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Defensive Medicine

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161. Precision medicine: Hype over hope?

Precision medicine: Hype over hope? Precision medicine: Hype over hope? | ScienceBlogs Advertisment Search Search Toggle navigation Main navigation Precision medicine: Hype over hope? By on September 8, 2015. I am fortunate to have become a physician in a time of great scientific progress. Back when I was in college and medical school, the thought that we would one day be able to sequence the human genome (and now sequence hundreds of cancer genomes), to measure the expression of every gene (...) in the genome simultaneously on a single "gene chip," and to assess the relative abundance of every RNA transcript, coding and noncoding (such as microRNAs) simultaneously through next generation sequencing (NGS) techniques was considered, if not science fiction, so far off in the future as to be unlikely to impact medicine in my career. Yet here I am, mid-career, and all of these are a reality. The cost of rapidly sequencing a genome has plummeted. Basically, the first human genome cost nearly $3 billion

2015 Respectful Insolence

162. Respect my authoritah on “integrative medicine”!

castigates us with a post entitled . Yes, right off the bat, it's the same old strategy, to paint advocates of "integrative medicine" as the "reasonable" ones while those of us who object to integrating prescientific quackery into medicine are clearly the "fanatics" (or, if you prefer, the fools). In it, as usual, Dr. Katz lays down some real howlers in defense of his integration of woo with medicine. David Katz’s bragging reminds me of the threat display of Chlamydosaurus king, or the frilled-neck (...) Respect my authoritah on “integrative medicine”! Respect my authoritah on "integrative medicine"! | ScienceBlogs Advertisment Search Search Toggle navigation Main navigation Respect my authoritah on "integrative medicine"! By on November 8, 2015. David Katz doesn't much like skeptics, particularly those of us who question the value of "integrative medicine." In fairness, I can't say that I much blame him. We have been very critical of his writings and talks over the years to my criticism of his

2015 Respectful Insolence

163. The flying carpet retort to “integrative medicine”

defensive, I make no apologies for that, either. Attacks based on ignorance of what I do irritate me. I write about plenty of other medical topics that have nothing to do with CAM. What they do have to do with is exactly what Dr. Katz accuses us of ignoring: Calling out areas of medicine where the application of scientific evidence is not so rigorous. He ought to love me for that, but he doesn't. I wonder why. The flying carpet problem Dr. Katz uses a recent systematic review published in presenting (...) as it seems for Dr. Katz to believe. Near the end of his article, Dr. Katz pontificates: Were I tasked with rebutting the very case I am making in this column, I would say: Well, the articles cited here are evidence that conventional medicine is policing itself, seeking ever more evidence and a higher standard. That is just what we would hope to see. That is the best, and perhaps only argument for the defense, and might matter if it managed to thrive, but alas, it is stillborn. The simple fact

2015 Respectful Insolence

164. American College of Sports Medicine Roundtable on exertional heat stroke--return to duty/return to play: conference proceedings. (PubMed)

American College of Sports Medicine Roundtable on exertional heat stroke--return to duty/return to play: conference proceedings. On October 22-23, 2008, an ACSM Roundtable was convened at the Uniformed Services University (Bethesda, MD) to discuss return-to-play or return-to-duty for people who have experienced exertional heat illness (EHI) and to develop consensus-based recommendations. The conference assembled experts from the civilian sports medicine community and the Department of Defense

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2017 Current Sports Medicine Reports

165. Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)

Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01976130 Recruitment Status : Unknown Verified

2013 Clinical Trials

166. A self-defense program reduces the incidence of sexual assault in Kenyan adolescent girls. (PubMed)

of disclosure increased in the intervention group, but not in controls.A standardized 6-week self-defense program is effective in reducing the incidence of sexual assault in slum-dwelling high school girls in Nairobi, Kenya.Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. (...) A self-defense program reduces the incidence of sexual assault in Kenyan adolescent girls. To determine the effect of a standardized 6-week self-defense program on the incidence of sexual assault in adolescent high school girls in an urban slum in Nairobi, Kenya.Population-based survey of 522 high school girls in the Korogocho-Kariobangi locations in Nairobi, Kenya, at baseline and 10 months later. Subjects were assigned by school attended to either a "No Means No Worldwide" self-defense course

2013 The Journal of Adolescent Health

167. Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study (DoD-PLP-Tx) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01824082 Recruitment Status : Active

2013 Clinical Trials

168. White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis

White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis (DMS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01848379 Recruitment Status : Active, not recruiting First Posted : May 7

2013 Clinical Trials

169. Young Smokers Have Impaired Airway Defense

Enrollment : 72 participants Observational Model: Cohort Time Perspective: Cross-Sectional Official Title: Young Smokers Have Impaired Airway Defense That is Not Associated With Pulmonary Function Study Start Date : April 2012 Actual Primary Completion Date : October 2012 Actual Study Completion Date : November 2012 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Nonsmokers Young healthy nonsmokers Smokers<2.5 pack years Young "healthy (...) Young Smokers Have Impaired Airway Defense Young Smokers Have Impaired Airway Defense - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Young Smokers Have Impaired Airway Defense The safety and scientific

