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Defensive Medicine

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61. Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) Full Text available with Trip Pro

Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) Twin studies have revealed a significant contribution of the fetal genome to risk of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm delivery. Infection and inflammation of the fetal membranes is commonly found associated with PPROM.We carried out whole exome sequencing (WES) of genomic (...) DNA from neonates born of African-American mothers whose pregnancies were complicated by PPROM (76) or were normal term pregnancies (N = 43) to identify mutations in 35 candidate genes involved in innate immunity and host defenses against microbes. Targeted genotyping of mutations in the candidates discovered by WES was conducted on an additional 188 PPROM cases and 175 controls.We identified rare heterozygous nonsense and frameshift mutations in several of the candidate genes, including CARD6

2017 Molecular Genetics & Genomic Medicine

62. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb Full Text available with Trip Pro

Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb 28862506 2018 02 21 2018 11 13 1535-4989 57 3 2017 09 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb. 263-264 10.1165/rcmb.2017-0149ED Kulkarni Ritwij R 0000-0002-9753-8899 1 Department of Biology University of Louisiana at Lafayette Lafayette, Louisiana. Jeyaseelan Samithamby S 0000-0002 (...) -1959-1328 2 Department of Pathobiological Sciences Louisiana State University (LSU) Baton Rouge, Louisiana and. 3 Department of Medicine LSU Health Sciences Center New Orleans, Louisiana. eng R01 AI113720 AI NIAID NIH HHS United States R01 HL091958 HL NHLBI NIH HHS United States Editorial United States Am J Respir Cell Mol Biol 8917225 1044-1549 6M3C89ZY6R Nicotine IM Animals Cigarette Smoking adverse effects epidemiology Humans Mycobacterium tuberculosis Nicotine adverse effects Risk Factors

2017 American journal of respiratory cell and molecular biology

63. Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? Full Text available with Trip Pro

Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 28942622 2018 12 19 2018 12 19 2287-285X 23 3 2017 09 Clinical and molecular hepatology Clin Mol Hepatol Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 219-221 10.3350/cmh.2017.0045 Lee Yun Bin YB Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea. Lee Jeong-Hoon JH 0000-0002-0315-2080 Department (...) of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. eng Editorial Comment 2017 09 19 Korea (South) Clin Mol Hepatol 101586730 2287-2728 2T8Q726O95 Lamivudine 5968Y6H45M entecavir 5Z93L87A1R Guanine 99YXE507IL Tenofovir IM Clin Mol Hepatol. 2017 Sep;23(3):230-238 28669175 Guanine analogs & derivatives Hepatitis B virus Hepatitis B, Chronic Humans Lamivudine Tenofovir Chronic hepatitis B Entecavir Multi-drug resistance Rescue therapy Tenofovir 2017

2017 Clinical and molecular hepatology

64. Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses Full Text available with Trip Pro

antiviral defense in plants as they are able to degrade foreign RNA of viral origin. This review aims to provide a comprehensive and up-to-date picture of plant proteins participating in antiviral defense. As a result we discuss proteins conferring plant antiviral resistance and their potential future applications in different fields of life including agriculture and medicine. (...) Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses Plants have evolved a variety of defense mechanisms to tackle virus attack. Endogenous plant proteins can function as virus suppressors. Different types of proteins mediate defense responses against plant viruses. Pathogenesis-related (PR) proteins are activated upon pathogen infections or in different stress situations and their production is one of many

2017 International journal of molecular sciences

65. Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida Full Text available with Trip Pro

Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida 28806437 2019 01 28 2019 01 28 2168-6114 177 10 2017 10 01 JAMA internal medicine JAMA Intern Med Association Between Enactment of a "Stand Your Ground" Self-defense Law and Unlawful Homicides in Florida. 1523-1524 10.1001/jamainternmed.2017.3433 Humphreys David K DK Department of Social Policy and Intervention, University of Oxford, Oxford, England. Gasparrini Antonio A Department (...) of Social & Environmental Health Research, London School of Hygiene and Tropical Medicine, London, England. Wiebe Douglas J DJ Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania. eng Journal Article United States JAMA Intern Med 101589534 2168-6106 AIM IM Female Firearms legislation & jurisprudence Florida Homicide legislation & jurisprudence statistics & numerical data Humans Male Wounds, Gunshot epidemiology 2017 8 15 6 0 2019 1 29 6 0 2017 8 15 6 0

