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Defensive Medicine

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121. MEDICAL DEFENSE AND INDEMNITY DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE AND INDEMNITY DEFENSE 18738776 2008 08 29 2008 11 20 0093-402X 20 8 1922 Aug California state journal of medicine Cal State J Med MEDICAL DEFENSE AND INDEMNITY DEFENSE. 278 eng Journal Article United States Cal State J Med 0414327 0093-402X 1922 8 1 0 0 1922 8 1 0 1 1922 8 1 0 0 ppublish 18738776 PMC1517303

1922 California state journal of medicine

122. MEDICAL DEFENSE AND INDEMNITY DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE AND INDEMNITY DEFENSE 18739075 2008 08 29 2008 11 20 0093-402X 21 8 1923 Aug California state journal of medicine Cal State J Med MEDICAL DEFENSE AND INDEMNITY DEFENSE. 351 eng Journal Article United States Cal State J Med 0414327 0093-402X 1923 8 1 0 0 1923 8 1 0 1 1923 8 1 0 0 ppublish 18739075 PMC1517692

1923 California state journal of medicine

123. Physical Therapy: First Line of Defense Against Sexual Dysfunction

by approximately 50%, and 73% of patients were not prescribed any medications for low back pain (Fuhrmans 2007). Early access to physical therapy can prevent unnecessary medical spending. Early access to physical therapy may prevent unnecessary medical spending We are movement experts, with defined evidence-based treatment strategies and pain management skills that allow patients to take control of their bodies, and rely less on prescription drugs for relief. The APTA campaign, , aims to educate about (...) Physical Therapy: First Line of Defense Against Sexual Dysfunction Physical Therapy: First Line of Defense Against Sexual Dysfunction - Students 4 Best Evidence A network for students interested in evidence-based health care Menu Physical Therapy: First Line of Defense Against Sexual Dysfunction Posted on March 29, 2017 by Evidence Reviews Sexual health is an important part of overall mental and physical well-being. For men and women, physical therapy in the context of sexual health takes

2017 Students 4 Best Evidence

124. Efficacy of Complementary and Alternative Medicine Therapies for Posttraumatic Stress Disorder

questions regarding CAM therapies for PTSD is, What effects might one expect of a given intervention relative to no intervention? This clinically relevant question is best addressed by a randomized clinical trial with a no-treatment (waitlist) comparator. However, study designs that withhold or delay treatment to those with PTSD may not be institutionally feasible or ethically defensible. Hence, alternative strategies merit consideration. 4 Efficacy of Complementary and Alternative Medicine Therapies (...) , accessible, adequate, or congruent with patient preferences. Complementary and Alternative Medicine CAM is commonly used to describe a wide range of therapies that are not generally considered standard components of modern medicine as practiced by physicians in the U.S. Yet, many CAM treatments, such as acupuncture, are part of traditional medical practices in other parts 8 Efficacy of Complementary and Alternative Medicine Therapies for Posttraumatic Stress Disorder Evidence-based Synthesis Program

2011 Veterans Affairs Evidence-based Synthesis Program Reports

125. Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells Full Text available with Trip Pro

Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells Plants are a source of complex bioactive compounds, with value as pharmaceuticals, or leads for synthetic modification. Many of these secondary metabolites have evolved as defenses against competing organisms and their pharmaceutical value is "accidental", resulting from homology between target proteins in these competitors, and human molecular therapeutic targets. Here we show that it is possible (...) transporter protein. Many of the resulting selected mutants are overproducing the active metabolite found in the wild-type plant, but others overproduce active metabolites that are not readily detectable in non-mutants. This technology can access the whole genomic capability of a plant species to biosynthesize metabolites with a specific target. It has potential value as a novel platform for plant drug discovery and production, or as a means of optimizing the therapeutic value of medicinal plant

