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Dermal Filler Injection

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41. Skin Remodeling Using Hyaluronic Acid Filler Injections in Photoaged Faces. (PubMed)

increase in collagen fibers at 3 and 9 months after the procedure (34.2% ± 31.5% and 39.5% ± 39.7%, respectively, p < .05).Sustained clinical results for HA filler can be explained not only by the presence of HA gel on the dermis but also by the dermal remodeling induced by HA filler injected into the face. (...) Skin Remodeling Using Hyaluronic Acid Filler Injections in Photoaged Faces. Hyaluronic acid (HA) filler is an important dermatological procedure. Although many studies have reported clinical improvement with this procedure, histology with morphometric evidence is not well documented.To evaluate the clinical and histological results of a HA filler injection and to quantify dermis remodeling at 3 and 9 months after HA injections into aged faces.Twenty patients were enrolled in this study

2016 Dermatologic Surgery

42. Safety and efficacy of a continuous-flow, injection-assisted device in delivery of dermal fillers. (PubMed)

Safety and efficacy of a continuous-flow, injection-assisted device in delivery of dermal fillers. A device to assist in the delivery of dermal filler may achieve reductions in patient discomfort and adverse events, as well physician fatigue. It may also increase the accuracy of material placement.The authors assess the safety and performance of the Artiste Assisted Injection System (Nordson Micromedics, St Paul, Minnesota) in normal therapeutic use compared with the standard manual (...) administration of dermal fillers.At 3 study sites, a total of 52 patients (48 women and 4 men) received bilateral full-correction injections of dermal fillers into randomized nasolabial folds (NLF). Injection into 1 NLF was made via Artiste, and injection into the other NLF was made via manual delivery. Immediately posttreatment and through 29 days, physician investigators, patients, and blinded evaluators recorded treatment durations and volumes, evaluated designated posttreatment characteristics using

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2013 Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery

43. Non-ablative 1540 fractional laser: How far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? a randomized controlled trial. (PubMed)

Non-ablative 1540 fractional laser: How far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? a randomized controlled trial. Rejuvenation of the lower face can be challenging and no single modality can accomplish all its complex events.This 18-month study included 24 female patients with a primary complaint of lower-face aging signs. They were randomly allocated to either Group A, who received injection lipolysis and hyaluronic acid dermal filler, or Group B who (...) significant in the long-term evaluations (13 and 18 months) (P < 0.05).This study further documents the importance of combination therapy in facial rejuvenation, offering a treatment protocol combining injection lipolysis and hyaluronic acid as an effective, safe, short-term therapeutic option in lower-face rejuvenation. The addition of 1540 non-ablative fractional laser to the protocol offers a higher efficacy with longer-term effects and no adverse events.

2013 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

44. Autologous fat grafting and injectable dermal fillers for human immunodeficiency virus-associated facial lipodystrophy: a comparison of safety, efficacy, and long-term treatment outcomes. (PubMed)

Autologous fat grafting and injectable dermal fillers for human immunodeficiency virus-associated facial lipodystrophy: a comparison of safety, efficacy, and long-term treatment outcomes. Facial lipoatrophy is a common side effect of human immunodeficiency virus treatment with highly active antiretroviral therapy. To identify the most clinically durable and efficient way of addressing facial lipoatrophy, the authors reviewed all available evidence for the use of injectable dermal fillers (...) and autologous fat transfers as treatment modalities, focusing on safety, outcomes, and long-term durability.A systematic review of the Cochrane and MEDLINE databases for autologous fat transfer and injectable dermal fillers for the treatment of human immunodeficiency virus-associated lipodystrophy was performed. Based on U.S. Food and Drug Administration approval in human immunodeficiency virus lipoatrophy, studies were limited to the use of hyaluronic acid and/or poly-L-lactic acid. Facial volume

2013 Plastic and reconstructive surgery

45. The efficacy of combined diluted calcium hydroxylapatite-based filler and an energy-based device in the treatment of facial atrophic acne scars. (PubMed)

