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Defensive Medicine

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161. Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. Full Text available with Trip Pro

Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. Terminalia catappa L. (Combretaceae) is a medicinal plant listed as a pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was to evaluate the gastroprotective and healing effect of the aqueous fraction (FrAq) obtained from the leaves of Terminalia catappa and to determine the antiulcer mechanism of action (...) by the activation of defensive mucosa-protective factors, such as increases in mucus production, the nitric oxide (NO) pathway and endogenous prostaglandins. Oral treatment with FrAq for seven and 14 days significantly reduced the lesion area (80% and 37%, respectively) compared to the negative control group. Analyses of MMP-9 and MMP-2 activity from gastric mucosa confirmed the accelerated gastric healing effect of FrAq. This extract also presented considerable activity against Helicobacter pylori. The mass

2015 Journal of Ethnopharmacology

162. Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers Full Text available with Trip Pro

Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers Trauma is a leading cause of death in both military and civilian populations worldwide. Although medical advances have improved the overall morbidity and mortality often associated with trauma, additional research and innovative advancements in therapeutic interventions are needed to optimize patient outcomes. Cell-based therapies present a novel opportunity to improve trauma and critical care at both the acute (...) are critical areas in need of development. In 2015, the Department of Defense Combat Casualty Care Research Program held a joint military-civilian meeting as part of its effort to inform the research community about this field and allow for effective planning and programmatic decisions regarding research and development. The objective of this article is to provide a "state of the science" review regarding cellular therapies in trauma and critical care, and to provide a foundation from which the potential

2015 Shock (Augusta, Ga.)

163. Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. (Abstract)

Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer. Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase (...) . Glutathione peroxidase activities in postoperative patients were higher compared to inoperative patients.Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

2012 European journal of internal medicine

164. Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus Full Text available with Trip Pro

Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus Madagascar periwinkle is an ornamental and a medicinal plant, and is also an indicator plant that is highly susceptible to phytoplasma and spiroplasma infections from different crops. Periwinkle lethal yellows, caused by Spiroplasma citri, is one of the most devastating diseases of periwinkle. The response of plants to S. citri infection is very little (...) known at the transcriptome level. In this study, quantitative real-time PCR (RT-qPCR) was used to investigate the expression levels of four selected genes involved in defense and stress responses in naturally and experimentally Spiroplasma citri infected periwinkles. Strictosidine β-glucosidase involved in terpenoid indole alkaloids (TIAs) biosynthesis pathway showed significant upregulation in experimentally and naturally infected periwinkles. The transcript level of extensin increased in leaves

2012 International journal of molecular sciences

165. Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues Full Text available with Trip Pro

Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues Azadirachta indica has been reported to correct altered glycaemia in diabetes.The aqueous extract of A. indica leaf and bark has been evaluated for its effect on antioxidant status of alloxan diabetic rats and compared with insulin treatment.The oral effective dose of A. indica leaf (500 mg/kg body weight) and A. indica bark (100 mg/kg body weight) were given once daily for 21 days to separate groups (...) with insulin, A. indica leaf extract (AILE), and A. indica bark extract (AIBE) restored the above altered parameters close to the control ones.Both AILE and AIBE were found significantly effective in reducing hyperglycemia-induced oxidative stress. The findings suggest further investigations for the possible use of A. indica as alternative medicine to prevent long-term complications of diabetes.

2012 Journal of Ayurveda and integrative medicine

166. Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. Full Text available with Trip Pro

Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room. To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of training about diagnosing pulmonary embolism (PE) on positive results of CTPA.Physicians in the emergency department of a tertiary care (...) . 14.5 %, OR 1.40, 95 % CI 0.98-2.0, p = 0.067).Reasons for CTPA reflecting defensive behavior-such as "fear of missing PE"-were frequent, and were associated with a decreased odds of positive CTPA. Defensive behavior might be modifiable by training in using guidelines.

