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Dermal Filler Injection

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101. Hyaluronic Acid Filler for Dorsal Finger Volume Loss

effect prior to injection (10-15 minutes). Ice packs will also be applied to the area temporarily for numbing effect just prior to injection. The patient's fingers will be injected with 0.5-2.0 mL of hyaluronic acid total at the level of the sub-dermal plane. The injected filler will be molded as needed to optimize the correction of the fingers. Syringes used and amount injected into each finger, as well as the total per hand, will be documented to the 0.1 mL increment (e.g. 3.4 mL). The expected (...) Summary: Fingers are a part of the body that are often subject to increased signs of aging due to physical use, trauma and exposure to the environment. The FDA's recent approval of a dermal filler, calcium hydroxylapatite, in hands has led to increased patient demand for hand fillers which, in turn, has led to the question of rejuvenation of the dorsal fingers. Due to the different anatomy of the fingers than the dorsal hand plus the new demand to improve the entire hand plus the finger area, we aim

2016 Clinical Trials

102. Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers. (Abstract)

Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers. An unknown percentage of men will take every risk to develop a larger penis. Thus far, most injectables have caused serious problems. Polymethylmethacrylate (PMMA) microspheres have been injected as a wrinkle filler and volumizer with increasing safety since 1989.To report on a safe and permanently effective method to enhance penile girth and length with an approved dermal filler (ie, PMMA).Since 2007, the senior (...) author has performed penile augmentation in 752 men mainly with Metacrill, a suspension of PMMA microspheres in carboxymethyl-cellulose.The data of 729 patients and 203 completed questionnaires were evaluated statistically.The overall satisfaction rate was 8.7 on a scale of 1 to 10. After one to three injection sessions, average girth increased by 3.5 cm, or 134% (10.2 to 13.7 cm = 134.31%). Penile length also increased by weight and stretching force of the implant from an average of 9.8 to 10.5 cm

2016 Journal Of Sexual Medicine

103. Soft tissue fillers as non-specific modulators of adipogenesis. change of the paradigm? (Abstract)

Soft tissue fillers as non-specific modulators of adipogenesis. change of the paradigm? Dermal filler injection is a cornerstone of facial rejuvenation procedures. Based on available data in animal and human studies, we suppose that the activation and proliferation of adipose-derived stem cells and expansion of mature adipocytes play a crucial role in long-term effects of volumizing, tissue tightening and beautification. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2015 Experimental Dermatology

104. A Study to Assess the Efficacy of Skin Rejuvenation Therapy in Combination With Neurotoxin and Full Facial Filler Treatments

or any aesthetic procedure (e.g. neurotoxins, dermal fillers, laser treatments, and chemical peels), which are not specified in this protocol, during the course of the study; A known allergy or sensitivity to any component of the study ingredients; Use of systemic steroids or anticoagulation medications; Subjects with a history of bleeding disorders; Subjects with severe allergies manifested by a history of anaphylaxis or presence of multiple severe allergies; Subjects with hypersensitivity (...) to botulinum neurotoxin; Subject with allergies to gram positive bacterial proteins; Sensitivity to sulfides; Subjects with allergy to cow's milk protein; Subjects with previous history of sensitivity to amide type local anesthetics; Subject with surgical alterations to the facial anatomy or marked facial asymmetry; Inflammation or infection at the injection site(s); Subjects with a history of eyelid or eyebrow ptosis; Excessive dermatochalasis, deep dermal scarring, or thick sebaceous skin; Subjects

2015 Clinical Trials

105. Voluma Filler Agent For The Treatment of HIV-associated Facial Lipoatrophy

-initial treatment. Device: Voluma Other Name: 20 mg/ml hyaluronic acid-based dermal filler Outcome Measures Go to Primary Outcome Measures : Number of Participants Rated Very Much Improved on the Global Aesthetic Improvement Scale (GAIS) by Prinicple Investigator [ Time Frame: Baseline to 12 months ] To evaluate the effectiveness of Voluma injections as a treatment for HIV-associated facial lipoatrophy over 12 months by assessing changes in the Global Aesthetic Improvement Scale (GAIS) based on pre (...) Jagdeo, MD, MS, Medical Physician, VA Northern California Health Care System ClinicalTrials.gov Identifier: Other Study ID Numbers: Allergan-97727 First Posted: January 19, 2015 Results First Posted: January 16, 2017 Last Update Posted: January 16, 2017 Last Verified: November 2016 Keywords provided by Jared Jagdeo, MD, MS, VA Northern California Health Care System: human immunodeficiency virus facial lipoatrophy facial lipodystrophy hyaluronic acid dermal filler filler agent Additional relevant MeSH

