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Dermal Filler Injection

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1. Polymethylmethacrylate Collagen Gel-Injectable Dermal Filler for Full Face Atrophic Acne Scar Correction. (PubMed)

Polymethylmethacrylate Collagen Gel-Injectable Dermal Filler for Full Face Atrophic Acne Scar Correction. This trial evaluated the effectiveness and safety of Bellafill for full-face acne scar treatment.In this open-label, nonrandomized, multicenter pilot study investigating the use of polymethylmethacrylate for full-face atrophic acne scar correction, 42 adult subjects with a mean age of 43 years were treated and assessed for safety and effectiveness at Months 4 and 7. There were

2019 Dermatologic Surgery

2. Lumen Diameter and Associated Anatomy of the Superior Labial Artery With a Clinical Application to Dermal Filler Injection. (PubMed)

Lumen Diameter and Associated Anatomy of the Superior Labial Artery With a Clinical Application to Dermal Filler Injection. Vascular compromise and subsequent tissue necrosis is a rare but disfiguring complication of dermal filler injection that frequently occurs in regions of the lip and nasolabial fold supplied by the superior labial artery (SLA).The purpose of this study was to examine lumen diameter and other anatomical features of the SLA relevant to dermal filler injection in the clinical (...) of Cupid's bow (4.29 ± 1.54 mm; Point P2).The variable, superficial course of the SLA and its large caliber place it at significant risk for intra-arterial injection with dermal filler at all points along its course.

2019 Dermatologic Surgery

3. Biochemistry, Physiology, and Tissue Interactions of Contemporary Biodegradable Injectable Dermal Fillers. (PubMed)

Biochemistry, Physiology, and Tissue Interactions of Contemporary Biodegradable Injectable Dermal Fillers. Injectable dermal fillers are becoming increasingly popular for soft tissue augmentation and rejuvenation. Most contemporary biodegradable products are derived from hyaluronic acid, calcium hydroxylapatite, or poly-L-lactic acid. Achievement of desired cosmetic outcomes is largely dependent on selection of the optimal injectable product based on the chemical composition, the physiologic (...) of the most commonly used biodegradable dermal fillers. The underlying biochemical properties of each product and how they contribute to specific physiologic and adverse tissue reactions is described.Understanding of the innate differences in the physical properties, and physiologic responses to soft tissue fillers allows clinicians to achieve desired aesthetic outcomes with fewer adverse events.

2018 Dermatologic Surgery

4. A Case of Herpes Simplex Virus Type 1 (HSV-1) Encephalitis as a Possible Complication of Cosmetic Nasal Dermal Filler Injection (PubMed)

A Case of Herpes Simplex Virus Type 1 (HSV-1) Encephalitis as a Possible Complication of Cosmetic Nasal Dermal Filler Injection BACKGROUND Dermal fillers are increasingly used for medical and aesthetic purposes in clinical practice. Common complications following filler injections include bruising, itching, infections, allergic reactions, and tissue necrosis. This case is the first report of Herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of dermal filler injection (...) . CASE REPORT A 27-year-old woman with no past medical history presented with altered mental state, headaches, and seizures. She had a nasal dermal filler injection for aesthetic purpose five weeks before her acute presentation. A diagnosis of HSV-1 encephalitis was made based on brain imaging with computed tomography and magnetic resonance imaging (MRI) findings that showed bilateral frontotemporal lobe hyperintensity. Analysis of her cerebrospinal fluid (CSF) confirmed the presence of HSV-1 DNA

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2018 The American journal of case reports

5. Influence of the Topographic Vascular Distribution of the Face on Dermal Filler Accidents. (PubMed)

Influence of the Topographic Vascular Distribution of the Face on Dermal Filler Accidents. Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. The aim of this study is to provide an overview of the vascular territories (...) of the face to avoid many possible complications when using facial fillings. Anatomical localization of the main arterial supply to the face has been described to assess the risk of vascular injury.The authors dissected 17 hemifaces of embalmed adult cadavers that had previously been injected, through the common carotid artery, with latex containing a red dye.A topographic distribution was generated by facial regions following a clinical approach from where the facial fillings were placed and related

2019 Dermatology

6. Treatment of Atrophic Facial Acne Scars With Microneedling Followed by Polymethylmethacrylate-Collagen Gel Dermal Filler. (PubMed)

