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Demulen 1/35

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41. Prediction of Imminent Preeclampsia at 35-37 Weeks' Gestation. (Abstract)

Prediction of Imminent Preeclampsia at 35-37 Weeks' Gestation. In the weeks preceding the clinical onset of preeclampsia (PE) the maternal serum level of the angiogenic placental growth factor (PLGF) is decreased and that of the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT) is increased. Women presenting at specialist clinics with signs or symptoms of hypertensive disorders have been stratified according to concentrations of PLGF or the ratio of concentrations of sFLT and PLGF (...) to determine clinical management for the subsequent 1-4 weeks. An alternative approach for the prediction of PE is use of the competing risks model, a Bayes' theorem based method, to derive patient-specific risk for PE by various combinations of maternal characteristics and medical history with multiples of the median (MoM) values of biomarkers.To compare the performance of screening for delivery with PE at ≤2 and ≤4 weeks after assessment at 35+0 - 36+6 weeks' gestation between the use of percentile cut

2019 American Journal of Obstetrics and Gynecology

42. Clinical Presentation of Influenza in Children 6 to 35 Months of Age: Findings From a Randomized Clinical Trial of Inactivated Quadrivalent Influenza Vaccine. Full Text available with Trip Pro

Clinical Presentation of Influenza in Children 6 to 35 Months of Age: Findings From a Randomized Clinical Trial of Inactivated Quadrivalent Influenza Vaccine. In an exploratory analysis of an inactivated quadrivalent influenza vaccine (IIV4) trial in children 6-35 months without risk factors for influenza, we evaluated clinical presentation of influenza illness and vaccine impact on health outcomes.This phase III trial was conducted in 13 geographically diverse countries across 5 influenza (...) seasons (2011-2014). Children were randomized 1:1 to IIV4 or control. Active surveillance was performed for influenza-like episodes (ILE); influenza was confirmed by reverse transcription polymerase chain reaction (RT-PCR). The total vaccinated cohort was evaluated (N = 12,018).5702 children experienced ≥1 ILE; 356 (IIV4 group) and 693 (control group) children had RT-PCR-confirmed influenza. Prevalence of ILE was similar in RT-PCR-positive and RT-PCR-negative cases regardless of vaccination

2019 The Pediatric infectious disease journal Controlled trial quality: uncertain

43. Hemostatic characteristics of thawed, pooled cryoprecipitate stored for 35 days at refrigerated and room temperatures. Full Text available with Trip Pro

Hemostatic characteristics of thawed, pooled cryoprecipitate stored for 35 days at refrigerated and room temperatures. Cryoprecipitate's shelf life is limited due to concerns over decreased clotting factor activity and contamination with extended storage. Hemostatic characteristics of thawed cryoprecipitate stored up to 35 days at refrigerated and room temperatures were assessed.Pooled cryoprecipitate was thawed and aliquoted for storage at 1-6°C or 21-24°C. Samples were tested immediately (...) after thawing and at 4 h, 24 h, 72 h, and weekly for 35 days. At each time point fibrinogen, factor VIII (FVIII), and von Willebrand factor (vWF) were assessed. Thrombin generation and rotational thromboelastometry (ROTEM) were also performed. Further, packed red cells, platelet concentrates, frozen plasma, and stored cryoprecipitate were combined (1:1:1:1) to simulate massive transfusion and analyzed by ROTEM. Day 35 samples were cultured for bacterial contamination.Precipitation was observed

2019 Transfusion

44. Impact of American Academy of Pediatrics Palivizumab Guidance for Children ≥29 and <35 Weeks of Gestational Age. (Abstract)

Impact of American Academy of Pediatrics Palivizumab Guidance for Children ≥29 and <35 Weeks of Gestational Age. To evaluate the impact of the American Academy of Pediatrics revised recommendations (2014) for palivizumab prophylaxis on respiratory syncytial virus (RSV) admissions and severity of illness among children ≥29 weeks and <35 weeks of gestational age.We evaluated patients hospitalized with RSV infection from October 1, 2012, through April 30, 2017. RSV hospitalizations, community (...) RSV activity, duration of hospitalization, disease severity, and mortality were reviewed. Data were compared before and after implementation of the guideline changes.A total of 91 patients were born at ≥29 weeks and <35 weeks of gestational age and hospitalized within the first year of life during the evaluation period. Gestational age, birth weight, age at diagnosis, and sex remained constant over the seasons evaluated. RSV hospitalizations and activity in the community were unchanged over 5

2019 Journal of Pediatrics

45. Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice. Full Text available with Trip Pro

