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Defensive Medicine

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41. Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03481725 Recruitment Status : Enrolling by invitation First Posted : March 29

2018 Clinical Trials

42. STAT1 gain-of-function compromises skin host defense in the context of interferon-γ signaling. (Full text)

STAT1 gain-of-function compromises skin host defense in the context of interferon-γ signaling. 30576757 2019 02 04 1097-6825 2018 Dec 18 The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling. S0091-6749(18)32731-3 10.1016/j.jaci.2018.11.033 Niehues Hanna H Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands (...) . Rösler Berenice B Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. van der Krieken Danique A DA Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. van Vlijmen-Willems Ivonne M J J IMJJ Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Rodijk

2018 Journal of Allergy and Clinical Immunology

43. Emergency medicine autonomy is under siege

Emergency medicine autonomy is under siege Emergency medicine autonomy is under siege - CanadiEM Emergency medicine autonomy is under siege In , by Jesse Kellar February 8, 2017 The opposite of a motivated physician is a burnt-out physician. In healthcare, preventing physician burnout and promoting physician wellness is of increasing importance. Healthcare organizations are under tremendous pressure to retain quality physicians and push physicians to perform at the highest level possible (...) , and a bigger stick (penalty) will prevent poor performance) may be true for some fields, it is not true for many. What motivates us? Pink asserted that organizations which require their employees to perform more complex tasks and/or creative solutions (such as in Emergency Medicine), a simple bonus or pay raise will likely not result in higher performance. In addition to these conclusions, research by Jha, et al. in the New England Journal of Medicine showed no difference in mortality benefit when

2017 CandiEM

44. In Defense of the International Collaboration of Breast Registry Activities (ICOBRA) (Full text)

In Defense of the International Collaboration of Breast Registry Activities (ICOBRA) 27053073 2017 07 13 2018 11 13 1527-330X 36 7 2016 Jul Aesthetic surgery journal Aesthet Surg J In Defense of the International Collaboration of Breast Registry Activities (ICOBRA). NP225-7 10.1093/asj/sjw055 Cooter Rod R Dr Cooter is Clinical Head, International Collaboration of Breast Registry Activities, and Adjunct Clinical Professor, Department of Epidemiology and Preventive Medicine, Monash University (...) , Melbourne, Victoria, Australia. Dr Barnett is a retired plastic and reconstructive surgeon and Chairman of the Australasian Foundation for Plastic Surgery. Dr Deva is an Associate Professor of Plastic and Reconstructive Surgery, Macquarie University, Sydney, Australia. Dr Magnusson is a plastic and reconstructive surgeon in private practice in Toowoomba, Queensland, Australia. Dr McNeil is a Professor and Head, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria

2016 Aesthetic surgery journal

45. The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung (Full text)

The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung 28102763 2018 04 24 2018 12 02 2150-5608 8 6 2017 08 18 Virulence Virulence The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung. 625-627 10.1080/21505594.2016.1278335 Miller Lisa A LA a Department of Anatomy , Physiology, and Cell Biology, UC Davis School of Veterinary Medicine & California National Primate Research Center

2017 Virulence

46. Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity (Full text)

Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity 28546561 2018 08 17 2018 11 13 2092-6413 49 5 2017 05 26 Experimental & molecular medicine Exp. Mol. Med. Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity. e337 10.1038/emm.2017.55 Koh Jung Hee JH 0000-0002-6617-1449 Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea (...) , Seoul, Korea. Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Kim Wan-Uk WU Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea, Seoul, Korea. Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. eng Editorial Introductory

2017 Experimental & molecular medicine

47. The Naturally Occurring Host Defense Peptide, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro (Full text)

The Naturally Occurring Host Defense Peptide, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. It is also plausible that truncated versions (...) will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. The host defense peptide, LL-37, and two truncated mimetics, KE-18 and KR-12, were tested for their inhibitory effects and antibiofilm properties against Candida albicans, Staphylococcus aureus, and Escherichia coli, microorganisms commonly implicated in biofilm-related infections such as ventilator-associated pneumonia (VAP). Using in silico prediction

2017 Frontiers in microbiology

48. Vitamin D in Host Defense: Implications for Future Research (Full text)

Vitamin D in Host Defense: Implications for Future Research 28569596 2018 02 21 2018 12 02 1535-4989 56 6 2017 06 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Vitamin D in Host Defense: Implications for Future Research. 692-693 10.1165/rcmb.2017-0064ED Weiss Scott T ST 0000-0001-7196-303X 1 Channing Division of Network Medicine Brigham and Women's Hospital Harvard Medical School Boston, Massachusetts. Litonjua Augusto A AA 1 Channing Division (...) of Network Medicine Brigham and Women's Hospital Harvard Medical School Boston, Massachusetts. eng R01 HL091528 HL NHLBI NIH HHS United States Editorial United States Am J Respir Cell Mol Biol 8917225 1044-1549 0 Antimicrobial Cationic Peptides 0 Cathelicidins 0 Cytokines 1406-16-2 Vitamin D 143108-26-3 CAP18 lipopolysaccharide-binding protein IM Animals Antimicrobial Cationic Peptides Autophagy immunology Cathelicidins immunology Cytokines immunology Humans Infection immunology pathology Oxidative

