How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

5,098 results for

Defensive Medicine

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

4961. Lifestyle and Chronic Disease in College Alumni (Harvard Alumni Health Study)

. In: Heart Disease and Rehabilitation, M Pollock (Ed). New York: John Wiley & Sons, 2nd Ed., 1986. Paffenbarger RS Jr, Hyde RT, Jung DL, Wing AL: Epidemiology of Exercise and Coronary Heart Disease. In: Symposium on Cardiac Rehabilitation, B Franklin (Ed). Philadelphia, PA: WB Saunders. Clinics in Sports Medicine 3:297-318, 1984 Paffenbarger RS Jr: Physical Activity as a Defense Against Coronary Heart Disease. In: Coronary Heart Disease, WE Connor and JD Bristow (Eds). Philadelphia: JB Lippincott Company (...) and mortality. Condition or disease Cardiovascular Diseases Heart Diseases Coronary Disease Hypertension Cerebrovascular Accident Study Design Go to Layout table for study information Study Type : Observational Study Start Date : September 1984 Study Completion Date : June 2000 Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family

2000 Clinical Trials

4962. Vietnam Era Twin (VET) Registry

on cardiovascular, respiratory, and other major systemic disease and risk factors in members of the Vietnam Era Twin Registry. Condition or disease Cardiovascular Diseases Blood Disease Heart Diseases Lung Diseases Detailed Description: BACKGROUND: The Vietnam Veteran Twin Registry, maintained by the NAS-NRC, was created with funding from the Veterans Administration. Department of Defense records were searched for subjects born between 1939-1957 and having the same last name and date of birth. Follow-up (...) the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: up to 100 Years (Child, Adult, Older Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers

2000 Clinical Trials

4963. Study of Mycobacterial Infections

Atypical Mycobacterium Infections Cystic Fibrosis Detailed Description: The nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms foundin soil and water that rarely cause disease in humans. Since exposure to these organisms is universal and disease is rare, it can be concluded that normal host defenses are almost always sufficient to prevent infection. It follows that otherwise healthy individuals who develop disease must have abnormal susceptibility or immune defects that permit (...) nontuberculous mycobacterial infection without HIV, suggesting this is a critical pathway for host defense against these organisms. We seek to better characterize the predisposition to mycobacterial infection. This study will specifically address several aspects of immune function and investigate the proposed link to body morphotype in the relevant population. By collecting this information, we hope to provide insight into disease associations, infection susceptibility, and genetic predisposition

2001 Clinical Trials

4964. The Epidemiology of Infection With Vancomycin-Resistant Enterococci

will study the effect of antibiotic use, particularly vancomycin, and impaired host defenses on VRE infection in a large cohort study of VRE colonized patients. The goal is to develop a statistical model, which will allow us to identify alterable risk factors, which could reduce the risk of VRE infection. Many case-control studies have been performed to study VRE colonization and infection; however, most of these studies were small with insufficient sample sizes for multivariate modeling. Vancomycin (...) With Vancomycin-Resistant Enterococci Study Start Date : July 1998 Study Completion Date : June 2001 Resource links provided by the National Library of Medicine available for: Groups and Cohorts Go to Group/Cohort Group 1 Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you

2001 Clinical Trials

4965. Interleukin-12 in the Treatment of Severe Nontuberculous Mycobacterial Infections

that IL-12 may be an important adjunct to antimycobacterial therapy. We seek to use IL-12 in a phase I/II trial in the treatment of severe nontuberculous mycobacterial infections in patients who have not been cured by the best tolerated conventional therapy with IFN gamma. Patients will be studied for inborn or acquired immune defects as well as IL-12 responsiveness in vitro under protocol 93-I-0119 "Detection and Characterization of Host Defense Defects". Patients will receive IL-12 subcutaneously 2 (...) Nontuberculous Mycobacterial Infections Study Start Date : July 1999 Study Completion Date : July 2003 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about

1999 Clinical Trials

4966. Study of TNFR:Fc (Enbrel) in the Treatment of Asthma

Date : August 17, 1999 Actual Primary Completion Date : December 31, 2002 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Whether subcutaneous administration of TNFR:Fc alters TNF bioactivity in brochoalveolar lavage fluid (BALF) samples. [ Time Frame: 3 years ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important (...) viruses (to exclude patients with hepatitis-related lung disease, such as pleural effusions, interstitial pneumonitis and fibrosis). History of Crohn's disease (to exclude patients with inflammatory bowel disease-related alveolar lymphocytosis). History of diseases associated with impaired host defenses, such as diabetes mellitus or congestive heart failure. Patients with impaired host defenses also include individuals with either acquired or congenital, quantitative or qualitative defects

1999 Clinical Trials

4967. A Phase I Study of the Safety and Immunogenicity of Rgp 120/HIV-1IIIB Vaccine in HIV-1 Seropositive Adult Volunteers

