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181. Depletion of vacuolar protein sorting-associated protein 35 is associated with increased lysosomal degradation of aquaporin-2. (PubMed)

Depletion of vacuolar protein sorting-associated protein 35 is associated with increased lysosomal degradation of aquaporin-2. The carboxyl terminus of aquaporin-2 (AQP2c) undergoes posttranslational modifications, including phosphorylation and ubiquitination, in the process of regulating aquaporin-2 (AQP2) translocation and protein abundance. We aimed to identify novel proteins interacting with AQP2c. Recombinant AQP2c protein was made in Escherichia coli BL21 (DE3) cells by exploiting (...) the pET32 TrxA fusion system. Lysates of rat kidney inner medullary collecting duct (IMCD) tubule suspensions interacted with rat AQP2c bound to Ni2+-resin were subjected to LC-MS/MS proteomic analysis. Potential interacting proteins were identified, including vacuolar protein sorting-associated protein 35 (Vps35). Coimmunoprecipitation assay demonstrated that Vps35 interacted with AQP2c. Immunohistochemistry of rat kidney revealed that AQP2 and Vps35 were partly colocalized at the intracellular

2016 American Journal of Physiology. Renal physiology

182. A comparative study of the metabolic effects of LSG and LRYGB in Chinese diabetes patients with BMI&lt;35 kg/m<sup>2</sup>. (PubMed)

A comparative study of the metabolic effects of LSG and LRYGB in Chinese diabetes patients with BMI<35 kg/m2. The metabolic effects of laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in type 2 diabetes (T2D) patients who do not meet National Institutes of Health indications has not been well studied.To compare the effectiveness of LSG and LRYGB in Chinese T2D patients with body mass index (BMI)<35 kg/m2.University hospital, China.A (...) group had significantly higher percentage of excess weight loss and lower BMI. The total (complete and partial) remission rate achieved with both bariatric procedures was 75.9% at 1 year and 56.4% at 3 years. Surgical safety, diabetes remission, and remission of other obesity-related co-morbidities were comparable between the 2 groups. Patients who achieved complete or partial remission had lower fasting plasma glucose, lower plasma glucose at 2 hours, lower glycated hemoglobin, and higher fasting C

2016 Surgery for Obesity and Related Diseases

183. Congenital Stapes Ankylosis in Children: Surgical Findings and Results in 35 Cases. (PubMed)

Congenital Stapes Ankylosis in Children: Surgical Findings and Results in 35 Cases. To evaluate surgical findings and hearing results in children undergoing middle ear surgery for congenital stapes ankylosis with or without other ossicular malformations (Teunissen and Cremers class I and class II malformations).A nonrandomized, nonblinded case series of prospectively collected data.A tertiary referral center.Twenty-eight consecutive pediatric patients who underwent 35 surgical procedures (...) for congenital stapes ankylosis with or without other ossicular malformations and had available postoperative pure-tone audiometry.Primary stapedotomy with vein graft interposition and reconstruction with a Teflon piston, bucket handle prosthesis or total ossicular replacement prosthesis.Pre- and postoperative audiometric evaluation using four-frequency (0.5, 1, 2, and 4 kHz) audiometry. Air-conduction thresholds, bone-conduction thresholds, and air-bone gaps (ABGs) were measured. Postoperative audiometry

2016 Otology and Neurotology

184. Loop Duodenojejunal Bypass with Sleeve Gastrectomy: Comparative Study with Roux-en-Y Gastric Bypass in Type 2 Diabetic Patients with a BMI &lt;35 kg/m<sup>2</sup>, First Year Results. (PubMed)

Loop Duodenojejunal Bypass with Sleeve Gastrectomy: Comparative Study with Roux-en-Y Gastric Bypass in Type 2 Diabetic Patients with a BMI <35 kg/m2, First Year Results. Roux-en-Y gastric bypass (RYGB) has shown good diabetes remission in obese patients with type 2 diabetes mellitus (T2DM), but long-term complications were observed. We developed loop duodenojejunal bypass with sleeve gastrectomy (LDJB-SG) to achieve diabetes remission and avoid the drawbacks of RYGB. We compare 1 (...) -year results between LDJB-SG and RYGB with body mass index (BMI) <35 kg/m(2) of T2DM patients.We conducted a case-matched study of BMI < 35 kg/m(2) T2DM patients who underwent RYGB and LDJB-SG matching on age, BMI, and duration of diabetes. The 1-year surgical results were compared.Sixty patients were included from March 2010 to August 2012. Thirty patients underwent RYGB and 30 underwent LDJB-SG. The operative time (mean ± SD) and length of stay (median [IQR]) were significantly longer in the LDJB