2012 Intensive Care Medicine

167. The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. (Abstract)

The prevalence of defensive orthopaedic imaging: a prospective practice audit in pennsylvania. Defensive medicine has been identified as an area of wasteful health-care spending. Estimates of its prevalence and its contribution to the cost of defensive practices have varied widely. To date, there has been no prospective evaluation of the use of defensive medicine for musculoskeletal conditions.Members of the Pennsylvania Orthopaedic Society were queried by means of an anonymous, prospective (...) litigation experiences and longer duration of orthopaedic practice were independent predictors of an increased use of defensive practices in ordering imaging studies. This real-time audit showed that a large proportion of MRI studies were ordered for primarily defensive medicine reasons.

2012 The Journal of Bone and Joint Surgery. American Volume

168. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses

The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01902394 Recruitment Status : Completed First Posted : July 18, 2013 Last Update Posted : May 21, 2015

2012 Clinical Trials

169. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO)

Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2012 Clinical Trials

170. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel

Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01540929 Recruitment Status : Completed First Posted : February 29, 2012 Last Update Posted : January 30, 2018 Sponsor: Emergent

2012 Clinical Trials

171. Why doctors will continue playing defense in the clinic

to be sued for malpractice. This finding was consistent across 6 of 7 different specialties evaluated and was particularly pronounced in obstetrics. Defensive medicine, defined as medical decision making and care provided solely for the purpose of avoiding malpractice litigation, accounts for a significant proportion of health care costs in the U.S. today. Physicians, while striving to provide excellent care for their patients are faced with the harsh realities of our litigious society — many are always (...) so that therapy may be initiated quickly. In many cases, a diagnosis can be confirmed simply by talking to and examining the patient — the medical history and physical exam — which is becoming a lost art. When defensive medicine is practiced, the entire system is perturbed. Why would we order a test when it is unlikely to substantially change what we do. Think “fork in the road.” If a test is ordered, the result should point us one direction or the other. So, just how can we expect to lower

2015 KevinMD blog

172. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. Full Text available with Trip Pro

The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. 5927117 1967 02 10 2018 11 13 0021-9738 45 10 1966 Oct The Journal of clinical investigation J. Clin. Invest. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. 1608-14 Lemann J J Jr Litzow J R JR Lennon E J EJ eng Journal Article United (...) 10 1 0 0 ppublish 5927117 10.1172/JCI105467 PMC292842 J Clin Invest. 1966 Oct;45(10):1601-7 5925517 J Clin Invest. 1955 Feb;34(2):205-12 13233342 J Clin Invest. 1965 Apr;44:507-17 14278167 J Clin Invest. 1931 Jun;10(2):221-49 16693975 Medicine (Baltimore). 1965 Sep;44(5):397-418 5318076 J Clin Invest. 1957 Mar;36(3):373-82 13406050

1966 Journal of Clinical Investigation

173. Studies on the pathophysiology and some host defense factors in staphylococcal arthritis in the rabbit and on the relationship of aseptic inflammation to infection rate. Full Text available with Trip Pro

Studies on the pathophysiology and some host defense factors in staphylococcal arthritis in the rabbit and on the relationship of aseptic inflammation to infection rate. 5981348 1967 11 14 2018 11 13 0044-0086 39 2 1966 Oct The Yale journal of biology and medicine Yale J Biol Med Studies on the pathophysiology and some host defense factors in staphylococcal arthritis in the rabbit and on the relationship of aseptic inflammation to infection rate. 119-28 Nagel D A DA Albright J A JA

1966 The Yale journal of biology and medicine

174. Neutrophils and host defense. Full Text available with Trip Pro

Neutrophils and host defense. 5578108 1971 07 15 2018 11 13 0008-1264 114 6 1971 Jun California medicine Calif Med Neutrophils and host defense. 47-9 eng Journal Article United States Calif Med 0410260 0008-1264 IM Communicable Diseases immunology Humans Neutrophils Phagocytosis 1971 6 1 1971 6 1 0 1 1971 6 1 0 0 ppublish 5578108 PMC1501942 Lancet. 1969 Mar 22;1(7595):630 4180157 J Pediatr. 1969 Aug;75(2):236-42 5815897 Lancet. 1970 Jul 11;1(7663):110 4193353 Science. 1970 Sep 11;169(3950):1095

