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Deep Vein Thrombosis Probability

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1. Graduated compression stockings for prevention of deep vein thrombosis. Full Text available with Trip Pro

Graduated compression stockings for prevention of deep vein thrombosis. Hospitalised patients are at increased risk of developing deep vein thrombosis (DVT) in the lower limb and pelvic veins, on a background of prolonged immobilisation associated with their medical or surgical illness. Patients with DVT are at increased risk of developing a pulmonary embolism (PE). The use of graduated compression stockings (GCS) in hospitalised patients has been proposed to decrease the risk of DVT (...) . This is an update of a Cochrane Review first published in 2000, and last updated in 2014.To evaluate the effectiveness and safety of graduated compression stockings in preventing deep vein thrombosis in various groups of hospitalised patients.For this review the Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), and trials registries on 21 March 2017; and the Cochrane Vascular Specialised Register, CENTRAL

2018 Cochrane

2. Suspected Upper-Extremity Deep Vein Thrombosis.

-403. 5. Mustafa S, Stein PD, Patel KC, Otten TR, Holmes R, Silbergleit A. Upper extremity deep venous thrombosis. Chest. 2003;123(6):1953-1956. 6. Patel MC, Berman LH, Moss HA, McPherson SJ. Subclavian and internal jugular veins at Doppler US: abnormal cardiac pulsatility and respiratory phasicity as a predictor of complete central occlusion. Radiology. 1999;211(2):579-583. 7. Schmittling ZC, McLafferty RB, Bohannon WT, Ramsey DE, Hodgson KJ. Characterization and probability of upper extremity (...) Suspected Upper-Extremity Deep Vein Thrombosis. Date of origin: 1995 Last review date: 2014 ACR Appropriateness Criteria ® 1 Upper Extremity Swelling American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Upper Extremity Swelling Radiologic Procedure Rating Comments RRL* US duplex Doppler upper extremity 9 This procedure is standard for arm veins. Other modalities are required for evaluating central veins. O X-ray chest 8 This procedure is a simple evaluation of lines

2019 American College of Radiology

3. Blood and Clots Series: How can I tell whether this patient has a deep vein thrombosis?

with increasing pain and edema in his left leg. In a recent hospital admission he was diagnosed with myeloma. This case reviews pretest probability of deep vein thrombosis, D-dimer and interpretation of compression ultrasound. Main Text Last week when I came onto a day shift I was handed over a patient who was waiting for an ultrasound scan. He was a 65 year old man who presented at midnight to the emergency department, 6 days after being discharged from hospital. He was diagnosed with multiple myeloma during (...) . There was no tenderness in the distribution of the deep calf veins although he was tender in the medial mid-thigh. There were no other signs of deep vein thrombosis (DVT). Clinical probability estimation No diagnostic test is either 100% sensitive or 100% specific. As physicians, we can’t diagnose or exclude a condition without considering the results within the clinical context of our individual patient. This is Bayes theorem, which uses the pretest probability of a condition to calculate the probability

2018 CandiEM

4. Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolism

Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolism Edo Edoxaban for treating and for pre xaban for treating and for prev venting enting deep v deep vein thrombosis and pulmonary ein thrombosis and pulmonary embolism embolism T echnology appraisal guidance Published: 26 August 2015 nice.org.uk/guidance/ta354 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our (...) , to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Deep vein thrombosis, pulmonary embolism (treatment, secondary prevention) - edoxaban tosylate (TA354) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions

2015 National Institute for Health and Clinical Excellence - Technology Appraisals

5. Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism

. The probability of Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism (TA327) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 15 of 48CTEPH in the model was taken from a study by Pengo et al. Although post-thrombotic syndrome was not reported in the trials, its incidence in the model was assumed to be the same for all comparators (based on data from a study (...) at a later date a 50-year rather than 60-year time horizon use of the ERG network meta-analysis for probability of VTE events and probability of bleeding Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism (TA327) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 21 of 48assuming a constant proportion of VTE event types across treatments assuming a constant

