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Deep Vein Thrombosis of the Upper Extremity

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181. Oestrogen deficiency symptoms in postmenopausal women: conjugated oestrogens and bazedoxifene acetate

adverse events experienced by women in the conjugated oestrogens and bazedoxifene 0.45 mg/20 mg group were nasopharyngitis (18.0%), headache (13.3%), back pain (9.7%) and pain in extremity (8.1%). Oestrogen deficiency symptoms in postmenopausal women: conjugated oestrogens and bazedoxifene acetate (ES3) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 31Oestrogen therapy can increase the risk of endometrial

2017 National Institute for Health and Clinical Excellence - Advice

183. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

SGastro oesophagal reflux Urinary incontinence Osteoarthritis Varicose veins Increased peripheral steroid interconversion in adipose tissue Hormone-dependent cancers (breast, uterus) Male hypogonadism Influence on polycystic ovarian syndrome or PCOS (infertility, hirsutism) Others Psychological morbidity / psychosocial impact (low self-esteem, body image disorder, depression, social isolation and stigmatisation) Socioeconomic disadvantage (lower income, un-employment, less likely to be promoted (...) and lifestyle modifications, there is increasing interest in performing MBS in adolescents with severe or morbid obesity, especially in those at very high risk or those with associated co- morbidities like hypertension, diabetes and non-alcoholic steatohepatitis (NASH), as well as in those with extreme BMI values, who cannot be managed successfully otherwise. A particular medical challenge constitute children and adolescents with monogenic traits causing morbid or super- obesity. Psychopathology and social

2019 Belgian Health Care Knowledge Centre

184. ESC/EACTS Guidelines on Myocardial Revascularization Full Text available with Trip Pro

for saphenous vein graft lesions 125 13.4 Repeat percutaneous coronary intervention 125 13.4.1 Restenosis 125 13.4.2 Disease progression 126 13.4.3 Stent thrombosis 126 14 Arrhythmias 127 14.1 Ventricular arrhythmias 127 14.1.1 Revascularization for the prevention of sudden cardiac death in patients with stable coronary artery disease and reduced left ventricular function 127 14.1.2 Revascularization for the treatment of electrical storm 128 14.1.3 Revascularization after out-of-hospital cardiac arrest 128 (...) harvesting 130 15.1.5 Saphenous vein harvesting 130 15.1.6 Construction of central anastomosis 131 15.1.7 Intraoperative quality control 131 15.1.8 On-pump and off-pump procedures 131 15.1.9 Minimally invasive and hybrid procedures 131 15.2 Reporting perioperative outcomes 131 15.3 Gaps in the evidence 131 16 Procedural aspects of percutaneous coronary intervention 133 16.1 Percutaneous coronary intervention devices 133 16.1.1 Balloon angioplasty 133 16.1.2 Choice of coronary stents 133 16.1.3

2018 European Society of Cardiology

185. DVT

contact us via jon.brassey@tripdatabase.com Top results for dvt 1. DVT prevention for travellers DVT prevention for travellers - NICE CKS Clinical Knowledge Summaries Share DVT prevention for travellers - Summary Deep vein thrombosis ( DVT ) can occur as a result of long distance travel. The risk of travel-related DVT in healthy people is extremely low, and increases with the duration of travel — the risk has been reported as 1 event per 4656 flights lasting over 4 hours, increasing to 1 event per (...) venous thrombosis ( DVT ) is clotting of blood in a deep vein of an extremity (usually calf or thigh) or the pelvis. DVT is the primary cause of pulmonary embolism. DVT results from conditions that impair venous return, lead to endothelial injury or dysfunction, or cause hypercoagulability. DVT may be asymptomatic or cause pain and swelling in an extremity; pulmonary embolism is an immediate 2013 14. Systematic review: A low Wells score and a negative D-dimer was not safe in patients with cancer

