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Defensive Medicine

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181. Notice. Medical Defense Full Text available with Trip Pro

Notice. Medical Defense 18734994 2008 08 29 2008 11 20 0093-402X 8 7 1910 Jul California state journal of medicine Cal State J Med Notice. Medical Defense. 249-50 Kenyon C G CG Jones P M PM eng Journal Article United States Cal State J Med 0414327 0093-402X 1910 7 1 0 0 1910 7 1 0 1 1910 7 1 0 0 ppublish 18734994 PMC1893447

1910 California state journal of medicine

182. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18734976 2008 08 29 2008 11 20 0093-402X 8 7 1910 Jul California state journal of medicine Cal State J Med MEDICAL DEFENSE. 217-8 eng Journal Article United States Cal State J Med 0414327 0093-402X 1910 7 1 0 0 1910 7 1 0 1 1910 7 1 0 0 ppublish 18734976 PMC1893469

1910 California state journal of medicine

183. Medical Defense Full Text available with Trip Pro

Medical Defense 18735388 2008 08 29 2008 11 20 0093-402X 9 10 1911 Oct California state journal of medicine Cal State J Med Medical Defense. 446 Carey H B HB eng Journal Article United States Cal State J Med 0414327 0093-402X 1911 10 1 0 0 1911 10 1 0 1 1911 10 1 0 0 ppublish 18735388 PMC1894037

1911 California state journal of medicine

184. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18735452 2008 08 29 2008 11 20 0093-402X 10 1 1912 Jan California state journal of medicine Cal State J Med MEDICAL DEFENSE. 4 eng Journal Article United States Cal State J Med 0414327 0093-402X 1912 1 1 0 0 1912 1 1 0 1 1912 1 1 0 0 ppublish 18735452 PMC1893951

1912 California state journal of medicine

185. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18735465 2008 08 29 2008 11 20 0093-402X 10 2 1912 Feb California state journal of medicine Cal State J Med MEDICAL DEFENSE. 48 eng Journal Article United States Cal State J Med 0414327 0093-402X 1912 2 1 0 0 1912 2 1 0 1 1912 2 1 0 0 ppublish 18735465 PMC1894118

1912 California state journal of medicine

186. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18735474 2008 08 29 2008 11 20 0093-402X 10 2 1912 Feb California state journal of medicine Cal State J Med MEDICAL DEFENSE. 52-3 Jones P M PM Kenyon C G CG eng Journal Article United States Cal State J Med 0414327 0093-402X 1912 2 1 0 0 1912 2 1 0 1 1912 2 1 0 0 ppublish 18735474 PMC1894132

1912 California state journal of medicine

187. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18735756 2008 08 29 2008 11 20 0093-402X 10 12 1912 Dec California state journal of medicine Cal State J Med MEDICAL DEFENSE. 492 eng Journal Article United States Cal State J Med 0414327 0093-402X 1912 12 1 0 0 1912 12 1 0 1 1912 12 1 0 0 ppublish 18735756 PMC1894547

1912 California state journal of medicine

188. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18735759 2008 08 29 2008 11 20 0093-402X 10 12 1912 Dec California state journal of medicine Cal State J Med MEDICAL DEFENSE. 493 Hatch W F WF eng Journal Article United States Cal State J Med 0414327 0093-402X 1912 12 1 0 0 1912 12 1 0 1 1912 12 1 0 0 ppublish 18735759 PMC1894564

1912 California state journal of medicine

189. OUR MEDICAL DEFENSE Full Text available with Trip Pro

OUR MEDICAL DEFENSE 18735797 2008 08 29 2008 11 20 0093-402X 11 1 1913 Jan California state journal of medicine Cal State J Med OUR MEDICAL DEFENSE. 37 Enloe N T NT eng Journal Article United States Cal State J Med 0414327 0093-402X 1913 1 1 0 0 1913 1 1 0 1 1913 1 1 0 0 ppublish 18735797 PMC1640151

1913 California state journal of medicine

190. MEDICAL DEFENSE NOTES Full Text available with Trip Pro

MEDICAL DEFENSE NOTES 18735871 2008 08 29 2008 11 20 0093-402X 11 3 1913 Mar California state journal of medicine Cal State J Med MEDICAL DEFENSE NOTES. 97 eng Journal Article United States Cal State J Med 0414327 0093-402X 1913 3 1 0 0 1913 3 1 0 1 1913 3 1 0 0 ppublish 18735871 PMC1640271

1913 California state journal of medicine

191. MEDICAL DEFENSE Full Text available with Trip Pro

MEDICAL DEFENSE 18736213 2008 08 29 2008 11 20 0093-402X 12 4 1914 Apr California state journal of medicine Cal State J Med MEDICAL DEFENSE. 130 eng Journal Article United States Cal State J Med 0414327 0093-402X 1914 4 1 0 0 1914 4 1 0 1 1914 4 1 0 0 ppublish 18736213 PMC1641058

1914 California state journal of medicine

192. IMPORTANT NOTICE!: New Medical Defense Rules Full Text available with Trip Pro

IMPORTANT NOTICE!: New Medical Defense Rules 18736482 2008 08 29 2008 11 20 0093-402X 13 1 1915 Jan California state journal of medicine Cal State J Med IMPORTANT NOTICE!: New Medical Defense Rules. 3-4 eng Journal Article United States Cal State J Med 0414327 0093-402X 1915 1 1 0 0 1915 1 1 0 1 1915 1 1 0 0 ppublish 18736482 PMC1641430