2) macrophages in infarcted hearts. IL-35 activated transcription of CX3C chemokine receptor 1(CX3CR1) and transforming growth factor beta 1 in macrophages by inducing GP130 signaling, via IL12Rβ2 and phosphorylation of STAT1 and STAT4 and subsequently promoted Ly6Clow macrophage survival and extracellular matrix deposition. Moreover, compared with control MI mice, IL-35-treated MI mice showed increased expression of α-SMA and collagen within scars, correlating with decreased left ventricular (...) Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice. Targeting inflammation has been shown to provide clinical benefit in the field of cardiovascular diseases. Although manipulating regulatory T cell (Treg) function is an important goal of immunotherapy, the molecules that mediate their suppressive activity remain largely unknown. Interleukin 35 (IL-35), an immunosuppressive cytokine mainly produced by Tregs, is a novel member of the IL-12

2019 Circulation Research

46. Metabolic surgery for the treatment of type 2 diabetes in patients with BMI lower than 35 kg/m<sup>2</sup> : Why caution is still needed. (Abstract)

brought by this consensus is highly relevant, the recommendation of metabolic surgery for patients with uncontrolled T2DM and a body mass index of 30 to 35 kg/m2 still lacks enough evidence. This article provides an overall view of the metabolic benefits of bariatric/metabolic surgery in patients with class 1 obesity, compares the procedure against clinical treatment, and presents our rationale for defending caution on recommending the procedure to less obese individuals.© 2019 World Obesity (...) Metabolic surgery for the treatment of type 2 diabetes in patients with BMI lower than 35 kg/m2 : Why caution is still needed. Bariatric surgery has shifted from being a risky procedure to an evidence-based one, with proven benefits on all-cause mortality, cardiovascular disease, cancer, and diabetes control. The procedure has an overall positive result on type 2 diabetes mellitus (T2DM), with a substantial number of patients achieving disease remission. This has resulted in several

2019 Obesity Reviews

47. Family-focused treatment improves attenuated psychotic symptoms, but does not differ from brief treatment in negative symptoms and social functioning in ultra high risk patients aged 12?35?years

), but there are no improvements in negative symptoms and social functioning. 1 , 2 Antipsychotic medications are not usually indicated unless the person meets criteria for a DSM-IV/ICD-10 psychotic disorder. 3 Methods of the study The sample consisted of young ultra high risk (UHR) patients aged from 12 to 35 years as assessed with the Structured Interview for Prodromal Symptoms (SIPS) and the Scale of Prodromal Symptoms (SOPS). One hundred and twenty-nine participants were recruited at eight sites of the North American (...) Family-focused treatment improves attenuated psychotic symptoms, but does not differ from brief treatment in negative symptoms and social functioning in ultra high risk patients aged 12?35?years Family-focused treatment improves attenuated psychotic symptoms, but does not differ from brief treatment in negative symptoms and social functioning in ultra high risk patients aged 12–35 years | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content

2015 Evidence-Based Mental Health

48. Transcutaneous bilirubinometry for the screening of neonatal hyperbilirubinemia ?35 weeks' gestation

Transcutaneous bilirubinometry for the screening of neonatal hyperbilirubinemia ?35 weeks' gestation Transcutaneous bilirubinometry for the screening of neonatal hyperbilirubinemia ≥35 weeks' gestation Transcutaneous bilirubinometry for the screening of neonatal hyperbilirubinemia ≥35 weeks' gestation Institute of Health Economics Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has (...) been made for the HTA database. Citation Institute of Health Economics. Transcutaneous bilirubinometry for the screening of neonatal hyperbilirubinemia ≥35 weeks' gestation. Edmonton: Institute of Health Economics (IHE). 2013 Authors' conclusions Early hospital discharge policies have resulted in increased hospital readmission rates of healthy term or late preterm neonates for phototherapy and in a resurgence of kernicterus—a serious neurological damage. Timely identification of neonates at high

2014 Health Technology Assessment (HTA) Database.

49. [Addendum to Commission A13-35 (dabrafenib)]

[Addendum to Commission A13-35 (dabrafenib)] Addendum zum Auftrag A13-35 (Dabrafenib) [Addendum to Commission A13-35 (dabrafenib)] Addendum zum Auftrag A13-35 (Dabrafenib) [Addendum to Commission A13-35 (dabrafenib)] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Addendum zum Auftrag A13-35 (Dabrafenib). [Addendum (...) to Commission A13-35 (dabrafenib)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 210. 2014 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Humans; Imidazoles; Melanoma; Oximes Language Published German Country of organisation Germany English summary There is no English language summary available. Address for correspondence IQWiG, Im Mediapark 8, DE-50670 Cologne, GERMANY, Tel: +49 (0) 221 - 35685 - 0, Fax: +49 (0) 221 - 35685