) Primary Purpose: Prevention Official Title: A Phase I Study of the Safety and Immunogenicity of Rgp 120/HIV-1IIIB Vaccine in HIV-1 Seropositive Adult Volunteers Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding (...) a written informed consent form, which must be obtained prior to study entry. Be available for 24 weeks so that follow up may be completed. Qualify for care as Department of Defense health care beneficiary. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: Prior history of clinically significant cardiac, pulmonary, hepatic, renal, neurologic or autoimmune disease, other than HIV-1 infection, and in less than average general health as determined

1999 Clinical Trials

4968. A Study of DTC in Patients With AIDS and AIDS Related Complex

Description Go to Brief Summary: To determine if ditiocarb sodium (sodium diethyldithiocarbamate; DTC) restores immune and host defense function; if DTC ameliorates the AIDS related complex (ARC) symptoms in patients with AIDS and ARC; if DTC prevents progression from ARC to AIDS or progression of AIDS; and if DTC prolongs survival in AIDS. Condition or disease Intervention/treatment Phase HIV Infections Drug: Ditiocarb sodium Not Applicable Study Design Go to Layout table for study information Study Type (...) : Interventional (Clinical Trial) Primary Purpose: Treatment Official Title: A Study of DTC in Patients With AIDS and AIDS Related Complex Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more

1999 Clinical Trials

4969. Hepatitis C in Clinically Discordant Hemophilic Siblings

immunodominant regions targeted by cytotoxic T cells using HLA class I matched hemophilic siblings. Finally, they are identifying specific host genes that are preferentially expressed or repressed in patients with delayed progression of their HCV disease. They are quantitating the expression of mRNAs encoding host antiviral defense and immunoregulatory elements in peripheral blood mononuclear cells (PBMCs) and liver tissue from sibling pairs that have discordant chronic hepatitis C using mRNA libraries (...) by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout

2000 Clinical Trials

4970. Plasmapheresis of Anthrax-Vaccinated Subjects for Production of Anthrax Immune Globulin

Clinical Center (CC) Information provided by: National Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: This protocol is a joint project of the National Institutes of Health, the Centers for Disease Control and the United States Army Medical Research Institute for Infectious Diseases. It is designed to collect plasma from healthy employees of the Department of Defense who have been vaccinated against anthrax. The collected plasma will be pooled to make (...) have received at least four doses of the anthrax vaccine and who meet the criteria for blood donors may be eligible to participate in this study. Volunteers will be recruited from Department of Defense civilian and military employees. Candidates will be screened with an interview and blood tests. Participants will undergo the following procedures: Have a health history screen for donating plasma Measurement of heart rate, blood pressure and temperature Fingerstick to check hemoglobin level Blood

2002 Clinical Trials

4971. Blood Component Collection From Patients With Rheumatic Disease and Healthy Volunteers

and from patients with rheumatic or kidney disorders for research purposes. Rheumatic disorders involve abnormalities of the immune system, the body s defense against disease. The immune system consists of white blood cells such as lymphocytes and monocytes, which produce substances such as antibodies and cytokines. White cells and plasma will be collected through a procedure called apheresis (described below). Healthy volunteers and patients with confirmed or suspected rheumatic or kidney disease who (...) With Rheumatic or Kidney Diseases and Healthy Volunteers Actual Study Start Date : February 13, 2002 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : PBMC and Mononuclear cell study [ Time Frame: One Year ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members

2002 Clinical Trials

4972. Extract of Ginkgo Biloba (EGB 761) and Vascular Function

is that it stimulates cells lining the inside of the arteries to produce the compound nitric oxide. These cells, known as endothelial cells, are susceptible to damage by blood cholesterol, smoking or high blood pressure and, when damaged, will allow cholesterol to deposit in arteries. Antioxidants can prevent the endothelial cell damage, therefore it is very important to know if EGb 761 works through that mechanism. These cells also produce nitric oxide naturally as a defense against injury, so an EGb 761 effect (...) : Parallel Assignment Masking: Double Primary Purpose: Treatment Official Title: Extract of Ginkgo Biloba (Egb 761) and Vascular Function Study Start Date : September 2000 Study Completion Date : July 2005 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Maximal and pain-free walking distance Secondary Outcome Measures : Flow mediated vasodilation of the brachial artery Antibodies to epitopes

2002 Clinical Trials

4973. Magnesium and Asthma

control, indirect biomarkers of inflammation, bronchial hyperresponsiveness, and indices of oxidative defense and damage in subjects with mild to moderate persistent asthma. Condition or disease Intervention/treatment Phase Asthma Drug: Magnesium Phase 2 Detailed Description: Over the past twenty years a number of studies of acute bronchial asthma have shown that i.v. or nebulized MgS04 may improve symptoms over a course of hours. With respect to dietary supplementation, short term (3 wk) oral Mg has (...) Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below