2015 Clinical Trials

106. Skin Necrosis of the Nasal Ala after Injection of Dermal Fillers. (Abstract)

Skin Necrosis of the Nasal Ala after Injection of Dermal Fillers. 21342316 2011 05 20 2011 03 17 1524-4725 37 3 2011 Mar Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Skin necrosis of the nasal ala after injection of dermal fillers. 375-80 10.1111/j.1524-4725.2011.01891.x Kang Moon Seok MS Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea (...) . Park Eun Soo ES Shin Ho Seong HS Jung Sung Gyun SG Kim Yong Bae YB Kim Dong Won DW eng Case Reports Journal Article 2011 02 22 United States Dermatol Surg 9504371 1076-0512 0 Gels 9004-61-9 Hyaluronic Acid IM Adult Female Gels Humans Hyaluronic Acid administration & dosage adverse effects Injections, Intradermal adverse effects Necrosis chemically induced Nose blood supply pathology Nose Deformities, Acquired chemically induced Peripheral Vascular Diseases chemically induced Skin pathology 2011 2

2011 Dermatologic Surgery

107. Safety and Effectiveness of Hyaluronic Acid Injectable Gel in Correcting Moderate Nasolabial Folds in Chinese Subjects. (Abstract)

Safety and Effectiveness of Hyaluronic Acid Injectable Gel in Correcting Moderate Nasolabial Folds in Chinese Subjects. The hyaluronic acid (HA) dermal filler, Juvéderm® Ultra, which employs Hylacross® technology, produces a gel with a smooth consistency and has demonstrated effectiveness in correcting nasolabial folds (NLFs) in Caucasian populations.To evaluate the safety and effectiveness of Juvéderm Ultra vs Restylane® for the correction of moderate NLFs in Chinese subjects.In this double (...) -blind randomized study, adult Chinese subjects with moderate NLFs received Juvéderm Ultra (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. NLFs were evaluated using the validated 5-point photonumeric Allergan NLF Severity Scale (NLFSS); scores ranged from 0 ("no wrinkle") to 4 ("very deep wrinkle"). Response was defined as ≥1-point improvement at 6 months. Investigator-assessed responder rate (primary outcome), NLF mean improvement, and subject-assessed responder rate

2016 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

108. Safety and Effectiveness of VYC-12 Hyaluronic Acid Injectable Gel for Treatment of Superficial Cutaneous Depressions

augmentation with dermal fillers including HA, calcium hydroxylapatite, autologous fat, mesotherapy, or other cosmetic procedures (eg. face-lift, laser, photomodulation, intense pulsed light, radiofrequency, dermabrasion, chemical peel, or other ablative procedures) in the face or neck within the past 12 months Has received any crosslinked HA filler in any anatomic area within the past 12 months Has undergone treatment with botulinum toxins in the face or neck within the past 6 months Has ever received (...) Safety and Effectiveness of VYC-12 Hyaluronic Acid Injectable Gel for Treatment of Superficial Cutaneous Depressions Safety and Effectiveness of VYC-12 Hyaluronic Acid Injectable Gel for Treatment of Superficial Cutaneous Depressions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2016 Clinical Trials

109. Evaluation of the MJGS Following Radiesse (+) Injection Into the Jawline

and accepts the obligation and is logistically able to present for all scheduled study visits and meet all study requirements. Exclusion Criteria: Has ever been treated with silicone, PMMA (polymethyl methacrylate), fat injections, poly-L-lactic acid (PLLA; Sculptra®) or permanent dermal fillers below the orbital rim including the neck. Has had surgery on the jawbone or has surgical permanent implant to the face or neck. Has bruxism, masseter muscle hypertrophy or asymmetry of masseter muscles, active (...) Evaluation of the MJGS Following Radiesse (+) Injection Into the Jawline Evaluation of the MJGS Following Radiesse (+) Injection Into the Jawline - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation

2016 Clinical Trials

110. The Efficacy and Safety of HA IDF Plus (with Lidocaine) Versus HA IDF (Without Lidocaine) in Nasolabial Folds Injection: A Randomized, Multicenter, Double-Blind, Split-Face Study. (Abstract)

The Efficacy and Safety of HA IDF Plus (with Lidocaine) Versus HA IDF (Without Lidocaine) in Nasolabial Folds Injection: A Randomized, Multicenter, Double-Blind, Split-Face Study. Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation. Reducing the pain could improve overall patient satisfaction.The purpose of this study was to compare the pain relief, efficacy, and safety of HA IDF plus containing lidocaine with HA IDF (...) , wrinkle severity rating scale, and adverse events.Immediately after injection, 91.94% of subjects experienced at least 10 mm decrease in VAS scores at the side injected with HA IDF plus compared with HA IDF, and the rate of subjects is statistically significant. The two fillers were not significantly different in safety profile or wrinkle correction during the follow-up visit.HA IDF plus significantly reduced the injection-related pain during NLFs correction compared with HA IDF without altering