The efficacy of combined diluted calcium hydroxylapatite-based filler and an energy-based device in the treatment of facial atrophic acne scars. Treatment options for atrophic acne scars include the use of various energy-based devices (EBDs) and dermal fillers.To evaluate the level of improvement and safety of four treatment modalities for atrophic acne scars employed in our center.We reviewed the medical records of all acne scar patients treated between 2013-2016 with one of four treatment (...) adverse effects.In total, 352 patients (mean age 28.7±8.7, 65.6% females) were treated for acne scars. The integrated mean dermatologists' and patients' GAS scores were the highest for the patients treated with the combined FACL-CaHA modality at separate sessions (P < 0.001). Patients treated with FACL reported more side effects and longer downtime and duration of erythema.The combination of a diluted CaHA-based filler injection followed by fractional ablative CO2 laser in separate treatment sessions

2019 Clinical & Experimental Dermatology

46. Periocular hyaluronic acid fillers: applications, implications, complications. (PubMed)

Periocular hyaluronic acid fillers: applications, implications, complications. The use of dermal filler in the periocular area is increasing - both for functional and aesthetic indications. Hyaluronic acid fillers dominate the market; these treatments offer an alternative to some surgical procedures with the advantage of instant results, minimal healing time and low complication rates. However, success depends on judicious selection of patients, products and procedures to achieve favourable (...) vascular occlusions are not uncommon, cases of blindness secondary to facial filler injections are thought to be rare. Timely enzymatic degradation with injectable hyaluronidase can be effective in the treatment of some such complications. But recent studies demonstrate lack of penetration through arterial walls and optic nerve sheath, casting doubt on the role of retrobulbar hyaluronidase in the management of vision loss because of embolism with hyaluronic acid filler.Hyaluronic acid fillers represent

2019 Current opinion in ophthalmology

47. Analysis of U.S. Food and Drug Administration Data on Soft-Tissue Filler Complications. (PubMed)

Analysis of U.S. Food and Drug Administration Data on Soft-Tissue Filler Complications. With the rising popularity of dermal fillers, the number of complications associated with fillers has increased.To identify and review reports of adverse events involving cosmetic injectable soft-tissue fillers from the FDA Manufacturer and User Facility Device Experience (MAUDE) database from June 1993 to August 2014.The authors conducted a search of adverse events within the U.S. Food and Drug (...) Administration database that involved injectable dermal fillers for soft-tissue augmentation from June 1993 to August 2014. Search terms included generic and trade names of commercially available soft-tissue fillers.Three thousand seven hundred eighty-two complications involving dermal fillers were identified in the MAUDE database. Forty-four percent of complications implicated hyaluronic acid fillers, 40% involved poly-L-lactic acid fillers, 15% complications included calcium hydroxylapatite fillers, and <1

2019 Dermatologic Surgery

48. Nitroglycerin, or Not, When Treating Impending Filler Necrosis. (PubMed)

Nitroglycerin, or Not, When Treating Impending Filler Necrosis. Dermal necrosis is a rare yet serious risk associated with cosmetic filler injections, and although current consensus recommends the use of hyaluronidase injections in cases of hyaluronic acid filler, the efficacy of topical nitroglycerin as a treatment has not yet been fully investigated.To review the literature on tissue necrosis resulting from soft tissue augmentation and to highlight the use of topical nitroglycerin as a first (...) . Few reports of novel treatments for necrosis included the use of topical growth factors and injection of adipose-derived stem cells.Topical nitroglycerin is a potentially effective and underused treatment for tissue necrosis from soft tissue augmentation, but because data are very limited, topical nitroglycerin should be used in conjunction with hyaluronidase injections in cases of hyaluronic acid filler dermal necrosis.

2019 Dermatologic Surgery

49. Beauty is only mucosa deep: a retrospective analysis of oral lumps and bumps caused by cosmetic fillers. (PubMed)

Beauty is only mucosa deep: a retrospective analysis of oral lumps and bumps caused by cosmetic fillers. Introduction The injection of dermal fillers into orofacial tissues is becoming increasingly popular for cosmetic purposes, in particular for lip augmentation. Both natural and synthetic filler materials are available, producing a spectrum of clinical and histological appearances.Aims The aim of this study was to review the clinicopathological characteristics of dermal filler cases from 2006 (...) disease, including neoplasms (30%, n = 3), cysts (20%, n = 2) or inflammatory disease (10%, n = 1). Only two cases (20%) were clinically thought to be related to previous cosmetic injections. A variety of filler materials were seen, including collagen, hydroxyapatite and silicone. However, hyaluronic acid-based materials were the most common (50%, n = 5).Conclusions Complications of cosmetic dermal fillers are becoming more common and should be considered within a differential diagnosis for unusual

