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Dermal Filler Injection

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21. Pilot Trial to Assess the Performance and Tolerance of mRDX-02-17 Dermal Filler in the Facial Rejuvenation

of wrinkles and dermal depressions. The primary hypothesis of this clinical investigation is that, at 30 days after the 60 days of treatment with mRDX-02-17, the mean WSRS score assessed by the investigator will decrease with at least 0.5 points compared to baseline evaluation. Condition or disease Intervention/treatment Phase Facial Rejuvenation Device: mRDX-02-17 Not Applicable Detailed Description: Minimally invasive procedures (injectable dermal fillers) are among the techniques preferred (...) Completion Date : March 2019 Estimated Study Completion Date : March 2019 Arms and Interventions Go to Arm Intervention/treatment Experimental: mRDX-02-17 mRDX-02-17 is a dermal filler recommended for correction and treatment of wrinkles and dermal depressions, which are administered by intradermal injections. It encourages repair and restructuring of skin tissue, reducing the signs of aging and has the following indications: Hypotrophic tissues Tissue hypotonicity Crow's feet Glogau III - IV Fiztpatrick

2018 Clinical Trials

22. Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers

Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03425721

2018 Clinical Trials

23. Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model. Full Text available with Trip Pro

Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model. 26910121 2018 02 12 2019 01 11 1600-0625 25 6 2016 06 Experimental dermatology Exp. Dermatol. Optical coherence tomography as a tool for real-time visual feedback and biomechanical assessment of dermal filler injections: preliminary results in a pig skin model. 475-6 10.1111/exd.12983 Singh Manmohan M Department of Biomedical (...) , Russia. eng R01 HL095586 HL NHLBI NIH HHS United States U54 HG006348 HG NHGRI NIH HHS United States R01 EY022362 EY NEI NIH HHS United States R01 HL120140 HL NHLBI NIH HHS United States R01 HD086765 HD NICHD NIH HHS United States Evaluation Studies Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2016 05 18 Denmark Exp Dermatol 9301549 0906-6705 0 Dermal Fillers IM Animals Dermal Fillers pharmacology Injections Outcome Assessment (Health Care) Skin diagnostic imaging drug

2016 Experimental Dermatology

24. Foreign body reaction triggered by CTLA-4 blockade 25 years after dermal filler injection, a case report. (Abstract)

Foreign body reaction triggered by CTLA-4 blockade 25 years after dermal filler injection, a case report. Foreign body reactions are regularly seen as a late complication of cosmetic treatment with synthetic dermal fillers. Often this foreign body reaction is triggered by a systemic infection, but other systemic triggers are also reported. In this case report, we present a woman in her 60s who was treated with ipilimumab for metastatic melanoma. After two courses of treatment she developed (...) painless facial nodules. A foreign body reaction to dermal fillers was suspected because the patient had received cosmetic treatment with dermal fillers 25 years previously. This reaction was confirmed by excision and histological examination. In the absence of other known triggers, this case revealed immunotherapy (ipilimumab) and subsequent activation of the adaptive immune system as potential triggers of foreign body reactions to dermal fillers. Immunotherapy is increasingly used as anticancer

2016 British Journal of Dermatology

25. Topographic anatomy of the superior labial artery for dermal filler injection. (Abstract)

Topographic anatomy of the superior labial artery for dermal filler injection. The superior labial artery, which is a branch of the facial artery, supplies the upper lip area. The aim of this study was to determine the distribution pattern of the superior labial artery and provide precise topographic information of the artery for dermal filler injection.Sixty hemifaces from 18 Korean and 18 Thai cadavers were used for this study. The various distribution patterns of the superior labial artery (...) percent), in which the artery is absent. The origin of the superior labial artery was located 12.1 ± 3.1 mm (mean ± SD) lateral and at a variable angle of 42.8 ± 26.9 degrees relative to the mouth corner.The superior labial artery proceeded from the origin of the artery located within a 1.5-cm-side square superolateral to the mouth corner as running along the vermilion border of the upper lip to the facial sagittal midline at a depth of 3 mm. Thus, clinicians should be careful when injecting dermal

