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Dermal Filler Injection

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81. Association between collagen production and mechanical stretching in dermal extracellular matrix: In vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study. (PubMed)

Association between collagen production and mechanical stretching in dermal extracellular matrix: In vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study. The effects of hyaluronic acid (HA) injection on tissue collagen anabolism are suggested to be related to the induction of mechanical stress, causing biochemical changes in skin physiology.To ascertain the association between dermal mechanics modulated by a hyaluronic acid-based filler effect (...) digital modelling.One month after injection, the filler induced an increase in procollagen (p=0.0016) and TIMP-1 (p=0.0485) levels and relative gene expression of procollagen III and I isoforms compared with the controls. After 3 months, procollagen levels remained greater than in the controls (p=0.0005), whereas procollagen expression and TIMP-1 and MMP content were no longer different. Forty-three percent of the injected filler volume was found at 1 month, 26% after 3 months and 20% after 6

2013 Journal of dermatological science

82. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. (PubMed)

related to medical dermal filler injections/prosthesis.A comprehensive MEDLINE, PubMed, and Google Scholar electronic database search was performed (2000-January 2012). Selected articles published before 2000 referring to general concerns regarding the studied topic were also included. The search provided almost 300 articles. Finally, 235 studies were selected and included.All known fillers present in the market have been shown to be able to provoke early- and late-onset inflammatory adverse reactions (...) Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. An increasing number of persons seek medical solutions for esthetic indications and for diverse pathological conditions, such as malformations, trauma, or cancer. Despite manufacturers' and different authors' claims that fillers are non-immunogenic or that complications are uncommon, unwanted adverse reactions do occur.To review the literature regarding the multiple types of immune-mediated adverse reactions

2013 Seminars in arthritis and rheumatism

83. Early granulomatous foreign body reactions to a novel alginate dermal filler: the system's failure? (PubMed)

Early granulomatous foreign body reactions to a novel alginate dermal filler: the system's failure? Cutaneous granulomas after a soft filler injection represent one of the worst scenarios for both patient and injector.To present clinical and histopathological features of granulomatous nodular reactions induced by a new alginate-based dermal filler (Novabel(®)), and put it in context of the process of injectable soft tissue fillers approval and promotion in the EU.A case series of four patients (...) injected with Novabel(®) for volume restoration of the face and hands, who developed severe foreign body reactions.Four patients injected with Novabel(®) into tear troughs and/or dorsa of hands developed severe granulomatous reactions within months after injections. As we injected with the new filler into a total of 10 patients, a high incidence of 40% of the disfiguring adverse effect was observed. The inadequate response of manufacturer to our reporting the side-effects along with the available data

2013 Journal of the European Academy of Dermatology and Venereology

84. Study for the Evaluation of the Efficacy and Safety of the Dermal Filler Princess® VOLUME in Nasolabial Folds

Study for the Evaluation of the Efficacy and Safety of the Dermal Filler Princess® VOLUME in Nasolabial Folds Study for the Evaluation of the Efficacy and Safety of the Dermal Filler Princess® VOLUME in Nasolabial Folds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study for the Evaluation of the Efficacy and Safety of the Dermal Filler Princess® VOLUME in Nasolabial Folds The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01798498 Recruitment Status : Completed First Posted : February 26, 2013

2013 Clinical Trials

85. Dermal filler complications from unknown biomaterials: identification by attenuated total reflectance spectroscopy. (PubMed)

Dermal filler complications from unknown biomaterials: identification by attenuated total reflectance spectroscopy. In the last decade, an increase in complications related to dermal filler injections has been reported, especially in patients who underwent multiple treatments with different products. Imaging or histological examinations may suggest what kind of substance was used, but none can precisely identify the biomaterial. The aim of this study was to evaluate the use of Fourier transform (...) complications due to multiple injections with unknown fillers provided a sample of the pathological tissue for the analysis.Two granulomas, two infiltrated tissues, and three abscesses were studied. Attenuated total reflectance/Fourier transform infrared analysis of pathological tissues revealed the presence of absorption bands absent in the healthy tissue. Comparison of these bands to the filler database made it possible to identify the dermal fillers injected.This pilot study has demonstrated the absolute