2002 Clinical Trials

4974. Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets

to a machine that measures levels of the gas in each breath. Condition or disease Healthy Detailed Description: Nitric oxide (NO) has been recognized for its multifaceted roles in many physiological processes (e.g., vasodilatation, host defense, neurotransmission, bronchodilatation, and inflammation.) NO is produced by a family of nitric oxide synthase (NOS) isoforms in a reaction that converts L-arginine to L-citrulline. NO metabolites in vivo include nitrite (NO2) and nitrate (NO3). Plasma NO2/NO3 (...) . Study Design Go to Layout table for study information Study Type : Observational Enrollment : 18 participants Official Title: The Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets Study Start Date : April 2000 Study Completion Date : April 2003 Resource links provided by the National Library of Medicine available for: Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from

2001 Clinical Trials

4975. Vaccination Against High Risk Breast Cancer Using Tumor Derived Heat Shock Protein 70

of immunotherapy in advanced and widespread cancers. First, the tumor burden is too overwhelming. Host defenses are simply over powered. Second, patients at this stage usually have significant co-morbidities, which prevent optimal immune responses. Third, advanced cancer patients often have a compromised functional state of the immune system either quantitatively or qualitatively due to prior cytotoxic therapy, radiation therapy, or as a result of active secretion of immunosuppressive agents by the tumor cells (...) information Study Type : Interventional (Clinical Trial) Enrollment : 15 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Vaccination Against High Risk Breast Cancer With Autologous Tumor-Derived Heat Shock Protein 70-Peptide Complexes (HSP70) Study Start Date : December 2000 Study Completion Date : October 2002 Resource links provided by the National Library of Medicine related topics: related topics

2001 Clinical Trials

4976. Research in Skin Inflammation

to NIH for removal of the stitches. New molecular biology techniques will be used to measure changes in chemokine production in the biopsied tissue. Condition or disease Psoriasis Detailed Description: In the skin, T lymphocytes are critical modulators and effectors of acquired defense responses such as delayed-type hypersensitivity (DTH). T lymphocytes and other leukocytes are recruited to the challenged site via the interaction of selectins, integrins, immunoglobulin gene superfamily molecules (...) of cutaneous inflammatory diseases such as psoriasis. Study Design Go to Layout table for study information Study Type : Observational Enrollment : 10 participants Official Title: Expression of Chemokine and Chemokine Receptors in Skin in a Model of Delayed-Type Hypersensitivity Study Start Date : March 2001 Study Completion Date : January 2002 Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2001 Clinical Trials

4977. Exercise and Behavioral Therapy Trial (EBT).

, or attention). Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00007748 Sponsors and Collaborators US Department of Veterans Affairs United States Department of Defense More Information Go to Layout table for additonal information ClinicalTrials.gov (...) and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00007748 Recruitment Status : Completed First Posted : January 1, 2001 Last Update Posted : June 26, 2015 Sponsor: US Department of Veterans Affairs Collaborator: United States Department of Defense Information provided by: VA Office of Research and Development Study

2000 Clinical Trials

4978. Antibiotic Treatment of Gulf War Veterans' Illnesses

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00007735 Recruitment Status : Completed First Posted : January 1, 2001 Last Update Posted : January 21, 2009 Sponsor: US Department of Veterans Affairs Collaborators: Pfizer United States Department of Defense Information provided by: VA Office of Research (...) (200mg/day) or Placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Enrollment : 450 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Official Title: CSP #475 - Persian Gulf - Antibiotic Treatment Trial of Gulf War Veterans' Illnesses Study Start Date : January 1999 Study Completion Date : October 2001 Resource links provided by the National Library of Medicine related topics: available for: Arms

2000 Clinical Trials

4979. Amyotrophic Lateral Sclerosis (ALS) Gulf War Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00007722 Recruitment Status : Completed First Posted : January 1, 2001 Last Update Posted : October 9, 2009 Sponsor: US Department of Veterans Affairs Collaborators: United States Department of Defense Centers for Disease Control and Prevention Department (...) Completion Date : March 2003 Resource links provided by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Group/Cohort 1 Outcome Measures Go to Primary Outcome Measures : Probability of ALS among veterans both deployed and non-deployed to the Gulf Region(8/2/1990-7/31/1991) [ Time Frame: Ongoing ] Biospecimen Retention: Samples With DNA DNA samples of blood or mouthwash were collected in veterans' homes by nurses. Eligibility Criteria Go to Information

2000 Clinical Trials

4980. Blood Donation--Immune Sequelae and Recruitment

with the most marked changes occurring in long-term plasmapheresis donors. To ascertain whether donation of blood or blood products altered specific immune parameters, studies were conducted on white blood cell (WBC) receptors known to be involved in normal host defense mechanisms, lymphocyte subpopulations, plasma proteins, and complement activation products from 30 individuals in each of four separate donor groups: whole blood donors, bulk plasma donors, plasma donors stimulated with incompatible RBC (...) there was any clinical significance to the findings. New donors were enrolled in donation groups and followed longitudinally for a period of up to two years. The study was extended through January, 1997 on FY 1995 funds. Study Design Go to Layout table for study information Study Type : Observational Study Start Date : February 1992 Study Completion Date : January 1997 Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing

2000 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>