2016 Journal of biotechnology

126. Pharmaceutical Expenditure and Burden of Non-communicable Diseases in Serbia Full Text available with Trip Pro

Belgrade, Serbia. Segrt Zoran Z Military Medical Academy Medical Faculty, Management of the Military Medical Academy, University of Defense Belgrade, Serbia. Dragojevic-Simic Viktorija V Centre for Clinical Pharmacology, Military Medical Academy Medical Faculty, University of Defense Belgrade, Serbia. eng Journal Article 2016 10 13 Switzerland Front Pharmacol 101548923 1663-9812 Serbia drug utilization gross domestic product non-communicable diseases pharmaceutical expenditure 2016 07 28 2016 09 27 (...) Pharmaceutical Expenditure and Burden of Non-communicable Diseases in Serbia 27790144 2018 11 13 1663-9812 7 2016 Frontiers in pharmacology Front Pharmacol Pharmaceutical Expenditure and Burden of Non-communicable Diseases in Serbia. 373 Kovacevic Aleksandra A Centre for Clinical Pharmacology, Military Medical Academy Medical Faculty, University of Defense Belgrade, Serbia. Rancic Nemanja N Centre for Clinical Pharmacology, Military Medical Academy Medical Faculty, University of Defense

2016 Frontiers in pharmacology

127. RPB5-mediating protein promotes cholangiocarcinoma tumorigenesis and drug resistance by competing with NRF2 for KEAP1 binding. (Abstract)

and is associated with poor prognosis. CONCLUSION: These findings reveal that RMP is involved in the oxidative stress defense program and could be exploited for targeted cancer therapies.© 2019 by the American Association for the Study of Liver Diseases. (...) RPB5-mediating protein promotes cholangiocarcinoma tumorigenesis and drug resistance by competing with NRF2 for KEAP1 binding. Cancer cell survival depends on the balance between reactive oxygen species production and scavenging, which is mainly regulated by NRF2 during tumorigenesis. Here, we demonstrated that deletion of RBP5-mediating protein (RMP) in an autonomous mouse model of intrahepatic cholangiocarcinoma (ICC) delays tumor progression. RMP-overexpressing tumor cells exhibited enhanced

2019 Hepatology

128. The Judgment Defense in Medical Malpractice Full Text available with Trip Pro

The Judgment Defense in Medical Malpractice 23934031 2013 12 17 2014 11 01 1528-1132 471 11 2013 Nov Clinical orthopaedics and related research Clin. Orthop. Relat. Res. The judgment defense in medical malpractice. 3405-8 10.1007/s11999-013-3223-0 Bal B Sonny BS Department of Orthopaedic Surgery, University of Missouri, Columbia, 1100 Virginia Ave. DC953.00, Columbia, MO, 65212, USA, balb@health.missouri.edu. Brenner Lawrence H LH eng Journal Article 2013 08 10 United States Clin Orthop Relat (...) Res 0075674 0009-921X AIM IM Clinical Competence economics legislation & jurisprudence Compensation and Redress Humans Judgment Liability, Legal economics Malpractice economics legislation & jurisprudence Medical Errors legislation & jurisprudence Probability Risk Assessment Risk Factors Terminology as Topic Uncertainty 2013 07 30 2013 07 31 2013 8 13 6 0 2013 8 13 6 0 2013 12 18 6 0 ppublish 23934031 10.1007/s11999-013-3223-0 PMC3792272

2013 Clinical Orthopaedics and Related Research

129. In Defense of Basic Science Funding: Today’s Scientific Discovery Is Tomorrow’s Medical Advance Full Text available with Trip Pro

In Defense of Basic Science Funding: Today’s Scientific Discovery Is Tomorrow’s Medical Advance In this address, I will discuss the importance of basic science in tackling our health problems. I will also describe how the funding cuts are damaging our economic competitiveness and turning our young people away from science.

2013 Cold Spring Harbor perspectives in medicine

130. Relationships among CFTR expression, HCO3− secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies Full Text available with Trip Pro

Relationships among CFTR expression, HCO3− secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Airway disease is the major source of morbidity and mortality. Successful implementation of gene- and cell-based therapies for CF airway disease requires knowledge of relationships among percentages of targeted cells, levels (...) of CFTR expression, correction of electrolyte transport, and rescue of host defense defects. Previous studies suggested that, when ∼10-50% of airway epithelial cells expressed CFTR, they generated nearly wild-type levels of Cl(-) secretion; overexpressing CFTR offered no advantage compared with endogenous expression levels. However, recent discoveries focused attention on CFTR-mediated HCO3 (-) secretion and airway surface liquid (ASL) pH as critical for host defense and CF pathogenesis. Therefore, we

2016 Proceedings of the National Academy of Sciences of the United States of America

131. Assessment and Management of Patients at Risk for Suicide: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines. Full Text available with Trip Pro