2015 National Institute for Health and Clinical Excellence - Technology Appraisals

6. Diagnosis and management of iliofemoral deep vein thrombosis: clinical practice guideline

Diagnosis and management of iliofemoral deep vein thrombosis: clinical practice guideline Guidelines CMAJ ©2015 8872147 Canada Inc. or its licensors CMAJ 1 CME V enous thromboembolism, presenting as deep vein thrombosis (DVT) or pul- monary embolism, affects over 35 000 Canadians each year. 1 It is associated with substantial morbidity, mortality and burden on the Canadian health care system, with one- month mortality rates estimated at 6% for DVT and 12% for pulmonary embolism. 1 Iliofemoral (...) Association clinical practice method- ology 17 (Box 1) to classify the recommenda- tions and levels of evidence and translated these to the corresponding GRADE strengths of rec- ommendations and confidence in effect esti - mates (Box 2). 17–20 We applied the Appraisal of Guidelines for Research and Evaluation (AGREE II) appraisal tools for clinical practice guidelines. 21,22 Diagnosis and management of iliofemoral deep vein thrombosis: clinical practice guideline David Liu MD, Erica Peterson MD MSc, James

2015 CPG Infobase

7. Deep Vein Thrombosis: Diagnosis

of DVT presence [see Deep Vein Thrombosis (DVT): Treatment guide]. The accurate exclusion of DVT also eliminates unnecessary exposure to anticoagulants, associated with inconvenience and risk of bleeding. DIAGNOSIS: The diagnosis of DVT is based on: 1) Pre-test probability (clinical suspicion) There are several formal risk models available to assess the pre-test probability of DVT. The Wells Score is the most widely used (see Table 1). Physicians can also use their clinical gestalt to determine pre (...) -test probability. The accuracy of this type of intuitive approach, however, is dependent on physician experience. Use of a structured score is encouraged. TABLE 1: TWO-LEVEL WELLS SCORE FOR DVT DIAGNOSIS CLINICAL FINDINGS POINTS Paralysis, paresis or recent orthopedic casting of lower extremity 1 Bedridden >3 days recently or major surgery within past 12 weeks 1 Localized tenderness of the deep veins 1 © 2016 Thrombosis Canada Page 2 of 6 Swelling of entire leg 1 Calf swelling 3 cm greater than

2016 Thrombosis Interest Group of Canada

8. Deep vein thrombosis

16 years onwards. Management of suspected DVT How should I manage suspected deep vein thrombosis? Refer immediately for same-day assessment and management, if deep vein thrombosis (DVT) is suspected in a woman who is pregnant or has given birth within the past 6 weeks. For all other people with suspected DVT, use the two-level DVT Wells score to assess the probability of a DVT. Score one point for each of the following: Active cancer (treatment ongoing, within the last 6 months, or palliative (...) mandates further testing. A negative D-dimer test is good enough to exclude the diagnosis of DVT in people with an unlikely pre-test clinical probability, but it is not good enough to exclude the diagnosis of DVT in those with a likely pre-test probability. Follow up for DVT How should I follow up a person with confirmed deep vein thrombosis? Provided there are no contraindications (such as pregnancy or cancer), people who have been diagnosed with deep vein thrombosis (DVT) will require maintenance

2018 NICE Clinical Knowledge Summaries

9. Deep Vein Thrombosis Probability

Deep Vein Thrombosis Probability Deep Vein Thrombosis Probability Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Deep Vein Thrombosis (...) Probability Deep Vein Thrombosis Probability Aka: Deep Vein Thrombosis Probability , DVT Probability , Wells Clinical Prediction Rule for DVT II. Indications Assess DVT Pretest Probability III. Criteria Active malignancy within last six months: 1 point Lower extremity immobility: 1 point Cast Paralysis Restricted mobility within last 4 weeks: 1 point Bedridden for more than 3 days Major surgery Localized pain over deep venous course: 1 point Calf circumference 3 cm over opposite calf: 1 point Measure 10

2018 FP Notebook

10. Probability of developing proximal deep-vein thrombosis and/or pulmonary embolism after distal deep-vein thrombosis. (Abstract)

Probability of developing proximal deep-vein thrombosis and/or pulmonary embolism after distal deep-vein thrombosis. Isolated distal deep-vein thrombosis (DDVT) of the lower extremities can be associated with subsequent proximal deep-vein thrombosis (PDVT) and/or acute pulmonary embolism (PE). We aimed to develop a model predicting the probability of developing PDVT and/or PE within three months after an isolated episode of DDVT. We conducted a retrospective cohort study of patients (...) with symptomatic DDVT confirmed by lower extremity vein ultrasounds between 2001-2012 in the Cleveland Clinic Health System. We reviewed all the ultrasounds, chest ventilation/perfusion and computed tomography scans ordered within three months after the initial DDVT to determine the incidence of PDVT and/or PE. A multiple logistic regression model was built to predict the rate of developing these complications. The final model included 450 patients with isolated DDVT. Within three months, 30 (7 %) patients

