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Defensive Medicine

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21. Genome survey sequencing for the characterization of genetic background of Dracaena cambodiana and its defense response during dragon's blood formation. (PubMed)

Genome survey sequencing for the characterization of genetic background of Dracaena cambodiana and its defense response during dragon's blood formation. Dragon's blood collected from the genus Dracaena is used as a renowned traditional medicine in various cultures worldwide. However, the genetics of the genus Dracaena and the formation mechanism of dragon's blood remain poorly understood. Here, we generate the first draft genome reference assembly of an elite Chinese Dracaena species, Dracaena

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2018 PLoS ONE

22. In Defense of the International Collaboration of Breast Registry Activities (ICOBRA) (PubMed)

In Defense of the International Collaboration of Breast Registry Activities (ICOBRA) 27053073 2017 07 13 2018 11 13 1527-330X 36 7 2016 Jul Aesthetic surgery journal Aesthet Surg J In Defense of the International Collaboration of Breast Registry Activities (ICOBRA). NP225-7 10.1093/asj/sjw055 Cooter Rod R Dr Cooter is Clinical Head, International Collaboration of Breast Registry Activities, and Adjunct Clinical Professor, Department of Epidemiology and Preventive Medicine, Monash University (...) , Melbourne, Victoria, Australia. Dr Barnett is a retired plastic and reconstructive surgeon and Chairman of the Australasian Foundation for Plastic Surgery. Dr Deva is an Associate Professor of Plastic and Reconstructive Surgery, Macquarie University, Sydney, Australia. Dr Magnusson is a plastic and reconstructive surgeon in private practice in Toowoomba, Queensland, Australia. Dr McNeil is a Professor and Head, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria

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2016 Aesthetic surgery journal

23. Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action (PubMed)

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action Oxidative stress plays a central role in the pathogenesis of many human diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the intracellular antioxidant response and is an emerging target for the prevention and therapy of oxidative stress (...) -related diseases. Salviae Miltiorrhizae Radix et Rhizoma (SMRR) is a traditional Chinese medicine (TCM) and is commonly used for the therapy of cardiac cerebral diseases. Cumulative evidences indicated that the extract of SMRR and its constituents, represented by lipophilic diterpenoid quinones and hydrophilic phenolic acids, were capable of activating Nrf2 and inhibiting oxidative stress. These bioactive constituents demonstrated a therapeutic potential against human diseases, exemplified

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2018 Oxidative medicine and cellular longevity

24. A Growth-Promoting Bacteria, Paenibacillus yonginensis DCY84T Enhanced Salt Stress Tolerance by Activating Defense-Related Systems in Panax ginseng (PubMed)

A Growth-Promoting Bacteria, Paenibacillus yonginensis DCY84T Enhanced Salt Stress Tolerance by Activating Defense-Related Systems in Panax ginseng Panax ginseng (C.A. Mayer) is a well-known medicinal plant used in traditional medicine in Korea that experiences serious salinity stress related to weather changes or incorrect fertilizer application. In ginseng, the use of Paenibacillus yonginensis DCY84T to improve salt stress tolerance has not been thoroughly explored. Therefore, we studied (...) hydrolyzing enzymes and inducing osmolyte production. Upon exposure to salinity stress (oxidative and ionic stress), strain DCY84T-primed ginseng seedlings were protected by the induction of defense-related systems such as ion transport, ROS scavenging enzymes, proline content, total sugars, and ABA biosynthetic genes, as well as genes involved in root hair formation. Additionally, ginseng primed with DCY84T and exposed to 300 mM NaCl showed the same metabolite profile as control ginseng plants

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2018 Frontiers in plant science

25. Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2018 Clinical Trials

26. In defense of FOX’s The Resident

In defense of FOX’s The Resident In defense of FOX's The Resident In defense of FOX’s The Resident | | February 13, 2018 12 Shares The public’s apparently insatiable appetite for medical drama continues unabated as yet another prime-time TV show set in a hospital has hit our screens. FOX’s The Resident has generated discussion like no other. This may simply be due to the fact it’s the first major launch in the era of widespread social media, but it seems to have enraged a vast swathe of our (...) stopped health care professionals loving a TV show. Grey’s Anatomy is more soap than medical realism; House’s team were clearly the only people working at Princeton Plainsboro, forced to undertake every procedure themselves and whilst Scrubs has rightly won plaudits as most accurately capturing the banter and camaraderie that makes health care such a wonderful job, the medicine was rudimentary at best. But of course, it didn’t matter. Don’t get me wrong: Laughing at ludicrous science on TV is one