Assessment and Management of Patients at Risk for Suicide: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines. In May 2019, the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved an update to the 2013 joint clinical practice guideline for assessing and managing patients who are at risk for suicide. This guideline provides health care providers with a framework by which to screen for, evaluate (...) , treat, and manage the individual needs and preferences of VA and DoD patients who may be at risk for suicide.In January 2018, the VA/DoD Evidence-Based Practice Work Group convened to develop a joint VA/DoD guideline including clinical stakeholders and conforming to the National Academy of Medicine's tenets for trustworthy clinical practice guidelines. The guideline panel drafted key questions, systematically searched and evaluated the literature through April 2018, created algorithms, and advanced

2019 Annals of Internal Medicine

132. Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats. Full Text available with Trip Pro

Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats. Herbal supplements are widely used in the treatment of various liver disases, but some of them may also induce liver injuries. Regarding the infuence of thyme and its constituents on the liver, conflicting results have been reported in the literature. The objective of this study was to examine the influence of two commonly used pharmaceutical formulations containing thyme (Thymus (...) by a marked elevation of AST and ALT activities, and histopathologic alterations. Co-administration of thyme tincture resulted in unexpected exacerbation of AST and ALT values in serum, while thyme syrup managed to reduce activites of aminotransferases, in comparison to carbon tetrachloride-treated animals.Despite demonstrated antioxidant activity, mediated through both direct free radical scavenging and activation of antioxidant defense mechanisms, thyme preparations could not ameliorate liver injury

2015 BMC Complementary and Alternative Medicine

133. In defense of medical societies – especially ACP

In defense of medical societies – especially ACP db's Medical Rants » Blog Archive » In defense of medical societies – especially ACP Internal medicine, American health care, and especially medical education 9 Posted by rcentor | Posted on 25-05-2016 Category : A recent comment attacked medical societies as being impotent on several issues. The commenter clearly expects these societies to work quick visible changes. Here is my take: My recent leadership role at ACP makes this answer biased (...) out their English overlords. Medicine deperately needs its William Wallace to rally the troops to preserve their professional integrity, autonomy, the doctor patient relationship and, yes, their Freedom. said on 30-05-2016 I would be interested if your defense of ACP would include the authorship and promulgation of the “professionalism ” of the Charter for a new millennium which imposes an obligation to work for social justice and to be a steward of medical resources. rcentor said on 30-05-2016

2016 db's Medical Rants blog

134. Suboxone for Drug Detoxification: Clinical Effectiveness and Guidelines

, Cockayne L. Medically assisted recovery from opiate dependence within the context of the UK drug strategy: methadone and Suboxone (buprenorphine-naloxone) patients compared. J Subst Abuse Treat. 2012 Jun 15. Epub ahead of print. PubMed: PM22703715 Suboxone for Drug Detoxification 3 7. Steele A, Cunningham P. A comparison of Suboxone and clonidine treatment outcomes in opiate detoxification. Arch Psychiatr Nurs. 2012 Aug;26(4):316-23. PubMed: PM22835751 8. Rapeli P, Fabritius C, Alho H, Salaspuro M (...) . J Subst Use. 2011;16(3):171-8. 29. Maremmani I, Gerra G. Buprenorphine-based regimens and methadone for the medical management of opioid dependence: Selecting the appropriate drug for treatment. Am J Addict. 2010;19(6):557-68. PubMed: PM20958853 30. Sullivan LE, Fiellin DA. Narrative review: buprenorphine for opioid-dependent patients in office practice. Ann Intern Med. 2008 May 6;148(9):662-70. PubMed: PM18458279 31. Stock C, Shum JH. Bupreorphine: a new pharmacotherapy for opioid addictions

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

135. Remembering the Host in Tuberculosis Drug Development. (Abstract)

Remembering the Host in Tuberculosis Drug Development. New therapeutics to augment current approaches and shorten treatment duration are of critical importance for combating tuberculosis (TB), especially those with novel mechanisms of action to counter the emergence of drug-resistant TB. Host-directed therapy (HDT) offers a novel strategy with mechanisms that include activating immune defense mechanisms or ameliorating tissue damage. These and related concepts will be discussed along (...) with issues that emerged from the workshop organized by the Stop TB Working Group on New Drugs, held at the Gordon Research Conference for Tuberculosis Drug Development in Lucca, Italy in June 2017, titled "Strategic Discussion on Repurposing Drugs & Host Directed Therapies for TB." In this review, we will highlight recent data regarding drugs, pathways, and concepts that are important for successful development of HDTs for TB.