1915 California state journal of medicine

193. MEDICAL DEFENSE RESULTS Full Text available with Trip Pro

MEDICAL DEFENSE RESULTS 18736499 2008 08 29 2008 11 20 0093-402X 13 2 1915 Feb California state journal of medicine Cal State J Med MEDICAL DEFENSE RESULTS. 45 eng Journal Article United States Cal State J Med 0414327 0093-402X 1915 2 1 0 0 1915 2 1 0 1 1915 2 1 0 0 ppublish 18736499 PMC1641462

1915 California state journal of medicine

194. MEDICAL DEFENSE DISCUSSION Full Text available with Trip Pro

MEDICAL DEFENSE DISCUSSION 18736557 2008 08 29 2008 11 20 0093-402X 13 4 1915 Apr California state journal of medicine Cal State J Med MEDICAL DEFENSE DISCUSSION. 131-4 eng Journal Article United States Cal State J Med 0414327 0093-402X 1915 4 1 0 0 1915 4 1 0 1 1915 4 1 0 0 ppublish 18736557 PMC1641556

1915 California state journal of medicine

195. OPINIONS REGARDING MEDICAL DEFENSE RULES Full Text available with Trip Pro

OPINIONS REGARDING MEDICAL DEFENSE RULES 18736539 2008 08 29 2008 11 20 0093-402X 13 3 1915 Mar California state journal of medicine Cal State J Med OPINIONS REGARDING MEDICAL DEFENSE RULES. 87-8 eng Journal Article United States Cal State J Med 0414327 0093-402X 1915 3 1 0 0 1915 3 1 0 1 1915 3 1 0 0 ppublish 18736539 PMC1641526

1915 California state journal of medicine

196. Genome survey sequencing for the characterization of genetic background of Dracaena cambodiana and its defense response during dragon's blood formation. Full Text available with Trip Pro

Genome survey sequencing for the characterization of genetic background of Dracaena cambodiana and its defense response during dragon's blood formation. Dragon's blood collected from the genus Dracaena is used as a renowned traditional medicine in various cultures worldwide. However, the genetics of the genus Dracaena and the formation mechanism of dragon's blood remain poorly understood. Here, we generate the first draft genome reference assembly of an elite Chinese Dracaena species, Dracaena

2018 PLoS ONE

197. Trade-offs between growth, reproduction and defense in response to resource availability manipulations. Full Text available with Trip Pro

Trade-offs between growth, reproduction and defense in response to resource availability manipulations. The Brazilian Cerrado is one of the most endangered biomes in the world. We evaluated the sustainability of leaf harvest in one of the most important Cerrado tree species, Stryphnodendron adstringens. The bark of this tree is used as a source of medicinal tannin. Harvesting bark, however, often kills the tree. In a manipulative field experiment, we tested the hypothesis that harvesting leaves (...) , which might serve as an alternative source of tannin, would be less detrimental for tree survival, growth, reproduction, and defense than harvesting bark. In a two-way crossed experimental design, we either clipped 100% of a plant's leaves or applied NPK fertilizer to the soil. Our predictions of the experimental outcomes were based on plant resource and defense theory. Growth was determined by total leaf dry mass production, reproduction by inflorescence and fruit production traits, and defense

2018 PLoS ONE

198. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models. Full Text available with Trip Pro

Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models. MiRNA molecules are important post-transcriptional regulators of gene expression in the brain function. Altered miRNA profiles could represent a defensive response against the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (AD). Endogenous miRNAs have lower toxic effects than other gene silencing methods, thus enhancing the expression of defensive miRNA (...) could be an effective therapy. However, little is known about the potential of targeting miRNAs for the treatment of AD. Here, we examined the function of the miR-200 family (miR-200a, -141, -429, -200b, -200c), identified using miRNA microarray analysis of cortical tissue from Tg2576 transgenic mice. In murine primary neurons, we found that upregulation of miR-200b or -200c was induced by the addition of amyloid beta (Aβ). Neurons transfected with miR-200b or -200c reduced secretion of Aβ

2018 PLoS ONE

199. Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont Full Text available with Trip Pro

metabolites, which are small-molecule organic compounds produced by living organisms, provide or inspire drugs for many different diseases. These natural products have evolved over millions of years to provide a survival benefit to the producing organism and often display potent biological activity with important therapeutic applications. For instance, defensive compounds in the environment may be cytotoxic to eukaryotic cells, a property exploitable for cancer treatment. Here, we describe the genome (...) Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont A symbiotic lifestyle frequently results in genome reduction in bacteria; the isolation of small populations promotes genetic drift and the fixation of deletions and deleterious mutations over time. Transitions in lifestyle, including host restriction or adaptation to an intracellular habitat, are thought to precipitate a wave of sequence degradation events and consequent proliferation of pseudogenes. We

2017 mSystems

200. Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians. Full Text available with Trip Pro

Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians. The American College of Physicians developed this guidance statement to guide clinicians in selecting targets for pharmacologic treatment of type 2 diabetes.The National Guideline Clearinghouse and the Guidelines International Network library were searched (May 2017) for national guidelines, published (...) , and the U.S. Department of Veterans Affairs and Department of Defense. The AGREE II (Appraisal of Guidelines for Research and Evaluation II) instrument was used to evaluate the guidelines.Clinicians should personalize goals for glycemic control in patients with type 2 diabetes on the basis of a discussion of benefits and harms of pharmacotherapy, patients' preferences, patients' general health and life expectancy, treatment burden, and costs of care.Clinicians should aim to achieve an HbA1c level between

2018 Annals of Internal Medicine

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