2018 Trip Latest and Greatest

186. ESC/ESH Management of Arterial Hypertension Full Text available with Trip Pro

8.17 Hypertension and vascular disease3088 8.17.1 Carotid atherosclerosis3088 8.17.2 Arteriosclerosis and increased arterial stiffness3088 8.17.3 Lower extremity arterial disease3089 8.18 Hypertension in valvular disease and aortopathy3089 8.18.1 Coarctation of the aorta3089 8.18.2 Prevention of aortic dilation and dissection in high-risk subjects3089 8.18.3 Hypertension bicuspid aortic valve-related aortopathy3089 8.19 Hypertension and sexual dysfunction3089 8.20 Hypertension and cancer (...) Rosuvastatin LDH Lactate dehydrogenase LDL-C LDL cholesterol LEAD Lower extremity artery disease LIFE Losartan Intervention For Endpoint reduction in hypertension LV Left ventricular LVH Left ventricular hypertrophy MAP Mean arterial pressure MI Myocardial infarction MR Magnetic resonance MRA Mineralocorticoid receptor antagonist MRI Magnetic resonance imaging MUCH Masked uncontrolled hypertension NORDIL Nordic Diltiazem NS Non-significant NT-proBNP N-terminal pro-B natriuretic peptide o.d. Omni die (every

2018 European Society of Cardiology

188. Inotersen sodium (Tegsedi) - Amyloidosis

filtration rate ELISA Enzyme-linked immunosorbent assay EOT End of treatment ERG Electroretinogram FAC Familial amyloid cardiomyopathy FAP Familial amyloid polyneuropathy FAS Full Analysis Set GLS Global longitudinal strain hATTR Hereditary transthyretin amyloidosis hATTR-CM Hereditary transthyretin amyloidosis with cardiomyopathy hATTR-PN Hereditary transthyretin amyloidosis with polyneuropathy HED Human equivalent dose HRDB Heart rate to deep breathing I max Maximum inhibitory effect IVS (...) Upper limit of normal 3’-UTR 3’-untranslated region V30M Val30Met Assessment report EMA/411876/2018 Page 6/142 V ss /F Steady state apparent volume of distribution wtATTR Wild-type transthyretin amyloidosis +7 SUM 7 Test Assessment report EMA/411876/2018 Page 7/142 1. Background information on the procedure 1.1. Submission of the dossier The applicant IONIS USA Ltd submitted on 3 November 2017 an application for marketing authorisation to the European Medicines Agency (EMA) for Tegsedi, through

2018 European Medicines Agency - EPARs

190. Guidelines for Gender Affirming Healthcare for Gender Diverse and Transgender Children, Young People and Adults in Aotearoa New Zealan

, transgender people experience the same health needs as other patients. Those who have not undergone surgical removal of their breasts, cervix, uterus, ovaries, prostate or testicles remain at risk of cancer in these organs and should undergo screening as recommended for these cancers. It is important to be aware that this needs to be managed carefully by primary care health teams, as many gender diverse people find cancer screening extremely challenging, both physically and emotionally. For cervical

2018 New Zealand Sexual Health Society

191. Benign Prostatic Hyperplasia: Surgical Management of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms

, cerebrovascular disease, deep vein thrombosis) that necessitate anticoagulation or antiplatelet therapy, use of TURP or OSP can present significant clinical challenges or in some cases may be contraindicated. In addition, known complications associated with TURP and open prostatectomy, such as intraoperative and perioperative bleeding requiring transfusion, urethral stricture, bladder neck contracture, stress urinary incontinence, erectile dysfunction (ED), and retrograde ejaculation (RE), can negatively (...) strong observational studies with consistent findings), Grade B (RCTs with some weaknesses of procedure or generalizability or moderately strong observational studies with consistent findings), or Grade C (RCTs with serious deficiencies of procedure or generalizability or extremely small sample sizes or observational studies that are inconsistent, have small sample sizes, or have other problems that potentially confound interpretation of data). By definition, Grade A evidence is evidence about which

2019 American Urological Association

192. Management of Stroke Rehabilitation

for or against early supported discharge. Neither for nor against Reviewed, Amended Motor Therapy Upper and Lower Limbs Rehabilitation 5. We recommend task-specific practice (also known as task- oriented practice or repetitive task practice) for improving upper and lower extremity motor function, gait, posture, and activities of daily living. Strong for Reviewed, New-replaced 6. We recommend cardiovascular exercise to increase maximum walking speed after stroke. Strong for Reviewed, New-replaced 7. We (...) , and the wrist. Weak for Reviewed, Amended 10. There is insufficient evidence to recommend for or against mirror therapy for improvements in limb function. Neither for nor against Reviewed, Amended Technology-Assisted Physical Rehabilitation 11. We suggest offering functional electrical stimulation, neuromuscular electrical stimulation, or transcutaneous electrical nerve stimulation as an adjunctive treatment to improve upper and lower extremity motor function. Weak for Reviewed, New-replaced 12. We suggest