2017 JAMA Internal Medicine

66. Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses Full Text available with Trip Pro

Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses 29269994 2018 09 04 2018 11 13 1466-1861 2017 2017 Mediators of inflammation Mediators Inflamm. Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses. 1264974 10.1155/2017/1264974 Bocca Anamélia Lorenzetti AL Cell Biology Department of Biology Institute, Laboratory of Applied Immunology, University of Brasília, 70910-900 Brasília, DF, Brazil. de (...) Almeida Soares Célia Maria CM Laboratory of Biochemistry and Molecular Biology of the Interaction between Host-Pathogenic Fungi, Biology Institute, University of Goiás, 74001-970 Goiânia, GO, Brazil. Nosanchuk Joshua D JD 0000-0001-9905-5754 Departments of Medicine and Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Silva-Pereira Ildinete I 0000-0003-1403-9363 Cell Biology Department of Biology Institute, Laboratory of Molecular Biology of Pathogenic Fungi

2017 Mediators of inflammation

67. Dangers in the practice of defensive medicine in hemostasis testing for investigation of bleeding or thrombosis: part I--routine coagulation testing. (Abstract)

Dangers in the practice of defensive medicine in hemostasis testing for investigation of bleeding or thrombosis: part I--routine coagulation testing. Defensive medicine is a term conventionally used for defining the medical (mal)practice of ordering medically questionable diagnostic testing, procedures, or visits, or to avoid high-risk patients or procedures. The practice of defensive medicine may primarily be aimed to reduce exposure to malpractice liability, to avoid patient criticism (...) regarding "medical inaction," or to avoid "missing" some otherwise potential identifiable defect(s). Although the precise impact of defensive medicine in the field of laboratory testing is difficult to estimate from the current literature, the overuse or inappropriate use of laboratory resources ranges from 23 to 67%, and a large part of this can be attributed to medical liability concerns, with apparently little clinical awareness of the adverse consequences that may be associated with this practice

2014 Seminars In Thrombosis And Hemostasis

68. The doctor-patient relationship, defensive medicine and overprescription in Chinese public hospitals: Evidence from a cross-sectional survey in Shenzhen city. (Abstract)

The doctor-patient relationship, defensive medicine and overprescription in Chinese public hospitals: Evidence from a cross-sectional survey in Shenzhen city. Defensive medicine describes physicians' behavioral response to threats from medical malpractice litigation. Previous studies have found widespread practice of defensive medicine that is responsible for the global escalation of health care costs. Defying the traditional explanations, this study, with a case of a Chinese city, reveals (...) the literature on defensive medicine, multivariate analysis revealed that physicians' previous experience of medical disputes is significantly associated with defensive behaviors, particularly overprescription. Low income continued to be a critical predictor, reinforcing the target income hypothesis and suggesting the resilience of perverse economic incentives. This study sheds fresh light on China's recent health policy reforms by highlighting the critical impact of the doctor-patient relationship

2014 Social Science & Medicine

69. [Treatment of Facial Acne Vulgaris by Chinese Medicine Combined Western Medicine]. (Abstract)

[Treatment of Facial Acne Vulgaris by Chinese Medicine Combined Western Medicine]. Objective To comparatively observe clinical efficacies of Fusidic Acid Cream (FAC) , Longzhu Ointment (LO) , and their combination of minocycline hydrochloride for treating facial acne vulgaris. Methods Totally 186 patients with acne vulgaris were randomly assigned to the FAC group (103 cases) and the LO group (83 cases). Each group was further divided into two subgroups ac- cording to the severity of acne (...) , red area, sclererythrin of united treatment group of the FAC group and the LO group (P <0. 05). Conclusions FAC and LO could effectively control the inflammation of acne. LO had a rapid onset. Combined with minocy- cline hydrochloride, FAC could significantly reduce the secretion of fats, and LO could defense against ultraviolet more significantly.

