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Demulen 1/35

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81. Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes (PubMed)

Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dimyristoyl (...) -sn-glycero-3-phospho-L-serine (DMPS) and added the trans-membrane segment Aβ25-35. Peptide plaques spontaneously form in these membranes at high peptide concentrations of 20 mol%, which show the characteristic cross-β motif (concentrations are relative to the number of membrane lipids and indicate the peptide-to-lipid ratio). We used atomic force microscopy, fluorescence microscopy, x-ray microscopy, x-ray diffraction, UV-vis spectroscopy and Molecular Dynamics (MD) simulations to study three

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2018 Scientific reports

82. C. elegans RAB-35: Dual roles in apoptotic cell clearance (PubMed)

C. elegans RAB-35: Dual roles in apoptotic cell clearance 30138327 2018 12 17 2018 12 17 1553-7404 14 8 2018 08 PLoS genetics PLoS Genet. C. elegans RAB-35: Dual roles in apoptotic cell clearance. e1007534 10.1371/journal.pgen.1007534 Rocheleau Christian E CE 0000-0001-6738-5636 Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada. Program in Metabolic (...) .1007534 PGENETICS-D-18-01227 PMC6107104 Mol Cell Biol. 2010 Mar;30(6):1421-33 20065041 Nature. 2010 Apr 1;464(7289):778-82 20305638 Dev Cell. 2006 Jun;10(6):743-57 16740477 Nat Rev Immunol. 2014 Mar;14(3):166-80 24481336 Small GTPases. 2010 Nov;1(3):170-173 21686272 Nat Cell Biol. 2008 May;10(5):556-66 18425118 Cell Death Differ. 2014 Jun;21(6):845-53 24632947 PLoS Biol. 2008 Mar 18;6(3):e61 18351800 Nat Cell Biol. 2011 Jun 26;13(8):981-8 21706022 Science. 2009 Sep 4;325(5945):1250-4 19729655 Cell Mol

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2018 PLoS genetics

83. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells (PubMed)

further identified TBC-10 as a putative GTPase-activating protein (GAP), and FLCN-1 and RME-4 as two putative Guanine Nucleotide Exchange Factors (GEFs), for RAB-35. We found that RAB-35 was required for the efficient incorporation of early endosomes to phagosomes and for the timely degradation of apoptotic cell corpses. More specifically, RAB-35 promotes two essential events that initiate phagosome maturation: the switch of phagosomal membrane phosphatidylinositol species from PtdIns(4,5)P2 to PtdIns (...) (3)P, and the recruitment of the small GTPase RAB-5 to phagosomal surfaces. These functions of RAB-35 were previously unknown. Remarkably, although the phagocytic receptor CED-1 regulates these same events, RAB-35 and CED-1 appear to function independently. Upstream of degradation, RAB-35 also facilitates the recognition of apoptotic cells independently of the known CED-1 and CED-5 pathways. RAB-35 localizes to extending pseudopods and is further enriched on nascent phagosomes, consistent

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2018 PLoS genetics

84. A 35 MHz/105 MHz Dual-Element Focused Transducer for Intravascular Ultrasound Tissue Imaging Using the Third Harmonic (PubMed)

ultrasound (IVUS) imaging is particularly demanding because of its small size of less than 1 mm. Here, we report a recently developed dual-element focused IVUS transducer for the third harmonic imaging of tissue, which consists of a 35-MHz element for ultrasound transmission and a 105-MHz element for third harmonic reception. For high quality third harmonic imaging, both elements were fabricated to have the same focus at 2.5 mm. The results of tissue mimicking phantom tests demonstrated that the third (...) A 35 MHz/105 MHz Dual-Element Focused Transducer for Intravascular Ultrasound Tissue Imaging Using the Third Harmonic The superharmonic imaging of tissue has the potential for high spatial and contrast resolutions, compared to the fundamental and second harmonic imaging. For this technique, the spectral bandwidth of an ultrasound transducer is divided for transmission of ultrasound and reception of its superharmonics (i.e., higher than the second harmonic). Due to the spectral division

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2018 Sensors (Basel, Switzerland)

85. CBS mutations are good predictors for B6‐responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients (PubMed)

CBS mutations are good predictors for B6‐responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients 30264510 2018 11 14 2324-9269 6 5 2018 09 Molecular genetics & genomic medicine Mol Genet Genomic Med CBS mutations are good predictors for B6-responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients. 861 10.1002/mgg3.462 eng Journal Article Published Erratum United States Mol Genet Genomic Med 101603758 2324-9269 Mol (...) Genet Genomic Med. 2018 Mar;6(2):160-170 29352562 2018 9 29 6 0 2018 9 29 6 0 2018 9 29 6 1 ppublish 30264510 10.1002/mgg3.462 PMC6160707 Mol Genet Genomic Med. 2018 Mar;6(2):160-170 29352562

