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Defensive Medicine

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61. Candida Host Defense Response After Septic Shock in the Critically Ill

: May 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Septic shock and candidiasis The realized analyses will be two types: 1/an immunological analysis that is the characterization of the capacities of defense against germs and 2/a search(research) of Candida by microscopic examination and culture on circles of growth but also the research for the genome of the mushroom by a state-of-the-art technique (...) Candida Host Defense Response After Septic Shock in the Critically Ill Candida Host Defense Response After Septic Shock in the Critically Ill - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Candida Host

2017 Clinical Trials

62. Effects of Gum Disease Treatment on Host Defense Factors

Effects of Gum Disease Treatment on Host Defense Factors Effects of Gum Disease Treatment on Host Defense Factors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Gum Disease Treatment on Host (...) Defense Factors (PETREBED) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03146975 Recruitment Status : Completed First Posted : May 10, 2017 Last Update Posted : July 2, 2017 Sponsor: Federal University of Minas Gerais Information provided by (Responsible Party): Fernando O Costa, Federal University

2017 Clinical Trials

63. The Naturally Occurring Host Defense Peptide, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro (PubMed)

The Naturally Occurring Host Defense Peptide, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. It is also plausible that truncated versions (...) will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. The host defense peptide, LL-37, and two truncated mimetics, KE-18 and KR-12, were tested for their inhibitory effects and antibiofilm properties against Candida albicans, Staphylococcus aureus, and Escherichia coli, microorganisms commonly implicated in biofilm-related infections such as ventilator-associated pneumonia (VAP). Using in silico prediction

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2017 Frontiers in microbiology

64. Vitamin D in Host Defense: Implications for Future Research (PubMed)

Vitamin D in Host Defense: Implications for Future Research 28569596 2018 02 21 2018 12 02 1535-4989 56 6 2017 06 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Vitamin D in Host Defense: Implications for Future Research. 692-693 10.1165/rcmb.2017-0064ED Weiss Scott T ST 0000-0001-7196-303X 1 Channing Division of Network Medicine Brigham and Women's Hospital Harvard Medical School Boston, Massachusetts. Litonjua Augusto A AA 1 Channing Division (...) of Network Medicine Brigham and Women's Hospital Harvard Medical School Boston, Massachusetts. eng R01 HL091528 HL NHLBI NIH HHS United States Editorial United States Am J Respir Cell Mol Biol 8917225 1044-1549 0 Antimicrobial Cationic Peptides 0 Cathelicidins 0 Cytokines 1406-16-2 Vitamin D 143108-26-3 CAP18 lipopolysaccharide-binding protein IM Animals Antimicrobial Cationic Peptides Autophagy immunology Cathelicidins immunology Cytokines immunology Humans Infection immunology pathology Oxidative

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2017 American journal of respiratory cell and molecular biology

65. Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity (PubMed)

Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity 28546561 2018 08 17 2018 11 13 2092-6413 49 5 2017 05 26 Experimental & molecular medicine Exp. Mol. Med. Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity. e337 10.1038/emm.2017.55 Koh Jung Hee JH 0000-0002-6617-1449 Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea (...) , Seoul, Korea. Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Kim Wan-Uk WU Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea, Seoul, Korea. Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. eng Editorial Introductory

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2017 Experimental & molecular medicine

66. Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida (PubMed)

Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida 28806437 2019 01 28 2019 01 28 2168-6114 177 10 2017 10 01 JAMA internal medicine JAMA Intern Med Association Between Enactment of a "Stand Your Ground" Self-defense Law and Unlawful Homicides in Florida. 1523-1524 10.1001/jamainternmed.2017.3433 Humphreys David K DK Department of Social Policy and Intervention, University of Oxford, Oxford, England. Gasparrini Antonio A Department (...) of Social & Environmental Health Research, London School of Hygiene and Tropical Medicine, London, England. Wiebe Douglas J DJ Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania. eng Journal Article United States JAMA Intern Med 101589534 2168-6106 AIM IM Female Firearms legislation & jurisprudence Florida Homicide legislation & jurisprudence statistics & numerical data Humans Male Wounds, Gunshot epidemiology 2017 8 15 6 0 2019 1 29 6 0 2017 8 15 6 0

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2017 JAMA Internal Medicine

67. A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells (PubMed)

A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells Sijunzi Decoction (SJZD) is a formula used for the treatment of spleen deficiency and gastrointestinal diseases in Traditional Chinese Medicine. Polysaccharides are reported to be the main components of SJZD responsible for its bio-functions. However, highly purified and clearly characterized polysaccharides from SJZD are not well described. Here we obtained a purified polysaccharide (SJZDP-II-I