2014 Health Technology Assessment (HTA) Database.

50. Effect of pH on whitening efficacy of 35% hydrogen peroxide and enamel microhardness. (Abstract)

Effect of pH on whitening efficacy of 35% hydrogen peroxide and enamel microhardness. This study aimed to evaluate the effect of 35% hydrogen peroxide at different pH values and the degree of tooth staining on whitening efficacy and enamel microhardness.90 enamel-dentin specimens were obtained from bovine incisors. They were randomly divided into 2 groups (n = 45), 1 group was immersed in a staining broth for 14 days, and another group was not stained and kept in distilled water at 37°C. Twenty (...) -four hours after the staining procedure, each group was distributed into 3 subgroups that were whitened by 35% hydrogen peroxide with different pH values (5, 7, and 8.4) for 30 minutes. The color was measured at baseline and 7 days after whitening. Microhardness was measured at baseline, immediate, 24 hours, and 1 month after the whitening procedure. Data were submitted to 2-way analysis of variance (ANOVA) and the Tukey test for multiple comparisons for color analysis. Repeated measures ANOVA

2018 Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] Controlled trial quality: uncertain

51. Prevention of vaccine-matched and mismatched influenza in children aged 6-35 months: a multinational randomised trial across five influenza seasons. Full Text available with Trip Pro

Prevention of vaccine-matched and mismatched influenza in children aged 6-35 months: a multinational randomised trial across five influenza seasons. Despite the importance of vaccinating children younger than 5 years, few studies evaluating vaccine prevention of influenza have been reported in this age group. We evaluated efficacy of an inactivated quadrivalent influenza vaccine (IIV4) in children aged 6-35 months.In this phase 3, observer-blinded, multinational trial, healthy children from 13 (...) countries in Europe, Central America, and Asia were recruited in five independent cohorts, each in a different influenza season. Participants were randomly assigned (1:1) to either IIV4 (15 μg haemagglutinin antigen per strain per 0·5 mL dose; a single dose on day 0 for vaccine-primed children, and two doses, on days 0 and 28, for vaccine-unprimed children) or to one or two doses of a non-influenza control vaccine. Primary endpoints were moderate-to-severe influenza or all influenza (irrespective

2018 The Lancet. Child & Adolescent Health Controlled trial quality: uncertain

52. Behavioral Effects of Drugs: Inpatient (35)

Behavioral Effects of Drugs: Inpatient (35) Behavioral Effects of Drugs: Inpatient (35) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Behavioral Effects of Drugs: Inpatient (35) (BED IN 35) The safety (...) provided by (Responsible Party): Craig Rush, University of Kentucky Study Details Study Description Go to Brief Summary: This study will determine the influence of methylphenidate (Metadate®) and duloxetine (Cymbalta®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine. Condition or disease Intervention/treatment Phase Cocaine Use Disorder Drug: Cocaine Drug: Placebo oral capsule Drug: Methylphenidate Early Phase 1 Study Design Go to Layout table for study

2018 Clinical Trials

53. Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Kenyan Children 6-35 Months

) and the study statistician can be blinded to the group assignment Primary Purpose: Prevention Official Title: Programme Effectiveness of an Integrated Programme to Reduce Maternal and Child Malnutrition in Kenya: Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Children 6-35 Months of Age at Recruitment Actual Study Start Date : March 12, 2018 Estimated Primary Completion Date : July 1, 2020 Estimated Study Completion Date : July 1, 2020 Arms and Interventions Go to Arm (...) Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Kenyan Children 6-35 Months Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Kenyan Children 6-35 Months - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

54. Tuberculosis Clinical Trials Consortium Study 35

Tuberculosis Clinical Trials Consortium Study 35 Tuberculosis Clinical Trials Consortium Study 35 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tuberculosis Clinical Trials Consortium Study 35 The safety (...) infection (LTBI) or with exposure to Mycobacterium tuberculosis (M. tuberculosis) will require higher mg/kg rifapentine dosing than adults to achieve adult- exposures which are correlated with efficacy in trials of TB prevention. Investigators further hypothesize that rifapentine will be safe and well-tolerated in HIV-infected and uninfected children who require treatment for LTBI. Condition or disease Intervention/treatment Phase Latent Tuberculosis Drug: Rifapentine Drug: Isoniazid Phase 1 Phase 2