2015 Thrombosis and haemostasis

11. Early mobilization versus bed rest for deep vein thrombosis. Full Text available with Trip Pro

a summary of findings table following the GRADE approach. We concluded early ambulation is probably effective in reducing deep vein thrombosis progression and improving limb pain, and might not increase the risk of thromboembolism. (...) Early mobilization versus bed rest for deep vein thrombosis. Aiming to prevent thromboembolic events, bed rest was historically considered in the management of patient with deep vein thrombosis. Nevertheless early ambulation could have beneficial effects. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified seven systematic reviews including 10 randomized trials answering this question. We combined the evidence using meta-analysis and generated

2017 Medwave

12. The use of age-related D-dimers to rule out deep vein thrombosis

in patients with low clinical probability without the need for ultrasound scanning. References Schouten HJ, Koek HL, Oudega R et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ 2012, Vol. 344:e2985 Douma RA, Tan M, Schutgens REG et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can (...) The use of age-related D-dimers to rule out deep vein thrombosis BestBets: The use of age-related D-dimers to rule out deep vein thrombosis The use of age-related D-dimers to rule out deep vein thrombosis Report By: Catherine Taylor - Medical Student Search checked by Laith Sultan - Consultant in Emergency Medicine Institution: University of Manchester, University Hospital South Manchester, Manchester, UK Date Submitted: 17th August 2014 Date Completed: 26th August 2015 Last Modified: 26th

2015 BestBETS

13. Cost-Effectiveness of Pharmacomechanical Catheter-Directed Thrombolysis Versus Standard Anticoagulation in Patients With Proximal Deep Vein Thrombosis: Results From the ATTRACT Trial. (Abstract)

Cost-Effectiveness of Pharmacomechanical Catheter-Directed Thrombolysis Versus Standard Anticoagulation in Patients With Proximal Deep Vein Thrombosis: Results From the ATTRACT Trial. In patients with acute deep vein thrombosis (DVT), pharmacomechanical catheter-directed thrombolysis (PCDT) in conjunction with anticoagulation therapy is increasingly used with the goal of preventing postthrombotic syndrome. Long-term costs and cost-effectiveness of these 2 treatment strategies from (...) the perspective of the US healthcare system have not been compared.Between 2009 and 2014, the ATTRACT trial (Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis) randomized 692 patients with acute proximal DVT to PCDT plus anticoagulation (n=337) or standard treatment with anticoagulation alone (n=355). Costs (2017 US dollars) were assessed over a 24-month follow-up period using a combination of resource-based costing, hospital bills, Medicare reimbursement rates

2019 Circulation. Cardiovascular quality and outcomes

14. Proximal and isolated distal deep vein thrombosis and Wells score accuracy in hospitalized patients. (Abstract)

Proximal and isolated distal deep vein thrombosis and Wells score accuracy in hospitalized patients. Deep vein thrombosis (DVT) is an important cause of morbidity and mortality in hospitalized patients. The Wells score for DVT pretest probability (PTP) was validated in outpatients, but its utility for inpatients is unclear. The aim of this study was to establish the prevalence of inpatient proximal and distal DVT and the Wells score performance in inpatients. A single-center cross-sectional

2019 Internal and emergency medicine

15. Changing Patterns of Anticoagulation After Total Hip Arthroplasty in the United States: Frequency of Deep Vein Thrombosis, Pulmonary Embolism, and Complications With Rivaroxaban and Warfarin. (Abstract)

THA were followed for use of anticoagulants after surgery. Logistic regression models were used to compare differences in deep vein thrombosis (DVT), pulmonary embolism (PE), and adverse events, within 90 days after THA, among warfarin and rivaroxaban users. Inverse probability treatment weighting was used to account for selection bias.There were 12,876 users of warfarin and 10,892 users of rivaroxaban in commercially insured (CI) patients, and 7416 warfarin users and 4739 rivaroxaban users (...) Changing Patterns of Anticoagulation After Total Hip Arthroplasty in the United States: Frequency of Deep Vein Thrombosis, Pulmonary Embolism, and Complications With Rivaroxaban and Warfarin. This study evaluated the trends in anticoagulation use after total hip arthroplasty (THA), and the effectiveness and safety of rivaroxaban compared to warfarin.This retrospective database analysis used healthcare claims from the Truven Health MarketScan database (2010-2015). Patients undergoing elective