2016 Aesthetic plastic surgery Controlled trial quality: uncertain

111. Ethnic and Gender Considerations in the Use of Facial Injectables: Male Patients. (Abstract)

Ethnic and Gender Considerations in the Use of Facial Injectables: Male Patients. The contemporary male look includes sharp contours of the face with strong nose, significant malar-midface structure, and a powerful chin with well-defined jawline. Neurotoxins in the upper facial lines should preserve a lower position of the brows and flatter arch in men. Excessive lifting of the eyebrows and full correction of forehead and periorbital lines are not desirable. The use of dermal fillers is fully (...) reshape in male patients is very much rejected. It requires expertise both in communication and in technical skills to convince male patients to undergo lip treatments with fillers. The use of injectables in male patients is growing. Neurotoxins in the upper facial lines and the use of dermal fillers in the nasolabial folds are widely accepted. The use of volumizers in the chin is highly appreciated. There is clear need of volumizers in the cheek to correct sagginess and hollowness in men. However

2015 Plastic and reconstructive surgery

112. A Slit Face Trial Using Micro-injections of Transparent Hyaluronic Acid Gel for Rejuvenation of the Cheek

is a transparent injectable HA gel that received FDA approval in June 2014 for use in the lips and peri-oral region. Its unique synthesis results in smaller and finer particles that demonstrate significant hygroscopic properties and give rise to the potential for unique applications. One such application concerns the concept of "skin boosting" whereby microaliquots of HA are placed into the skin to induce biophysical improvement in dermal characteristics (1). Using this technique, a recent split-body study (...) Intervention/treatment Phase Problem of Aging Device: Hyaluronic Acid filler Other: Sham Comparator Not Applicable Detailed Description: This is a single center, prospective, randomized, sham-controlled, double-blind, split-face trial using micro-injections of Restylane® Silk for correction of mid to low cheek fine lines and wrinkles. Twenty (20) subjects will be enrolled. Each subject will receive Restylane® Silk to a defined area of mid to low cheek in a randomized blinded fashion with the contralateral

2015 Clinical Trials

113. A Prospective, Comparative, Evaluator-blind Clinical Study Investigating Efficacy and Safety of Two Injection Techniques with Radiesse(®) for the Correction of Skin Changes in Aging Hands. Full Text available with Trip Pro

A Prospective, Comparative, Evaluator-blind Clinical Study Investigating Efficacy and Safety of Two Injection Techniques with Radiesse(®) for the Correction of Skin Changes in Aging Hands. Dermal fillers are used to correct age-related changes in hands.Assess efficacy and safety of two injection techniques to treat age-related changes in the hands using calcium hydroxylapatite filler, Radiesse(®).This was a prospective, comparative, evaluator-blind, single-center study.Radiesse(®) (0.8 mL/0.2 (...) mL 2% lidocaine) was injected subdermally on Day (D)01, using a needle multipoint technique in one hand (N) and a fan-like cannula technique in the other (C). Assessments were made pre-injection, on D14, Month (M)02, M03 and M05 using the Merz Aesthetics Hand Grading Scale (MAS) and Global Aesthetic Improvement Scale (GAIS). Participants completed questionnaires on satisfaction, pain and adverse events (AEs).Data distribution was tested with the Shapiro-Wilk and Levene's tests. The Wilcoxon

2015 Journal of cutaneous and aesthetic surgery Controlled trial quality: uncertain

114. A Study of Hyaluronic Acid Injectable Gel (VYC-25L) for Restoration and Creation of Facial Volume in the Chin and Jaw

Inclusion Criteria: -Has chin retrusion. Exclusion Criteria: Has ever received or is planning to receive permanent facial implants during the study. Has tattoos, piercings, facial hair or scars that would interfere with visual assessments of the chin or jaw. Has dentures or any device covering part of the palate or plans to undergo any dental procedure other than prophylaxis during the study. Has undergone semipermanent dermal filler treatment to the chin or jaw within 36 months or is planning treatment (...) A Study of Hyaluronic Acid Injectable Gel (VYC-25L) for Restoration and Creation of Facial Volume in the Chin and Jaw A Study of Hyaluronic Acid Injectable Gel (VYC-25L) for Restoration and Creation of Facial Volume in the Chin and Jaw - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2015 Clinical Trials

115. Efficacy and Safety of Porcine Collagen Filler for Nasolabial Fold Correction in Asians: A Prospective Multicenter, 12 Months Follow-up Study Full Text available with Trip Pro