2015 Plastic and reconstructive surgery

26. A Cross-sectional Analysis of Adverse Events and Litigation for Injectable Fillers. Full Text available with Trip Pro

A Cross-sectional Analysis of Adverse Events and Litigation for Injectable Fillers. Injectable fillers are increasing in popularity as a noninvasive option to address concerns related to facial aging and volume loss. To our knowledge, there have been no large-scale analyses of adverse events and associated litigation related to filler injections.To determine risks of injectable fillers and analyze factors raised in litigation related to injectable fillers.In this cross-sectional review, the US (...) Food and Drug Administration's (FDA) manufacturer and user facility device experience (MAUDE) database was evaluated for complications from the use of the following fillers: Juvederm, Restylane, Belotero, Sculptra, Radiesse, Artefill, Bellafill, and Juvederm Voluma from 2014 to 2016. The Westlaw Next database was used to identify jury verdicts.Complications were organized by type of filler used, location of injection, and severity. Intra-arterial injections without sequelae and those resulting

2017 JAMA facial plastic surgery

27. A Novel Needle Structure that Can Avoid Intravascular Injection of Any Filler Full Text available with Trip Pro

A Novel Needle Structure that Can Avoid Intravascular Injection of Any Filler With increasing use of dermal fillers, more and more adverse effects are reported. The most devastating one is intravascular injection. We propose a novel needle prototype that allows physicians to prevent intravascular injection.

2017 Plastic and Reconstructive Surgery Global Open

28. Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers Full Text available with Trip Pro

Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Both clinical

2017 Imaging Science in Dentistry

29. Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers Full Text available with Trip Pro

Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers Even though injectable hyaluronic acid (HA)-based fillers are considered safe, rare complications, such as late-onset inflammatory reactions have been reported. Possible causes and effective treatments have not been formally described, so this work aims to discuss these and offer a formal protocol for treatment.This article presents 5 clinical cases of late-onset inflammatory response occurring at least 3 months after uneventful (...) injection of HA dermal filler.Inflammation appeared spontaneously, usually 4-5 months after the last injection, but in 1 patient, almost 14 months later. One patient was injected at the same time with fillers manufactured by 2 different technologies. In this case, all areas treated with the same filler showed diffuse swelling of inflammatory nature, whereas the lips, treated with the second filler brand, remained unaffected. Four patients reported a flu-like illness or gastrointestinal upset a few days

2017 Plastic and Reconstructive Surgery Global Open

30. Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report Full Text available with Trip Pro

these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur.A multidisciplinary group of experts in aesthetic treatments reviewed the main factors associated with the complications that arise when using dermal fillers. A search of English, French and Spanish language articles in PubMed was performed using the terms "complications" OR "soft filler complications" OR "injectable complications" AND "dermal fillers". An initial document was drafted (...) Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid

2017 Aesthetic plastic surgery

31. Calcium Hydroxylapatite Dermal Filler for Treatment of Dorsal Hand Volume Loss: Results From a 12-Month, Multicenter, Randomized, Blinded Trial. (Abstract)

Calcium Hydroxylapatite Dermal Filler for Treatment of Dorsal Hand Volume Loss: Results From a 12-Month, Multicenter, Randomized, Blinded Trial. Calcium hydroxylapatite (CaHA) microspheres suspended in a carrier gel is an opaque dermal filler that has been used to provide immediate volume correction in the dorsal hands.To assess the safety and effectiveness of CaHA for the correction of volume loss in the hands up to 12 months.This multicenter, controlled, single-blind study (NCT01832090 (...) . Proportions of subjects reporting improvement ranged from 98% (3 months) to 86% (12 months). There were no clinically significant differences between control and CaHA-treated subjects in any hand function measure. Adverse events were generally expected, minor, short-lived, injection-related, and similar to those observed in previous CaHA clinical studies.Treatment with CaHA results in significant improvement in the appearance of the dorsal hand and is well tolerated.