2019 Journal of Arthroplasty

16. Deep vein thrombosis: update on diagnosis and management. (Abstract)

Deep vein thrombosis: update on diagnosis and management. Diagnosis of deep vein thrombosis (DVT) requires a multifaceted approach that includes clinical assessment, evaluation of pre-test probability, and objective diagnostic testing. Common symptoms and signs of DVT are pain, swelling, erythema and dilated veins in the affected limb. The pre-test probability of DVT can be assessed using a clinical decision rule that stratifies DVT into "unlikely" or "likely". If DVT is "unlikely", refer for D

2019 Medical Journal of Australia

17. Assessment of the Probability of Post-thrombotic Syndrome in Patients with Lower Extremity Deep Venous Thrombosis Full Text available with Trip Pro

Assessment of the Probability of Post-thrombotic Syndrome in Patients with Lower Extremity Deep Venous Thrombosis This study was performed to assess the probability of post-thrombotic syndrome (PTS) after treatment of lower extremity deep venous thrombosis (LEDVT). Patients with LEDVT undergoing their first treatments in Nanjing First Hospital from January 2013 to December 2014 were enrolled in this study (156 patients were enrolled in the training cohort, and 135 patients were enrolled (...) in the validation cohort). 51 and 45 patients developed PTS in the two cohorts, respectively. Independent risk factors for PTS were investigated in the training cohort, and these independent risk factors were employed to develop the APTSD scoring system with which to predict the probability of PTS. Four independent risk factors for PTS were identified: iliac vein compression syndrome, residual iliac-femoral vein thrombosis, residual femoral-popliteal vein thrombosis and insufficient anticoagulation. Patients

2018 Scientific reports

18. Primary Upper Limb Deep Vein Thrombosis. Is First Rib Resection Necessary?

Primary Upper Limb Deep Vein Thrombosis. Is First Rib Resection Necessary? Primary Upper Limb Deep Vein Thrombosis. Is First Rib Resection Necessary? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Primary (...) Upper Limb Deep Vein Thrombosis. Is First Rib Resection Necessary? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03547921 Recruitment Status : Not yet recruiting First Posted : June 6, 2018 Last Update Posted : June 6

2018 Clinical Trials

19. Validation of the STA-Liatest DDi assay for exclusion of proximal deep vein thrombosis according to the latest Clinical and Laboratory Standards Institute/Food and Drug Administration guideline: results of a multicenter management study Full Text available with Trip Pro

Validation of the STA-Liatest DDi assay for exclusion of proximal deep vein thrombosis according to the latest Clinical and Laboratory Standards Institute/Food and Drug Administration guideline: results of a multicenter management study : Recommended strategy for venous thromboembolism (VTE) diagnosis includes the use of sensitive D-dimer (DDi) assays along with pretest probability (PTP) assessment. The Clinical and Laboratory Standards Institute (CLSI) recently issued a guideline (US FDA (...) endorsed) on DDi in VTE exclusion. Such guideline specifies the ideal D-dimer assay characteristics and target population. Demonstrate STA-LiatestD-Di performance combined with a PTP score for proximal deep vein thrombosis (pDVT) exclusion in a CLSI compliant study. International, multicenter, prospective nonrandomized, noninterventional clinical outcome management study conducted in a standard-of-care setting. DDi was measured in DVT-suspected consecutive low/moderate PTP outpatients, without

2018 Blood Coagulation & Fibrinolysis

20. Incidence of deep vein thrombosis before and after total knee arthroplasty without pharmacologic prophylaxis: a 128-row multidetector CT indirect venography study. Full Text available with Trip Pro

Incidence of deep vein thrombosis before and after total knee arthroplasty without pharmacologic prophylaxis: a 128-row multidetector CT indirect venography study. We sought to document the incidences of deep vein thrombosis (DVT) before and after total knee arthroplasty (TKA). In addition, we aimed to explor whether routine preoperative DVT evaluation was useful to establish DVT treatment strategies after TKA. Finally, we wanted to evaluate whether the incidences of DVT differed between (...) DVTs were distal in nature and asymptomatic. After TKA, newly developed thrombi were evident in various calf veins, without propagation of any pre-existing thrombi. Postoperatively, the overall incidences of DVT were 69.9% per patient and 58.5% per knee. The DVT incidences were 66% per patient and 69.8% per knee in the unilateral TKA group. In contrast, the incidences were 72% per patient and 55.5% per knee in the staged bilateral TKA group. There was one case of symptomatic distal (unilateral TKA

2018 BMC Musculoskeletal Disorders

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