2016 Obesity Surgery

185. Discrimination in the workplace, reported by people with major depressive disorder: a cross-sectional study in 35 countries. (PubMed)

, especially from their own perspective. We aimed to assess, in a working age population including respondents with MDD from 35 countries: (1) if people with MDD anticipate and experience discrimination when trying to find or keep paid employment; (2) if participants in high, middle and lower developed countries differ in these respects; and (3) if discrimination experiences are related to actual employment status (ie, having a paid job or not).Participants in this cross-sectional study (N=834) had (...) Discrimination in the workplace, reported by people with major depressive disorder: a cross-sectional study in 35 countries. Whereas employment has been shown to be beneficial for people with Major Depressive Disorder (MDD) across different cultures, employers' attitudes have been shown to be negative towards workers with MDD. This may form an important barrier to work participation. Today, little is known about how stigma and discrimination affect work participation of workers with MDD

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2016 BMJ open

186. Infective Endocarditis With Paravalvular Extension: 35-Year Experience. (PubMed)

Infective Endocarditis With Paravalvular Extension: 35-Year Experience. We investigated our surgical strategy and clinical results in patients from active infective endocarditis (AIE) complicated by paravalvular involvement to determine the risk factors of early and late death and reoperation.From October 1979 to December 2014, 955 patients underwent operations for AIE; among them 207 had AIE with paravalvular extension. The patients were a mean age of 59.9 ± 15.4 years, and 162 (78%) were male (...) . Of these patients, 137 (66%) had isolated aortic valve endocarditis, and 138 (67%) had native valve endocarditis. Follow-up was 99% complete.The operative mortality of the cohort was 16% (n = 34). Abnormal communication, mechanical valve implantation, and renal failure were independent predictors of 30-day death. Survival at 1, 5, 10, and 15 years was 90.3% ± 2.3%, 62.4% ± 3.7%, 49.3% ± 4.1%, and 37.9% ± 4.4%, respectively. Streptococcus endocarditis (all species), complex annular repair, and preoperative heart

2016 Annals of Thoracic Surgery

187. Results of Laparoscopic Sleeve Gastrectomy in 541 Consecutive Patients with Low Baseline Body Mass Index (30-35 kg/m<sup>2</sup>). (PubMed)

 years (13-65) and 419 (77.4 %) were women. Preoperative weight was 92.0 ± 8.8 kg (65-121) and BMI was 32.6 ± 1.5 kg/m2 (30-35). Comorbidities were detected in 210 (39 %) patients. Operative time was 74 ± 12 min (40-110) and postoperative stay was 1.7 ± 0.22 days (1-3). There were no deaths, leaks, abscesses or strictures and the rate of hemorrhage was 1.2 %. At 1 year, 98 % were followed and BMI decreased to 24.7 ± 1.6, the percentage of total weight loss (% TWL) was 24.1 ± 4.7 while the percentage (...) Results of Laparoscopic Sleeve Gastrectomy in 541 Consecutive Patients with Low Baseline Body Mass Index (30-35 kg/m2). Laparoscopic sleeve gastrectomy (LSG) is currently the leading bariatric procedure and targets, among other obesity classes, patients with BMI 30-35 kg/m2, which are reaching alarming proportions.Between February 2010 and August 2015, data on 541 consecutive patients with BMI 30-35 kg/m2 undergoing LSG were prospectively collected and analyzed.Mean age was 32 ± 8

2016 Obesity Surgery

188. A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 2 to 35 Months Old

Status : Active, not recruiting First Posted : August 31, 2017 Last Update Posted : August 31, 2017 Sponsor: Enimmune Corporation Information provided by (Responsible Party): Enimmune Corporation Study Details Study Description Go to Brief Summary: The objectives of this study are to evaluate the immune response and safety profiles of two injections of EV71 vaccine administrated with or without adjuvant Al(OH)3 at 0.5-μg and 1-μg dose in children aged 3 to 6 years old and 2 to 35 months old infants (...) vaccine ([0.5 μg total protein + adjuvant 150 μg AI(OH)3] per dose) Two vaccinations at 28 days apart Experimental: Group A2 3 to 6 years Biological: EV71 vaccine ([1 μg total protein + adjuvant 150 μg AI(OH)3] per dose) Two vaccinations at 28 days apart Experimental: Group A3 3 to 6 years Biological: EV71 vaccine ([1 μg total protein ] per dose) Two vaccinations at 28 days apart Experimental: Group B1 2 to 35 months Biological: EV71 vaccine ([0.5 μg total protein + adjuvant 150 μg AI(OH)3] per dose

