Primary Outcome Measures : Full Face Global Aesthetic Improvement [ Time Frame: 3 weeks after last injection ] Global aesthetic improvement scale score from baseline: -1: worse 0: no change improved much improved very much improved Full Face Global Aesthetic

2010 Clinical Trials

153. Dermal Fillers Patient Satisfaction

. Condition or disease Loss of Facial Fat Detailed Description: The first part of this study will involve a retrospective review of patients who have had a dermal filler injection between 01/01/1998 through 12/31/2008 and then following up with one (1) patient satisfaction survey. The first part of the study, which is retrospective, may involve approximately 500 subjects. The data collected from the retrospective review will be the subject's name, medical record number, and address for contact information (...) . Any other data collected will come from the answers on the questionnaire. The second part of this study will be a prospective study involving 100 subjects who are scheduled to have a dermal filler injection. These subjects will be asked to complete one (1) patient satisfaction survey two weeks after injection. Facial photos will be taken before the injection and then two weeks after injection at the follow up visit. This will complete the subject's participation in this study. Study Design Go

2010 Clinical Trials

154. Update on botulinum toxin and dermal fillers. Full Text available with Trip Pro

Update on botulinum toxin and dermal fillers. The art and science of facial rejuvenation is an ever-evolving field of medicine, as evidenced by the continual development of new surgical and nonsurgical treatment modalities. Over the past 10 years, the use of botulinum toxin and dermal fillers for aesthetic purposes has risen sharply. Herein, we discuss properties of several commonly used injectable products and provide basic instruction for their use toward the goal of achieving facial (...) rejuvenation.The demand for nonsurgical injection-based facial rejuvenation products has risen enormously in recent years. Used independently or concurrently, botulinum toxin and dermal filler agents offer an affordable, minimally invasive approach to facial rejuvenation.Botulinum toxin and dermal fillers can be used to diminish facial rhytides, restore facial volume, and sculpt facial contours, thereby achieving an aesthetically pleasing, youthful facial appearance.

2010 Current Opinion in Ophthalmology

156. Clinical indications, image acquisition and data interpretation for white blood cells and anti-granulocyte monoclonal antibody scintigraphy

activity) thus avoiding any operator bias [1]. This method alsoallows to correctly detect a true increase of uptakeinsuspectedregionsovertime,animportantcriteriaof positivity for bone infections and for most soft tissue infec- tions.Themethodhasbeenrecentlyvalidatedinamulticentre European study [69, 70] as being highly accurate for osteo- myelitis,prostheticjointinfections,diabeticfootosteomyelitis and some soft tissue infections (such as dermal filler infec- tions, endocarditis, abscesses, brain (...) devices for WBC labelling (Leukokit® and WBC Marker kit®) [9], functioning as disposable mini-isola- tors, has enormously facilitated the labelling procedure that, however, remains time consuming and requires with- drawing 30–40 ml of blood from patient. Once injected i.v. in the patient, radiolabelled WBC migrate rapidly to the lungs and, if not damaged, proceed to liver, spleen and the reticulo-endothelial system, including bone marrow. Approximately 1 h after injection, labeled cells further

2018 European Association of Nuclear Medicine

158. Needle and syringe programmes

to their use in the general population through needle and syringe programmes seeking information after clients reported injecting these types of drugs (Evans-Brown et al. 2009). It is not known how many people in the United Kingdom use drugs such as botulinum toxin or dermal fillers to reduce the appearance of wrinkles and lines but a number of factors suggest that Needle and syringe programmes (PH52) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms (...) Recommendation 1 Consult with and involve users, practitioners and the local community 8 Recommendation 2 Collate and analyse data on injecting drug use 9 Recommendation 3 Commission both generic and targeted services to meet local need 10 Recommendation 4 Monitor services 11 Recommendation 5 Develop a policy for young people who inject drugs 11 Recommendation 6 Provide a mix of services 13 Recommendation 7 Provide people with the right type of equipment and advice 14 Recommendation 8 Provide community

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

159. Resources for earthquakes

conducted and reported randomised trials that compare nerve blocks with systemic analgesia are required to confirm this result. Fractures (breaks) of the thigh bone can be very painful. Often children arriving at hospital emergency departments are moved several times during their assessments and therefore prompt pain relief is essential. This review investigated whether a nerve block, involving the injection of a freezing/numbing medication (FICB) at the top of the thigh, would provide more effective (...) substitutes. This review aimed to assess the effects (benefits and harms) of different surgical interventions, and the use of bone void fillers, for treating tibial plateau fractures. There is insufficient evidence on the effectiveness of surgical versus conservative treatments for acute middle third clavicle fractures. Treatment options must be chosen on an individual patient basis, after careful consideration of the relative benefits and harms of each intervention and of patient preferences

2016 Evidence Aid

160. The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz? Full Text available with Trip Pro

The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz? Lip augmentation procedures have increased drastically in the last years as patients seek to enhance the shape and size of their lips with dermal fillers. One of the main concerns faced with these procedures is the pain inflicted through injections. On the other hand, many different techniques have been introduced for the reduction of pain while performing office-based minimal invasive (...) procedures.This study aims to determine the analgesic effect of vibration anesthesia during lip augmentation procedures and to evaluate its overall effect on the comfort of patients.A split-lip study was designed in a randomized fashion for 25 lip augmentation patients who received hyaluronic acid fillers with or without with a concurrent vibration stimulus on either half of their lips. Patients were asked to score the pain that they felt during lip injections on a scale from 0 to 10 (0 being no pain and 10

2018 Aesthetic surgery journal Controlled trial quality: uncertain

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