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Defensive Medicine

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161. Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)

Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01976130 Recruitment Status : Unknown Verified

2013 Clinical Trials

162. A self-defense program reduces the incidence of sexual assault in Kenyan adolescent girls. (PubMed)

of disclosure increased in the intervention group, but not in controls.A standardized 6-week self-defense program is effective in reducing the incidence of sexual assault in slum-dwelling high school girls in Nairobi, Kenya.Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. (...) A self-defense program reduces the incidence of sexual assault in Kenyan adolescent girls. To determine the effect of a standardized 6-week self-defense program on the incidence of sexual assault in adolescent high school girls in an urban slum in Nairobi, Kenya.Population-based survey of 522 high school girls in the Korogocho-Kariobangi locations in Nairobi, Kenya, at baseline and 10 months later. Subjects were assigned by school attended to either a "No Means No Worldwide" self-defense course

2013 The Journal of Adolescent Health

163. Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study (DoD-PLP-Tx) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01824082 Recruitment Status : Active

2013 Clinical Trials

164. White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis

White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis (DMS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01848379 Recruitment Status : Active, not recruiting First Posted : May 7

2013 Clinical Trials

165. Young Smokers Have Impaired Airway Defense

Enrollment : 72 participants Observational Model: Cohort Time Perspective: Cross-Sectional Official Title: Young Smokers Have Impaired Airway Defense That is Not Associated With Pulmonary Function Study Start Date : April 2012 Actual Primary Completion Date : October 2012 Actual Study Completion Date : November 2012 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Nonsmokers Young healthy nonsmokers Smokers<2.5 pack years Young "healthy (...) Young Smokers Have Impaired Airway Defense Young Smokers Have Impaired Airway Defense - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Young Smokers Have Impaired Airway Defense The safety and scientific

2013 Clinical Trials

166. Randomised controlled trial: Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use

improves appropriate antimicrobial use Article Text Therapeutics Randomised controlled trial Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use Forest W Arnold Statistics from Altmetric.com Commentary on: Camins BC , King MD , Wells JB , et al . Impact of an antimicrobial utilization program on antimicrobial use at a large teaching hospital: a randomized controlled trial . Getting defensive about antimicrobial orders (...) Randomised controlled trial: Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about

2010 Evidence-Based Medicine (Requires free registration)

167. Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues (PubMed)

Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues Azadirachta indica has been reported to correct altered glycaemia in diabetes.The aqueous extract of A. indica leaf and bark has been evaluated for its effect on antioxidant status of alloxan diabetic rats and compared with insulin treatment.The oral effective dose of A. indica leaf (500 mg/kg body weight) and A. indica bark (100 mg/kg body weight) were given once daily for 21 days to separate groups (...) with insulin, A. indica leaf extract (AILE), and A. indica bark extract (AIBE) restored the above altered parameters close to the control ones.Both AILE and AIBE were found significantly effective in reducing hyperglycemia-induced oxidative stress. The findings suggest further investigations for the possible use of A. indica as alternative medicine to prevent long-term complications of diabetes.

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2012 Journal of Ayurveda and integrative medicine

168. Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus (PubMed)

Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus Madagascar periwinkle is an ornamental and a medicinal plant, and is also an indicator plant that is highly susceptible to phytoplasma and spiroplasma infections from different crops. Periwinkle lethal yellows, caused by Spiroplasma citri, is one of the most devastating diseases of periwinkle. The response of plants to S. citri infection is very little (...) known at the transcriptome level. In this study, quantitative real-time PCR (RT-qPCR) was used to investigate the expression levels of four selected genes involved in defense and stress responses in naturally and experimentally Spiroplasma citri infected periwinkles. Strictosidine β-glucosidase involved in terpenoid indole alkaloids (TIAs) biosynthesis pathway showed significant upregulation in experimentally and naturally infected periwinkles. The transcript level of extensin increased in leaves

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2012 International journal of molecular sciences

169. Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. (PubMed)

Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase (...) . Glutathione peroxidase activities in postoperative patients were higher compared to inoperative patients.Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

2012 European journal of internal medicine

170. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO)

Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2012 Clinical Trials

171. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel

Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01540929 Recruitment Status : Completed First Posted : February 29, 2012 Last Update Posted : January 30, 2018 Sponsor: Emergent

2012 Clinical Trials

172. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses

The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01902394 Recruitment Status : Completed First Posted : July 18, 2013 Last Update Posted : May 21, 2015

2012 Clinical Trials

173. The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. (PubMed)

The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. Defensive medicine has been identified as an area of wasteful health-care spending. Estimates of its prevalence and its contribution to the cost of defensive practices have varied widely. To date, there has been no prospective evaluation of the use of defensive medicine for musculoskeletal conditions.Members of the Pennsylvania Orthopaedic Society were queried by means of an anonymous, prospective (...) litigation experiences and longer duration of orthopaedic practice were independent predictors of an increased use of defensive practices in ordering imaging studies. This real-time audit showed that a large proportion of MRI studies were ordered for primarily defensive medicine reasons.

2012 The Journal of Bone and Joint Surgery. American Volume

174. Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. (PubMed)

Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of training about diagnosing pulmonary embolism (PE) on positive results of CTPA.Physicians in the emergency department of a tertiary care (...) . 14.5 %, OR 1.40, 95 % CI 0.98-2.0, p = 0.067).Reasons for CTPA reflecting defensive behavior-such as "fear of missing PE"-were frequent, and were associated with a decreased odds of positive CTPA. Defensive behavior might be modifiable by training in using guidelines.