Efficacy and Safety of Porcine Collagen Filler for Nasolabial Fold Correction in Asians: A Prospective Multicenter, 12 Months Follow-up Study Recently, injectable dermal fillers have become important alternatives to surgical procedures for the correction of facial wrinkles. Bovine collagen is the first approved material for filler injection, and several studies have shown its efficacy. However, the risk of developing an allergic reaction and xenogenic transmission of bovine spongiform (...) encephalopathy remain among its disadvantages. In this randomized, double-blinded, split-face study, we compared the efficacy and safety of a porcine collagen filler (TheraFill®) with that of a bovine collagen filler (KOKEN®) for nasolabial fold correction. A total of sixty one patients with mild to severe nasolabial fold were randomized to receive TheraFill® and KOKEN® on contralateral sides of the face. During the 12-month follow-up period, improvement in the Wrinkle-Severity Rating Scale score

2014 Journal of Korean medical science Controlled trial quality: uncertain

116. Transarterial degradation of hyaluronic Acid filler by hyaluronidase. (Abstract)

Transarterial degradation of hyaluronic Acid filler by hyaluronidase. Hyaluronidase (HYAL) has been recommended in the emergency treatment of ischemia caused by accidental intra-arterial injection of hyaluronic acid (HA) dermal fillers. To date, there have been no published studies showing that HYAL can pass through intact arterial wall to hydrolyze HA emboli.The goal of this study was to study whether or not HYAL could cross intact human facial arterial wall to hydrolyze HA filler.Short tied (...) -off segments of fresh human cadaver-sourced facial artery specimens, overfilled with a monophasic dermal filler (dermal filler "sausages"), were immersed in either HYAL or normal saline as controls. At 4 and 24 hours, the vessels were removed from the preparations, and one end of each vessel was cut open.Only the HYAL-immersed specimens showed degradation of filler gel.In conclusion, cross-linked HA is susceptible to hydrolysis by HYAL when contained within the intact facial artery in a cadaver

2014 Dermatologic Surgery

117. Twenty-four-week multicenter, evaluator-blinded clinical study of the efficacy and safety of a dextran filler in the treatment of nasolabial folds. (Abstract)

Twenty-four-week multicenter, evaluator-blinded clinical study of the efficacy and safety of a dextran filler in the treatment of nasolabial folds. Cross-linked dextran shows complete degradation in the vital tissue and has characteristics of neocollagenesis. However, its efficacy as a dermal filler in treating facial soft tissue defects has not been investigated.To evaluate the efficacy and safety of subcutaneous injection of a dextran filler in treating nasolabial folds for 24 weeks.Twenty (...) patients were enrolled in this 24-week multicenter, evaluator-blinded clinical study. Each patient received a single session of a dextran filler treatment in both nasolabial folds, and no touch-up injections were given. Treatment efficacy was evaluated by blinded investigators at 4, 12, and 24 weeks after baseline. Safety data were collected from patient diaries and interviews at each follow-up visit.There were significant improvements (p<.0001) in the Wrinkle Severity Rating Scale scores compared

2014 Dermatologic Surgery

118. Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment

of a questionnaire Wrinkle severity score of Azzalure/Dysport treated facial lines [ Time Frame: 0-18 months ] To evaluate Wrinkle severity score of treated lines by validated photo scales First impression and perceived age of subjects (evaluation of photos) [ Time Frame: 1, 7 and 13 months ] To evaluate First impression and perceived age of subjects by evaluation of photos Injected filler volume [ Time Frame: 0-18 months ] To evaluate the filler volume injected at initial single treatment and at following (...) Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2014 Clinical Trials

119. Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster

score of treated glabellar lines (validated photo scales) [ Time Frame: 0-18 months ] To evaluate Wrinkle severity score of treated glabellar lines by validated photo scales First impression and perceived age of subjects [ Time Frame: 1, 7 and 13 months ] To evaluate First impression and perceived age of subjects by evaluation of photos Injected filler volume [ Time Frame: 0-18 months ] To evaluate the filler volume injected at initial single treatment and at following repeated combined treatment (...) Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2014 Clinical Trials

120. In vivo Bio-Integration of Three Hyaluronic Acid Fillers in Human Skin: A Histological Study. Full Text available with Trip Pro

In vivo Bio-Integration of Three Hyaluronic Acid Fillers in Human Skin: A Histological Study. Hyaluronic acid (HA) formulations are used for aesthetic applications. Different cross-linking technologies result in HA dermal fillers with specific characteristic visco-elastic properties.Bio-integration of three CE-marked HA dermal fillers, a cohesive (monophasic) polydensified, a cohesive (monophasic) monodensified and a non-cohesive (biphasic) filler, was analysed with a follow-up of 114 days (...) after injection. Our aim was to study the tolerability and inflammatory response of these fillers, their patterns of distribution in the dermis, and influence on tissue integrity.Three HA formulations were injected intradermally into the iliac crest region in 15 subjects. Tissue samples were analysed after 8 and 114 days by histology and immunohistochemistry, and visualized using optical and transmission electron microscopy.Histological results demonstrated that the tested HA fillers showed specific

2014 Dermatology

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