2013 Plastic and reconstructive surgery

86. Hyaluronic Acid Filler for Dorsal Finger Volume Loss

effect prior to injection (10-15 minutes). Ice packs will also be applied to the area temporarily for numbing effect just prior to injection. The patient's fingers will be injected with 0.5-2.0 mL of hyaluronic acid total at the level of the sub-dermal plane. The injected filler will be molded as needed to optimize the correction of the fingers. Syringes used and amount injected into each finger, as well as the total per hand, will be documented to the 0.1 mL increment (e.g. 3.4 mL). The expected (...) Summary: Fingers are a part of the body that are often subject to increased signs of aging due to physical use, trauma and exposure to the environment. The FDA's recent approval of a dermal filler, calcium hydroxylapatite, in hands has led to increased patient demand for hand fillers which, in turn, has led to the question of rejuvenation of the dorsal fingers. Due to the different anatomy of the fingers than the dorsal hand plus the new demand to improve the entire hand plus the finger area, we aim

2016 Clinical Trials

87. Safety Study of Filler Agent Composed of Umbilical Cord Mesenchymal Stem Cells and Hyaluronic Acid

and Regenerative Medicine. Recruitment status was: Not yet recruiting First Posted : March 4, 2016 Last Update Posted : March 4, 2016 Sponsor: South China Research Center for Stem Cell and Regenerative Medicine Information provided by (Responsible Party): South China Research Center for Stem Cell and Regenerative Medicine Study Details Study Description Go to Brief Summary: The overall goal of this study is to evaluate the safety and exploratory efficacy of the injectable filler agent composed of umbilical (...) Masking: Double (Participant, Care Provider) Primary Purpose: Treatment Study Start Date : December 2016 Estimated Primary Completion Date : December 2018 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: UCMSCs-HA Multipoint of Transdermal injection into the wrinkles. Injectable filler agent composed of umbilical cord mesenchymal stem cells (UCMSCs) and hyaluronic acid (HA). Biological: umbilical cord

2016 Clinical Trials

88. A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds. (PubMed)

A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds. Hyaluronic acid dermal fillers are most frequently used for unwanted wrinkles. Recently, lidocaine has been incorporated into hyaluronic acid fillers to reduce injection discomfort.A randomized, multicenter, double-blind, intraindividual trial was designed to compare a new lidocaine-containing monophasic hyaluronic acid filler (Neuramis Deep Lidocaine (...) ) with a lidocaine-containing biphasic hyaluronic acid filler (Restylane Perlane-L) in moderate to severe nasolabial folds. Fifty-eight patients with moderate to severe nasolabial folds were randomized to an injection of Neuramis or Perlane-L in the left or right side of the face. Clinical efficacy and safety were assessed by blinded investigators, independent expert panels, and patients based on the Wrinkle Severity Rating Scale and the Global Aesthetic Improvement Scale at weeks 8, 16, and 24 after

2016 Plastic and reconstructive surgery

89. Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers. (PubMed)

Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers. An unknown percentage of men will take every risk to develop a larger penis. Thus far, most injectables have caused serious problems. Polymethylmethacrylate (PMMA) microspheres have been injected as a wrinkle filler and volumizer with increasing safety since 1989.To report on a safe and permanently effective method to enhance penile girth and length with an approved dermal filler (ie, PMMA).Since 2007, the senior (...) author has performed penile augmentation in 752 men mainly with Metacrill, a suspension of PMMA microspheres in carboxymethyl-cellulose.The data of 729 patients and 203 completed questionnaires were evaluated statistically.The overall satisfaction rate was 8.7 on a scale of 1 to 10. After one to three injection sessions, average girth increased by 3.5 cm, or 134% (10.2 to 13.7 cm = 134.31%). Penile length also increased by weight and stretching force of the implant from an average of 9.8 to 10.5 cm

2016 Journal Of Sexual Medicine

90. Treatment of the Ageing Hand with Dermal Fillers (PubMed)

with a number of long-lasting dermal fillers with varying degrees of improvement and treatment longevity. The dermal fillers used in hand rejuvenation include autologous fat, collagen, hyaluronic acid, calcium hydroxylapatite and poly-L-lactic acid. Here, we describe our preferred injection method for hand rejuvenation using calcium hydroxylapatite and a single-bolus injection. (...) Treatment of the Ageing Hand with Dermal Fillers Following the trend in facial cosmetic procedures, patients are now increasingly requesting hand rejuvenation treatments. Intrinsic ageing of the hands is characterized by loss of dermal elasticity and atrophy of the subcutaneous tissue. Thus, veins, tendons and bony structures become apparent. Among the available procedures, intrinsic ageing of the hands is best improved by restoring the volume of soft tissue. Volume restoration can be achieved

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2012 Journal of cutaneous and aesthetic surgery