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2012 Intensive Care Medicine

175. Economic analysis of bedside ultrasonography (US) implementation in an Internal Medicine department. (PubMed)

Economic analysis of bedside ultrasonography (US) implementation in an Internal Medicine department. The economic crisis, the growing healthcare demand, and Defensive Medicine wastefulness, strongly recommend the restructuring of the entire medical network. New health technology, such as bedside ultrasonography, might successfully integrate the clinical approach optimizing the use of limited resources, especially in a person-oriented vision of medicine. Bedside ultrasonography is a safe (...) and reliable technique, with worldwide expanding employment in various clinical settings, being considered as "the stethoscope of the 21st century". However, at present, bedside ultrasonography lacks economic analysis. We performed a Cost-Benefit Analysis "ex ante", with a break-even point computing, of bedside ultrasonography implementation in an Internal Medicine department in the mid-term. Number and kind estimation of bedside ultrasonographic studies were obtained by a retrospective study, whose data

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2015 Internal and emergency medicine

176. Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers (PubMed)

Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers Trauma is a leading cause of death in both military and civilian populations worldwide. Although medical advances have improved the overall morbidity and mortality often associated with trauma, additional research and innovative advancements in therapeutic interventions are needed to optimize patient outcomes. Cell-based therapies present a novel opportunity to improve trauma and critical care at both the acute (...) are critical areas in need of development. In 2015, the Department of Defense Combat Casualty Care Research Program held a joint military-civilian meeting as part of its effort to inform the research community about this field and allow for effective planning and programmatic decisions regarding research and development. The objective of this article is to provide a "state of the science" review regarding cellular therapies in trauma and critical care, and to provide a foundation from which the potential

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2015 Shock (Augusta, Ga.)

177. Medical Student Perceptions of Cost-Conscious Care in an Internal Medicine Clerkship: A Thematic Analysis. (PubMed)

included increased time and effort (n = 19), ingrained practices (n = 17), and defensive medicine or fear of missing something (n = 18.)Even with minimal clinical experience, medical students were able to identify instances of lack of attention to cost-conscious care as well as potential solutions. Although students identified the hierarchy in healthcare teams as a potential barrier to improving high value care, most students stated they would feel comfortable engaging the team in discussion. Future (...) Medical Student Perceptions of Cost-Conscious Care in an Internal Medicine Clerkship: A Thematic Analysis. Although as much as 87 % of all healthcare spending is directed by physicians, studies have demonstrated that they lack knowledge about the costs of medical care. Similarly, learners have not traditionally received instruction on cost-conscious care.To examine medical students' perceptions of healthcare delivery as it relates to cost consciousnessRetrospective qualitative analysis

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2015 Journal of General Internal Medicine

178. The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants. (PubMed)

The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants. In sub-Saharan Africa, concomitant occurrence of malaria and invasive infections with micro-organisms such as Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and yeasts or fungi such as Candida albicans and Aspergillus fumigatus is common. Non-tuberculous mycobacteriosis caused by Mycobacterium chelonae has been recognized as a pulmonary pathogen (...) with increasing frequency without effective therapy. Although less important, the high incidence of Trichophyton rubrum infections along with its ability to evade host defense mechanisms, accounts for the high prevalence of infections with this dermatophyte. Considering the treatment cost of both malaria and microbial infections, along with the level of poverty, most affected African countries are unable to cope with the burden of these diseases. In sub-Saharan Africa, many plant species are widely used

2015 Journal of Ethnopharmacology

179. Less is More: The dangers of too much medicine

Less is More: The dangers of too much medicine Less is More: The dangers of too much medicine - Students 4 Best Evidence A network for students interested in evidence-based health care Menu Less is More: The dangers of too much medicine Posted on January 16, 2015 by Tutorials and Fundamentals Key message Many people throughout the world are rightly concerned that they are not getting enough of the quality healthcare they need. Yet, there is also a growing concern that the opposite issue (...) of overtreatment, and too much medicine, is actually causing harm, as well as increasing costs of care. What is the problem? There is good evidence that in some developed countries, particularly in the US, healthcare providers are overtreating. This means people receive too many unnecessary treatments, tests, and screenings. Additionally, there is also frequent overdiagnosis of many medical conditions. One example of excessive screening is the annual health check-up for otherwise healthy adults. A recent

2015 Students 4 Best Evidence

180. Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. (PubMed)

Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. Terminalia catappa L. (Combretaceae) is a medicinal plant listed as a pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was to evaluate the gastroprotective and healing effect of the aqueous fraction (FrAq) obtained from the leaves of Terminalia catappa and to determine the antiulcer mechanism of action (...) by the activation of defensive mucosa-protective factors, such as increases in mucus production, the nitric oxide (NO) pathway and endogenous prostaglandins. Oral treatment with FrAq for seven and 14 days significantly reduced the lesion area (80% and 37%, respectively) compared to the negative control group. Analyses of MMP-9 and MMP-2 activity from gastric mucosa confirmed the accelerated gastric healing effect of FrAq. This extract also presented considerable activity against Helicobacter pylori. The mass

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2015 Journal of Ethnopharmacology

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