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Dermal Filler Injection

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101. Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection

. ClinicalTrials.gov Identifier: NCT03738007 Recruitment Status : Completed First Posted : November 12, 2018 Last Update Posted : November 26, 2018 Sponsor: LG Life Sciences Information provided by (Responsible Party): LG Life Sciences Study Details Study Description Go to Brief Summary: This study was purposed to evaluate the non-inferiority of YVOIRE volume, a hyaluronic acid product, in terms of correction of wrinkles and safety in nasolabial fold deep-dermal injection, compared to Perlane, the control (...) Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2018 Clinical Trials

102. Study of the Safety and Effectiveness of JUVÉDERM VOLUX™ XC Injectable Gel for Restoring Jawline Definition

been obtained Exclusion Criteria: Has ever received permanent facial implants (eg, polymethylmethacrylate, silicone, polytetrafluoroethylene) anywhere in the face or neck, or is planning to be implanted with any of these products during the study Has ever undergone fat injections in the malar, chin or jawline area or is planning to undergo this procedure during the study Has undergone semipermanent dermal filler treatment (eg, calcium hydroxyapatite, poly-L-lactic acid) below the subnasale within (...) Study of the Safety and Effectiveness of JUVÉDERM VOLUXâ„¢ XC Injectable Gel for Restoring Jawline Definition Study of the Safety and Effectiveness of JUVÉDERM VOLUX™ XC Injectable Gel for Restoring Jawline Definition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

103. Long-term 24-month Follow-up Study on Safety and Maintenance of Efficacy of ATX-101 (Sodium Deoxycholate Injection)

with systemic corticosteroids, liposuction, surgery or other lipolytic treatment in the submental area, treatment with radio frequency, laser procedures, chemical peels, dermal fillers in the neck or chin area or botulinum toxin injections in the neck or chin area) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Long-term 24-month Follow-up Study on Safety and Maintenance of Efficacy of ATX-101 (Sodium Deoxycholate Injection) Long-term 24-month Follow-up Study on Safety and Maintenance of Efficacy of ATX-101 (Sodium Deoxycholate Injection) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

104. Anatomy of the Superficial Venous Structures of the Neck: A Cadaveric Study to Guide Superficial Injections. (PubMed)

anatomical landmarks and to determine dangerous areas for dermal filler injections into the neck.Thirty sides of the neck from Korean adult cadavers were dissected for this study.Four anatomical variants were identified. In Type Ia, the CV ran along the anterior border of the sternocleidomastoid muscle (SCM) (33.4%); in Type Ib, a single vein was observed connecting the CV and the EJV at the level of laryngeal prominence (23.3%); in Type Ic, the CV proceeded separately from the medial side (...) of the anterior border of the SCM (13.3%); and in Type II, the CV was absent while the EJV and AJV were observed (30%).Given the 4 anatomical variants identified in this study, the authors recommend exerting caution when performing dermal filler injections approximately 10, 30, and 60 mm lateral to the midsagittal line to avoid iatrogenic side effects.

2018 Dermatologic Surgery

105. A Study to Assess the Efficacy of Skin Rejuvenation Therapy in Combination With Neurotoxin and Full Facial Filler Treatments

or any aesthetic procedure (e.g. neurotoxins, dermal fillers, laser treatments, and chemical peels), which are not specified in this protocol, during the course of the study; A known allergy or sensitivity to any component of the study ingredients; Use of systemic steroids or anticoagulation medications; Subjects with a history of bleeding disorders; Subjects with severe allergies manifested by a history of anaphylaxis or presence of multiple severe allergies; Subjects with hypersensitivity (...) to botulinum neurotoxin; Subject with allergies to gram positive bacterial proteins; Sensitivity to sulfides; Subjects with allergy to cow's milk protein; Subjects with previous history of sensitivity to amide type local anesthetics; Subject with surgical alterations to the facial anatomy or marked facial asymmetry; Inflammation or infection at the injection site(s); Subjects with a history of eyelid or eyebrow ptosis; Excessive dermatochalasis, deep dermal scarring, or thick sebaceous skin; Subjects

