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121. Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age. (Abstract)

Lung Function and CT Densitometry in Subjects with alpha-1-Antitrypsin Deficiency and Healthy Controls at 35 Years of Age. Alpha-1-antitrypsin (AAT) deficiency is a genetic risk factor for pulmonary emphysema. In 1972-74 all 200,000 Swedish new-born infants were screened for AAT deficiency. The aim of the present study was to investigate whether the PiZZ and PiSZ individuals identified by this screening have signs of emphysema and the role of smoking in this, compared with a random sample (...) of control subjects at 35 years of age. The study participants underwent complete pulmonary function tests (PFT) and CT densitometry. The fifteenth percentile density (PD15) and the relative area below -910 HU (RA-910) were analyzed. Fifty-four PiZZ, 21 PiSZ and 66 PiMM control subjects participated in the study. No significant differences were found in lung function between the never-smoking AAT-deficient and control subjects. The 16 PiZZ ever-smokers had significantly lower carbon monoxide transfer

2015 COPD

122. A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein and Adenovirus 35 Gag-RT-Int-Nef Vaccine in Healthy HIV-Uninfected African Adults. (Full text)

A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein and Adenovirus 35 Gag-RT-Int-Nef Vaccine in Healthy HIV-Uninfected African Adults. Sequential prime-boost or co-administration of HIV vaccine candidates based on an adjuvanted clade B p24, RT, Nef, p17 fusion protein (F4/AS01) plus a non-replicating adenovirus 35 expressing clade A Gag, RT, Int and Nef (Ad35-GRIN) may lead to a unique immune profile (...) , inducing both strong T-cell and antibody responses.In a phase 1, double-blind, placebo-controlled trial, 146 healthy adult volunteers were randomized to one of four regimens: heterologous prime-boost with two doses of F4/AS01E or F4/AS01B followed by Ad35-GRIN; Ad35-GRIN followed by two doses of F4/AS01B; or three co-administrations of Ad35-GRIN and F4/AS01B. T cell and antibody responses were measured.The vaccines were generally well-tolerated, and did not cause serious adverse events. The response

2015 PloS one Controlled trial quality: uncertain PubMed abstract

123. Public satisfaction with GP services drops to lowest level in 35 years

Public satisfaction with GP services drops to lowest level in 35 years Public satisfaction with GP services drops to lowest level in 35 years | The King's Fund Main navigation Health and care services Leadership, systems and organisations Patients, people and society Policy, finance and performance Search term Apply Public satisfaction with GP services drops to lowest level in 35 years This content relates to the following topics: Part of Jump link block Jump to section Share this content (...) with other NHS services have not experienced such a steep decline and have tended to fluctuate year on year. And as respondents are more likely to have used GP services rather than the other services covered in the survey, this is likely to be an accurate reflection of their recent experiences. Satisfaction is usually highest among older respondents (Figure 1). For example, in 2017, satisfaction among those aged 65 or older was much higher (77 per cent) than among those aged 18 to 64 (62 per cent

2018 King's Fund blog

124. Polyvalent immunoglobulins – Part 1: A rapid review

Polyvalent immunoglobulins – Part 1: A rapid review 2019 www.kce.fgov.be KCE REPORT 327 POLYVALENT IMMUNOGLOBULINS – PART 1: A RAPID REVIEW 2019 www.kce.fgov.be KCE REPORT 327 HEALTH TECHNOLOGY ASSESSMENT POLYVALENT IMMUNOGLOBULINS – PART 1: A RAPID REVIEW JOLYCE BOURGEOIS, NICOLAS FAIRON, LORENA SAN MIGUEL COLOPHON Title: Polyvalent immunoglobulins – Part 1: A rapid review Authors: Jolyce Bourgeois (KCE), Nicolas Fairon (KCE), Lorena San Miguel (KCE) Information specialist: Nicolas Fairon (KCE (...) : 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence http://kce.fgov.be/content/about-copyrights-for-kce-publications. How to refer to this document? Bourgeois J, Fairon F, San Miguel L. Polyvalent immunoglobulins – Part 1: A rapid review. Health Technology Assessment (HTA) Brussels: Belgian Health Care Knowledge Centre (KCE). 2019. KCE Reports 327. D/2019/10.273/82. This document is available on the website of the Belgian Health Care Knowledge Centre. KCE