Treatment of Atrophic Facial Acne Scars With Microneedling Followed by Polymethylmethacrylate-Collagen Gel Dermal Filler. Microneedling and soft-tissue filler injections have been used independently to improve acne scarring. The effectiveness of a combined approach using microneedling followed by polymethylmethacrylate (PMMA)-collagen gel has not been carefully studied.The goal of this study was to assess the effectiveness and safety of microneedling alone versus microneedling followed (...) by injection of PMMA-collagen gel filler for correction of atrophic facial acne scars.We conducted a multicenter, open-label, randomized, prospective study on subjects with distensible atrophic acne scars in the face to determine whether microneedling with PMMA-collagen gel is a superior acne scar treatment over microneedling alone. Forty-four subjects received 3 microneedling treatments over a 12-week period followed by randomization to treatments with PMMA-collagen gel (treatment group) or no further

2019 Dermatologic Surgery

7. Lip and Perioral Enhancement With Hyaluronic Acid Dermal Fillers in Individuals With Skin of Color. (PubMed)

), 90.9% and 46.4%, respectively, were responders. Injection site responses were generally mild or moderate in severity, resolved within 2 weeks, and were consistent with those expected for HA dermal filler treatment. The most common AEs were injection site mass (19.4%) and bruising (12.5%).Lip and perioral enhancement with HA dermal fillers is effective and safe in subjects with skin of color. (...) Lip and Perioral Enhancement With Hyaluronic Acid Dermal Fillers in Individuals With Skin of Color. Individuals with skin of color are underrepresented in studies of lip and perioral enhancement.To examine the effectiveness and safety of hyaluronic acid (HA) dermal filler treatment for lip and perioral enhancement in subjects with skin of color.Data were pooled from subjects with Fitzpatrick skin phototypes IV, V, or VI in 2 pivotal studies of HA dermal fillers. Photonumeric scales were used

2019 Dermatologic Surgery

8. Safety and effectiveness of hyaluronic acid dermal filler in correction of moderate-to-severe nasolabial folds in Chinese subjects. (PubMed)

Safety and effectiveness of hyaluronic acid dermal filler in correction of moderate-to-severe nasolabial folds in Chinese subjects. Modified sodium hyaluronate gel for injection, Princess® VOLUME (PV), has been on the European market since 2009 to correct deeper wrinkles and folds, increasing or restoring volume of the face, and remodeling facial contours.To evaluate the safety and effectiveness of PV in correction of moderate-to-severe nasolabial folds (NLF) in Chinese subjects.In (...) is noninferior to RL (p<0.001). Most frequently reported adverse events for both devices were injection site swelling and procedural pain. The severity of the majority of the adverse events was mild.This study confirms that PV is a safe and effective treatment for the correction of moderate-to-severe NLFs in Chinese subjects.

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2019 Clinical, cosmetic and investigational dermatology

9. Improvement of Radial Cheek Lines With Hyaluronic Acid-Based Dermal Filler VYC-17.5L: Results of the BEAM Study. (PubMed)

Improvement of Radial Cheek Lines With Hyaluronic Acid-Based Dermal Filler VYC-17.5L: Results of the BEAM Study. Radial cheek lines (RCL) may convey an older, potentially less attractive appearance.To evaluate the effectiveness of hyaluronic acid-based dermal filler VYC-17.5L for correcting RCL.Fifty-three women (40-65 years) received injections of VYC-17.5L in both cheeks on Day 1 (optional Day 14 touch-up). Effectiveness was evaluated on Day 45 by subject-rated dynamic RCL improvement (Global (...) Aesthetic Improvement Scale [GAIS]; primary end point) and independent, noninjecting investigator-rated GAIS; subject Self-Perception of Age (SPA); subject-assessed satisfaction with and natural look of treatment; and instrument-assessed changes in static and dynamic RCL roughness, amplitude, and texture (secondary end points). Safety assessments included injection site responses (ISRs).On Day 45, 98% of subjects rated RCL as improved or much improved (investigator rated: 95%). Subjects with same