2018 Clinical Trials

55. Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years

Assignment Masking: Triple (Participant, Care Provider, Outcomes Assessor) Primary Purpose: Other Official Title: Magnetic Nanoparticle Sperm Separation for ICSI Cycles With Teratozoospermia and Over 35 Years Old Women Age Actual Study Start Date : September 17, 2018 Estimated Primary Completion Date : September 20, 2019 Estimated Study Completion Date : October 1, 2019 Arms and Interventions Go to Arm Intervention/treatment Experimental: Magnetic nanoparticle selection for teratozoospermia Other: Sperm (...) Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

56. Chain pain following cardiac surgery in a 35-year-old man. (Abstract)

Chain pain following cardiac surgery in a 35-year-old man. A 35-year-old man with multiple cardiovascular risk factors presented with a recent history of fever and acute heart failure. His initial echocardiogram showed evidence of severe aortic regurgitation due to ongoing infective endocarditis. Preoperative coronary angiography revealed no coronary abnormalities. Urgent aortic valve replacement was performed and a 29 mm St Jude mechanical valve was implanted. While blood and resected valvular (...) tissue cultures were negative for bacteria, a PCR-based analysis revealed the presence of penicillin-sensitive Streptococcus pneumoniae. Echocardiographic follow-up study at day 3 showed excellent mechanical valve function with no persistent signs of endocarditis. Eight days after surgery, our patient presented with severe chest pain. The ECG is shown in figure 1A and coronary angiography was performed for diagnostic confirmation (figure 1B-D and online supplementary video 1).DC1SP110.1136/heartjnl

2018 Heart

57. Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 Full Text available with Trip Pro

and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian cities Novosibirsk and Arkhangelsk. The study population was 4542 men and women aged 35-69 years recruited from the general population. Fieldwork took place between 2015-18. There were two study components: 1) a baseline interview to collect information on socio-demographic characteristics and cardiovascular risk factors, usually conducted at home, and 2) a comprehensive health check at a primary (...) Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature

2018 Wellcome open research

58. A 35 MHz/105 MHz Dual-Element Focused Transducer for Intravascular Ultrasound Tissue Imaging Using the Third Harmonic Full Text available with Trip Pro

ultrasound (IVUS) imaging is particularly demanding because of its small size of less than 1 mm. Here, we report a recently developed dual-element focused IVUS transducer for the third harmonic imaging of tissue, which consists of a 35-MHz element for ultrasound transmission and a 105-MHz element for third harmonic reception. For high quality third harmonic imaging, both elements were fabricated to have the same focus at 2.5 mm. The results of tissue mimicking phantom tests demonstrated that the third (...) A 35 MHz/105 MHz Dual-Element Focused Transducer for Intravascular Ultrasound Tissue Imaging Using the Third Harmonic The superharmonic imaging of tissue has the potential for high spatial and contrast resolutions, compared to the fundamental and second harmonic imaging. For this technique, the spectral bandwidth of an ultrasound transducer is divided for transmission of ultrasound and reception of its superharmonics (i.e., higher than the second harmonic). Due to the spectral division

2018 Sensors (Basel, Switzerland)

59. Outcomes of Unilateral Total Hip Arthroplasty in Patients Aged Under 35 Years in Iranian Population: A Preliminary Study Full Text available with Trip Pro

Outcomes of Unilateral Total Hip Arthroplasty in Patients Aged Under 35 Years in Iranian Population: A Preliminary Study The purpose of this study is to report outcomes of total hip arthroplasty (THA) in patients under the age of 35 years regarding pain and joint function.This preliminary analytic-descriptive study was performed in prospective consecutive series of forty-three patients younger than 35 years old who had undergone unilateral THA during a 36-month period. As the primary outcome (...) , the severity of pain using visual analog scale (VAS) of 1-10, and as the secondary outcomes, joint range of motion (ROM) and the Harris Hip Score (HHS) were assessed in the preoperative visit, 1, 6, and 18 months after operation for each patient. Complications were recorded at 6 months and 18 months after surgery.The data of VAS showed the mean severity of pain was significant between preoperation measurements and postoperative assessments (P < 0.001). The means of HHS and hip ROM were also statistically

2018 Advanced biomedical research

60. Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes Full Text available with Trip Pro

Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dimyristoyl (...) -sn-glycero-3-phospho-L-serine (DMPS) and added the trans-membrane segment Aβ25-35. Peptide plaques spontaneously form in these membranes at high peptide concentrations of 20 mol%, which show the characteristic cross-β motif (concentrations are relative to the number of membrane lipids and indicate the peptide-to-lipid ratio). We used atomic force microscopy, fluorescence microscopy, x-ray microscopy, x-ray diffraction, UV-vis spectroscopy and Molecular Dynamics (MD) simulations to study three

2018 Scientific reports

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