2018 KevinMD blog

27. ‘From Defensive Paranoia to …Openness to Outside Scrutiny’: Prison Medical Officers in England and Wales, 1979–86 (PubMed)

‘From Defensive Paranoia to …Openness to Outside Scrutiny’: Prison Medical Officers in England and Wales, 1979–86 This article examines how a branch of medicine based within the criminal justice system responded to a society which by the 1970s and 1980s was increasingly critical of the prison system and medical authority. The Prison Medical Service, responsible for the health care of prisoners in England and Wales, was criticised by prison campaigners and doctors alike for being (...) unethical, isolated, secretive, and beholden to the interests of the Home Office rather than those of their patients. While prison doctors responded defensively to criticisms in the 1970s and 1980s, comparing their own standards of practice favourably with those found in the NHS, and arguing that doctors from outside would struggle to cope in the prison environment, by 1985 their attitudes had changed. Giving evidence to a House of Commons committee, prison doctors displayed a much greater willingness

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2018 Medical history

28. Enhancing the defensibility of examiners’ marks in high stake OSCEs (PubMed)

Enhancing the defensibility of examiners’ marks in high stake OSCEs Most assessments in health professions education consist of knowledge-based examinations as well as practical and clinical examinations. Among the most challenging aspects of clinical assessments is decision making related to borderline grades assigned by examiners. Borderline grades are commonly used by examiners when they do not have sufficient information to make clear pass/fail decisions. The interpretation (...) of these borderline grades is rarely discussed in the literature. This study reports the application of the Objective Borderline Method (version 2, henceforth: OBM2) to a high stakes Objective Structured Clinical Examination undertaken at the end of the final year of a Medicine program in Australia.The OBM2 uses all examination data to reclassify borderline grades as either pass or fail. Factor analysis was used to estimate the suitability of data for application of OBM2. Student's t-tests, utilising

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2018 BMC medical education

29. Endophyte-Mediated Modulation of Defense-Related Genes and Systemic Resistance in Withania somnifera (L.) Dunal under Alternaria alternata Stress (PubMed)

Endophyte-Mediated Modulation of Defense-Related Genes and Systemic Resistance in Withania somnifera (L.) Dunal under Alternaria alternata Stress Endophytes have been explored and found to perform an important role in plant health. However, their effects on the host physiological function and disease management remain elusive. The present study aimed to assess the potential effects of endophytes, singly as well as in combination, in Withania somnifera (L.) Dunal, on various physiological (...) parameters and systemic defense mechanisms against Alternaria alternata Seeds primed with the endophytic bacteria Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated an enhanced vigor index and germination rate. Interestingly, plants treated with the two-microbe combination showed the lowest plant mortality rate (28%) under A. alternata stress. Physiological profiling of treated plants showed improved photosynthesis, respiration, transpiration, and stomatal

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2018 Applied and environmental microbiology

30. Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease (PubMed)

Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease 29692382 2018 10 29 2018 11 14 2542-5641 131 9 2018 May 05 Chinese medical journal Chin. Med. J. Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease. 1099-1107 10.4103/0366-6999.230743 Amatngalim Gimano D GD Department of Pulmonology, Leiden University Medical Center, Leiden; Department of Pediatrics, Wilhelmina Children's Hospital, Regenerative (...) Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands. Hiemstra Pieter S PS Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. eng Journal Article China Chin Med J (Engl) 7513795 0366-6999 IM Epithelial Cells immunology Humans Pulmonary Disease, Chronic Obstructive physiopathology Respiratory System physiopathology There are no conflicts of interest 2018 4 26 6 0 2018 4 26 6 0 2018 10 30 6 0 ppublish 29692382

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2018 Chinese medical journal

31. Salvia castanea Hairy Roots are More Tolerant to Phosphate Deficiency than Salvia miltiorrhiza Hairy Roots Based on the Secondary Metabolism and Antioxidant Defenses (PubMed)

Salvia castanea Hairy Roots are More Tolerant to Phosphate Deficiency than Salvia miltiorrhiza Hairy Roots Based on the Secondary Metabolism and Antioxidant Defenses Salvia miltiorrhiza is a well-known traditional Chinese herb which is used to treat heart disease. Salvia castanea is a substitute product for S. miltiorrhiza in the medicinal field. Previous study has shown that phosphate (Pi) deficiency could promote the accumulation of secondary metabolism in herbs, and it has also developed (...) the antioxidant activity in these two Salvia species. The data demonstrated that Pi deficiency increased the quality of the medicinal material in the plant. The hairy roots of S. castanea were more adaptive to Pi deficiency than those of S. miltiorrhiza in terms of biomass, secondary metabolism, and antioxidant activity. The results of this study provide insights into breeding herbs that are better adapted to Pi deficiency, which could increase the yield of active ingredients in herbs and save Pi resources.