2020 Belgian Health Care Knowledge Centre

125. Dapagliflozin (type 1 diabetes mellitus) - Benefit assessment according to §35a Social Code Book V

Studies included 7 2.3.2 Study characteristics 8 2.4 Results on added benefit 18 2.4.1 Outcomes included 18 2.4.2 Risk of bias 20 2.4.3 Results 21 2.4.4 Subgroups and other effect modifiers 29 2.5 Probability and extent of added benefit 31 2.5.1 Assessment of the added benefit at outcome level 31 2.5.2 Overall conclusion on added benefit 34 2.6 List of included studies 35 References for English extract 38 Extract of dossier assessment A19-37 Version 1.0 Dapagliflozin (type 1 diabetes mellitus) 30 July (...) Dapagliflozin (type 1 diabetes mellitus) - Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Dapagliflozin (Diabetes mellitus Typ 1) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 30 July 2019). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

126. Proposed clinical management of pregnancies after combined screening for preeclampsia at 35-37 weeks' gestation. (Full text)

Proposed clinical management of pregnancies after combined screening for preeclampsia at 35-37 weeks' gestation. To estimate the patient-specific risk of pre-eclampsia (PE) at 35-37 weeks' gestation by a combination of maternal characteristics and medical history with multiples of the median (MoM) values of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PlGF) and serum soluble fms-like tyrosine kinase-1 (sFlt-1), and stratify women (...) into high-, intermediate- and low-risk management groups.This was a prospective observational study in women attending a third-trimester ultrasound scan at 35-37 weeks as part of routine pregnancy care. Patient-specific risks of delivery with PE at < 4 weeks from assessment and PE at < 42 weeks' gestation were calculated using the competing-risks model to combine the prior risk from maternal characteristics and medical history with MoM values of MAP, UtA-PI, PlGF and sFlt-1. On the basis of these risks

2017 Ultrasound in Obstetrics and Gynecology PubMed abstract

127. Pedicled Temporalis Muscle Flap for Craniofacial Reconstruction: A 35-Year Clinical Experience with 366 Flaps. (Abstract)

Pedicled Temporalis Muscle Flap for Craniofacial Reconstruction: A 35-Year Clinical Experience with 366 Flaps. In the past 130 years, the temporalis muscle flap has been used for a variety of different indications. In this age of microsurgery and perforator flaps, the temporalis muscle flap still has many useful applications for craniofacial reconstruction.Three hundred sixty-six temporalis muscle flaps were performed in a single center between 1978 and 2012. The authors divided the cases (...) of material extrusion at the donor site decreased after porous polyethylene was uniformly used for reconstruction from 17.1 to 7.9 percent.The pedicled temporalis muscle flap continues to have many applications in craniofacial reconstruction. With increasing use of free flaps, the authors' indications for the pedicled temporalis muscle flap are now restricted to (1) orbital filling for congenital or acquired anophthalmia; (2) filling of unilateral maxillectomy defects; and (3) facial reanimation

2017 Plastic and reconstructive surgery

128. Corrigendum to "Effects of Triple P parenting intervention on child health outcomes for childhood asthma and eczema: Randomised controlled trial" [Behav. Res. Ther. 83 (2016) 35-44]. (Abstract)

, Australia. eng Journal Article Published Erratum 2017 01 24 England Behav Res Ther 0372477 0005-7967 Behav Res Ther. 2016 Aug;83:35-44 27295179 2017 1 29 6 0 2017 1 29 6 1 2017 1 29 6 0 ppublish 28129879 S0005-7967(16)30244-3 10.1016/j.brat.2016.12.017 (...) Corrigendum to "Effects of Triple P parenting intervention on child health outcomes for childhood asthma and eczema: Randomised controlled trial" [Behav. Res. Ther. 83 (2016) 35-44]. 28129879 2018 02 03 1873-622X 92 2017 05 Behaviour research and therapy Behav Res Ther Corrigendum to "Effects of Triple P parenting intervention on child health outcomes for childhood asthma and eczema: Randomised controlled trial" [Behav. Res. Ther. 83 (2016) 35-44]. 107 S0005-7967(16)30244-3 10.1016/j.brat