2019 British Dental Journal

50. The Efficacy and Safety of Lidocaine-Containing Hyaluronic Acid Dermal Filler for Treatment of Nasolabial Folds: A Multicenter, Randomized Clinical Study. (PubMed)

The Efficacy and Safety of Lidocaine-Containing Hyaluronic Acid Dermal Filler for Treatment of Nasolabial Folds: A Multicenter, Randomized Clinical Study. The use of injectable hyaluronic acid-based gel is well established in aesthetic facial procedures especially on the nasolabial fold (NLF).To compare the efficacy and safety of PP-501-A-Lidocaine dermal filler with RestylaneLidocaine(®) when administered to the NLF.Sixty-six subjects seeking correction of NLFs, with moderate or severe wrinkle (...) severity, were recruited for this multicenter, randomized, patient and evaluator-blind, matched pairs, and active-controlled design clinical study. PP-501-A-Lidocaine and RestylaneLidocaine(®) were injected into the deep layer of the dermis and/or subcutis of the NLF. The first validity evaluation variable was the average wrinkle severity rating scale (WSRS), as scored by independent blinded evaluators at week 24. The second validity evaluation variable including the global aesthetic improvement scale

2015 Aesthetic plastic surgery

51. Patient factors influencing dermal filler complications: prevention, assessment, and treatment (PubMed)

the procedure itself. Guidance is given on both immediate and long-term management of adverse reactions. The majority of complications are related to accepting patients inappropriate for treatment or issues of sterility, placement, volume, and injection technique. It is clear that esthetic practitioners need an in-depth knowledge of all aspects of treatment with dermal fillers to achieve optimal outcomes for their patients. (...) Patient factors influencing dermal filler complications: prevention, assessment, and treatment While rare, complications do occur with the esthetic use of dermal fillers. Careful attention to patient factors and technique can do much to avoid these complications, and a well-informed practitioner can mitigate problems when they do occur. Since cosmetic surgery is usually an elective process, requested by the patient, clinical trials are complex to organize and run. For this reason

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2015 Clinical, cosmetic and investigational dermatology

52. Dermal Fillers: An Update. (PubMed)

Dermal Fillers: An Update. Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the USA. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. Dermatologists and cosmetic surgeons should regularly review treatment options to provide (...) patients with safe and effective filler options. This paper extensively reviews the properties of the available fillers, such as their rheology, longevity, and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, trends in dermal filler injections are discussed.

2015 American journal of clinical dermatology

53. Basics of dermal filler rheology. (PubMed)

Basics of dermal filler rheology. Hyaluronic acid injectable fillers are the most widely used dermal fillers to treat facial volume deficits, providing long-term facial aesthetic enhancement outcomes for the signs of aging and/or facial contouring.The purpose of this article was to explain how rheology, the study of the flow of matter, can be used to help physicians differentiate between dermal fillers targeted to certain areas of the face.This article describes how rheological properties (...) spreading.Selection of dermal filler with the right rheological properties is a key factor in achieving a natural-looking long-lasting desired aesthetic outcome.

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2015 Dermatologic Surgery

54. A systematic review of dermal fillers for age-related lines and wrinkles.

A systematic review of dermal fillers for age-related lines and wrinkles. Dermal fillers are gaining popularity for rapid aesthetic improvement. Long-term efficacy and safety have not been well documented. The aim of this systematic review was to assess the safety and efficacy of injectable dermal fillers compared with other facial augmentation techniques for the management of age-related lines and wrinkles.Studies including patients receiving injectable semi-permanent or permanent dermal (...) fillers for age-related lines and wrinkles were included in this review. Efficacy outcomes (including changes in skin thickness and patient satisfaction) and safety outcomes (including mortality, lumps and infections) were examined.Three randomized control trials and six case series were included. Permanent and semi-permanent dermal fillers improved subjective ratings of appearance and resulted in higher patient satisfaction than temporary fillers. Long-term efficacy appeared good in the few studies

2015 ANZ journal of surgery

55. Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers

Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01492140 Recruitment Status : Unknown Verified December 2011 by TKL Research, Inc.. Recruitment status was: Active, not recruiting First Posted : December 14

2011 Clinical Trials

56. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic Acid-based dermal filler. (PubMed)

