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61. C. elegans RAB-35: Dual roles in apoptotic cell clearance Full Text available with Trip Pro

C. elegans RAB-35: Dual roles in apoptotic cell clearance 30138327 2018 12 17 2018 12 17 1553-7404 14 8 2018 08 PLoS genetics PLoS Genet. C. elegans RAB-35: Dual roles in apoptotic cell clearance. e1007534 10.1371/journal.pgen.1007534 Rocheleau Christian E CE 0000-0001-6738-5636 Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada. Program in Metabolic (...) .1007534 PGENETICS-D-18-01227 PMC6107104 Mol Cell Biol. 2010 Mar;30(6):1421-33 20065041 Nature. 2010 Apr 1;464(7289):778-82 20305638 Dev Cell. 2006 Jun;10(6):743-57 16740477 Nat Rev Immunol. 2014 Mar;14(3):166-80 24481336 Small GTPases. 2010 Nov;1(3):170-173 21686272 Nat Cell Biol. 2008 May;10(5):556-66 18425118 Cell Death Differ. 2014 Jun;21(6):845-53 24632947 PLoS Biol. 2008 Mar 18;6(3):e61 18351800 Nat Cell Biol. 2011 Jun 26;13(8):981-8 21706022 Science. 2009 Sep 4;325(5945):1250-4 19729655 Cell Mol

2018 PLoS genetics

62. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells Full Text available with Trip Pro

further identified TBC-10 as a putative GTPase-activating protein (GAP), and FLCN-1 and RME-4 as two putative Guanine Nucleotide Exchange Factors (GEFs), for RAB-35. We found that RAB-35 was required for the efficient incorporation of early endosomes to phagosomes and for the timely degradation of apoptotic cell corpses. More specifically, RAB-35 promotes two essential events that initiate phagosome maturation: the switch of phagosomal membrane phosphatidylinositol species from PtdIns(4,5)P2 to PtdIns (...) (3)P, and the recruitment of the small GTPase RAB-5 to phagosomal surfaces. These functions of RAB-35 were previously unknown. Remarkably, although the phagocytic receptor CED-1 regulates these same events, RAB-35 and CED-1 appear to function independently. Upstream of degradation, RAB-35 also facilitates the recognition of apoptotic cells independently of the known CED-1 and CED-5 pathways. RAB-35 localizes to extending pseudopods and is further enriched on nascent phagosomes, consistent

2018 PLoS genetics

63. Vaccination Coverage Among Children Aged 19–35 Months — United States, 2017 Full Text available with Trip Pro

Vaccination Coverage Among Children Aged 19–35 Months — United States, 2017 The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination by age 24 months against 14 potentially serious illnesses (1). CDC used data from the 2017 National Immunization Survey-Child (NIS-Child) to assess vaccination coverage at national, state, territorial, and selected local levels among children aged 19-35 months in the United States. Coverage remained high and stable overall (...) , exceeding 90% for ≥3 doses of poliovirus vaccine, ≥1 dose of measles, mumps, and rubella vaccine (MMR), ≥3 doses of hepatitis B vaccine (HepB), and ≥1 dose of varicella vaccine. Although the proportion of children who received no vaccine doses by age 24 months was low, this proportion increased gradually from 0.9% for children born in 2011 to 1.3% for children born in 2015. Coverage was lower for most vaccines among uninsured children and those insured by Medicaid, compared with those having private

2018 Morbidity and Mortality Weekly Report

64. Association between availability of children’s book and the literacy-numeracy skills of children aged 36 to 59 months: secondary analysis of the UNICEF Multiple-Indicator Cluster Surveys covering 35 countries Full Text available with Trip Pro

is beneficial at large scale in low and middle-income settings.We conducted a secondary analysis using data from the multiple-indicator cluster survey, covering 100 012 children aged 36-59 months, from 35 countries. The outcome was children being on-track for a literacy-numeracy index (LNI) constructed from three questions assessing children's ability to identify/name at least 10 letters of the alphabet, read at least four simple popular words and know the names and symbols of all numbers from 1-10 (...) Association between availability of children’s book and the literacy-numeracy skills of children aged 36 to 59 months: secondary analysis of the UNICEF Multiple-Indicator Cluster Surveys covering 35 countries Stimulating home environments that have children's books, pictures and play toys facilitate caregiver-child interactions and enhance children's development. Although this has been demonstrated in small-scale intervention studies, it is important to document whether book ownership

2018 Journal of global health

65. Sex Differences in the Temporal Recovery of Neuromuscular Function Following Resistance Training in Resistance Trained Men and Women 18 to 35 Years Full Text available with Trip Pro