2017 Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine Controlled trial quality: uncertain

70. Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force Full Text available with Trip Pro

Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Personalized Medicine Collaborative expanded to create a military (...) Department of Defense. Over the longer term, analyses will further contribute to the development of policies and processes relevant to clinical decision support and data sharing within the US military, and on-going work with the Air Force Medical Service sub-cohort will generate critical insights into how best to deploy useful genomic information in clinical care. Here we discuss challenges faced and critical success factors for military-civilian collaborations around genomic research.

2017 NPJ genomic medicine

71. In defense of FOX’s The Resident

In defense of FOX’s The Resident In defense of FOX's The Resident In defense of FOX’s The Resident | | February 13, 2018 12 Shares The public’s apparently insatiable appetite for medical drama continues unabated as yet another prime-time TV show set in a hospital has hit our screens. FOX’s The Resident has generated discussion like no other. This may simply be due to the fact it’s the first major launch in the era of widespread social media, but it seems to have enraged a vast swathe of our (...) stopped health care professionals loving a TV show. Grey’s Anatomy is more soap than medical realism; House’s team were clearly the only people working at Princeton Plainsboro, forced to undertake every procedure themselves and whilst Scrubs has rightly won plaudits as most accurately capturing the banter and camaraderie that makes health care such a wonderful job, the medicine was rudimentary at best. But of course, it didn’t matter. Don’t get me wrong: Laughing at ludicrous science on TV is one

2018 KevinMD blog

72. Acute Pain Medicine in the United States: A Status Report Full Text available with Trip Pro

Acute Pain Medicine in the United States: A Status Report Acute Pain Medicine in the United States: A Status Report | Pain Medicine | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article (...) Navigation September 2015 Article Contents Article Navigation Acute Pain Medicine in the United States: A Status Report Patrick Tighe, MD, MS Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida Reprint requests to : Patrick Tighe, MD, MS, University of Florida, P.O. Box 100254, 1600 SW Archer Road, Gainesville, FL 32610-0254, USA. Tel: 352-273-7844; Fax: 352–392-7029; E-mail: . Search for other works by this author on: Chester C. Buckenmaier, III, MD Search

2015 American Academy of Pain Medicine

73. Study of Medical Students' Malpractice Fear and Defensive Medicine: A “Hidden Curriculum?” Full Text available with Trip Pro

Study of Medical Students' Malpractice Fear and Defensive Medicine: A “Hidden Curriculum?” Defensive medicine is a medical practice in which health care providers' primary intent is to avoid criticism and lawsuits, rather than providing for patients' medical needs. The purpose of this study was to characterize medical students' exposure to defensive medicine during medical school rotations.We performed a cross-sectional survey study of medical students at the beginning of their third year (...) . We gave students Likert scale questionnaires, and their responses were tabulated as a percent with 95% confidence interval (CI).Of the 124 eligible third-year students, 102 (82%) responded. Most stated they rarely worried about being sued (85.3% [95% CI=77.1% to 90.9%]). A majority felt that faculty were concerned about malpractice (55.9% [95% CI=46.2% to 65.1%]), and a smaller percentage stated that faculty taught defensive medicine (32.4% [95% CI=24.1% to 41.9%]). Many students believed

2013 Western Journal of Emergency Medicine

74. Medical nihilism: The limits of a decontextualised critique of medicine. (Abstract)

Medical nihilism: The limits of a decontextualised critique of medicine. In a new and interesting book entitled Medical Nihilism (2018), Jacob Stegenga attempts to convince us that modern medical therapies are less effective than we think. Given the heterogeneity of hypotheses in medicine and the evidence for or against them, I argue that such a decontextualised critique cannot be made unless substantially weakened. Instead, I put forward an alternative, more nuanced and defensible epistemic (...) view of medicine. According to this view, evaluating medical evidence requires analysis of both the methods of research e.g. randomised controlled trial (RCT), and context-specific information. This is because the way a trial (even an RCT) is conducted e.g. the population recruited and how it is intervened on, will vary and will have significant effects on the likelihood of a positive outcome. Moreover, the relationship between the positive outcome of a trial and the actual effectiveness