2017 Dermatologic Surgery Controlled trial quality: uncertain

32. Vibration anesthesia for the reduction of pain with facial dermal filler injections. (Abstract)

Vibration anesthesia for the reduction of pain with facial dermal filler injections. Vibration anesthesia is an effective pain-reduction technique for facial cosmetic injections. The analgesic effect of this method was tested in this study during facial dermal filler injections. The study aimed to evaluate the safety and efficacy of vibration anesthesia for these facial injections.This prospective study analyzed 41 patients who received dermal filler injections to the nasolabial folds, tear (...) troughs, cheeks, and other facial sites. The injections were administered in a randomly assigned split-face design. One side of the patient's face received vibration together with dermal filler injections, whereas the other side received dermal filler injections alone. The patients completed a posttreatment questionnaire pertaining to injection pain, adverse effects, and preference for vibration with future dermal filler injections.The patients experienced both clinically and statistically significant

2014 Aesthetic plastic surgery Controlled trial quality: uncertain

33. Self injection of dermal filler: an under-diagnosed entity? (Abstract)

Self injection of dermal filler: an under-diagnosed entity? Dermal fillers are increasingly used by clinicians (and nonclinicians) in patients requiring facial rejuvenation, as well as for other aesthetic uses such as treatment of age-related wrinkles, skin folds and depressed scars. We report the case of a patient who injected herself with dermal filler purchased over the internet and who required intervention for the undesired effect. We would like to highlight the ease with which

2014 British Journal of Dermatology

34. Skin extracellular matrix stimulation following injection of a hyaluronic acid-based dermal filler in a rat model. (Abstract)

Skin extracellular matrix stimulation following injection of a hyaluronic acid-based dermal filler in a rat model. Hyaluronic acid-based dermal fillers have gained rapid acceptance for treating facial wrinkles and deep tissue folds. Although their space-filling properties are well understood, this study evaluates the cellular and molecular changes in skin, as a secondary effect, following injection of a commercially available, 24-mg/ml, cross-linked hyaluronic acid-based filler (HYC-24L (...) expression levels of collagen types I and III in rat dermal tissue for up to 12 weeks. The ratio of collagen type III to type I protein, however, remained unchanged, suggesting maintenance of collagen homeostasis. A significant increase in dermal elastin after HYC-24L+ injection was also observed. Gene expression analysis confirmed that several genes associated with extracellular matrix production and assembly were also transiently up-regulated, and that these changes temporally preceded those observed

2014 Plastic and reconstructive surgery

35. Autologous fat grafting and injectable dermal fillers for human immunodeficiency virus-associated facial lipodystrophy: a comparison of safety, efficacy, and long-term treatment outcomes. (Abstract)

Autologous fat grafting and injectable dermal fillers for human immunodeficiency virus-associated facial lipodystrophy: a comparison of safety, efficacy, and long-term treatment outcomes. Facial lipoatrophy is a common side effect of human immunodeficiency virus treatment with highly active antiretroviral therapy. To identify the most clinically durable and efficient way of addressing facial lipoatrophy, the authors reviewed all available evidence for the use of injectable dermal fillers (...) and autologous fat transfers as treatment modalities, focusing on safety, outcomes, and long-term durability.A systematic review of the Cochrane and MEDLINE databases for autologous fat transfer and injectable dermal fillers for the treatment of human immunodeficiency virus-associated lipodystrophy was performed. Based on U.S. Food and Drug Administration approval in human immunodeficiency virus lipoatrophy, studies were limited to the use of hyaluronic acid and/or poly-L-lactic acid. Facial volume

2013 Plastic and reconstructive surgery

36. Non-ablative 1540 fractional laser: How far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? a randomized controlled trial. Full Text available with Trip Pro

Non-ablative 1540 fractional laser: How far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? a randomized controlled trial. Rejuvenation of the lower face can be challenging and no single modality can accomplish all its complex events.This 18-month study included 24 female patients with a primary complaint of lower-face aging signs. They were randomly allocated to either Group A, who received injection lipolysis and hyaluronic acid dermal filler, or Group B who (...) significant in the long-term evaluations (13 and 18 months) (P < 0.05).This study further documents the importance of combination therapy in facial rejuvenation, offering a treatment protocol combining injection lipolysis and hyaluronic acid as an effective, safe, short-term therapeutic option in lower-face rejuvenation. The addition of 1540 non-ablative fractional laser to the protocol offers a higher efficacy with longer-term effects and no adverse events.

