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Depression in Older Adults

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1. Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults

Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults Comparative Effectiveness Review Number 215 RComparative Effectiveness Review Number 215 Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract (...) multiple medications. Major depression was mostly diagnosed using DSM criteria. Based on scores from the Hamilton Depression Rating Scale (HAM-D) or the Montgomery-Asberg Depression Scale (MADRS) for study eligibility, the population represents those with moderate severity depression. The doses of antidepressants studied were rarely reflective of the full range cited in guideless as the usual dose range for older adults, and were ES-8 more often reflective of the lower half of that range. The data

2019 Effective Health Care Program (AHRQ)

2. Delirium, Dementia, and Depression in Older Adults: Assessment and Care, Second Edition

Delirium, Dementia, and Depression in Older Adults: Assessment and Care, Second Edition Delirium, Dementia, and Depression in Older Adults: Assessment and Care, Second Edition | Registered Nurses' Association of Ontario l’Association des infirmières et infirmiers autorisés de l’Ontario Speaking out for nursing. Speaking out for health. » » Delirium, Dementia, and Depression in Older Adults: Assessment and Care, Second Edition Type of Guideline: Clinical Status: Published Publish Date: 2016 (...) About this Guideline : This nursing Best Practice Guideline (BPG) is intended to replace the RNAO (2010) BPGs Screening for Delirium, Dementia and Depression in Older Adults and Caregiving Strategies for Older Adults with Delirium, Dementia and Depression. It is to be used by nurses and other members of the interprofessional health-care team to enhance the quality of their practice pertaining to delirium, dementia, and depression in older adults, ultimately optimizing clinical outcomes through

2017 Registered Nurses' Association of Ontario

3. Work status, retirement, and depression in older adults: An analysis of six countries based on the Study on Global Ageing and Adult Health (SAGE) (PubMed)

Work status, retirement, and depression in older adults: An analysis of six countries based on the Study on Global Ageing and Adult Health (SAGE) The aim of the present study was to analyse the association between the occurrence of a major depressive episode among older adults and work status in low- and medium-income countries. A cross-sectional study was conducted with people 60 years of age and older from the six countries (Mexico, India, China, Russian Federation, Ghana and South Africa (...) ) included in the Study on Global Ageing and Adult Health (SAGE) and who participated in its first wave (2009-2010). The occurrence of a major depressive episode (MDE) over the previous 12 months was determined based on an adaptation of the ICD-10 diagnostic criteria. The association between current work status and the presence of an MDE was estimated using binary logistic regression models with country-level fixed effects, and interaction terms between the country and work status. Results showed

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2018 SSM - population health

4. Prevalence of depression and depressive symptoms among older adults in Asian developing countries: a systematic review and meta-analysis

Prevalence of depression and depressive symptoms among older adults in Asian developing countries: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

5. The effect of group exercises on balance, mobility, and depressive symptoms in older adults with mild cognitive impairment: a randomized controlled trial

The effect of group exercises on balance, mobility, and depressive symptoms in older adults with mild cognitive impairment: a randomized controlled trial To determine the effects of group exercises on balance, mobility, and depressive symptoms in community-dwelling older adults with mild cognitive impairment.Single blinded, randomized, matched pairs clinical trial.Four primary healthcare units.Fifty-two sedentary subjects with mild cognitive impairment were paired (age, sex, body mass index (...) symptoms (median before: 3.5 (2-7.3); after: 4 (2-5.3)), while their balance and mobility showed no significant modification. Small effect sizes were observed in the intervention group and control group depressive symptoms, as well as in the control group's mobility and balance. Large effect sizes were observed the intervention group's mobility and balance.Group exercises improved balance, mobility, and depressive symptoms in community-dwelling older adults with mild cognitive impairment.