Sex Differences in the Temporal Recovery of Neuromuscular Function Following Resistance Training in Resistance Trained Men and Women 18 to 35 Years To investigate sex differences in the temporal recovery of neuromuscular function following resistance training (RT), eleven men and eight women 18-35 years completed a single RT bout (barbell back-squats, 80 % 1RM, 5 sets × 5 reps, 25 % duty cycle, then 1 set × max reps). Measures of muscle function (isometric, concentric, eccentric knee extensor (...) strength, and countermovement jump (CMJ) height), serum creatine kinase activity (CK) and lower-body muscle pain were assessed before RT (0 h), +4 h, +24 h, +48 h, and +72 h post-RT. Data are mean % change from PRE (SD) and effect size (ω2, d). Men and women had similar RT-experience (men, 2.1 (0.8) years vs. women 2.4 (1.0) years, P = 0.746, and d = 0.3) and 1RM strength per kg lean mass (men, 1.9 (0.2) kg⋅kg-1 vs. women, 1.8 (0.3) kg⋅kg-1, P = 0.303, and d = 0.3). A 36 (12)% increase in lower-body

2018 Frontiers in physiology

66. Acute multifocal retinitis: a retrospective review of 35 cases Full Text available with Trip Pro

Acute multifocal retinitis: a retrospective review of 35 cases Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis.This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All (...) patients had complete ophthalmological examination, fundus photography, and fluorescein angiography. Twelve patients (34.3%) had optical coherence tomography. An extensive work-up was performed including a detailed comprehensive medical history, examination by an internist and an infectious disease specialist, a chest X-ray, Mantoux test, and laboratory tests for syphilis, human immunodeficiency virus, Bartonella, and Rickettsia. Of the 35 patients, 25 (71.4%) had bilateral involvement and 10 (28.6

2018 Journal of ophthalmic inflammation and infection

67. CBS mutations are good predictors for B6‐responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients Full Text available with Trip Pro

CBS mutations are good predictors for B6‐responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients 30264510 2018 11 14 2324-9269 6 5 2018 09 Molecular genetics & genomic medicine Mol Genet Genomic Med CBS mutations are good predictors for B6-responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients. 861 10.1002/mgg3.462 eng Journal Article Published Erratum United States Mol Genet Genomic Med 101603758 2324-9269 Mol (...) Genet Genomic Med. 2018 Mar;6(2):160-170 29352562 2018 9 29 6 0 2018 9 29 6 0 2018 9 29 6 1 ppublish 30264510 10.1002/mgg3.462 PMC6160707 Mol Genet Genomic Med. 2018 Mar;6(2):160-170 29352562

2018 Molecular Genetics & Genomic Medicine

68. Xiuyi Zhi: bent on the fight against lung cancer in his 35-year career Full Text available with Trip Pro

Xiuyi Zhi: bent on the fight against lung cancer in his 35-year career 29915685 2018 06 19 2072-1439 10 Suppl 11 2018 May Journal of thoracic disease J Thorac Dis Xiuyi Zhi: bent on the fight against lung cancer in his 35-year career. S1322-S1329 10.21037/jtd.2018.05.04 Gao Chen C eng News China J Thorac Dis 101533916 2072-1439 Conflicts of Interest: The author has no conflicts of interest to declare. 2018 6 20 6 0 2018 6 20 6 0 2018 6 20 6 1 ppublish 29915685 10.21037/jtd.2018.05.04 jtd-10-S11

2018 Journal of thoracic disease

69. Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report Full Text available with Trip Pro

Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report In the publication of this article [1], there is an error in Table 1 at the Test Ca2+ at the Result. The error in Test Ca2+ Result: '1.24' Should instead read Test Ca2+ Result: '2.24' This has now been included in this erratum.

2018 Journal of medical case reports

70. Diagnostic yield of electromagnetic navigational bronchoscopy: results of initial 35 cases in a Japanese institute Full Text available with Trip Pro

included 35 consecutive patients who underwent ENB with superDimensionTM (Medtronic, MN, USA) for the diagnosis of pulmonary lesions from February 2016 to May 2017 in Kyoto University Hospital. The size of the target lesion varied from 8 to 25 mm (median, 15.28±5.48 mm). All ENB procedures were performed under conscious sedation using 2 to 10 mg midazolam and 1 to 10 mg morphine hydrochloride. No fluoroscopic guide was employed except in three cases.A total of 25 patients were diagnosed via ENB (...) Diagnostic yield of electromagnetic navigational bronchoscopy: results of initial 35 cases in a Japanese institute Electromagnetic navigational bronchoscopy (ENB) is a new bronchoscopic technique for navigational transbronchial lung biopsy (TBLB) that guides the sheath to the target lesion in real time. Herein, we report our experience with this navigational system, its diagnostic yields, and associated complications.A single-center, single-operator retrospective chart review was performed. We

2018 Journal of thoracic disease

71. Heart Disease Death Rates Among Blacks and Whites Aged ≥35 Years — United States, 1968–2015 Full Text available with Trip Pro