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2018 Molecular Genetics & Genomic Medicine

86. The clinical potential of IL-12/IL-35 in treating chemotherapy drug-induced cardiac injury – Authors' reply (PubMed)

23050732 Hypertension. 2009 Sep;54(3):619-24 19620507 Hypertension. 2017 Oct;70(4):839-845 28847894 Immunol Rev. 2018 Jan;281(1):179-190 29247987 EBioMedicine. 2018 Sep;35:2-3 30143465 Atherosclerosis. 2015 Oct;242(2):506-14 26298743 (...) The clinical potential of IL-12/IL-35 in treating chemotherapy drug-induced cardiac injury – Authors' reply 30174280 2018 11 14 2352-3964 35 2018 Sep EBioMedicine EBioMedicine The clinical potential of IL-12/IL-35 in treating chemotherapy drug-induced cardiac injury - Authors' reply. 4-5 S2352-3964(18)30341-4 10.1016/j.ebiom.2018.08.049 Ye Jing J Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases

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2018 EBioMedicine

87. Reminiscing on 35 years with Environmental Toxicology in Korea (PubMed)

Reminiscing on 35 years with Environmental Toxicology in Korea 30286587 2018 10 24 2233-6567 33 3 2018 Sep Environmental health and toxicology Environ Health Toxicol Reminiscing on 35 years with Environmental Toxicology in Korea. e2018011-0 10.5620/eht.e2018011 Kim Yong-Hwa YH Department of Chemistry, Faculty of Natural Sciences, National University of Laos, Vientiane Capital, Lao PDR. eng Journal Article 2018 08 31 Korea (South) Environ Health Toxicol 101570455 2233-6567 2018 10 6 6 0 2018 10 (...) 6 6 0 2018 10 6 6 1 ppublish 30286587 eht.e2018011 10.5620/eht.e2018011 PMC6182248

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2018 Environmental health and toxicology

88. Acute multifocal retinitis: a retrospective review of 35 cases (PubMed)

Acute multifocal retinitis: a retrospective review of 35 cases Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis.This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All (...) patients had complete ophthalmological examination, fundus photography, and fluorescein angiography. Twelve patients (34.3%) had optical coherence tomography. An extensive work-up was performed including a detailed comprehensive medical history, examination by an internist and an infectious disease specialist, a chest X-ray, Mantoux test, and laboratory tests for syphilis, human immunodeficiency virus, Bartonella, and Rickettsia. Of the 35 patients, 25 (71.4%) had bilateral involvement and 10 (28.6

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2018 Journal of ophthalmic inflammation and infection

89. Vaccination Coverage Among Children Aged 19–35 Months — United States, 2017 (PubMed)

Vaccination Coverage Among Children Aged 19–35 Months — United States, 2017 The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination by age 24 months against 14 potentially serious illnesses (1). CDC used data from the 2017 National Immunization Survey-Child (NIS-Child) to assess vaccination coverage at national, state, territorial, and selected local levels among children aged 19-35 months in the United States. Coverage remained high and stable overall (...) , exceeding 90% for ≥3 doses of poliovirus vaccine, ≥1 dose of measles, mumps, and rubella vaccine (MMR), ≥3 doses of hepatitis B vaccine (HepB), and ≥1 dose of varicella vaccine. Although the proportion of children who received no vaccine doses by age 24 months was low, this proportion increased gradually from 0.9% for children born in 2011 to 1.3% for children born in 2015. Coverage was lower for most vaccines among uninsured children and those insured by Medicaid, compared with those having private

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2018 Morbidity and Mortality Weekly Report

90. Chain pain following cardiac surgery in a 35-year-old man. (PubMed)

Chain pain following cardiac surgery in a 35-year-old man. A 35-year-old man with multiple cardiovascular risk factors presented with a recent history of fever and acute heart failure. His initial echocardiogram showed evidence of severe aortic regurgitation due to ongoing infective endocarditis. Preoperative coronary angiography revealed no coronary abnormalities. Urgent aortic valve replacement was performed and a 29 mm St Jude mechanical valve was implanted. While blood and resected valvular (...) tissue cultures were negative for bacteria, a PCR-based analysis revealed the presence of penicillin-sensitive Streptococcus pneumoniae. Echocardiographic follow-up study at day 3 showed excellent mechanical valve function with no persistent signs of endocarditis. Eight days after surgery, our patient presented with severe chest pain. The ECG is shown in figure 1A and coronary angiography was performed for diagnostic confirmation (figure 1B-D and online supplementary video 1).DC1SP110.1136/heartjnl

2018 Heart

91. Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report (PubMed)

Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report In the publication of this article [1], there is an error in Table 1 at the Test Ca2+ at the Result. The error in Test Ca2+ Result: '1.24' Should instead read Test Ca2+ Result: '2.24' This has now been included in this erratum.