2017 Behaviour research and therapy Controlled trial quality: uncertain

129. Corrigendum to "A randomised, controlled, double-blind crossover study on the effects of isovolumetric and isoeffective infusions of colloid versus crystalloid on blood volume, cardiac output and renal blood flow" [Clin Nutr 35 (2016) S22]. (Full text)

Corrigendum to "A randomised, controlled, double-blind crossover study on the effects of isovolumetric and isoeffective infusions of colloid versus crystalloid on blood volume, cardiac output and renal blood flow" [Clin Nutr 35 (2016) S22]. 27771021 2018 10 05 1532-1983 36 1 2017 02 Clinical nutrition (Edinburgh, Scotland) Clin Nutr Corrigendum to "A randomised, controlled, double-blind crossover study on the effects of isovolumetric and isoeffective infusions of colloid versus crystalloid (...) on blood volume, cardiac output and renal blood flow" [Clin Nutr 35 (2016) S22]. 319 S0261-5614(16)31273-0 10.1016/j.clnu.2016.10.001 Bragg D D Department of Gastrointestinal Surgery, University of Nottingham, Nottingham, United Kingdom. Electronic address: damianbragg@gmail.com. Bradley C C Physics, University of Nottingham, Nottingham, United Kingdom. El-Sharkawy A A Department of Gastrointestinal Surgery, University of Nottingham, Nottingham, United Kingdom. Chowdhury A A Department

2017 Clinical nutrition (Edinburgh, Scotland) Controlled trial quality: uncertain PubMed abstract

130. Corrigendum to "Persistence of bactericidal antibodies following booster vaccination with 4CMenB at 12, 18 or 24months and immunogenicity of a fifth dose administered at 4years of age-a phase 3 extension to a randomised controlled trial" [Vaccine 35 (2017 (Full text)

Corrigendum to "Persistence of bactericidal antibodies following booster vaccination with 4CMenB at 12, 18 or 24months and immunogenicity of a fifth dose administered at 4years of age-a phase 3 extension to a randomised controlled trial" [Vaccine 35 (2017 28483197 2018 03 09 1873-2518 35 24 2017 05 31 Vaccine Vaccine Corrigendum to "Persistence of bactericidal antibodies following booster vaccination with 4CMenB at 12, 18 or 24months and immunogenicity of a fifth dose administered at 4years (...) of age-a phase 3 extension to a randomised controlled trial" [Vaccine 35 (2017) 395-402]. 3279 S0264-410X(17)30582-0 10.1016/j.vaccine.2017.04.081 Iro Mildred A MA Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: mildred.iro@paediatrics.ox.ac.uk. Snape Matthew D MD Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. Voysey

2017 Vaccine Controlled trial quality: uncertain PubMed abstract

131. Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study. (Full text)

and Control RBCs was comparable (83·2 ± 5·2 and 84·9 ± 5·9%, respectively; P = 0·06) and consistent with the US Food and Drug Administration (FDA) criteria for acceptable RBC viability. There were differences in the T50 between Test and Control RBCs (33·5 and 39·7 days, respectively; P < 0·001), however, these were within published reference ranges of 28-35 days. The AUC (per cent surviving × days) for Test and Control RBCs was similar (22·6 and 23·1 per cent surviving cells × days, respectively; P > 0·05 (...) Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study. Pathogen reduction technology using amustaline (S-303) was developed to reduce the risk of transfusion-transmitted infection and adverse effects of residual leucocytes. In this study, the viability of red blood cells (RBCs) prepared with a second-generation process and stored for 35 days was evaluated in two different