A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic Acid-based dermal filler. Soft-tissue augmentation with fillers is an aesthetic procedure for restoring age-related volume loss.To compare neocollagenesis and elastin production stimulated by Radiesse® (calcium hydroxylapatite; CaHA, Merz Pharmaceuticals GmbH) and a hyaluronic acid-based filler (HA; Juvéderm® VOLUMA®).Twenty-four women, aged 35-45, participated in this split-face (...) , comparative study. Punch biopsies were taken 4 and 9 months after supraperiostal injection of each filler into the ipsilateral or contralateral postauricular area. Samples were analyzed for collagens type I and III, elastin, Ki-67, and inflammatory and angiogenic markers.At month 4, collagen type III was greater with CaHA vs HA (P=0.0052). By month 9, type I staining was higher with CaHA vs HA (P=0.0135), whereas type III was lower with CaHA than HA (P=0.0019). Staining for elastin, Ki-67 and angiogenesis

2014 Journal of drugs in dermatology : JDD

57. Relationship Between Delayed Reactions to Dermal Fillers and Biofilm: Facts and Considerations. (PubMed)

, and methods to recognize biofilms will be reviewed. These are increasingly important for physicians who implant these devices and for those who see patients with implanted devices.We review the relevant literature and explore some of these issues.Preventative measures may decrease delayed reactions and biofilm formation after injection of dermal fillers. Infection through biofilms should be considered and carefully evaluated to ensure timely treatment. (...) Relationship Between Delayed Reactions to Dermal Fillers and Biofilm: Facts and Considerations. Delayed reactions associated with dermal fillers have often been attributed to hypersensitivity reactions; however, the evolving literature suggests that biofilms may represent an underrecognized cause and a difficult diagnosis to establish. As implanted devices become more popular, biofilms present an increasing risk to patients.The mechanism of action for biofilm formation, diagnostic challenges

2014 Dermatologic Surgery

58. Volume Restoration of Plantar Pad With a Hyaluronic Acid Dermal Filler in Metatarsalgia

Volume Restoration of Plantar Pad With a Hyaluronic Acid Dermal Filler in Metatarsalgia Volume Restoration of Plantar Pad With a Hyaluronic Acid Dermal Filler in Metatarsalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Volume Restoration of Plantar Pad With a Hyaluronic Acid Dermal Filler in Metatarsalgia (ELFE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02369380 Recruitment Status : Completed First Posted : February 23, 2015 Last Update Posted : November 10, 2015 Sponsor: Galderma

2014 Clinical Trials

59. Superficial dermal injection of hyaluronic Acid soft tissue fillers: comparative ultrasound study. (PubMed)

Superficial dermal injection of hyaluronic Acid soft tissue fillers: comparative ultrasound study. Superficial dermal injection of hyaluronic acids (HAs) has not been well studied.To study HAs injected into the superficial dermis using ultrasound examination and measurements, to evaluate induration and pain, and to examine histology.Three commercial HAs were injected into the superficial dermis (0.2 mL). The HAs used were a biphasic gel, a monophasic monodensified gel, and a monophasic (...) polydensified gel. Ultrasound measurements and images were obtained, pain assessed, and biopsies performed at 7 days.Participants experienced pain from the HAs that did not contain lidocaine. After 8 days, the biphasic HA papules appeared erythematous, with two-thirds reporting the biphasic HA papules as tender. Ultrasound demonstrated superficial placement of HA gels in the upper dermis. The gels each exhibited unique characteristic patterns on ultrasound. Skin biopsies of the superficial dermal placement

2012 Dermatologic Surgery

60. Dermal Filler Injection

Dermal Filler Injection Dermal Filler Injection Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermal Filler Injection Dermal Filler (...) Injection Aka: Dermal Filler Injection , Dermal Filler , Collagen Filler , Cosmoplast , Hyaluronic Acid Filler , Restylane , Perlane , Juvederm , Calcium Hydroxylapatite Filler , Radiesse , Poly-L-lactic Acid Filler , Sculptra II. Indications Lip enhancement Facial wrinkles and folds in lower two thirds of face Nosolabial folds (old FDA approved use) Oral commissures Marionette lines (long vertical lines around the chin) III. Mechanism Injectable substances that increase soft-tissue volume for 3-24

2015 FP Notebook

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