91. A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds. (PubMed)

A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds. Data regarding several hyaluronic acids (HAs) used identically for facial tissue augmentation have heretofore been unavailable.This prospective, split-face, randomized, two-armed study sought to determine the long-term safety and effectiveness of three HAs (HA-1 (Belotero Basic/Balance), HA-2 (Restylane), and HA-3 (...) (Juvéderm Ultra 3/Juvéderm Ultra Plus XC) in the treatment of nasolabial folds (NLFs).Twenty participants in Arm A received HA-1 in one NLF and HA-2 in the other. In Arm B, 20 participants received HA-1 in one NLF and HA-3 in the other. Injection was at visit 2, with follow-up visits at 1, 6, 9, and 12 months. Mean volume of HA was slightly <1.5 mL/NLF.Adverse events were unremarkable across all HAs, with injection site erythema being the most frequent adverse event. Mean pretreatment NLF severity

2012 Dermatologic Surgery

92. The Use of J-Plasma® for Dermal Resurfacing

is willing to release rights to study Sponsor for the use of the photos, including in potential publication. Subject is willing to abstain from other facial cosmetic procedures through the 6 month follow-up visit; examples include, but are not limited to, laser or chemical re-surfacing, dermabrasion, neuromodulator and/or filler injections, aesthetic facial surgery, etc. Exclusion Criteria: Subject with a Fitzpatrick Skin Scale score >III. Subject is pregnant or lactating. Active HSV-1 or diabetes (...) The Use of J-Plasma® for Dermal Resurfacing The Use of J-Plasma® for Dermal Resurfacing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Use of J-Plasma® for Dermal Resurfacing The safety and scientific

2017 Clinical Trials

93. Dynamic High-Resolution Ultrasound In Vivo Imaging of Hyaluronic Acid Filler Injection. (PubMed)

Dynamic High-Resolution Ultrasound In Vivo Imaging of Hyaluronic Acid Filler Injection. High-resolution ultrasound (HRU) imaging is a useful tool to study hyaluronic acid (HA) filler injected in the face.To observe real-time injection of HA using HRU and describe behavior of the gel injection in various anatomic layers and the effect of massage.Deep (preperiosteal), intermediate (subdermal), and superficial (dermal) injections of HA were performed in the supraclavicular area under (...) ultrasonography visualization on a healthy volunteer. Videos were obtained during injection and static images at several time points, including during injection, immediately after injection, 5 minutes after massage of the treated area, and at 2 weeks after injection.During injection, dermally injected HA stayed within the dermis, increasing its echogenicity; subdermally injected HA formed multiple anechoic pearls; and preperiosteal HA produced a single anechoic bubble with diffuse margins. No vertical

2013 Dermatologic Surgery

94. A systematic review of dermal fillers for age-related lines and wrinkles.

A systematic review of dermal fillers for age-related lines and wrinkles. Dermal fillers are gaining popularity for rapid aesthetic improvement. Long-term efficacy and safety have not been well documented. The aim of this systematic review was to assess the safety and efficacy of injectable dermal fillers compared with other facial augmentation techniques for the management of age-related lines and wrinkles.Studies including patients receiving injectable semi-permanent or permanent dermal (...) fillers for age-related lines and wrinkles were included in this review. Efficacy outcomes (including changes in skin thickness and patient satisfaction) and safety outcomes (including mortality, lumps and infections) were examined.Three randomized control trials and six case series were included. Permanent and semi-permanent dermal fillers improved subjective ratings of appearance and resulted in higher patient satisfaction than temporary fillers. Long-term efficacy appeared good in the few studies

2011 ANZ journal of surgery

95. Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. (PubMed)

Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. Hyaluronic acid (HA) fillers such as Restylane(®) are frequently used for the correction of facial soft tissue defects.To compare the efficacy and safety of a novel HA filler, Emervel(®) Classic, with those of Restylane in the treatment of moderate nasolabial folds.This was a split-face (...) are reported. At week 24, the mean improvement in WSRS from baseline was 0.83 ± 0.51 for Emervel Classic, similar to that for Restylane (0.90 ± 0.57). A similar volume of both fillers was injected. Most local tolerability events were mild and transient. Erythema, oedema/swelling and pain/tenderness were significantly less severe and disappeared faster with Emervel Classic than with Restylane (at least p < 0.05).Emervel Classic provides similar efficacy and better overall local tolerability compared

2011 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

96. Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of severe nasolabial lines - 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. (PubMed)

Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of severe nasolabial lines - 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. Hyaluronic acid (HA) fillers are frequently used for the correction of facial soft tissue defects.To compare the efficacy and safety of a novel HA filler, HA(E) (Emervel Deep), with those of HA(P) (Restylane Perlane) in the treatment of severe nasolabial folds (NLF).A split-face, randomized (...) at week 24; P=0.002). Similar volume of both products was injected at baseline and touch-up. Both fillers were well tolerated, with similar worst score distribution and mean score for erythema, edema/swelling, bruising, and pruritus. Significantly less severe pain/tenderness was reported with HA(E) than with HA(P) (P<0.05).The new HA filler HA(E) provides better efficacy and similar local tolerability compared with HA(P) 6 months after the treatment of severe NLF.© 2011 Wiley Periodicals, Inc.