2019 EvidenceUpdates

6. Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults

Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults To assess adverse effects of pharmacologic antidepressants for treatment of major depressive disorder (MDD) in adults 65 years of age or older.Systematic review and meta-analysis.Specialist or generalist outpatient setting, rehabilitation facility, and nursing facilities.Persons 65 years and older with MDD.Selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs (...) to a statistically similar frequency of overall adverse events vs placebo (moderate strength of evidence [SOE]), but SNRIs caused more overall adverse events vs placebo (high SOE) during the acute treatment phase. Both SSRIs and SNRIs led to more study withdrawals due to adverse events vs placebo (SSRIs low SOE; SNRIs moderate SOE). Duloxetine led to a more falls vs placebo (moderate SOE) during 24 weeks of acute and continuation treatment of MDD.In patients 65 years of age or older with MDD, treatment

2019 EvidenceUpdates

7. Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial. (PubMed)

Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial. There is little evidence to guide management of depressive symptoms in older people.To evaluate whether a collaborative care intervention can reduce depressive symptoms and prevent more severe depression in older people.Randomized clinical trial conducted from May 24, 2011, to November 14, 2014, in 32 primary care centers in the United Kingdom (...) % (76/324), respectively (difference, -6.3% [95% CI, -12.8% to 0.2%]; relative risk, 0.83 [95% CI, 0.61-1.27]; P = .25) and at 12-month follow-up were 15.7% (37/235) vs 27.8% (79/284) (difference, -12.1% [95% CI, -19.1% to -5.1%]; relative risk, 0.65 [95% CI, 0.46-0.91]; P = .01).Among older adults with subthreshold depression, collaborative care compared with usual care resulted in a statistically significant difference in depressive symptoms at 4-month follow-up, of uncertain clinical importance

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2017 JAMA

8. Exploring Singapore's consumption of local fish, vegetables and fruits, meat and problematic alcohol use as risk factors of depression and subsyndromal depression in older adults. (PubMed)

Exploring Singapore's consumption of local fish, vegetables and fruits, meat and problematic alcohol use as risk factors of depression and subsyndromal depression in older adults. Depression is a chronic mental disorder that severely impacts the older adult population globally. Nutritional psychiatry is an approach that has gained traction over the years. Exploring locally relevant consumption of common types of fish, vegetables and fruits (V&F), meat and problematic alcohol use (PAU) as risk (...) factors associated with depression and subsyndromal depression (SSD) could reveal modifiable factors that could be targeted in the local older adult population in Singapore.Data collected from the Well-being of the Singapore Elderly (WiSE) study, a cross-sectional population-based epidemiological study of Singapore's older adult population was analysed for the purposes of this study. Two thousand five hundred sixty-five participants were recruited and comprised of Singapore citizens and permanent

2019 BMC Geriatrics

9. Negative Emotions and the Course of Depression During Psychotherapy in Suicidal Older Adults With Depression and Cognitive Impairment. (PubMed)

Negative Emotions and the Course of Depression During Psychotherapy in Suicidal Older Adults With Depression and Cognitive Impairment. The study examines the relationship of negative emotions with: 1) non-emotional symptoms (e.g., vegetative and physical symptoms) and 2) the course of depression in suicidal older adults with Major Depressive Disorder (MDD) and cognitive impairment treated with psychotherapy.The authors identified a subgroup of participants (N = 26) who expressed suicidal (...) ideation at Baseline or Week 12 from a randomized controlled trial (RCT) of two psychosocial interventions, Problem Adaptation Therapy (PATH) and Supportive Therapy for Cognitively Impaired. The authors assessed negative emotions, non-emotional symptoms of depression, depression severity, and suicidal ideation at entry, week 4, week 8, and week 12.Participants were 65 years and older and had a diagnosis of unipolar depression, varying degrees of cognitive impairment (up to moderate dementia

2019 The American Journal of Geriatric Psychiatry

10. Gender differences in the impact of retirement on depressive symptoms among middle-aged and older adults: A propensity score matching approach. (PubMed)

Gender differences in the impact of retirement on depressive symptoms among middle-aged and older adults: A propensity score matching approach. Retirement is one of the most important later-life status transitions related to changes in workforce participation, lifestyle, and social roles among older adults. The purpose of this study was to investigate the impact of retirement on depressive symptoms by gender in middle-aged and older adult Koreans, using a large, nationally representative (...) sample.Using year 2010 and 2012 data from the Korea Longitudinal Study of Aging, we investigated the relationship between adults' retirement status and depressive symptoms measured by the 10-item Center for Epidemiological Studies-Depression (CES-D10) scale. A series of propensity score matching models were calculated to test the potential retirement effect on adults' depressive symptoms.Overall, the level of depressive symptoms of the retired group was not different from that of the employed counterpart