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2017 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

68. The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung (PubMed)

The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung 28102763 2018 04 24 2018 12 02 2150-5608 8 6 2017 08 18 Virulence Virulence The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung. 625-627 10.1080/21505594.2016.1278335 Miller Lisa A LA a Department of Anatomy , Physiology, and Cell Biology, UC Davis School of Veterinary Medicine & California National Primate Research Center

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2017 Virulence

69. Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? (PubMed)

Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 28942622 2018 12 19 2018 12 19 2287-285X 23 3 2017 09 Clinical and molecular hepatology Clin Mol Hepatol Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 219-221 10.3350/cmh.2017.0045 Lee Yun Bin YB Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea. Lee Jeong-Hoon JH 0000-0002-0315-2080 Department (...) of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. eng Editorial Comment 2017 09 19 Korea (South) Clin Mol Hepatol 101586730 2287-2728 2T8Q726O95 Lamivudine 5968Y6H45M entecavir 5Z93L87A1R Guanine 99YXE507IL Tenofovir IM Clin Mol Hepatol. 2017 Sep;23(3):230-238 28669175 Guanine analogs & derivatives Hepatitis B virus Hepatitis B, Chronic Humans Lamivudine Tenofovir Chronic hepatitis B Entecavir Multi-drug resistance Rescue therapy Tenofovir 2017

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2017 Clinical and molecular hepatology

70. Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) (PubMed)

Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) Twin studies have revealed a significant contribution of the fetal genome to risk of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm delivery. Infection and inflammation of the fetal membranes is commonly found associated with PPROM.We carried out whole exome sequencing (WES) of genomic (...) DNA from neonates born of African-American mothers whose pregnancies were complicated by PPROM (76) or were normal term pregnancies (N = 43) to identify mutations in 35 candidate genes involved in innate immunity and host defenses against microbes. Targeted genotyping of mutations in the candidates discovered by WES was conducted on an additional 188 PPROM cases and 175 controls.We identified rare heterozygous nonsense and frameshift mutations in several of the candidate genes, including CARD6

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2017 Molecular Genetics & Genomic Medicine

71. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb (PubMed)

Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb 28862506 2018 02 21 2018 11 13 1535-4989 57 3 2017 09 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb. 263-264 10.1165/rcmb.2017-0149ED Kulkarni Ritwij R 0000-0002-9753-8899 1 Department of Biology University of Louisiana at Lafayette Lafayette, Louisiana. Jeyaseelan Samithamby S 0000-0002 (...) -1959-1328 2 Department of Pathobiological Sciences Louisiana State University (LSU) Baton Rouge, Louisiana and. 3 Department of Medicine LSU Health Sciences Center New Orleans, Louisiana. eng R01 AI113720 AI NIAID NIH HHS United States R01 HL091958 HL NHLBI NIH HHS United States Editorial United States Am J Respir Cell Mol Biol 8917225 1044-1549 6M3C89ZY6R Nicotine IM Animals Cigarette Smoking adverse effects epidemiology Humans Mycobacterium tuberculosis Nicotine adverse effects Risk Factors

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2017 American journal of respiratory cell and molecular biology

72. Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. (PubMed)

Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. 27100598 2016 09 05 2017 11 16 1532-5415 64 4 2016 Apr Journal of the American Geriatrics Society J Am Geriatr Soc Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. 901-4 10.1111/jgs.14062 Lopez-Moreno Javier J Lipids and Atherosclerosis Unit (...) . CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain. Perez-Martinez Pablo P Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain. CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain. Striker Gary E GE Division of Experimental Diabetes and Aging, Department of Geriatrics, Icahn School of Medicine at Mount Sinai, New

2016 Journal of the American Geriatrics Society

73. Trait Anxiety and Defensive Networks

Trait Anxiety and Defensive Networks Trait Anxiety and Defensive Networks - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trait Anxiety and Defensive Networks The safety and scientific validity (...) by (Responsible Party): Keith Kendrick, University of Electronic Science and Technology of China Study Details Study Description Go to Brief Summary: to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it Condition or disease Intervention/treatment Phase Healthy Behavioral: trait anxiety scale Drug: Oxytocin Drug: Placebo Not Applicable Detailed Description: Individuals with high trait anxiety show stable anxiety proneness even in the absence