2019 Dermatologic Surgery

10. Foreign body reaction triggered by CTLA-4 blockade 25 years after dermal filler injection, a case report. (PubMed)

Foreign body reaction triggered by CTLA-4 blockade 25 years after dermal filler injection, a case report. Foreign body reactions are regularly seen as a late complication of cosmetic treatment with synthetic dermal fillers. Often this foreign body reaction is triggered by a systemic infection, but other systemic triggers are also reported. In this case report, we present a woman in her 60s who was treated with ipilimumab for metastatic melanoma. After two courses of treatment she developed (...) painless facial nodules. A foreign body reaction to dermal fillers was suspected because the patient had received cosmetic treatment with dermal fillers 25 years previously. This reaction was confirmed by excision and histological examination. In the absence of other known triggers, this case revealed immunotherapy (ipilimumab) and subsequent activation of the adaptive immune system as potential triggers of foreign body reactions to dermal fillers. Immunotherapy is increasingly used as anticancer

2016 British Journal of Dermatology

11. Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model. (PubMed)

Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model. 26910121 2018 02 12 2019 01 11 1600-0625 25 6 2016 06 Experimental dermatology Exp. Dermatol. Optical coherence tomography as a tool for real-time visual feedback and biomechanical assessment of dermal filler injections: preliminary results in a pig skin model. 475-6 10.1111/exd.12983 Singh Manmohan M Department of Biomedical (...) , Russia. eng R01 HL095586 HL NHLBI NIH HHS United States U54 HG006348 HG NHGRI NIH HHS United States R01 EY022362 EY NEI NIH HHS United States R01 HL120140 HL NHLBI NIH HHS United States R01 HD086765 HD NICHD NIH HHS United States Evaluation Studies Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2016 05 18 Denmark Exp Dermatol 9301549 0906-6705 0 Dermal Fillers IM Animals Dermal Fillers pharmacology Injections Outcome Assessment (Health Care) Skin diagnostic imaging drug

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2016 Experimental Dermatology

12. Dermal Filler Injection

Dermal Filler Injection Dermal Filler Injection Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermal Filler Injection Dermal Filler (...) Injection Aka: Dermal Filler Injection , Dermal Filler , Collagen Filler , Cosmoplast , Hyaluronic Acid Filler , Restylane , Perlane , Juvederm , Calcium Hydroxylapatite Filler , Radiesse , Poly-L-lactic Acid Filler , Sculptra II. Indications Lip enhancement Facial wrinkles and folds in lower two thirds of face Nosolabial folds (old FDA approved use) Oral commissures Marionette lines (long vertical lines around the chin) III. Mechanism Injectable substances that increase soft-tissue volume for 3-24

2018 FP Notebook

13. An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers. (PubMed)

An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers. Following intradermal injection, hyaluronic acid (HA)-based fillers tend to spread within the reticular dermis and to distribute between the dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a "toolbox" consisting of a visual scoring and a semi-automatic image analysis method using internal developed algorithm to quantitate (...) . Furthermore, the results calculated with the semi-automatic method were consistent with the visual scores obtained on injected human skin samples by means of a 5-grade photographic scale. A modified hematoxylin-eosin staining was found adequate to visualize both, the filler and the general morphology, on the same section. An excellent correlation was observed between the integration results obtained with PAS/Alcian Blue and HE-stained slides, allowing for a single staining in future studies.We developed

2018 Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

14. Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration. (PubMed)

Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration. QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing

2018 Aesthetic plastic surgery

15. Randomized, Patient/Evaluator-Blinded, Intraindividual Comparison Study to Evaluate the Efficacy and Safety of a Novel Hyaluronic Acid Dermal Filler in the Treatment of Nasolabial Folds. (PubMed)

Randomized, Patient/Evaluator-Blinded, Intraindividual Comparison Study to Evaluate the Efficacy and Safety of a Novel Hyaluronic Acid Dermal Filler in the Treatment of Nasolabial Folds. Comparative research on the characteristics of filler products is limited, especially in the preclinical analysis of hyaluronic acid (HA) fillers.This study was performed to compare the preclinical characteristics, clinical efficacy, and safety of a new HA filler, IDHF-001, with Restylane SubQ in the treatment (...) injection force (8.89 N) than Restylane SubQ (464.6 Pa·s; 674.8 Pa; 19.14 N). No significant difference in WSRS was detected between IDHF-001 side and Restylane SubQ side at 24 weeks (mean improvement in WSRS from baseline at Week 24-IDHF-001: 1.85 ± 0.61, Restylane SubQ: 1.88 ± 0.61). The noninferiority was sustained until Week 48.The novel HA filler IDHF-001 shows suitable characteristics and tolerability, widening the selection possibilities for clinicians and patients in the treatment of NLFs.