2019 Studies in history and philosophy of biological and biomedical sciences Controlled trial quality: uncertain

75. Defensive Medicine

Defensive Medicine Defensive Medicine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Defensive Medicine Defensive Medicine Aka (...) : Defensive Medicine II. Definitions Defensive Medicine Deviation from evidence-based medical decisions due to liability threat Example: Ordering advanced imaging (e.g. ) despite reassuring decision rules (e.g. ) Sub-types of Defensive Medicine Assurance behavior Additional services offered that add little medical value Avoidance behavior Replacing care by referring to another medical provider Reducing care by refusing to treat a patient III. Epidemiology Defensive Medicine is practiced by a majority

2015 FP Notebook

76. Medical Malpractice in Connecticut: Defensive Medicine, Real Problem or a Red Herring – Example of Assessment of Quality Outcomes Variables Full Text available with Trip Pro

Medical Malpractice in Connecticut: Defensive Medicine, Real Problem or a Red Herring – Example of Assessment of Quality Outcomes Variables Using the survey data obtained from doctors in Connecticut, we estimate the "true" costs of defensive medicine and medical malpractice awards via litigation in the overall aggregate picture of U.S. national annual health expenditures.Progressives claim that these costs amount only to approximately 2% of total annual health expenditures, while

2012 Acta Informatica Medica

77. How Prepared Are We for Possible Bioterrorist Attacks: An Approach from Emergency Medicine Perspective Full Text available with Trip Pro

How Prepared Are We for Possible Bioterrorist Attacks: An Approach from Emergency Medicine Perspective Preparedness for bioterrorist attacks and early recognition of specific agents are essential for public health. Emergency departments may play an important role in this field. The large spectrum of bioterrorism involves not only disastrous terrorism with mass casualties, but also microevents using low technology but producing civil unrest, disruption, disease, disabilities, and death. It aims (...) not only to cause mortality and morbidity, but also to lead to social and political disruption. Preparedness appears to be the most potent defense against possible bioterrorist events. In this article, we aim to create awareness against biological agents and underline the importance of emergency departments in this public health problem.

2018 The Scientific World Journal

78. Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus Full Text available with Trip Pro

Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT) is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims are to examine the pharmacokinetics (...) blood-absorbed flavonoids which enhance macrophage functions in host defense. Flavonoid-rich KRT may be a beneficial treatment for infectious skin inflammation.

2018 International journal of molecular sciences

79. AromaDb: A Database of Medicinal and Aromatic Plant’s Aroma Molecules With Phytochemistry and Therapeutic Potentials Full Text available with Trip Pro

AromaDb: A Database of Medicinal and Aromatic Plant’s Aroma Molecules With Phytochemistry and Therapeutic Potentials In traditional, herbal medicine, and aromatherapy, use of essential oils and their aroma compounds have been known since long, for the management of various human diseases. The essential oil is a mixture of highly complex, naturally occurring volatile aroma compounds synthesized by medicinal and aromatic plants as secondary metabolites. Essential oils widely used (...) in pharmaceutical, cosmetic, sanitary, food industry and agriculture for their antibacterial, antiviral, antifungal, antiparasitic, insecticidal, anticancer, neuroprotective, psychophysiological, and anti-aging activities. Moreover, volatile aroma compounds comprise a chemically diverse class of low molecular weight organic compounds with significant vapor pressure. However, aroma compounds produced by plants, mainly attract pollinators, seed dispersers and provide defense against pests or pathogens. However

2018 Frontiers in plant science

80. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats Full Text available with Trip Pro

Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced (...) the pathological features in the thyroid glands of hypothyroidism rats. The results suggested that the administration of pharmacopuncture may ameliorate the pathological progression of hypothyroidism by multiple actions, including normalization of the hypothyroidism-induced thyroid hormone imbalance, stimulation of the antioxidant defense system, and regulation of the T helper (Th)1/Th2 imbalance. Therefore, MOK extract may be used for the treatment of hypothyroidism in Korean clinics as a useful

2018 Experimental and therapeutic medicine

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