2015 Clinical Trials

106. Soft tissue fillers as non-specific modulators of adipogenesis. change of the paradigm? (PubMed)

Soft tissue fillers as non-specific modulators of adipogenesis. change of the paradigm? Dermal filler injection is a cornerstone of facial rejuvenation procedures. Based on available data in animal and human studies, we suppose that the activation and proliferation of adipose-derived stem cells and expansion of mature adipocytes play a crucial role in long-term effects of volumizing, tissue tightening and beautification. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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2015 Experimental Dermatology

107. Voluma Filler Agent For The Treatment of HIV-associated Facial Lipoatrophy

-initial treatment. Device: Voluma Other Name: 20 mg/ml hyaluronic acid-based dermal filler Outcome Measures Go to Primary Outcome Measures : Number of Participants Rated Very Much Improved on the Global Aesthetic Improvement Scale (GAIS) by Prinicple Investigator [ Time Frame: Baseline to 12 months ] To evaluate the effectiveness of Voluma injections as a treatment for HIV-associated facial lipoatrophy over 12 months by assessing changes in the Global Aesthetic Improvement Scale (GAIS) based on pre (...) Jagdeo, MD, MS, Medical Physician, VA Northern California Health Care System ClinicalTrials.gov Identifier: Other Study ID Numbers: Allergan-97727 First Posted: January 19, 2015 Results First Posted: January 16, 2017 Last Update Posted: January 16, 2017 Last Verified: November 2016 Keywords provided by Jared Jagdeo, MD, MS, VA Northern California Health Care System: human immunodeficiency virus facial lipoatrophy facial lipodystrophy hyaluronic acid dermal filler filler agent Additional relevant MeSH

2015 Clinical Trials

108. Biological properties of a new volumizing hyaluronic acid filler: a systematic review. (PubMed)

intermediate properties in three studies and high in one study compared to other HA dermal fillers. This 20 mg/ml HA dermal filler retained the highest elasticity and viscosity values at temperature of 37°C. Histology demonstrated that this 20 mg/ml HA dermal filler has an intermediate pattern of distribution within the superficial and deep reticular dermis.This 20 mg/ml HA dermal filler demonstrated volumizing ability, and maintaining viscosity and free-flowing characteristics for easy injection, tissue (...) Biological properties of a new volumizing hyaluronic acid filler: a systematic review. Hyaluronic acid (HA) dermal fillers are effective and safe for correction of facial rhytides. A new volumizing HA filler, 20 mg/ml HA dermal filler (Juvéderm® Voluma®, Allergan Inc., Irvine, CA), is the only HA filler with a FDA indication for facial volumization due to age-related facial volume loss.Evaluate the biological properties, including biochemical, biophysical and rheological, of this new 20 mg/ml

2015 Journal of drugs in dermatology : JDD

109. Cosmetic Facial Fillers and Severe Vision Loss. (PubMed)

Cosmetic Facial Fillers and Severe Vision Loss. Dermal injection of cosmetic fillers can lead to irreversible blindness when injected in the forehead, and this possible adverse effect is not typically mentioned to patients.Vision loss from central retinal artery occlusion occurring, after cosmetic facial enhancement, was irreversible in 3 patients. However, 1 patient had a small amount of recovery with aggressive therapy.Cosmetic facial fillers are not approved for use in the forehead, but off (...) -label use for enhancement in this region is common. To our knowledge, there have been no prior reports of blindness caused by filler injected into the forehead. We present findings of central retinal artery occlusion due to fillers in 3 patients shortly after their cosmetic procedures. The filler presumably enters the central retinal artery via the rich external-internal carotid anastomoses and becomes embedded in the retinal tissues, potentially leading to irreversible and severe vision loss