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2019 PLoS ONE

11. Internet Mindfulness Meditation Intervention (IMMI) Improves Depression Symptoms in Older Adults. (PubMed)

Internet Mindfulness Meditation Intervention (IMMI) Improves Depression Symptoms in Older Adults. Background: Older adults have fewer physiological reserves and are more likely to be affected by stress. Mindfulness meditation has the potential to be an effective treatment for depression, but little research has been conducted on older adults. The primary objective of this study was to evaluate depression symptom changes in older adults (55⁻80 years old) taking an Internet Mindfulness Meditation (...) : IMMI improved depression and related symptoms compared to controls despite minimal support from study staff. IMMI offers a low-dose, low-cost, easily accessible mindfulness meditation intervention for older adults with depression symptoms.

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2018 Medicines (Basel, Switzerland)

12. Association of alterations in smell and taste with depression in older adults (PubMed)

Association of alterations in smell and taste with depression in older adults Examine the relationship between depression and changes in smell or taste.Cross-sectional analysis of 2011-2012 and 2013-2014 National Health and Nutrition Examination Survey (NHANES).We examined 5,275 adults ≥40 years old who completed smell and taste questionnaires as well as a validated depression assessment instrument, the Patient Health Questionnaire (PHQ-9). Analyses incorporated sampling weights to account (...) , gender, education, major comorbidities, smoking history, heavy alcohol use, sinus disease, cold symptoms, and trauma history, adults ≥40 and <65 years old who reported alterations in smell (OR: 1.64, p = 0.004) and adults ≥40 years old who reported alterations in taste (OR: 1.77, p = 0.001) were more likely to meet criteria for major depressive disorder.There is a strong association between major depression and alterations in smell and taste among certain age groups in the general U.S. population

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2018 Laryngoscope investigative otolaryngology

13. Importance of modelling decisions on estimating trajectories of depressive symptoms and co-morbid conditions in older adults: Longitudinal studies from ten European countries. (PubMed)

Importance of modelling decisions on estimating trajectories of depressive symptoms and co-morbid conditions in older adults: Longitudinal studies from ten European countries. International comparisons of trajectories of depressive symptoms in older adults are scarce and longitudinal associations with co-morbid conditions not fully understood.To compare trajectories of depressive symptoms from participants living in 10 European Countries and identify ages at which the associations of co-morbid (...) conditions with these trajectories become more relevant.Latent growth curve models were fitted to depressive symptoms scores from participants of the Survey of Health and Retirement in Europe (SHARE) initiative (combined n = 21,253) and co-morbid conditions modelled as time varying covariates. To identify the ages at which the association between co-morbid conditions and depressive symptoms was significant the Johnson-Neyman (JN) technique was used.The shape of depressive symptoms trajectories varied

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2019 PLoS ONE

14. Assessing urban-rural differences in the relationship between social capital and depression among Ghanaian and South African older adults. (PubMed)

Assessing urban-rural differences in the relationship between social capital and depression among Ghanaian and South African older adults. Research has demonstrated benefits of social capital on depression, but variations in this relationship by geographic characteristics such as urbanicity have rarely been investigated.Using survey data on 4,209 Ghanaian and 3,148 South African adults aged 50 and above from the World Health Organization (WHO) Study on Global AGEing and Adult Health (SAGE (...) not substantially modify the effects of social capital on depression in either setting, but urban-rural differences in the measurement and level of social capital were observed. Urban Ghanaian older adults were less socially integrated and trusting than older rural residents (standardized mean difference: -0.28, -0.24, and -0.38 for community engagement, sociability, and trust, respectively) while urban South African older adults appeared less engaged in community activities but significantly more trusting

2019 PLoS ONE

15. Effectiveness of bright light therapy on depressive symptoms in older adults with non-seasonal depression: a systematic review protocol. (PubMed)

Effectiveness of bright light therapy on depressive symptoms in older adults with non-seasonal depression: a systematic review protocol. What is the effectiveness of bright light therapy (BLT) on depressive symptoms in older adults with non-seasonal depression?The review objective is to determine the current evidence related to the effectiveness of BLT on depressive symptoms in older adults with non-seasonal depression.