2016 Clinical Trials

189. Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature (PubMed)

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature Chronic lymphocytic leukemia (CLL) represents the most common hematological malignancy in Western countries, with a highly heterogeneous clinical course and prognosis. Translocations involving the immunoglobulin (IG) genes are regularly identified. From 2000 to 2014, we identified an IG gene translocation in 18 of the 396 patients investigated at diagnosis (4.6%) and in 17 (...) of the 275 analyzed during follow-up (6.2%). A total of 4 patients in whom the IG translocation was identified at follow-up did not carry the translocation at diagnosis. The IG heavy locus (IGH) was involved in 27 translocations (77.1%), the IG κ locus (IGK) in 1 (2.9%) and the IG λ locus (IGL) in 7 (20.0%). The chromosome band partners of the IG translocations were 18q21 in 16 cases (45.7%), 11q13 and 19q13 in 4 cases each (11.4% each), 8q24 in 3 cases (8.6%), 7q21 in 2 cases (5.7%), whereas 6 other

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2016 Molecular and clinical oncology

190. Suppression of the toxicity of Bac7 (1–35), a bovine peptide antibiotic, and its production in E. coli (PubMed)

Suppression of the toxicity of Bac7 (1–35), a bovine peptide antibiotic, and its production in E. coli Bac7 (1-35) is an Arg- and Pro-rich peptide antibiotic, produced in bovine cells to protect them from microbial infection. It has been demonstrated to inhibit the protein synthesis in E. coli, leading to cell death. Because of its toxicity, no cost effective methods have been developed for Bac7 production in Escherichia coli for its potential clinical use. Here, we found a method to suppress (...) Bac7 (1-35) toxicity in E. coli to establish its high expression system, in which Bac7 (1-35) was fused to the C-terminal end of protein S, a major spore-coat protein from Myxococcus xanthus, using a linker containing a Factor Xa cleavage site. The resulting His6-PrS2-Bac7 (1-35) (PrS2 is consisted of two N-terminal half domains of protein S connected in tandem) was well expressed using the Single-Protein Production (SPP) system at low temperature and subsequently purified in a single step by using

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2016 AMB Express

191. CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping (PubMed)

and CYP2D7-specific XL-PCR products revealed a CC>GT dinucleotide SNP in exon 1 of CYP2D7 that reverts the sequence to CYP2D6 and allows a TaqMan assay PCR primer to bind. Because CYP2D7 also carries a Tins, a false-positive mutation signal is generated. This CYP2D7 SNP was also responsible for generating false-positive signals for rs769258 (CYP2D6 (*) 35) which is also located in exon 1. Although alternative CYP2D6 (*) 15 and (*) 35 assays resolved the issue, we discovered a novel CYP2D6 (*) 15 (...) CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNPs) some of which reflect the wild-type sequence of the CYP2D7 pseudogene. The aim of this study was to identify

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2016 Frontiers in pharmacology

192. Time-course of myelination and atrophy on cerebral imaging in 35 patients with PLP1-related disorders. (PubMed)

Time-course of myelination and atrophy on cerebral imaging in 35 patients with PLP1-related disorders. Brain magnetic resonance imaging (MRI) motor development score (MDS) correlations were used to analyze the natural time-course of hypomyelinating PLP1-related disorders (Pelizaeus-Merzbacher disease [PMD] and spastic paraplegia type 2).Thirty-five male patients (ranging from 0.7-43.5y at the first MRI) with PLP1-related disorder were prospectively followed over 7 years. Patients were (...) classified according to best motor function acquired before 5 years (MDS) into five categories (from PMD0 without motor acquisition to PMD4 with autonomous walking). We determined myelination and atrophy scores and measured corpus callosum area, volume of cerebellum, white matter and grey matter on 63 MRI.Age-adjusted multivariate analysis revealed that patients with PMD0-1 had higher-severity atrophy scores and smaller corpus callosum area than did patients with PMD2 and PMD3-4. Myelination score