2018 Journal of Infectious Diseases

136. A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria Full Text available with Trip Pro

A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria Current research in the field of antimicrobials is focused on developing novel antimicrobial agents to counteract the huge dilemma that the human population is mainly facing in regards to the rise of bacterial resistance and biofilm infections. Host defense peptides (HDPs) are a promising group of molecules (...) and in combination with four different types of conventional antibiotics against clinical isolates of multi-drug resistant (MDR) Gram-positive bacteria. A3 was also evaluated for its cytotoxicity against mammalian cells. A3 managed to selectively inhibit the growth of a wide range of resistant strains of Gram-positive bacteria. Our results also showed that combining A3 with conventional antibiotics caused a synergistic antimicrobial behavior that resulted in decreasing the MIC value for A3 peptide as low

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

137. Hepatoprotective Evaluation of Trapa natans against Drug-induced Hepatotoxicity of Antitubercular Agents in Rats Full Text available with Trip Pro

Hepatoprotective Evaluation of Trapa natans against Drug-induced Hepatotoxicity of Antitubercular Agents in Rats Medicinal herbs are significantly effective against a variety of liver disorders and Trapa natans was traditionally used for the treatment of anti-inflammatory, pain disorder, and various types of hepatic ailment.The purpose of this study was to evaluate the hepatoprotective activity of T. natans fruit peel extract against antitubercular drugs (isoniazid + rifampicin [INH + RIF (...) liver marker enzymes and antioxidant defense status and thereby contributed to its antihepatotoxic potential.Hepatotoxicity was induced in rats by intraperitoneal injection of antitubercular drugs (Isoniazid + Rifampicin at dose level of 50 mg/kg each) for 15 daysThe liver was screened for various marker enzymes and antioxidant parameters, which showed significant increase in the level of marker enzymes confirming induced hepatotoxicityHepatotoxic rats on treatment with T. natans peel extract (200

2018 Pharmacognosy magazine

138. Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting Full Text available with Trip Pro

Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting Bacteria cause disease by two general mechanisms: the action of their toxins on host cells and induction of a pro-inflammatory response that can lead to a deleterious cytokine/chemokine response (e.g., the so-called cytokine storm) often seen in bacteremia/septicemia. These major mechanisms may overlap due to the action of surface structures (...) defense peptides termed cationic antimicrobial peptides. This review concentrates on the phosphoethanolamine (PEA) decoration of lipid A in the pathogenic species of the genus Neisseria [N. gonorrhoeae and N. meningitidis]. PEA decoration of lipid A is mediated by the enzyme EptA (formerly termed LptA) and promotes resistance to innate defense systems, induces the pro-inflammatory response and can influence the in vivo fitness of bacteria during infection. These important biological properties have

2018 Frontiers in microbiology

139. PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone Full Text available with Trip Pro

PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone Among cardiovascular diseases, atherosclerosis remains the first cause of death in the United States of America and Europe, as it leads to myocardial infarction or stroke. The high prevalence of heart diseases is due to the difficulty in diagnosing atherosclerosis, since it can develop for decades before symptoms occur, and to the complexity (...) of the treatment since targets are also important components of the host defenses. The antidiabetics thiazolidinediones, among which is rosiglitazone (RSG), have demonstrated anti-atherosclerotic effect in animal models, and are therefore promising candidates for the improvement of atherosclerosis management. Nevertheless, their administration is hindered by the insurgence of severe side effects. To overcome this limitation, rosiglitazone has been encapsulated into polymeric nanoparticles, which permit

2018 Materials

140. The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses—A Mini Review Full Text available with Trip Pro

The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses—A Mini Review The immune system is an integral aspect of the human defense system and is primarily responsible for and involved in the communication between the immune cells. It also plays an important role in the protection of the organism from foreign invaders. Recent studies in the literature have described its role in the process of hematopoiesis, lymphocyte recruitment, T cell subset differentiation (...) and inflammation. However, the specific molecular mechanisms underlying these observations remain elusive, impeding the elaborate manipulation of cytokine sequential delivery in tissue repair. Previously, the discovery of new drugs and systems biology went hand in hand; although Systems biology as a term has only originated in the last century. Various new chemicals were tested on the human body, and studied through observation. Animal models replaced humans for initial trials, but the interactions, response

2018 Medical Sciences

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