2016 Clinical Trials

74. The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia (ELDER-BIOME)

Perspective: Prospective Official Title: The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia Actual Study Start Date : October 1, 2016 Estimated Primary Completion Date : October 1, 2019 Estimated Study Completion Date : October 1, 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Pneumonia patients rectal swab (4x) divided over two time (...) The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia (ELDER-BIOME) The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia (ELDER-BIOME) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2016 Clinical Trials

75. Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits

Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dental Health (...) Epidemiology Among Israel Defense Forces (IDF) Recruits The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02958891 Recruitment Status : Unknown Verified November 2016 by Nirit Yavnai, Medical Corps, Israel Defense Force. Recruitment status was: Active, not recruiting First Posted : November 8, 2016 Last

2016 Clinical Trials

76. Psychometric Testing of the Defense and Veterans Pain Rating Scale (DVPRS): A New Pain Scale for Military Population. (PubMed)

Psychometric Testing of the Defense and Veterans Pain Rating Scale (DVPRS): A New Pain Scale for Military Population. The Defense and Veterans Pain Rating Scale (DVPRS 2.0) is a pain assessment tool that utilizes a numerical rating scale enhanced by functional word descriptors, color coding, and pictorial facial expressions matched to pain levels. Four supplemental questions measure how much pain interferes with usual activity and sleep, and affects mood and contributes to stress.Psychometric (...) of Pain Medicine. 2016. This work is written by US Government employee(s) and is in the public domain in the US.

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2016 Pain Medicine

77. IgE and mast cells in host defense against parasites and venoms. (PubMed)

IgE and mast cells in host defense against parasites and venoms. IgE-dependent mast cell activation is a major effector mechanism underlying the pathology associated with allergic disorders. The most dramatic of these IgE-associated disorders is the fatal anaphylaxis which can occur in some people who have developed IgE antibodies to otherwise innocuous antigens, such as those contained in certain foods and medicines. Why would such a highly "maladaptive" immune response develop in evolution (...) and be retained to the present day? Host defense against parasites has long been considered the only beneficial function that might be conferred by IgE and mast cells. However, recent studies have provided evidence that, in addition to participating in host resistance to certain parasites, mast cells and IgE are critical components of innate (mast cells) and adaptive (mast cells and IgE) immune responses that can enhance host defense against the toxicity of certain arthropod and animal venoms, including

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2016 Seminars in immunopathology

78. In defense of medical societies – especially ACP

In defense of medical societies – especially ACP db's Medical Rants » Blog Archive » In defense of medical societies – especially ACP Internal medicine, American health care, and especially medical education 9 Posted by rcentor | Posted on 25-05-2016 Category : A recent comment attacked medical societies as being impotent on several issues. The commenter clearly expects these societies to work quick visible changes. Here is my take: My recent leadership role at ACP makes this answer biased (...) out their English overlords. Medicine deperately needs its William Wallace to rally the troops to preserve their professional integrity, autonomy, the doctor patient relationship and, yes, their Freedom. said on 30-05-2016 I would be interested if your defense of ACP would include the authorship and promulgation of the “professionalism ” of the Charter for a new millennium which imposes an obligation to work for social justice and to be a steward of medical resources. rcentor said on 30-05-2016

2016 db's Medical Rants blog

79. Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1 (PubMed)

Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1 The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. Although several studies have focused on the anti-oxidative activity of this mushroom, the molecular mechanisms underlying its activity have not yet been clearly established. The present study investigated the cytoprotective effect of ethanol extract of Ganoderma lucidum (EGL) against (...) manner.Collectively, these results demonstrate that EGL augments the cellular anti-oxidant defense capacity through activation of Nrf2/HO-1, thereby protecting C2C12 myoblasts from H2O2-induced oxidative cytotoxicity.

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2016 Journal of pharmacopuncture

80. Investigating Therapeutic Potential of Trigonella foenum-graecum L. as Our Defense Mechanism against Several Human Diseases (PubMed)

Investigating Therapeutic Potential of Trigonella foenum-graecum L. as Our Defense Mechanism against Several Human Diseases Current lifestyle, stress, and pollution have dramatically enhanced the progression of several diseases in human. Globally, scientists are looking for therapeutic agents that can either cure or delay the onset of diseases. Medicinal plants from time immemorial have been used frequently in therapeutics. Of many such plants, fenugreek is one of the oldest herbs which have (...) been identified as an important medicinal plant by the researchers around the world. It is potentially beneficial in a number of diseases such as diabetes, hypercholesterolemia, and inflammation and probably in several kinds of cancers. It has industrial applications such as synthesis of steroidal hormones. Its medicinal properties and their role in clinical domain can be attributed to its chemical constituents. The 3 major chemical constituents which have been identified as responsible

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2016 Journal of toxicology

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