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2016 Developmental Medicine and Child Neurology

193. Waitlist Outcomes of Liver Transplant Candidates Reprioritized Under Share-35. (PubMed)

Waitlist Outcomes of Liver Transplant Candidates Reprioritized Under Share-35. Under Share 35, deceased donor (DD) livers are offered regionally to candidates with Model for End-Stage Liver Disease (MELD) scores ≥35 before being offered locally to candidates with MELD scores <35. Using Scientific Registry of Transplant Recipients data from June 2013 to June 2015, we identified 1768 DD livers exported to regional candidates with MELD scores ≥35 who were transplanted at a median MELD score of 39 (...) (interquartile range [IQR] 37-40) with 30-day posttransplant survival of 96%. In total, 1764 (99.8%) exports had an ABO-compatible candidate in the recovering organ procurement organization (OPO), representing 1219 unique reprioritized candidates who would have had priority over the regional candidate under pre-Share 35 allocation. Reprioritized candidates had a median waitlist MELD score of 31 (IQR 27-34) when the liver was exported. Overall, 291 (24%) reprioritized candidates had a comparable MELD score

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2016 American Journal of Transplantation

194. What can 35 years and over 700,000 measurements tell us about noise exposure in the mining industry? (PubMed)

What can 35 years and over 700,000 measurements tell us about noise exposure in the mining industry? To analyse over 700,000 cross-sectional measurements from the Mine Safety and Health Administration (MHSA) and develop statistical models to predict noise exposure for a worker.Descriptive statistics were used to summarise the data. Two linear regression models were used to predict noise exposure based on MSHA-permissible exposure limit (PEL) and action level (AL), respectively. Twofold cross (...) than after the law was implemented. Both models produced exposure predictions that were less than 1 dBA different than the holdout data.Overall noise levels in mines have been decreasing. However, this decrease has not been uniform across all mining sectors. The exposure predictions from the model will be useful to help predict hearing loss in workers in the mining industry.

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2016 International journal of audiology

195. β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice (PubMed)

via an insulin promoter (AAV8mIP-IL35) was used. AAV8mIP-IL35 vaccination of NOD mice at a late preclinical stage of type 1 diabetes (T1D) suppressed β-cell autoimmunity and prevented diabetes onset. Numbers of islet-resident conventional CD4+ and CD8+ T cells, and DCs were reduced within 4 weeks of AAV8mIP-IL35 treatment. The diminished islet T-cell pool correlated with suppressed proliferation, and a decreased frequency of IFN-γ-expressing Teff. Ectopic IL-35 also reduced islet Foxp3+ Treg (...) β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice IL-35 is a recently identified cytokine exhibiting potent immunosuppressive properties. The therapeutic potential and effects of IL-35 on pathogenic T effector cells (Teff) and Foxp3+ Treg, however, are ill defined. We tested the capacity of IL-35 to suppress ongoing autoimmunity in NOD mice. For this purpose, an adeno-associated virus vector in which IL-35 transgene expression is selectively targeted to β cells

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2016 European journal of immunology

196. Intrauterine Insemination Treatment Strategy for Women over 35 Years Old: Based on a Large Sample Multi-center Retrospective Analysis (PubMed)

Intrauterine Insemination Treatment Strategy for Women over 35 Years Old: Based on a Large Sample Multi-center Retrospective Analysis 27901004 2017 07 13 2018 11 13 2542-5641 129 23 2016 12 05 Chinese medical journal Chin. Med. J. Intrauterine Insemination Treatment Strategy for Women over 35 Years Old: Based on a Large Sample Multi-center Retrospective Analysis. 2873-2875 10.4103/0366-6999.194647 Yang Shuo S Reproductive Medical Center, Peking University Third Hospital, Beijing 100191, China (...) 0 Gonadotropins IM Adult Female Gonadotropins pharmacology Humans Infertility therapy Insemination, Artificial methods Male Ovulation drug effects Pregnancy Pregnancy Rate Retrospective Studies Treatment Outcome Young Adult There are no conflicts of interest. 2016 12 1 6 0 2016 12 3 6 0 2017 7 14 6 0 ppublish 27901004 ChinMedJ_2016_129_23_2873_194647 10.4103/0366-6999.194647 PMC5146798 Hum Reprod. 1996 Apr;11(4):732-6 8671318 Fertil Steril. 2010 Jan;93(1):79-88 18996517 J Assist Reprod Genet