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2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

32. Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03481725 Recruitment Status : Enrolling by invitation First Posted : March 29

2018 Clinical Trials

33. HEALTH AND EXERCISE IN THE DEFENSE FORCES

HEALTH AND EXERCISE IN THE DEFENSE FORCES HEALTH AND EXERCISE IN THE DEFENSE FORCES - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. HEALTH AND EXERCISE IN THE DEFENSE FORCES The safety and scientific (...) Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Encouraging physical activity Encouraging physical activity by using motion sensor and feedback. Other: Encouraging physical activity. Encouraging physical activity with motion sensor's feedback. No Intervention: CONTROL GROUP No intervention. Outcome Measures Go to Primary Outcome Measures : Better physical condition. [ Time Frame: 6 months. ] 12-minutes

2018 Clinical Trials

34. In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. In-vivo Effects of E (...) -cigarette Aerosol on Innate Lung Host Defense (Cinimic) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03700892 Recruitment Status : Recruiting First Posted : October 9, 2018 Last Update Posted : October 24, 2018 See Sponsor

2018 Clinical Trials

35. Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study

Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03449667

2018 Clinical Trials

36. In Defense of Best Interests: When Parents and Clinicians Disagree (PubMed)

In Defense of Best Interests: When Parents and Clinicians Disagree 30133405 2019 03 12 2019 03 12 1536-0075 18 8 2018 08 The American journal of bioethics : AJOB Am J Bioeth In Defense of Best Interests: When Parents and Clinicians Disagree. 67-69 10.1080/15265161.2018.1485766 Coulson-Smith Peta P a University of Southampton, Faculty of Medicine. Fenwick Angela A a University of Southampton, Faculty of Medicine. Lucassen Anneke A a University of Southampton, Faculty of Medicine. eng Journal

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2018 The American Journal of Bioethics

37. Correction for Wu et al., “Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling” (PubMed)

Correction for Wu et al., “Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling” 29463686 2018 09 10 1098-5522 86 3 2018 03 Infection and immunity Infect. Immun. Correction for Wu et al., "Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling". e00881-17 10.1128/IAI.00881-17 Wu Aimin A Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria (...) . Animal Nutrition Institute, Key Laboratory for Animal Disease, Sichuan Agricultural University, Ya'an, Sichuan, People's Republic of China. Tymoszuk Piotr P Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria. Haschka David D Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria. Heeke Simon S Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria. Dichtl Stefanie S Department of Internal Medicine

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2018 Infection and immunity

38. Evolutionary stability of antibiotic protection in a defensive symbiosis (PubMed)

Evolutionary stability of antibiotic protection in a defensive symbiosis The increasing resistance of human pathogens severely limits the efficacy of antibiotics in medicine, yet many animals, including solitary beewolf wasps, successfully engage in defensive alliances with antibiotic-producing bacteria for millions of years. Here, we report on the in situ production of 49 derivatives belonging to three antibiotic compound classes (45 piericidin derivatives, 3 streptochlorin derivatives

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2018 Proceedings of the National Academy of Sciences of the United States of America

39. NiO nanoparticles induce cytotoxicity mediated through ROS generation and impairing the antioxidant defense in the human lung epithelial cells (A549): Preventive effect of Pistacia lentiscus essential oil (PubMed)

NiO nanoparticles induce cytotoxicity mediated through ROS generation and impairing the antioxidant defense in the human lung epithelial cells (A549): Preventive effect of Pistacia lentiscus essential oil Nickel oxide nanoparticles (NiO NPs) have attracted increasing attention owing to potential capacity to penetrate to several human cell systems and exert a toxic effect. Elsewhere, the use of medicinal plants today is the form of the most widespread medicine worldwide. Utilizing aromatic

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2018 Toxicology reports

40. STAT1 gain-of-function compromises skin host defense in the context of interferon-γ signaling. (PubMed)

STAT1 gain-of-function compromises skin host defense in the context of interferon-γ signaling. 30576757 2019 02 04 1097-6825 2018 Dec 18 The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling. S0091-6749(18)32731-3 10.1016/j.jaci.2018.11.033 Niehues Hanna H Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands (...) . Rösler Berenice B Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. van der Krieken Danique A DA Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. van Vlijmen-Willems Ivonne M J J IMJJ Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Rodijk

2018 Journal of Allergy and Clinical Immunology

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