1971 California Medicine

175. Antibiotic agents and the immune mechanisms of defense. Full Text available with Trip Pro

Antibiotic agents and the immune mechanisms of defense. 1102003 1976 01 08 2018 11 13 0028-7091 51 9 1975 Oct Bulletin of the New York Academy of Medicine Bull N Y Acad Med Antibiotic agents and the immune mechanisms of defense. 1039-45 Alexander J W JW eng Journal Article Review United States Bull N Y Acad Med 7505398 0028-7091 0 Anti-Bacterial Agents 9007-36-7 Complement System Proteins IM Anti-Bacterial Agents adverse effects Antibody Formation drug effects Complement System Proteins Humans

1975 Bulletin of the New York Academy of Medicine

176. The control of operating room infection: discipline, defense mechanisms, drugs, design, and devices. Full Text available with Trip Pro

The control of operating room infection: discipline, defense mechanisms, drugs, design, and devices. 274162 1978 07 26 2018 11 13 0028-7091 54 5 1978 May Bulletin of the New York Academy of Medicine Bull N Y Acad Med The control of operating room infection: discipline, defense mechanisms, drugs, design, and devices. 465-83 Laufman H H eng Journal Article United States Bull N Y Acad Med 7505398 0028-7091 IM Cross Infection prevention & control Humans Operating Rooms Surgical Wound Infection

1978 Bulletin of the New York Academy of Medicine

177. Civil Defense — An Urgent Medical Problem Full Text available with Trip Pro

Civil Defense — An Urgent Medical Problem 14792345 2004 02 15 2018 12 01 0008-1264 73 6 1950 Dec California medicine Calif Med CIVIL defense--An urgent medical problem. 509-10 eng Journal Article United States Calif Med 0410260 0008-1264 OM Civil Defense 5120:23066 1950 12 1 1950 12 1 0 1 1950 12 1 0 0 ppublish 14792345 PMC1520782

1950 California Medicine

178. The Veterinarian's Responsibility in Civil Defense Full Text available with Trip Pro

The Veterinarian's Responsibility in Civil Defense 12976581 2003 05 01 2018 12 01 0002-9572 42 9 1952 Sep American journal of public health and the nation's health Am J Public Health Nations Health The veterinarian's responsibility in civil defense. 1095-8 BERGSMA D D eng Journal Article United States Am J Public Health Nations Health 1254075 0002-9572 OM Civil Defense Medicine Social Behavior Veterinarians Veterinary Medicine 5323:761:124:333 CIVIL DEFENSE MEDICINE, VETERINARY 1952 9 1 1952 9

1952 American Journal of Public Health and the Nations Health

179. “A Defense Against Socialized Medicine”? Full Text available with Trip Pro

“A Defense Against Socialized Medicine”? 18731859 2008 08 29 2008 11 20 0008-1264 78 1 1953 Jan California medicine Calif Med "A Defense Against Socialized Medicine"? 66-7 eng Journal Article United States Calif Med 0410260 0008-1264 1953 1 1 0 0 1953 1 1 0 1 1953 1 1 0 0 ppublish 18731859 PMC1521565

1953 California Medicine

180. The Public Health Veterinarian in National Defense Full Text available with Trip Pro

The Public Health Veterinarian in National Defense 14868807 2004 02 15 2018 12 01 0002-9572 41 9 1951 Sep American journal of public health and the nation's health Am J Public Health Nations Health The public health veterinarian in national defense. 1059-64 TODD F A FA eng Journal Article United States Am J Public Health Nations Health 1254075 0002-9572 OM Humans Medicine Public Health Veterinarians Veterinary Medicine 5221:1025:231:315 MEDICINE, VETERINARY PUBLIC HEALTH 1951 9 1 1951 9 1 0 1

1951 American Journal of Public Health and the Nations Health

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