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2016 Chinese medical journal

197. Amyloid beta peptide 22-35 induces a negative inotropic effect on isolated rat hearts (PubMed)

on isolated rat heart and ileum smooth muscle. Langendorff-perfused rat heart preparations were established. The hearts were perfused under constant pressure (60 mmHg) with modified Krebs-Henseleit solution. Aβ22-35 at doses of 1, 10 and 100 nM significantly decreased left ventricular developed pressure (LVDP; an index of cardiac contractility) and maximal rate of pressure development of left ventricle (+dP/dtmax; another index of cardiac contractility). This peptide at doses studied had no significant (...) Amyloid beta peptide 22-35 induces a negative inotropic effect on isolated rat hearts Evidences indicate that deposition of amyloid beta peptides (Aβs) plays an important role in the pathogenesis of Alzheimer disease. Aβs may influence cardiovascular system and ileum contractions. But the effect of amyloid beta peptide 22-35 (Aβ22-35) on cardiovascular functions and contractions of ileum has not been studied. Therefore, the present study aimed to investigate the possible effects of this peptide

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2016 International journal of physiology, pathophysiology and pharmacology

198. Predictors of RSV LRTI Hospitalization in Infants Born at 33 to 35 Weeks Gestational Age: A Large Multinational Study (PONI) (PubMed)

educational level (P = 0.0426), household presence of children aged 4 to 5 years (P = 0.0038), age on 1 October ≤3 months (P = 0.0422), and presence of paternal atopy (P<0.0001).During the 2013-2014 RSV season across 23 countries, for preterm infants 33-35 weeks gestation ≤6 months old on 1 October not receiving RSV prophylaxis, confirmed RSV LRTI hospitalization incidence was 4.1 per 100 infant years during the study period and 6.1 per 100 infant years during the RSV season. This study enhances (...) Predictors of RSV LRTI Hospitalization in Infants Born at 33 to 35 Weeks Gestational Age: A Large Multinational Study (PONI) Preterm infants are at high risk of developing respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI). This observational epidemiologic study evaluated RSV disease burden and risk factors for RSV-associated LRTI hospitalization in preterm infants 33 weeks+0 days to 35 weeks+6 days gestational age not receiving RSV prophylaxis.Preterm infants

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2016 PloS one

199. Over-Expression of the Pikh Gene with a CaMV 35S Promoter Leads to Improved Blast Disease (Magnaporthe oryzae) Tolerance in Rice (PubMed)

Over-Expression of the Pikh Gene with a CaMV 35S Promoter Leads to Improved Blast Disease (Magnaporthe oryzae) Tolerance in Rice Magnaporthe oryzae is a rice blast fungus and plant pathogen that causes a serious rice disease and, therefore, poses a threat to the world's second most important food security crop. Plant transformation technology has become an adaptable system for cultivar improvement and to functionally analyze genes in plants. The objective of this study was to determine (...) the effects (through over-expressing and using the CaMV 35S promoter) of Pikh on MR219 resistance because it is a rice variety that is susceptible to the blast fungus pathotype P7.2. Thus, a full DNA and coding DNA sequence (CDS) of the Pikh gene, 3172 bp, and 1206 bp in length, were obtained through amplifying the gDNA and cDNA template from a PH9-resistant rice variety using a specific primer. Agrobacterium-mediated transformation technology was also used to introduce the Pikh gene into the MR219 callus

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2016 Frontiers in plant science

200. Czech version of OPQOL-35 questionnaire: the evaluation of the psychometric properties (PubMed)

Czech version of OPQOL-35 questionnaire: the evaluation of the psychometric properties Both prognoses and real demographic trends in developed countries point to the increasing proportion in the population of people above 65 years of age. One of important themes of care for seniors is the assessment of their quality of life. To evaluate the quality of life of seniors three types of tools can be used: general generic tools; generic tools used for the age group of elderly persons; specific tools (...) to detect the quality of life of the elderly who are affected by specific diseases.The second type of tool is represented by the OPQOL - 35 questionnaire (Older People's Quality of Life Questionnaire), which was developed in the UK. It has 35 items and deals with 8 domains of quality of life. With the consent of the author the questionnaire was translated into Czech and verified in a group of 478 seniors aged 60 and above (40 % males, 60 % females). Unlike the British version, the Czech version has

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2016 Health and quality of life outcomes

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