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2018 Journal of medical case reports

92. Epidemiologic Factors, Clinical Presentation, Causes, and Outcomes of Liver Abscess: A 35-Year Olmsted County Study (PubMed)

Epidemiologic Factors, Clinical Presentation, Causes, and Outcomes of Liver Abscess: A 35-Year Olmsted County Study To report the changing incidence, clinical presentation, microbiologic spectrum, and outcomes of pyogenic liver abscess (PLA) in Olmsted County, Minnesota, over the past 35 years.The Rochester Epidemiology Project was used to identify residents with PLA from January 1, 1980, through December 31, 2014. The study included all patients older than 18 years, with the diagnosis of PLA (...) confirmed through radiographic review and microbiologic cultures.In total, 72 patients received a diagnosis of PLA from 1980 through 2014. The age-adjusted incidence for men was 3.92 cases per 100,000 person-years (95% CI, 2.76-5.09 cases per 100,000 person-years) compared with 1.87 cases per 100,000 person-years (95% CI, 1.15-2.59 cases per 100,000 person-years) for women. Incidence was higher in the period from January 1, 2001, through December 31, 2014, than in the period from January 1, 1980

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2018 Mayo Clinic Proceedings. Innovations, Quality & Outcomes

93. GCY-35/GCY-36—TAX-2/TAX-4 Signalling in O2 Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans (PubMed)

and even intoxication with increasing concentrations. Animals develop tolerance to ethanol. However, the underlying mechanisms are not well understood. In Caenorhabditis elegans, NPR-1 negatively regulates the development of acute tolerance to ethanol. Here, using in vivo Ca2+ imaging, behavioural tests and chemogenetic manipulation, we show that the soluble guanylate cyclase complex GCY-35/GCY-36-TAX-2/TAX-4 signalling pathway in O2 sensory neurons positively regulates acute functional tolerance (...) GCY-35/GCY-36—TAX-2/TAX-4 Signalling in O2 Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans Ethanol is a widely used beverage and abused drug. Alcoholism causes severe damage to human health and creates serious social problems. Understanding the mechanisms underlying ethanol actions is important for the development of effective therapies. Alcohol has a wide spectrum of effects on physiological activities and behaviours, from sensitization to sedation

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2018 Scientific reports

94. Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies (PubMed)

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies We generated an integrating, CD46-targeted, helper-dependent adenovirus HDAd5/35++ vector system for hematopoietic stem cell (HSC) gene therapy. The ∼12-kb transgene cassette included a β-globin locus control region (LCR)/promoter driven human γ-globin gene and an elongation factor alpha-1 (EF1α)-mgmtP140K expression cassette, which allows for drug-controlled increase of γ-globin-expressing erythrocytes (...) was performed with peripheral blood CD34+ cells from mobilized donors. 10 weeks after transplantation of transduced cells, human cells were harvested from the bone marrow and differentiated ex vivo into erythroid cells. Erythroid cells expressed γ-globin at a level of 20% of adult α-globin. Our studies suggest that HDAd35++ vectors allow for efficient transduction of long-term repopulating HSCs and high-level, almost pancellular γ-globin expression in erythrocytes. Furthermore, our HDAd5/35++ vectors have

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2018 Molecular therapy. Methods & clinical development

95. Tuberculosis Clinical Trials Consortium Study 35

Tuberculosis Clinical Trials Consortium Study 35 Tuberculosis Clinical Trials Consortium Study 35 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tuberculosis Clinical Trials Consortium Study 35 The safety (...) infection (LTBI) or with exposure to Mycobacterium tuberculosis (M. tuberculosis) will require higher mg/kg rifapentine dosing than adults to achieve adult- exposures which are correlated with efficacy in trials of TB prevention. Investigators further hypothesize that rifapentine will be safe and well-tolerated in HIV-infected and uninfected children who require treatment for LTBI. Condition or disease Intervention/treatment Phase Latent Tuberculosis Drug: Rifapentine Drug: Isoniazid Phase 1 Phase 2