2019 VA/DoD Clinical Practice Guidelines

193. Updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension Full Text available with Trip Pro

evaluation and AVT, the latter especially in the gray zone of forecast uncertainty. Red frames indicate likely inoperable. Green frames indicate operability (pursue complete shunt closure). Of note: This algorithm does not cover the difficult treatment of children and young adults with isolated or predominantly post-capillary PH because of post-capillary obstructive lesions, for example, in the setting of pulmonary vein stenosis, mitral stenosis or other small left-sided structures ( Supplementary Table (...) treatment of children and young adults with isolated or predominantly post-capillary PH because of post-capillary obstructive lesions, for example, in the setting of pulmonary vein stenosis, mitral stenosis or other small left-sided structures ( Supplementary Table S8 online), or cardiomyopathy with elevated left ventricular end-diastolic filling pressures. AVT, acute vasoreactivity testing; ASD, atrial septal defect; CHD, congenital heart disease; iNO, inhaled nitric oxide; PAH, pulmonary arterial

2019 International Society for Heart and Lung Transplantation

194. Pharmacological Management of Osteoporosis in Postmenopausal Women Full Text available with Trip Pro

have completed a course of teriparatide or abaloparatide, we recommend treatment with antiresorptive osteoporosis therapies to maintain bone density gains. (1|⊕⊕OO) Selective estrogen receptor modulators 5.1. In postmenopausal women with osteoporosis at high risk of fracture and with the patient characteristics below, we recommend raloxifene or bazedoxifene to reduce the risk of vertebral fractures. (1|⊕⊕⊕⊕) Patient characteristics: With a low risk of deep vein thrombosis and for whom (...) bisphosphonates or denosumab are not appropriate, or with a high risk of breast cancer. Menopausal hormone therapy and tibolone 6.1 In postmenopausal women at high risk of fracture and with the patient characteristics below, we suggest menopausal hormone therapy, using estrogen only in women with hysterectomy, to prevent all types of fractures. (2|⊕⊕⊕O) Patient characteristics: Under 60 years of age or <10 years past menopause; at low risk of deep vein thrombosis; those in whom bisphosphonates or denosumab

2019 The Endocrine Society

195. Global Vascular Guidelines for patients with chronic limb-threatening ischemia Full Text available with Trip Pro

trunk. CFA, Common femoral artery; CTO, chronic total occlusion; DFA, deep femoral artery; Pop, popliteal; SFA, superficial femoral artery. ---- | ---- Fig 5.3 Infrapopliteal (IP) disease grading in Global Limb Anatomic Staging System (GLASS). AT, Anterior tibial; CTO, chronic total occlusion; TP, tibioperoneal. ---- | ---- Fig 5.4 Representative angiograms of Global Limb Anatomic Staging System (GLASS) stage I disease patterns. The target arterial path (TAP) is outlined in yellow . Left panel , TAP (...) (EBR) in the treatment of chronic limb-threatening ischemia (CLTI). Patient risk, Limb severity, and ANatomic stage are integrated in the PLAN approach. WIfI, Wound, Ischemia, and foot Infection. ---- | ---- Fig 6.2 PLAN framework of clinical decision-making in chronic limb-threatening ischemia (CLTI); infrainguinal disease. Refer to Fig 6.4 for preferred revascularization strategy in standard-risk patients with available vein conduit, based on limb stage at presentation and anatomic complexity

2019 Society for Vascular Surgery

196. Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions—Part I: Review of Anticoagulation Agents and Clinical Considerations Full Text available with Trip Pro

be verified. Other tests include the thrombin time test, fibrinogen assay, and D-dimer assay. D-dimers are produced by the action of plasmin (fibrinolytic system) on a cross-linked fibrin clot and are often used to diagnose disseminated intravascular coagulation (DIC) or to aid in ruling out acute thrombosis. Various coagulopathies, the use of anticoagulant medications, or liver disease can be associated with abnormalities of the results of these routine coagulation tests ( Table 1 ). Therefore (...) , or IX deficiency Normal ↑ Normal Normal Normal Normal Without history of bleeding: lupus anticoagulant, factor XII deficiency ↑ ↑ ↓ ↑ ↑ ↓ Acute disseminated intravascular coagulation Normal Normal Normal ↑ Normal Normal Acute thrombosis (nonspecific) INR = International Normalized Ratio; PT = prothrombin time; PTT = partial thromboplastin time. There are several classes of anticoagulant medications, such as low molecular weight heparin (LMWH) and most direct oral anticoagulants (DOACs), that may