2016 JBI database of systematic reviews and implementation reports

16. Internet Cognitive-Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial

Internet Cognitive-Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial To determine the efficacy of an internet-based cognitive-behavioral therapy (iCBT) program for depression in older adults with osteoarthritis (OA) of the knee and comorbid major depressive disorder (MDD).We conducted a randomized controlled trial in 69 adults (ages ≥50 years) meeting criteria for MDD and OA of the knee with 1-week postintervention (week 11) and 3-month (...) followup (week 24) end points. Patients were allocated to either a 10-week iCBT program for depression added to treatment as usual (TAU) or to a TAU control group. Primary outcomes were depression symptoms (9-Item Patient Health Questionnaire [PHQ-9]) and psychological distress (Kessler-10 [K-10]). Secondary outcomes included arthritis self-efficacy (Arthritis Self-Efficacy Scale [ASES]), OA pain, stiffness, physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC

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2018 EvidenceUpdates

17. Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial

Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial Preventing depression in older adults living in low- and middle-income countries is important because of the scarcity of treatment resources and the risk of disability, suicide, and dementia.To assess whether an intervention for depression prevention provided by lay counselors is effective in older adults from low- and middle-income (...) countries.This parallel-group randomized clinical trial with masked outcome assessment was performed in 181 older adults (≥60 years) with subsyndromal depressive symptoms at rural and urban primary care clinics in Goa, India. The first participant entered the trial on March 31, 2015, and the last exited on June 2, 2017. Data analysis used the intention-to-treat approach.Lay counselors provided problem-solving therapy, brief behavioral treatment for insomnia, education in self-care of common medical disorders

2018 EvidenceUpdates

18. My watch knows when I’m anhedonic: wearable technology and social functioning in older adults with depression

My watch knows when I’m anhedonic: wearable technology and social functioning in older adults with depression Wearable technology and social functioning in older adults with depression Search National Elf Service Search National Elf Service » » » » My watch knows when I’m anhedonic: wearable technology and social functioning in older adults with depression May 26 2017 Posted by Facebook might be a different site if it was only for people over the age of 65 years with depression. Older adults (...) with depression have fewer intimate relationships, smaller social networks, reduced social participation, and are less active within their families, but with more familial arguments and more marital problems than older adults without depression. Maybe Facebook wouldn’t be so different after all. Conversely, good social relationships have been shown to be protective against depressive symptoms in older adults and can be a good prognostic sign for treatment. So far, just like younger adults with depression

2017 The Mental Elf

19. Collaborative care may help older adults with subthreshold depression: CASPER trial

Collaborative care may help older adults with subthreshold depression: CASPER trial Collaborative care may help older adults with subthreshold depression Search National Elf Service Search National Elf Service » » » » Collaborative care may help older adults with subthreshold depression: CASPER trial Feb 27 2017 Posted by At the start of this newly published paper in the Journal of the American Medical Association , Simon Gilbody and colleagues remind us of the misery of depression. It is, now (...) and anxiety; and prescription of mental health medications. Results At the key four month point collaborative care reduced older people’s self-reported depressive symptoms compared to symptoms reported by those receiving usual care, with statistically significant differences also found at one year follow-up. Harder to judge, as the CASPER team note, is the clinical meaningfulness of these reductions. Amongst the secondary outcomes, the proportion of participants with PHQ-9 scores of 10 or above

2017 The Mental Elf

20. Two-question screening for depression in older adults

Two-question screening for depression in older adults Two-question screening for depression in older adults Search National Elf Service Search National Elf Service » » » » Two-question screening for depression in older adults Mar 31 2017 Posted by This is the second in a series of Mental Elf blogs produced in partnership with the British Journal of Psychiatry. Each month we select a new paper from the BJPsych to be blogged by a young psychiatrist with research experience. We’re really excited (...) Tiredness and poor concentration Thoughts of dying or suicide A range of are available, including medication, psychological and social therapies, but rates of older people in treatment are lower than young adults (Rodda J. et. al. 2011). This is because depression is more difficult to detect as symptoms are incorrectly attributed to physical illness or dementia (Wells C. et. al. 1979), and due to (Burroughs H. et. al. 2006). Though stopping short of recommending screening, NICE does suggest

2017 The Mental Elf

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