2013 Clinical Trials

170. Humanizing the Mouse: In Defense of Murine Models of Critical Illness (PubMed)

Humanizing the Mouse: In Defense of Murine Models of Critical Illness 23634853 2013 06 27 2018 11 13 1535-4970 187 9 2013 May 01 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. Humanizing the mouse: in defense of murine models of critical illness. 898-900 10.1164/rccm.201303-0489ED Perlman Harris H Budinger G R Scott GR Ward Peter A PA eng ES013995 ES NIEHS NIH HHS United States R01 ES013995 ES NIEHS NIH HHS United States HL071643 HL NHLBI NIH HHS

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2013 American Journal of Respiratory and Critical Care Medicine

171. Randomised controlled trial: Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use

improves appropriate antimicrobial use Article Text Therapeutics Randomised controlled trial Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use Forest W Arnold Statistics from Altmetric.com Commentary on: Camins BC , King MD , Wells JB , et al . Impact of an antimicrobial utilization program on antimicrobial use at a large teaching hospital: a randomized controlled trial . Getting defensive about antimicrobial orders (...) Randomised controlled trial: Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about

2010 Evidence-Based Medicine (Requires free registration)

172. Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues (PubMed)

Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues Azadirachta indica has been reported to correct altered glycaemia in diabetes.The aqueous extract of A. indica leaf and bark has been evaluated for its effect on antioxidant status of alloxan diabetic rats and compared with insulin treatment.The oral effective dose of A. indica leaf (500 mg/kg body weight) and A. indica bark (100 mg/kg body weight) were given once daily for 21 days to separate groups (...) with insulin, A. indica leaf extract (AILE), and A. indica bark extract (AIBE) restored the above altered parameters close to the control ones.Both AILE and AIBE were found significantly effective in reducing hyperglycemia-induced oxidative stress. The findings suggest further investigations for the possible use of A. indica as alternative medicine to prevent long-term complications of diabetes.

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2012 Journal of Ayurveda and integrative medicine

173. Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus (PubMed)

Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus Madagascar periwinkle is an ornamental and a medicinal plant, and is also an indicator plant that is highly susceptible to phytoplasma and spiroplasma infections from different crops. Periwinkle lethal yellows, caused by Spiroplasma citri, is one of the most devastating diseases of periwinkle. The response of plants to S. citri infection is very little (...) known at the transcriptome level. In this study, quantitative real-time PCR (RT-qPCR) was used to investigate the expression levels of four selected genes involved in defense and stress responses in naturally and experimentally Spiroplasma citri infected periwinkles. Strictosidine β-glucosidase involved in terpenoid indole alkaloids (TIAs) biosynthesis pathway showed significant upregulation in experimentally and naturally infected periwinkles. The transcript level of extensin increased in leaves

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2012 International journal of molecular sciences

174. The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. (PubMed)

The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. Defensive medicine has been identified as an area of wasteful health-care spending. Estimates of its prevalence and its contribution to the cost of defensive practices have varied widely. To date, there has been no prospective evaluation of the use of defensive medicine for musculoskeletal conditions.Members of the Pennsylvania Orthopaedic Society were queried by means of an anonymous, prospective (...) litigation experiences and longer duration of orthopaedic practice were independent predictors of an increased use of defensive practices in ordering imaging studies. This real-time audit showed that a large proportion of MRI studies were ordered for primarily defensive medicine reasons.

2012 The Journal of Bone and Joint Surgery. American Volume

175. Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. (PubMed)

Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase (...) . Glutathione peroxidase activities in postoperative patients were higher compared to inoperative patients.Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

2012 European journal of internal medicine

176. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO)

Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2012 Clinical Trials

177. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel

Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01540929 Recruitment Status : Completed First Posted : February 29, 2012 Last Update Posted : January 30, 2018 Sponsor: Emergent

2012 Clinical Trials

178. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses

The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01902394 Recruitment Status : Completed First Posted : July 18, 2013 Last Update Posted : May 21, 2015

2012 Clinical Trials

179. Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. (PubMed)

Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of training about diagnosing pulmonary embolism (PE) on positive results of CTPA.Physicians in the emergency department of a tertiary care (...) . 14.5 %, OR 1.40, 95 % CI 0.98-2.0, p = 0.067).Reasons for CTPA reflecting defensive behavior-such as "fear of missing PE"-were frequent, and were associated with a decreased odds of positive CTPA. Defensive behavior might be modifiable by training in using guidelines.

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2012 Intensive Care Medicine

180. Economic analysis of bedside ultrasonography (US) implementation in an Internal Medicine department. (PubMed)

Economic analysis of bedside ultrasonography (US) implementation in an Internal Medicine department. The economic crisis, the growing healthcare demand, and Defensive Medicine wastefulness, strongly recommend the restructuring of the entire medical network. New health technology, such as bedside ultrasonography, might successfully integrate the clinical approach optimizing the use of limited resources, especially in a person-oriented vision of medicine. Bedside ultrasonography is a safe (...) and reliable technique, with worldwide expanding employment in various clinical settings, being considered as "the stethoscope of the 21st century". However, at present, bedside ultrasonography lacks economic analysis. We performed a Cost-Benefit Analysis "ex ante", with a break-even point computing, of bedside ultrasonography implementation in an Internal Medicine department in the mid-term. Number and kind estimation of bedside ultrasonographic studies were obtained by a retrospective study, whose data

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2015 Internal and emergency medicine

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