2013 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

37. Safety and efficacy of a continuous-flow, injection-assisted device in delivery of dermal fillers. Full Text available with Trip Pro

Safety and efficacy of a continuous-flow, injection-assisted device in delivery of dermal fillers. A device to assist in the delivery of dermal filler may achieve reductions in patient discomfort and adverse events, as well physician fatigue. It may also increase the accuracy of material placement.The authors assess the safety and performance of the Artiste Assisted Injection System (Nordson Micromedics, St Paul, Minnesota) in normal therapeutic use compared with the standard manual (...) administration of dermal fillers.At 3 study sites, a total of 52 patients (48 women and 4 men) received bilateral full-correction injections of dermal fillers into randomized nasolabial folds (NLF). Injection into 1 NLF was made via Artiste, and injection into the other NLF was made via manual delivery. Immediately posttreatment and through 29 days, physician investigators, patients, and blinded evaluators recorded treatment durations and volumes, evaluated designated posttreatment characteristics using

2013 Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery Controlled trial quality: uncertain

38. Skin Remodeling Using Hyaluronic Acid Filler Injections in Photoaged Faces. (Abstract)

increase in collagen fibers at 3 and 9 months after the procedure (34.2% ± 31.5% and 39.5% ± 39.7%, respectively, p < .05).Sustained clinical results for HA filler can be explained not only by the presence of HA gel on the dermis but also by the dermal remodeling induced by HA filler injected into the face. (...) Skin Remodeling Using Hyaluronic Acid Filler Injections in Photoaged Faces. Hyaluronic acid (HA) filler is an important dermatological procedure. Although many studies have reported clinical improvement with this procedure, histology with morphometric evidence is not well documented.To evaluate the clinical and histological results of a HA filler injection and to quantify dermis remodeling at 3 and 9 months after HA injections into aged faces.Twenty patients were enrolled in this study

2016 Dermatologic Surgery

39. Dermal Filler Injection

Dermal Filler Injection Dermal Filler Injection Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermal Filler Injection Dermal Filler (...) Injection Aka: Dermal Filler Injection , Dermal Filler , Collagen Filler , Cosmoplast , Hyaluronic Acid Filler , Restylane , Perlane , Juvederm , Calcium Hydroxylapatite Filler , Radiesse , Poly-L-lactic Acid Filler , Sculptra II. Indications Lip enhancement Facial wrinkles and folds in lower two thirds of face Nosolabial folds (old FDA approved use) Oral commissures Marionette lines (long vertical lines around the chin) III. Mechanism Injectable substances that increase soft-tissue volume for 3-24

2015 FP Notebook

40. Superficial dermal injection of hyaluronic Acid soft tissue fillers: comparative ultrasound study. (Abstract)

Superficial dermal injection of hyaluronic Acid soft tissue fillers: comparative ultrasound study. Superficial dermal injection of hyaluronic acids (HAs) has not been well studied.To study HAs injected into the superficial dermis using ultrasound examination and measurements, to evaluate induration and pain, and to examine histology.Three commercial HAs were injected into the superficial dermis (0.2 mL). The HAs used were a biphasic gel, a monophasic monodensified gel, and a monophasic (...) polydensified gel. Ultrasound measurements and images were obtained, pain assessed, and biopsies performed at 7 days.Participants experienced pain from the HAs that did not contain lidocaine. After 8 days, the biphasic HA papules appeared erythematous, with two-thirds reporting the biphasic HA papules as tender. Ultrasound demonstrated superficial placement of HA gels in the upper dermis. The gels each exhibited unique characteristic patterns on ultrasound. Skin biopsies of the superficial dermal placement

2012 Dermatologic Surgery

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