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2014 JAMA ophthalmology

110. In vivo Bio-Integration of Three Hyaluronic Acid Fillers in Human Skin: A Histological Study. (PubMed)

In vivo Bio-Integration of Three Hyaluronic Acid Fillers in Human Skin: A Histological Study. Hyaluronic acid (HA) formulations are used for aesthetic applications. Different cross-linking technologies result in HA dermal fillers with specific characteristic visco-elastic properties.Bio-integration of three CE-marked HA dermal fillers, a cohesive (monophasic) polydensified, a cohesive (monophasic) monodensified and a non-cohesive (biphasic) filler, was analysed with a follow-up of 114 days (...) after injection. Our aim was to study the tolerability and inflammatory response of these fillers, their patterns of distribution in the dermis, and influence on tissue integrity.Three HA formulations were injected intradermally into the iliac crest region in 15 subjects. Tissue samples were analysed after 8 and 114 days by histology and immunohistochemistry, and visualized using optical and transmission electron microscopy.Histological results demonstrated that the tested HA fillers showed specific

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2014 Dermatology

111. Twenty-four-week multicenter, evaluator-blinded clinical study of the efficacy and safety of a dextran filler in the treatment of nasolabial folds. (PubMed)

Twenty-four-week multicenter, evaluator-blinded clinical study of the efficacy and safety of a dextran filler in the treatment of nasolabial folds. Cross-linked dextran shows complete degradation in the vital tissue and has characteristics of neocollagenesis. However, its efficacy as a dermal filler in treating facial soft tissue defects has not been investigated.To evaluate the efficacy and safety of subcutaneous injection of a dextran filler in treating nasolabial folds for 24 weeks.Twenty (...) patients were enrolled in this 24-week multicenter, evaluator-blinded clinical study. Each patient received a single session of a dextran filler treatment in both nasolabial folds, and no touch-up injections were given. Treatment efficacy was evaluated by blinded investigators at 4, 12, and 24 weeks after baseline. Safety data were collected from patient diaries and interviews at each follow-up visit.There were significant improvements (p<.0001) in the Wrinkle Severity Rating Scale scores compared

2014 Dermatologic Surgery

112. Transarterial degradation of hyaluronic Acid filler by hyaluronidase. (PubMed)

Transarterial degradation of hyaluronic Acid filler by hyaluronidase. Hyaluronidase (HYAL) has been recommended in the emergency treatment of ischemia caused by accidental intra-arterial injection of hyaluronic acid (HA) dermal fillers. To date, there have been no published studies showing that HYAL can pass through intact arterial wall to hydrolyze HA emboli.The goal of this study was to study whether or not HYAL could cross intact human facial arterial wall to hydrolyze HA filler.Short tied (...) -off segments of fresh human cadaver-sourced facial artery specimens, overfilled with a monophasic dermal filler (dermal filler "sausages"), were immersed in either HYAL or normal saline as controls. At 4 and 24 hours, the vessels were removed from the preparations, and one end of each vessel was cut open.Only the HYAL-immersed specimens showed degradation of filler gel.In conclusion, cross-linked HA is susceptible to hydrolysis by HYAL when contained within the intact facial artery in a cadaver

2014 Dermatologic Surgery

113. Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment

of a questionnaire Wrinkle severity score of Azzalure/Dysport treated facial lines [ Time Frame: 0-18 months ] To evaluate Wrinkle severity score of treated lines by validated photo scales First impression and perceived age of subjects (evaluation of photos) [ Time Frame: 1, 7 and 13 months ] To evaluate First impression and perceived age of subjects by evaluation of photos Injected filler volume [ Time Frame: 0-18 months ] To evaluate the filler volume injected at initial single treatment and at following (...) Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2014 Clinical Trials

114. Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster

score of treated glabellar lines (validated photo scales) [ Time Frame: 0-18 months ] To evaluate Wrinkle severity score of treated glabellar lines by validated photo scales First impression and perceived age of subjects [ Time Frame: 1, 7 and 13 months ] To evaluate First impression and perceived age of subjects by evaluation of photos Injected filler volume [ Time Frame: 0-18 months ] To evaluate the filler volume injected at initial single treatment and at following repeated combined treatment (...) Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2014 Clinical Trials