2017 Vox sanguinis Controlled trial quality: uncertain PubMed abstract

132. IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression (Full text)

IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression IL-27 and IL-35 are heterodimeric cytokines, members of the IL-12 family and considered to have immunomodulatory properties. Their role during neuroinflammation had been investigated using mutant mice devoid of either one of their subunits or lacking components of their receptors, yielding conflicting results. We sought to understand the therapeutic potential of IL-27 and IL-35 delivered by gene therapy (...) in neuroinflammation. We constructed lentiviral vectors expressing IL-27 and IL-35 from a single polypeptide chain, and we validated in vitro their biological activity. We injected IL-27 and IL-35-expressing lentiviral vectors into the cerebrospinal fluid (CSF) of mice affected by experimental neuroinflammation (EAE), and performed clinical, neuropathological and immunological analyses. Both cytokines interfere with neuroinflammation, but only IL-27 significantly modulates disease development, both clinically

2017 Scientific reports PubMed abstract

133. Acetabular Reconstructions with Impaction Bone-Grafting and a Cemented Cup in Patients Younger Than 50 Years of Age: A Concise Follow-up, at 27 to 35 Years, of a Previous Report. (Abstract)

Acetabular Reconstructions with Impaction Bone-Grafting and a Cemented Cup in Patients Younger Than 50 Years of Age: A Concise Follow-up, at 27 to 35 Years, of a Previous Report. We present an update of 19 acetabular reconstructions, performed with a cemented total hip arthroplasty and impaction bone-grafting, in situ at the time of our previous report. At a mean follow-up of 30 years (range, 27 to 35 years), no additional patients were lost to follow-up. Two patients (3 reconstructions) died (...) for reasons unrelated to the hip surgery. Five reconstructions (5 patients) were revised, 4 for aseptic loosening and 1 for septic loosening, after a mean of 24 years (range, 22 to 27 years), leaving 11 surviving hips (11 patients) that were clinically and radiographically evaluated. Kaplan-Meier survival at 30 years was 0.40 (95% confidence interval [CI], 0.23 to 0.56) for revision for any reason, 0.56 (95% CI, 0.35 to 0.73) for aseptic loosening, and 0.53 (95% CI, 0.33 to 0.69) for radiographic

2017 The Journal of Bone and Joint Surgery. American Volume

134. Sleeve Gastrectomy Outcomes in Patients with BMI Between 30 and 35-3 Years of Follow-Up. (Full text)

Sleeve Gastrectomy Outcomes in Patients with BMI Between 30 and 35-3 Years of Follow-Up. Laparoscopic sleeve gastrectomy (LSG) in patients with a BMI between 30 and 35 kg/m2 plus comorbidities has shown to be safe and effective. The purpose of this study is to describe our outcomes in this group of patients after 3 years of follow-up.Retrospective descriptive analysis of patients with initial BMI between 30 and 35 kg/m2 plus comorbidities were submitted to LSG between 2006 and 2013. We analyzed (...) gender, age, comorbidities, BMI, total weight loss (%TWL), excess weight loss (%EWL), comorbidity resolution, morbidity, and mortality. Postoperative success was defined as %TWL over 20% and EWL% over 50% maintained for at least 1 year and comorbidity remission with no need of medication.Of the patients, 477 underwent a LSG in the above period and 252 met inclusion criteria; 188 (75%) were female and 64 (25%) were male. Median age was 39 years (15-70). Three-year follow-up was 43.9% (111 patients

2017 Obesity Surgery PubMed abstract

135. Long-term Results and Quality of Life Assessment in Biliary Atresia Patients: A 35-Year Experience in a Tertiary Hospital. (Abstract)

Long-term Results and Quality of Life Assessment in Biliary Atresia Patients: A 35-Year Experience in a Tertiary Hospital. To review long-term transplant-free survival and quality of life (QOL) of patients with biliary atresia (BA).A retrospective study reviewing all patients with Kasai operation between January 1, 1980 and December 31, 2015 was performed to evaluate the transplant-free survival. Subgroup analysis of patients older than 20 years was carried out to assess the QOL using the Short