2018 Clinical Trials

96. MKSAP: 35-year-old woman is evaluated for intermittent fever

MKSAP: 35-year-old woman is evaluated for intermittent fever Patients at high risk for posttransplant lymphoproliferative disease MKSAP: 35-year-old woman is evaluated for intermittent fever | | May 12, 2018 6 Shares Test your medicine knowledge with the , in partnership with the . A 35-year-old woman is evaluated for intermittent fever, sweats, fatigue, and dull midchest pain of 2 weeks’ duration. Medical history is significant for liver transplantation 6 months ago for primary biliary (...) is at increased risk for PTLD because she was seronegative for Epstein-Barr virus (EBV) and the organ donor was seropositive. PTLD is related to B-cell proliferation induced by infection with EBV in the setting of chronic immunosuppression and resulting decreased T-cell immune surveillance. She presents within a typical timeframe (first few months to 1 year after transplantation) with lymphadenopathy found on CT scan and systemic symptoms consistent with PTLD. In addition to PTLD, EBV after transplantation

2018 KevinMD blog

97. Emerging role of IL-35 in inflammatory autoimmune diseases. (PubMed)

cells. Recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 1 diabetes, psoriasis, multiple sclerosis, autoimmune hepatitis, experimental autoimmune uveitis. In addition, functional analysis suggested that IL-35 is critical in the onset and development of these diseases. Therefore, the present study will systematically review what had been occurred (...) Emerging role of IL-35 in inflammatory autoimmune diseases. Interleukin 35 (IL-35) is the recently identified member of the IL-12 family of cytokines and provides the possibility to be a target for new therapies for autoimmune, inflammatory diseases. It is composed of an α chain (p35) and a β chain (EBI3). IL-35 mediates signaling by binding to its receptors, activates subsequent signaling pathways, and therefore, regulates the differentiation, function of T, B cells, macrophages, dendritic

2018 Autoimmunity reviews

98. Risk of Cesarean Section in Primiparous Women Over 35 Years of Age.

Procedure: Cesarean section Procedure: No cesarean section Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 572 participants Observational Model: Cohort Time Perspective: Retrospective Official Title: Risk of Cesarean Section and Perinatal Complications in Primiparous Women Over 35 Years of Age. A Retrospective Cohort Study. Actual Study Start Date : April 1, 2017 Actual Primary Completion Date : January 1, 2018 Actual Study Completion Date : February (...) Risk of Cesarean Section in Primiparous Women Over 35 Years of Age. Risk of Cesarean Section in Primiparous Women Over 35 Years of Age. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Risk of Cesarean

2018 Clinical Trials

99. Prevention of vaccine-matched and mismatched influenza in children aged 6-35 months: a multinational randomised trial across five influenza seasons. (PubMed)

Prevention of vaccine-matched and mismatched influenza in children aged 6-35 months: a multinational randomised trial across five influenza seasons. Despite the importance of vaccinating children younger than 5 years, few studies evaluating vaccine prevention of influenza have been reported in this age group. We evaluated efficacy of an inactivated quadrivalent influenza vaccine (IIV4) in children aged 6-35 months.In this phase 3, observer-blinded, multinational trial, healthy children from 13 (...) countries in Europe, Central America, and Asia were recruited in five independent cohorts, each in a different influenza season. Participants were randomly assigned (1:1) to either IIV4 (15 μg haemagglutinin antigen per strain per 0·5 mL dose; a single dose on day 0 for vaccine-primed children, and two doses, on days 0 and 28, for vaccine-unprimed children) or to one or two doses of a non-influenza control vaccine. Primary endpoints were moderate-to-severe influenza or all influenza (irrespective

2018 The Lancet. Child & Adolescent Health Controlled trial quality: uncertain

100. Effect of pH on whitening efficacy of 35% hydrogen peroxide and enamel microhardness. (PubMed)

Effect of pH on whitening efficacy of 35% hydrogen peroxide and enamel microhardness. This study aimed to evaluate the effect of 35% hydrogen peroxide at different pH values and the degree of tooth staining on whitening efficacy and enamel microhardness.90 enamel-dentin specimens were obtained from bovine incisors. They were randomly divided into 2 groups (n = 45), 1 group was immersed in a staining broth for 14 days, and another group was not stained and kept in distilled water at 37°C. Twenty (...) -four hours after the staining procedure, each group was distributed into 3 subgroups that were whitened by 35% hydrogen peroxide with different pH values (5, 7, and 8.4) for 30 minutes. The color was measured at baseline and 7 days after whitening. Microhardness was measured at baseline, immediate, 24 hours, and 1 month after the whitening procedure. Data were submitted to 2-way analysis of variance (ANOVA) and the Tukey test for multiple comparisons for color analysis. Repeated measures ANOVA

2018 Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] Controlled trial quality: uncertain

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