2017 American journal of respiratory cell and molecular biology

49. Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? (Full text)

Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 28942622 2018 12 19 2018 12 19 2287-285X 23 3 2017 09 Clinical and molecular hepatology Clin Mol Hepatol Is tenofovir monotherapy a sufficient defense line against multi-drug resistant hepatitis B virus? 219-221 10.3350/cmh.2017.0045 Lee Yun Bin YB Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea. Lee Jeong-Hoon JH 0000-0002-0315-2080 Department (...) of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. eng Editorial Comment 2017 09 19 Korea (South) Clin Mol Hepatol 101586730 2287-2728 2T8Q726O95 Lamivudine 5968Y6H45M entecavir 5Z93L87A1R Guanine 99YXE507IL Tenofovir IM Clin Mol Hepatol. 2017 Sep;23(3):230-238 28669175 Guanine analogs & derivatives Hepatitis B virus Hepatitis B, Chronic Humans Lamivudine Tenofovir Chronic hepatitis B Entecavir Multi-drug resistance Rescue therapy Tenofovir 2017

2017 Clinical and molecular hepatology

50. Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses (Full text)

Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses 29269994 2018 09 04 2018 11 13 1466-1861 2017 2017 Mediators of inflammation Mediators Inflamm. Intracellular Eukaryotic Pathogens' Virulence Attributes and Their Interplay with Host Immune Defenses. 1264974 10.1155/2017/1264974 Bocca Anamélia Lorenzetti AL Cell Biology Department of Biology Institute, Laboratory of Applied Immunology, University of Brasília, 70910-900 Brasília, DF, Brazil. de (...) Almeida Soares Célia Maria CM Laboratory of Biochemistry and Molecular Biology of the Interaction between Host-Pathogenic Fungi, Biology Institute, University of Goiás, 74001-970 Goiânia, GO, Brazil. Nosanchuk Joshua D JD 0000-0001-9905-5754 Departments of Medicine and Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Silva-Pereira Ildinete I 0000-0003-1403-9363 Cell Biology Department of Biology Institute, Laboratory of Molecular Biology of Pathogenic Fungi

2017 Mediators of inflammation

51. Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses (Full text)

antiviral defense in plants as they are able to degrade foreign RNA of viral origin. This review aims to provide a comprehensive and up-to-date picture of plant proteins participating in antiviral defense. As a result we discuss proteins conferring plant antiviral resistance and their potential future applications in different fields of life including agriculture and medicine. (...) Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses Plants have evolved a variety of defense mechanisms to tackle virus attack. Endogenous plant proteins can function as virus suppressors. Different types of proteins mediate defense responses against plant viruses. Pathogenesis-related (PR) proteins are activated upon pathogen infections or in different stress situations and their production is one of many

2017 International journal of molecular sciences

52. Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida (Full text)

Association Between Enactment of a “Stand Your Ground” Self-defense Law and Unlawful Homicides in Florida 28806437 2019 01 28 2019 01 28 2168-6114 177 10 2017 10 01 JAMA internal medicine JAMA Intern Med Association Between Enactment of a "Stand Your Ground" Self-defense Law and Unlawful Homicides in Florida. 1523-1524 10.1001/jamainternmed.2017.3433 Humphreys David K DK Department of Social Policy and Intervention, University of Oxford, Oxford, England. Gasparrini Antonio A Department (...) of Social & Environmental Health Research, London School of Hygiene and Tropical Medicine, London, England. Wiebe Douglas J DJ Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania. eng Journal Article United States JAMA Intern Med 101589534 2168-6106 AIM IM Female Firearms legislation & jurisprudence Florida Homicide legislation & jurisprudence statistics & numerical data Humans Male Wounds, Gunshot epidemiology 2017 8 15 6 0 2019 1 29 6 0 2017 8 15 6 0

2017 JAMA Internal Medicine

53. A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells (Full text)

A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells Sijunzi Decoction (SJZD) is a formula used for the treatment of spleen deficiency and gastrointestinal diseases in Traditional Chinese Medicine. Polysaccharides are reported to be the main components of SJZD responsible for its bio-functions. However, highly purified and clearly characterized polysaccharides from SJZD are not well described. Here we obtained a purified polysaccharide (SJZDP-II-I

2017 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

54. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb (Full text)

Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb 28862506 2018 02 21 2018 11 13 1535-4989 57 3 2017 09 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Aiding and Abetting the Enemy: Nicotine Impairs the Macrophage Defense against Mtb. 263-264 10.1165/rcmb.2017-0149ED Kulkarni Ritwij R 0000-0002-9753-8899 1 Department of Biology University of Louisiana at Lafayette Lafayette, Louisiana. Jeyaseelan Samithamby S 0000-0002 (...) -1959-1328 2 Department of Pathobiological Sciences Louisiana State University (LSU) Baton Rouge, Louisiana and. 3 Department of Medicine LSU Health Sciences Center New Orleans, Louisiana. eng R01 AI113720 AI NIAID NIH HHS United States R01 HL091958 HL NHLBI NIH HHS United States Editorial United States Am J Respir Cell Mol Biol 8917225 1044-1549 6M3C89ZY6R Nicotine IM Animals Cigarette Smoking adverse effects epidemiology Humans Mycobacterium tuberculosis Nicotine adverse effects Risk Factors

2017 American journal of respiratory cell and molecular biology

55. Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) (Full text)

Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM) Twin studies have revealed a significant contribution of the fetal genome to risk of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm delivery. Infection and inflammation of the fetal membranes is commonly found associated with PPROM.We carried out whole exome sequencing (WES) of genomic (...) DNA from neonates born of African-American mothers whose pregnancies were complicated by PPROM (76) or were normal term pregnancies (N = 43) to identify mutations in 35 candidate genes involved in innate immunity and host defenses against microbes. Targeted genotyping of mutations in the candidates discovered by WES was conducted on an additional 188 PPROM cases and 175 controls.We identified rare heterozygous nonsense and frameshift mutations in several of the candidate genes, including CARD6

2017 Molecular Genetics & Genomic Medicine

56. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease (Full text)

Regulation of defensive function on gingival epithelial cells can prevent periodontal disease Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacterial invasion and a part of the innate immune (...) response to infectious inflammation in periodontal tissue. The disorganization of cell-cell interactions and subsequent inflammation contribute to the initiation of periodontal disease. These make us consider that regulation of host defensive functions, epithelial barrier and neutrophil activity, may become novel preventive methods for periodontal inflammation. Based on this concept, we have found that several agents regulate the barrier function of gingival epithelial cells and suppress

2017 The Japanese dental science review

57. Candida Host Defense Response After Septic Shock in the Critically Ill

: May 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Septic shock and candidiasis The realized analyses will be two types: 1/an immunological analysis that is the characterization of the capacities of defense against germs and 2/a search(research) of Candida by microscopic examination and culture on circles of growth but also the research for the genome of the mushroom by a state-of-the-art technique (...) Candida Host Defense Response After Septic Shock in the Critically Ill Candida Host Defense Response After Septic Shock in the Critically Ill - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Candida Host

2017 Clinical Trials

58. Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions

Enrollment : 300 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions Actual Study Start Date : August 4, 2017 Estimated Primary Completion Date : July 1, 2019 Estimated Study Completion Date : July 1, 2020 Resource links provided by the National Library of Medicine related topics: related topics: Groups and Cohorts Go to Group/Cohort Subjects with chronic skin conditions (...) Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

59. Cysteine-stabilised peptide extract of Morinda lucida (Benth) leaf exhibits antimalarial activity and augments antioxidant defense system in P. berghei-infected mice. (PubMed)

Cysteine-stabilised peptide extract of Morinda lucida (Benth) leaf exhibits antimalarial activity and augments antioxidant defense system in P. berghei-infected mice. Cysteine-stabilised peptides (CSP) are majorly explored for their bioactivities with applications in medicine and agriculture. Morinda lucida leaf is used indigenously for the treatment of malaria; it also contains CSP but the role of CSP in the antimalarial activity of the leaf has not been evaluated.This study was therefore (...) concentration and activities of glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase in a dose-dependent manner, which was significant (P < 0.05) at higher doses compared to the untreated controls.The results suggest that PPCPE may require bioactivation in vivo in order to exert its antimalarial effect and that PPCPE may augment the antioxidant defense system to alleviate the reactive oxygen species-mediated complications of malaria.Copyright © 2017 Elsevier Ireland Ltd. All

2017 Journal of Ethnopharmacology

60. Neuro-immune Interactions in Inflammation and Host Defense: Implications for Transplantation. (Full text)

Neuro-immune Interactions in Inflammation and Host Defense: Implications for Transplantation. Sensory and autonomic neurons of the peripheral nervous system (PNS) play a critical role in regulating the immune system during tissue inflammation and host defense. Recent studies have identified the molecular mechanisms underlying the bidirectional communication between the nervous system and the immune system. Here, we highlight the studies that demonstrate the importance of the neuro-immune (...) interactions in health and disease. Nociceptor sensory neurons detect immune mediators to produce pain, and release neuropeptides that act on the immune system to regulate inflammation. In parallel, neural reflex circuits including the vagus nerve-based inflammatory reflex are physiological regulators of inflammatory responses and cytokine production. In transplantation, neuro-immune communication could significantly impact the processes of host-pathogen defense, organ rejection, and wound healing

2017 American Journal of Transplantation

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