2011 Journal of cosmetic dermatology

97. Comparative study of a new dermal filler Uma Jeunesse® and Juvéderm®. (PubMed)

Comparative study of a new dermal filler Uma Jeunesse® and Juvéderm®. Innovation in technology has resulted in the emergence of better, longer-lasting hyaluronic acid implants with fewer side effects. The new dermal implant Uma Jeunesse® was compared to Juvéderm® in this split-face study.Uma Jeunesse® is crosslinked with butanediol diglycidyl ether (BDDE) using a new crosslinking technology. Uma Jeunesse® and Juvéderm® Ultra 3 were injected in a split-face study on 17 healthy volunteers (...) Jeunesse® than Juvéderm(®) . After 9 months of follow-up, Uma Jeunesse® lasted in tissues for longer as compared to Juvéderm(®) even in patients injected for the first time (P<0.0001). Patient acceptability rate of Uma Jeunesse® was also much higher. Perception of pain during injection was lesser with Juvéderm® probably because of the presence of lidocaine.The new dermal implant Uma Jeunesse® is a safe and patient-friendly product which resides in the tissues for longer with maintenance of aesthetic

2011 Journal of cosmetic dermatology

98. Commentary: subcision versus dermal collagen filler for acne scars. (PubMed)

Commentary: subcision versus dermal collagen filler for acne scars. 21481061 2011 06 16 2011 04 12 1524-4725 37 4 2011 Apr Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Commentary: subcision versus dermal collagen filler for acne scars. 432 10.1111/j.1524-4725.2011.01938.x Wasserman Daniel I DI Total Skin & Beauty Dermatology Center, Birmingham, Alabama, USA. dwass76@yahoo.com Monheit Gary D GD eng Comment Journal Article United (...) States Dermatol Surg 9504371 1076-0512 9007-34-5 Collagen IM Dermatol Surg. 2011 Apr;37(4):426-31 21388487 Acne Vulgaris complications Cicatrix etiology surgery Collagen administration & dosage Humans Injections Rhytidoplasty methods 2011 4 13 6 0 2011 4 13 6 0 2011 6 17 6 0 ppublish 21481061 10.1111/j.1524-4725.2011.01938.x

2011 Dermatologic Surgery

99. A comparison of the efficacy, safety, and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter, prospective, randomized, controlled, single-blind, within-subject study. (PubMed)

effectiveness, safety, and longevity; however, this requires confirmation in the clinic.To compare the efficacy, safety, and longevity of two distinct HA-based dermal fillers in the correction of severe nasolabial folds (NLFs), a 24 mg/mL smooth gel (Juvederm ULTRA PLUS™ [JUP]) and a 20 mg/mL particulate gel (Perlane(®) [PER]) were injected in a total of 80 normal, healthy subjects using a split face design and were followed for 12 months in this prospective, randomized, controlled, multicenter study.Both (...) A comparison of the efficacy, safety, and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter, prospective, randomized, controlled, single-blind, within-subject study. Commercially available hyaluronic acid (HA)-based fillers have distinct physicochemical properties related to their specific manufacturing technology, including HA concentration, cross-linking percentage, and particle size. These factors may determine treatment

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2011 Clinical, cosmetic and investigational dermatology

100. Pain and Bruising Levels After Lip Augmentation: A Comparison of Anterograde and Retrograde Techniques Using an Automated Motorized Injection Device. A Blinded, Prospective, Randomized, Parallel Within-Subject Trial. (PubMed)

Pain and Bruising Levels After Lip Augmentation: A Comparison of Anterograde and Retrograde Techniques Using an Automated Motorized Injection Device. A Blinded, Prospective, Randomized, Parallel Within-Subject Trial. Dermal fillers for lip augmentation can be injected using various techniques. Although all seem to provide acceptable results, it is not clear which technique is safer, less painful, and provides greater patient comfort.To compare patients' self-reported pain intensity during (...) the injection of hyaluronic acid dermal filler for lip augmentation, with 2 different techniques, anterograde versus retrograde.Prospective, single-center, within-subject, single-blinded, randomized controlled trial. All subjects received injections in the lip with hyaluronic acid-based filler, each side using the anterograde or retrograde injection technique. An automated motorized injection device was used to ensure a homogeneous deposition flow of the product injected and reduce operator bias. Pain

2019 Dermatologic Surgery

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