Heart Disease Death Rates Among Blacks and Whites Aged ≥35 Years — United States, 1968–2015 Heart disease is the leading cause of death in the United States. In 2015, heart disease accounted for approximately 630,000 deaths, representing one in four deaths in the United States. Although heart disease death rates decreased 68% for the total population from 1968 to 2015, marked disparities in decreases exist by race and state.1968-2015.The National Vital Statistics System (NVSS) data (...) on deaths in the United States were abstracted for heart disease using diagnosis codes from the eighth, ninth, and tenth revisions of the International Classification of Diseases (ICD-8, ICD-9, and ICD-10) for 1968-2015. Population estimates were obtained from NVSS files. National and state-specific heart disease death rates for the total population and by race for adults aged ≥35 years were calculated for 1968-2015. National and state-specific black-white heart disease mortality ratios also were

2018 MMWR Surveillance Summaries

72. Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher Full Text available with Trip Pro

or higher.Data from 546 patients with a BMI of 35 kg/m2 or higher who underwent bariatric surgery at Wolfson Medical Center from 2010 through 2014 was retrospectively extracted and analyzed for demographics, predictors of DI and intubation techniques employed. Difficult intubation was defined as the presence of at least one of the followings: laryngoscopy grade 3 or 4, need for >1 laryngoscopy or intubation attempt, need for changing the blade size, failed direct laryngoscopy (DL), difficult or failed (...) Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m2 or higher The incidence of difficult intubation (DI) in obese patients may reach a two-digit figure. No studies have assessed the effect of primary use of special intubation devices on lowering the incidence of DI. We assessed the effect of primary selection of special intubation techniques on the incidence of DI in patients with a BMI of 35 kg/m2

2018 Romanian Journal of Anaesthesia and Intensive Care

73. Dose-Dependent Cardioprotection of Moderate (32°C) Versus Mild (35°C) Therapeutic Hypothermia in Porcine Acute Myocardial Infarction. Full Text available with Trip Pro

) was equivalent in all groups (p = 0.2), but 32°C exhibited 77% and 91% reductions in IS size per AAR compared with 35°C and 38°C, respectively (AAR: 38°C, 45 ± 12%; 35°C, 17 ± 10%; 32°C, 4 ± 4%; p < 0.001) and comparable reductions per LV mass (LV mass: 38°C, 14 ± 5%; 35°C, 5 ± 3%; 32°C 1 ± 1%; p < 0.001). Importantly, 32°C showed a lower IS AAR (p = 0.013) and increased immunohistochemical granulation tissue versus 35°C, indicating higher tissue salvage. Delayed-enhancement cardiac magnetic resonance IS LV (...) also showed marked reduction at 32°C (38°C: 10 ± 4%, p < 0.001; 35°C: 8 ± 3%; 32°C: 3 ± 2%, p < 0.001). Cardiac output on day 6 was only preserved at 32°C (reduction in cardiac output: 38°C, -29 ± 19%, p = 0.041; 35°C: -17 ± 33%; 32°C: -1 ± 28%, p = 0.041). Using linear regression, the predicted IS reduction was 6.7% (AAR) and 2.1% (LV) per every 1°C reperfusion temperature decrease.Moderate (32°C) therapeutic hypothermia demonstrated superior and near-complete cardioprotection compared with 35°C

2018 JACC. Cardiovascular interventions

74. Liver Simulated Allocation Modeling: Were the Predictions Accurate for Share 35? (Abstract)

Liver Simulated Allocation Modeling: Were the Predictions Accurate for Share 35? The liver simulated allocation model (LSAM) can be used to study likely effects of liver transplant allocation policy changes on organ offers, acceptance, waitlist survival, and posttransplant survival. Implementation of Share 35 in June 2013 allowed for testing how well LSAM predicted actual changes.LSAM projections for 1 year of liver transplants before and after the Share 35 policy change were compared (...) with observed data during the same period. Numbers of organs recovered, organ sharing, transplant rates, and waitlist mortality rates (per 100 waitlist years) were evaluated by LSAM and compared with observed data.Candidate, recipient, and donor characteristics in the LSAM cohorts were similar to those in the observed population before and after Share 35. LSAM correctly predicted more accepted organs and fewer discarded organs with Share 35. LSAM also predicted increased regional and national sharing

2018 Transplantation

75. Advance directives from haematology departments: the patient's freedom of choice and communication with families. A qualitative analysis of 35 written documents. Full Text available with Trip Pro