115. Nonsurgical periocular rejuvenation: advanced cosmetic uses of neuromodulators and fillers. (PubMed)

Nonsurgical periocular rejuvenation: advanced cosmetic uses of neuromodulators and fillers. To review the current literature regarding aesthetic enhancement using facial neuromodulators and fillers and to present advanced techniques using facial injectables for periocular rejuvenation.The authors provide a summary of traditional periocular locations for the injection of neuromodulators and dermal fillers. The authors also present novel and advanced techniques utilizing injectables (...) in the periocular region.Minimally invasive procedures with little-to-no recovery time are continuing to increase in popularity. Neuromodulators and hyaluronic acid gel fillers have been shown to be well tolerated and efficacious nonsurgical alternatives in periocular rejuvenation.

2014 Current Opinion in Ophthalmology

116. Efficacy and Safety of Porcine Collagen Filler for Nasolabial Fold Correction in Asians: A Prospective Multicenter, 12 Months Follow-up Study (PubMed)

Efficacy and Safety of Porcine Collagen Filler for Nasolabial Fold Correction in Asians: A Prospective Multicenter, 12 Months Follow-up Study Recently, injectable dermal fillers have become important alternatives to surgical procedures for the correction of facial wrinkles. Bovine collagen is the first approved material for filler injection, and several studies have shown its efficacy. However, the risk of developing an allergic reaction and xenogenic transmission of bovine spongiform (...) encephalopathy remain among its disadvantages. In this randomized, double-blinded, split-face study, we compared the efficacy and safety of a porcine collagen filler (TheraFill®) with that of a bovine collagen filler (KOKEN®) for nasolabial fold correction. A total of sixty one patients with mild to severe nasolabial fold were randomized to receive TheraFill® and KOKEN® on contralateral sides of the face. During the 12-month follow-up period, improvement in the Wrinkle-Severity Rating Scale score

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2014 Journal of Korean medical science

117. Safety and Effectiveness of Juvéderm Ultra Plus Injectable Gel in Correcting Severe Nasolabial Folds in Chinese Subjects. (PubMed)

Safety and Effectiveness of Juvéderm Ultra Plus Injectable Gel in Correcting Severe Nasolabial Folds in Chinese Subjects. Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population.This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. NLFs

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2017 Plastic and reconstructive surgery. Global open

118. Face Photoaging: Efficacy and Tolerance Evaluation of an Intradermal Injective Treatment

) variation (± 1) during the study period; subjects not in menopause who do not accept to perform the pregnancy test during the basal visit, 30 days (T4i) and 2 months (T2M) after the first biomineralizing treatment execution; performing skin treatments for aesthetic correction (biomaterials implants, face lifting, botox injections, laser, chemical peeling) in the 12 months prior to the study start; performing permanent filler in the past; change in the normal habits regarding food, physical activity (...) Face Photoaging: Efficacy and Tolerance Evaluation of an Intradermal Injective Treatment Face Photoaging: Efficacy and Tolerance Evaluation of an Intradermal Injective Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2017 Clinical Trials

119. Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Correction of Temple Hollowing

. Exclusion Criteria: Has temple hollowing due to due to trauma, congenital malformations, or lipodystrophy Has received permanent facial implants in the face or neck Has undergone fat injections Has tattoos, piercings, facial hair or scars that would interfere with visual assessment of the temple Has undergone semipermanent dermal filler treatment in the temple or mid-face within the past 36 months Has undergone dermal filler injections above the subnasale within the past 24 months Has temporal arteritis (...) Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Correction of Temple Hollowing Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Correction of Temple Hollowing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2017 Clinical Trials

120. Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures (PubMed)

, aspiration biopsies and dermal fillers (DF). In this work, we develop two in vitro models to simulate the process of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively. Using the pig skin model, we tested three of the most common skin preparation wipes (alcohol, chlorhexidine and povidone iodine) and found that during wiping they reduced the biofilm bacterial burden of S. aureus (CFU cm-2) by three logs with no statistically significant differences between (...) Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures While surgical site preparation has been extensively studied, there is little information about resistance of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantitative models to study how biofilm might be transferred into sterile tissue/implant materials during injections for joint spine and tendon

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2017 Scientific reports

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