2019 Society of Interventional Radiology

197. Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions—Part II: Recommendations. Full Text available with Trip Pro

–898 ) (3) . Venous Thrombosis Risk Predicting VTE-related risk is challenging, and there are several factors to consider. First, the acuity of the clot is important, as most recurrence and embolization occur within 30 days of clot formation, with rate of clot recurrence decreasing after 3 months from the initial event ( x 14 Kearon, C. Natural history of venous thromboembolism. Circulation . 2003 ; 107 : I22–I30 ) (14) . Clot type and location are also important to consider. A deep vein thrombosis (...) (DVT) carries a higher risk of complications than a superficial vein clot, and a proximal lower-extremity DVT (ie, popliteal vein or more proximal vein) puts the patient at a higher risk for recurrence than a distal lower-extremity DVT (ie, calf) or an upper-extremity DVT. Most pulmonary emboli also carry a high risk of recurrence and complications, but the treatment of subsegmental pulmonary embolism should be considered on a per-case basis ( x 15 Douketis, J.D., Spyropoulos, A.C., Spencer, F.A

2019 Society of Interventional Radiology

198. Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults Full Text available with Trip Pro

grafts. AV access thrombosis Blood clot obstructing the AV access; indicates loss of anatomic, haemodynamic and clinical patency. AV fistula Surgically created autogenous vascular access used for chronic haemodialysis consisting of an anastomosis between an artery and a vein, with the vein serving as the accessible conduit (synonym: native AV fistula). AV graft Surgically created vascular access used for chronic haemodialysis, whereby an artificial or biological prosthetic segment is used to connect (...) recommendations intended to optimize patient care, which are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options (synonym: guideline). Maturation Process leading to a newly created AV access being usable for haemodialysis; it encompasses enlargement and thickening of the draining fistula vein, increases in the blood flow and absence of thrombosis and bleeding as mechanisms of AV access failure (synonym: suitability for dialysis). Recommendations

2019 European Renal Best Practice

199. Benign Prostatic Hyperplasia: Surgical Management of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms

, cerebrovascular disease, deep vein thrombosis) that necessitate anticoagulation or antiplatelet therapy, use of TURP or OSP can present significant clinical challenges or in some cases may be contraindicated. In addition, known complications associated with TURP and open prostatectomy, such as intraoperative and perioperative bleeding requiring transfusion, urethral stricture, bladder neck contracture, stress urinary incontinence, erectile dysfunction (ED), and retrograde ejaculation (RE), can negatively (...) with some weaknesses of procedure or generalizability or moderately strong observational studies with consistent findings), or Grade C (RCTs with serious deficiencies of procedure or generalizability or extremely small sample sizes or observational studies that are inconsistent, have small sample sizes, or have other problems that potentially confound interpretation of data). By definition, Grade A evidence is evidence about which the Panel has a high level of certainty, Grade B evidence is evidence

2019 American Urological Association

200. Pediatric Endoscopy and High-risk Patients: A Clinical Report From the NASPGHAN Endoscopy Committee

bleeding from the procedure and thromboembolic events from medication discontinuation in decid- ing to proceed with or to defer a procedure (42). Although the generalizability of these guidelines to children has not been rigor- ously examined, it seems reasonable that elective procedures may be deferred for patients on time-limited chronic anticoagulation, such as treatment for a deep vein thrombosis, until treatment is completed. Furthermore, anticoagulation should be stopped (...) and guidance regarding periprocedural antibiotics are also discussed. Key Words: adverse events, bleeding, endoscopy, pediatric (JPGN 2019;68: 595–606) P ediatric gastrointestinal (GI) endoscopy is a well-established and integral approach to the diagnosis and management of digestive disorders in children. Published data from the Pediatric Clinical Outcomes Research Initiative (PEDS-CORI) suggest the overall rate of complications during upper GI procedures is 2.3%, including a specific risk of respiratory

2019 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

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