Advance directives from haematology departments: the patient's freedom of choice and communication with families. A qualitative analysis of 35 written documents. In France, advance directives are favourably perceived by most of the population, although the drafting rate is low. This ambivalence is challenging because advance directives are meant to promote the autonomy and freedom of choice of patients. The purpose of this study was to analyse the content of advance directives written (...) on medical treatments or actions, or to communicate a message to the family. Three main themes emerged: (1) refusal of medical treatment (100%), in which patients express refusal of life-sustaining care (97.1%). The actual treatments or the moment when they should be limited or stopped were not always mentioned in detail. (2) A desire for effective pain relief to avoid suffering (57.1%) and (3) messages for their family (34.3%), such as funeral arrangements (17.1%) and messages of love or trust (14.3

2018 BMC Palliative Care

76. Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio. Full Text available with Trip Pro

Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio. Pancreatic islet transplantation is a promising treatment for type 1 diabetes (T1D). Interleukin-35 (IL-35) is a recently discovered cytokine that exhibits potent immunosuppressive functions. However, the role of IL-35 in islet transplant rejection remains to be elucidated. In this study, we isolated islet cells of BALB/c mouse and purified CD4+ T cell subsets of a C57BL/6 mouse (...) . The model for islet transplantation was established in vitro by co-culture of the islet cells and CD4+ T cells. IL-35 (20 ng/ml) was administered every other day. Following co-culture, the islet function and Treg/Th17 ratio were analyzed on days 1, 3, and 5. Furthermore, the Th17/Treg ratio was modulated (1:0-2), and the function of islet cells as well as proliferation of Th17 cells were analyzed. T cell sorting was performed using the magnetic bead sorting method; Treg and Th17 count using flow

2017 PLoS ONE

77. Emerging role of IL-35 in inflammatory autoimmune diseases. (Abstract)

cells. Recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 1 diabetes, psoriasis, multiple sclerosis, autoimmune hepatitis, experimental autoimmune uveitis. In addition, functional analysis suggested that IL-35 is critical in the onset and development of these diseases. Therefore, the present study will systematically review what had been occurred (...) Emerging role of IL-35 in inflammatory autoimmune diseases. Interleukin 35 (IL-35) is the recently identified member of the IL-12 family of cytokines and provides the possibility to be a target for new therapies for autoimmune, inflammatory diseases. It is composed of an α chain (p35) and a β chain (EBI3). IL-35 mediates signaling by binding to its receptors, activates subsequent signaling pathways, and therefore, regulates the differentiation, function of T, B cells, macrophages, dendritic

2018 Autoimmunity reviews

78. Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ≈43% of 35 Families With Midaortic Syndrome. Full Text available with Trip Pro

that in a high percentage of these patients, a monogenic cause of disease may be detected by evaluating whole exome sequencing data for mutations in 1 of 38 candidate genes previously described to cause vasculopathy. We studied a cohort of 36 individuals from 35 different families with MAS by exome sequencing. In 15 of 35 families (42.9%), we detected likely causal dominant mutations. In 15 of 35 (42.9%) families with MAS, whole exome sequencing revealed a mutation in one of the genes previously associated (...) Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ≈43% of 35 Families With Midaortic Syndrome. Midaortic syndrome (MAS) is a rare cause of severe childhood hypertension characterized by narrowing of the abdominal aorta in children and is associated with extensive vascular disease. It may occur as part of a genetic syndrome, such as neurofibromatosis, or as consequence of a pathological inflammatory disease. However, most cases are considered idiopathic. We hypothesized

2018 Hypertension

79. Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol. Full Text available with Trip Pro

large cell lymphoma (BV-HLALCL study) is being conducted for pediatric patients in order to evaluate the safety, feasibility and preliminary clinical effectiveness of brentuximab vedotin. SGN-35 is intravenously administered on Day 1 of each cycle (21 days/cycle). The dose of SGN-35 is calculated based on the body weight at the baseline. The primary endpoint is dose limiting toxicity and incidence of adverse events. The secondary endpoints are pharmacokinetics, response rate, complete remission rate (...) Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol. Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) are the two most common tumors expressing CD30. Internationally, a clinical study that is being conducted involving adults with recurrent or refractory HL or ALCL suggests efficacy

2018 BMC Cancer

80. A Multicomponent, Preschool to Third Grade Preventive Intervention and Educational Attainment at 35 Years of Age. Full Text available with Trip Pro

included in the Chicago Longitudinal Study and were followed up for 27 to 30 years after the end of a multicomponent intervention. A total of 1398 participants (90.8%) in the original sample had educational attainment records at 35 years of age. The study was performed from January 1, 2002, through May 31, 2015.The Child-Parent Center Program provides school-based educational enrichment and comprehensive family services from preschool to third grade (ages 3-9 years).Educational outcomes from (...) A Multicomponent, Preschool to Third Grade Preventive Intervention and Educational Attainment at 35 Years of Age. Educational attainment is the leading social determinant of health, but few studies of prevention programs have examined whether the programs are associated with educational attainment outcomes after the mid-20s, especially for large-scale programs that provide a longer duration of services.To examine the association between a preschool to third grade intervention and educational

2018 JAMA pediatrics

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