2018 Dermatologic Surgery

16. Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers

Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03425721

2018 Clinical Trials

17. In Vitro Analysis of the Degradation of Calcium Hydroxylapatite Dermal Filler: A Proof-of-Concept Study. (PubMed)

In Vitro Analysis of the Degradation of Calcium Hydroxylapatite Dermal Filler: A Proof-of-Concept Study. A dissolving agent for calcium hydroxylapatite (CaHA, Radiesse) soft-tissue filler would be of value should inadvertent intravascular injection, vascular compromise, nodule formation, or overcorrection occur.In a prospective, single-center, proof-of-concept study, 12 cadaveric porcine skin samples were injected with CaHA (0.4-0.8 mL). Samples were then randomized to intralesional injection (...) of 0.2-mL sodium thiosulfate (STS, 12.5 g/50 mL); 1 to 2 g of topical sodium metabisulfite (SMB, 25% SMB in 120-mL gel) applied with occlusion, or both intralesional STS and topical SMB. Control samples were not treated after CaHA injection. A 4-mm punch biopsy was obtained 24 hours after treatment, and tissue sections were stained with hematoxylin and eosin and prepared for light microscopy. A board-certified dermatopathologist estimated the amount of CaHA present in each sample.Intralesional STS

2018 Dermatologic Surgery

18. Pilot Trial to Assess the Performance and Tolerance of mRDX-02-17 Dermal Filler in the Facial Rejuvenation

of wrinkles and dermal depressions. The primary hypothesis of this clinical investigation is that, at 30 days after the 60 days of treatment with mRDX-02-17, the mean WSRS score assessed by the investigator will decrease with at least 0.5 points compared to baseline evaluation. Condition or disease Intervention/treatment Phase Facial Rejuvenation Device: mRDX-02-17 Not Applicable Detailed Description: Minimally invasive procedures (injectable dermal fillers) are among the techniques preferred (...) Completion Date : March 2019 Estimated Study Completion Date : March 2019 Arms and Interventions Go to Arm Intervention/treatment Experimental: mRDX-02-17 mRDX-02-17 is a dermal filler recommended for correction and treatment of wrinkles and dermal depressions, which are administered by intradermal injections. It encourages repair and restructuring of skin tissue, reducing the signs of aging and has the following indications: Hypotrophic tissues Tissue hypotonicity Crow's feet Glogau III - IV Fiztpatrick

2018 Clinical Trials

19. Safety, Effectiveness and Subject Satisfaction Study of a Dermal Filler ( of RADIESSE® (+) Lidocaine) in the Treatment of Ageing Signs in the Face

Completion Date : July 2020 Estimated Study Completion Date : July 2020 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: RADIESSE® (+) Lidocaine Device: RADIESSE® (+) Lidocaine RADIESSE® (+) Lidocaine will be injected as per its current approved labelling and investigator's usual practice Other Name: Radiesse® Injectable Dermal Filler with Lidocaine Outcome Measures Go to Primary Outcome Measures : Responder (...) rating at Day 1 as determined by the blinded rater and confirmed by the treating investigator afterwards. At least two of the inclusion criteria 3, 4, and 5 must be fulfilled. Depending on the fulfilled criteria, the respective indications will be treated. Exclusion Criteria: Any prior treatment with silicone, polymethyl methacrylate, fat injections, poly L lactic acid or permanent dermal fillers in the face. Any prior facial surgery, including facial plastic surgery, thread lift, any unknown

2018 Clinical Trials

20. Radiographic study of dermal fillers in the facial area: A series of 3 cases (PubMed)

of dermal fillers observed in panoramic and cone-beam computed tomographic (CBCT) images. All 3 elderly female patients had filler injected into their cheeks and chin area for cosmetic purposes decades ago. On panoramic images, multiple symmetric radiopacities were observed in the facial area; on CBCT, these calcifications were seen in the subcutaneous tissue in various shapes and with varying density. In conclusion, dentists should be aware of the imaging characteristics of dermal filler, and should (...) Radiographic study of dermal fillers in the facial area: A series of 3 cases In recent years, as interest in maintaining beauty and a youthful appearance has grown, filler procedures such as soft tissue augmentation have become more popular. These fillers are sometimes seen as radiopaque shadows on radiographic images, either due to the fillers themselves or because of secondary reactions; such findings may present a diagnostic challenge to dentists. The present report describes 3 cases

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2018 Imaging Science in Dentistry

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