2017 Journal of Pediatric Gastroenterology and Nutrition

136. Role of the IL-12/IL-35 balance in Sjögren's syndrome. (Full text)

Role of the IL-12/IL-35 balance in Sjögren's syndrome. An interferon signature is involved in the pathogenesis of primary Sjögren syndrome (pSS), but whether the signature is type 1 or type 2 remains controversial. Mouse models and genetic studies suggest the involvement of TH1 and type 2 interferon pathways. Likewise, polymorphisms of the IL-12A gene (IL12A), which encodes for IL-12p35, have been associated with pSS. The IL-12p35 subunit is shared by 2 heterodimers: IL-12 and IL-35.We sought (...) to confirm genetic association of the IL12A polymorphism and pSS and elucidate involvement of the IL-12/IL-35 balance in patients with pSS by using functional studies.The genetic study involved 673 patients with pSS from 2 French pSS cohorts and 585 healthy French control subjects. Functional studies were performed on sorted monocytes, irrespective of whether they were stimulated. IL12A mRNA expression and IL-12 and IL-35 protein levels were assessed by using quantitative RT-PCR and ELISA and a multiplex

2017 Journal of Allergy and Clinical Immunology PubMed abstract

137. Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: An English national cohort study. (Full text)

) inductions of labour at 40 weeks would be required to prevent 1 perinatal death. Limitations of the study include the reliance on observational data in which gestational age is recorded in weeks rather than days. There is also the potential for unmeasured confounders and under-recording of induction of labour or perinatal death in the dataset.Bringing forward the routine offer of induction of labour from the current recommendation of 41-42 weeks to 40 weeks of gestation in nulliparous women aged ≥35 (...) Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: An English national cohort study. A recent randomised controlled trial (RCT) demonstrated that induction of labour at 39 weeks of gestational age has no short-term adverse effect on the mother or infant among nulliparous women aged ≥35 years. However, the trial was underpowered to address the effect of routine induction of labour on the risk of perinatal death. We

2017 PLoS medicine PubMed abstract

138. Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35. (Full text)

Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35. Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including (...) 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years. Specifically, the CRT-SCORE was calculated using atrioventricular junction ablation, age, gender, etiology, New York Heart Association class, diabetes, hemoglobin level, renal function, left

2017 American Journal of Cardiology PubMed abstract

139. Evaluating the Efficacy of Xylitol Wipes on Cariogenic Bacteria in 19- to 35-month-old Children: A Double-blind Randomized Controlled Trial (Full text)

: Kayalvizhi G, Nivedha D, Sajeev R, Prathima GS, Suganya M, Ramesh V. Evaluating the Efficacy of Xylitol Wipes on Cariogenic Bacteria in 19- to 35-month-old Children: A Double-blind Randomized Controlled Trial. Int J Clin Pediatr Dent 2018;11(1):13-17. (...) Evaluating the Efficacy of Xylitol Wipes on Cariogenic Bacteria in 19- to 35-month-old Children: A Double-blind Randomized Controlled Trial Dental caries is an infectious disease with Streptococcus mutans as the main cariogenic bacteria. Children with early S. mutans colonization have a higher risk of developing dental caries than those with later colonization. Therefore, prevention or delay of S. mutans colonization may be advantageous for the prevention of early childhood caries (ECC

2017 International journal of clinical pediatric dentistry Controlled trial quality: uncertain PubMed abstract

140. Corrigendum to “Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation” [Biomaterials 35/24 (2014) 6278–6286] (Full text)

DE NIDCR NIH HHS United States Journal Article Published Erratum 2017 02 17 Netherlands Biomaterials 8100316 0142-9612 Biomaterials. 2014 Aug;35(24):6278-6286 24831973 2017 2 20 6 0 2017 2 20 6 1 2017 2 20 6 0 ppublish 28214704 S0142-9612(17)30082-0 10.1016/j.biomaterials.2017.02.008 PMC5563820 NIHMS890433 (...) Corrigendum to “Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation” [Biomaterials 35/24 (2014) 6278–6286] 28214704 2018 01 07 1878-5905 125 2017 05 Biomaterials Biomaterials Corrigendum to "Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation" [Biomaterials 35/24 (2014) 6278-6286]. 12 S0142-9612(17)30082-0 10.1016

2017 Biomaterials PubMed abstract

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